G12-G13 in Cellular Signaling

No Pathway Network information available for G12-G13 in Cellular Signaling

Pathways in the G12-G13 in Cellular Signaling SuperPath

#	Name	Source	Genes
1	G12-G13 in Cellular Signaling	QIAGEN	AKT1 AKT2 AKT3 APC ARHGAP1 ARHGAP4 ARHGAP5 ARHGDIB ARHGDIG ARHGEF1 AXIN1 BTK CDC42 CDH1 CDH10 CDH11 CDH12 CDH13 CDH15 CDH16 CDH17 CDH18 CDH19 CDH2 CDH20 CDH22 CDH23 CDH24 CDH26 CDH3 CDH4 CDH5 CDH6 CDH7 CDH8 CDH9 CHN1 CHN2 CHUK CTNNB1 DCHS1 DVL1 ELK1 F2 F2RL2 F2RL3 FZD1 FZD10 FZD2 FZD3 FZD4 FZD5 FZD6 FZD7 FZD8 FZD9 GNA12 GNA13 GSK3B HRAS IKBKB IKBKE IKBKG JUN KRAS LPAR1 LPAR2 LPAR3 MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7 MAP3K5 MAPK1 MAPK12 MAPK3 MAPK6 MAPK7 MAPK8 MEF2A MEF2C MEF2D MRAS MYL9 NFKB1 NFKBIA NFKBIB NFKBIE NRAS PDPK1 PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PTK2 PTK2B PXN RAC1 RAC2 RAC3 RAF1 RASA1 RHOA ROCK1 ROCK2 RRAS RRAS2 SLC9A1 SLC9A2 SLC9A3 SRC TBXA2R TEC VAV1 VAV2 VAV3 WNT1 WNT2 WNT3 (see all 123) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
2	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	1
3	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	1
4	APC	APC Regulator Of Wnt Signaling Pathway	Protein Coding	1
5	RHOA	Ras Homolog Family Member A	Protein Coding	1
6	ARHGAP1	Rho GTPase Activating Protein 1	Protein Coding	1
7	ARHGAP4	Rho GTPase Activating Protein 4	Protein Coding	1
8	ARHGAP5	Rho GTPase Activating Protein 5	Protein Coding	1
9	ARHGDIB	Rho GDP Dissociation Inhibitor Beta	Protein Coding	1
10	ARHGDIG	Rho GDP Dissociation Inhibitor Gamma	Protein Coding	1
11	ARHGEF1	Rho Guanine Nucleotide Exchange Factor 1	Protein Coding	1
12	AXIN1	Axin 1	Protein Coding	1
13	BTK	Bruton Tyrosine Kinase	Protein Coding	1
14	CDC42	Cell Division Cycle 42	Protein Coding	1
15	CDH1	Cadherin 1	Protein Coding	1
16	CDH10	Cadherin 10	Protein Coding	1
17	CDH11	Cadherin 11	Protein Coding	1
18	CDH12	Cadherin 12	Protein Coding	1
19	CDH13	Cadherin 13	Protein Coding	1
20	CDH15	Cadherin 15	Protein Coding	1
21	CDH16	Cadherin 16	Protein Coding	1
22	CDH17	Cadherin 17	Protein Coding	1
23	CDH18	Cadherin 18	Protein Coding	1
24	CDH19	Cadherin 19	Protein Coding	1
25	CDH2	Cadherin 2	Protein Coding	1
26	CDH20	Cadherin 20	Protein Coding	1
27	CDH22	Cadherin 22	Protein Coding	1
28	CDH23	Cadherin Related 23	Protein Coding	1
29	CDH24	Cadherin 24	Protein Coding	1
30	CDH26	Cadherin 26	Protein Coding	1
31	CDH3	Cadherin 3	Protein Coding	1
32	CDH4	Cadherin 4	Protein Coding	1
33	CDH5	Cadherin 5	Protein Coding	1
34	CDH6	Cadherin 6	Protein Coding	1
35	CDH7	Cadherin 7	Protein Coding	1
36	CDH8	Cadherin 8	Protein Coding	1
37	CDH9	Cadherin 9	Protein Coding	1
38	CHN1	Chimerin 1	Protein Coding	1
39	CHN2	Chimerin 2	Protein Coding	1
40	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	1
41	CTNNB1	Catenin Beta 1	Protein Coding	1
42	DVL1	Dishevelled Segment Polarity Protein 1	Protein Coding	1
43	LPAR1	Lysophosphatidic Acid Receptor 1	Protein Coding	1
44	LPAR2	Lysophosphatidic Acid Receptor 2	Protein Coding	1
45	LPAR3	Lysophosphatidic Acid Receptor 3	Protein Coding	1
46	ELK1	ETS Transcription Factor ELK1	Protein Coding	1
47	F2	Coagulation Factor II, Thrombin	Protein Coding	1
48	F2RL2	Coagulation Factor II Thrombin Receptor Like 2	Protein Coding	1
49	F2RL3	F2R Like Thrombin Or Trypsin Receptor 3	Protein Coding	1
50	FZD1	Frizzled Class Receptor 1	Protein Coding	1
51	FZD10	Frizzled Class Receptor 10	Protein Coding	1
52	FZD2	Frizzled Class Receptor 2	Protein Coding	1
53	FZD3	Frizzled Class Receptor 3	Protein Coding	1
54	FZD4	Frizzled Class Receptor 4	Protein Coding	1
55	FZD5	Frizzled Class Receptor 5	Protein Coding	1
56	FZD6	Frizzled Class Receptor 6	Protein Coding	1
57	FZD7	Frizzled Class Receptor 7	Protein Coding	1
58	FZD8	Frizzled Class Receptor 8	Protein Coding	1
59	FZD9	Frizzled Class Receptor 9	Protein Coding	1
60	GNA12	G Protein Subunit Alpha 12	Protein Coding	1
61	GNA13	G Protein Subunit Alpha 13	Protein Coding	1
62	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
63	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	1
64	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	1
65	IKBKE	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Epsilon	Protein Coding	1
66	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	1
67	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
68	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	1
69	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	1
70	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	1
71	MAP2K3	Mitogen-Activated Protein Kinase Kinase 3	Protein Coding	1
72	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	1
73	MAP2K5	Mitogen-Activated Protein Kinase Kinase 5	Protein Coding	1
74	MAP2K6	Mitogen-Activated Protein Kinase Kinase 6	Protein Coding	1
75	MAP2K7	Mitogen-Activated Protein Kinase Kinase 7	Protein Coding	1
76	MAP3K5	Mitogen-Activated Protein Kinase Kinase Kinase 5	Protein Coding	1
77	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
78	MAPK12	Mitogen-Activated Protein Kinase 12	Protein Coding	1
79	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
80	MAPK6	Mitogen-Activated Protein Kinase 6	Protein Coding	1
81	MAPK7	Mitogen-Activated Protein Kinase 7	Protein Coding	1
82	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
83	MEF2A	Myocyte Enhancer Factor 2A	Protein Coding	1
84	MEF2C	Myocyte Enhancer Factor 2C	Protein Coding	1
85	MEF2D	Myocyte Enhancer Factor 2D	Protein Coding	1
86	MRAS	Muscle RAS Oncogene Homolog	Protein Coding	1
87	MYL9	Myosin Light Chain 9	Protein Coding	1
88	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
89	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	1
90	NFKBIB	NFKB Inhibitor Beta	Protein Coding	1
91	NFKBIE	NFKB Inhibitor Epsilon	Protein Coding	1
92	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	1
93	PIK3R5	Phosphoinositide-3-Kinase Regulatory Subunit 5	Protein Coding	1
94	DCHS1	Dachsous Cadherin-Related 1	Protein Coding	1
95	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	1
96	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
97	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	1
98	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	1
99	PIK3R4	Phosphoinositide-3-Kinase Regulatory Subunit 4	Protein Coding	1
100	PTK2	Protein Tyrosine Kinase 2	Protein Coding	1
101	PTK2B	Protein Tyrosine Kinase 2 Beta	Protein Coding	1
102	PXN	Paxillin	Protein Coding	1
103	RAC1	Rac Family Small GTPase 1	Protein Coding	1
104	RAC2	Rac Family Small GTPase 2	Protein Coding	1
105	RAC3	Rac Family Small GTPase 3	Protein Coding	1
106	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
107	RASA1	RAS P21 Protein Activator 1	Protein Coding	1
108	ROCK1	Rho Associated Coiled-Coil Containing Protein Kinase 1	Protein Coding	1
109	ROCK2	Rho Associated Coiled-Coil Containing Protein Kinase 2	Protein Coding	1
110	RRAS	RAS Related	Protein Coding	1
111	RRAS2	RAS Related 2	Protein Coding	1
112	SLC9A1	Solute Carrier Family 9 Member A1	Protein Coding	1
113	SLC9A2	Solute Carrier Family 9 Member A2	Protein Coding	1
114	SLC9A3	Solute Carrier Family 9 Member A3	Protein Coding	1
115	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
116	TBXA2R	Thromboxane A2 Receptor	Protein Coding	1
117	TEC	Tec Protein Tyrosine Kinase	Protein Coding	1
118	VAV1	Vav Guanine Nucleotide Exchange Factor 1	Protein Coding	1
119	VAV2	Vav Guanine Nucleotide Exchange Factor 2	Protein Coding	1
120	VAV3	Vav Guanine Nucleotide Exchange Factor 3	Protein Coding	1
121	WNT1	Wnt Family Member 1	Protein Coding	1
122	WNT2	Wnt Family Member 2	Protein Coding	1
123	WNT3	Wnt Family Member 3	Protein Coding	1

Disorders associated with G12-G13 in Cellular Signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Noonan syndrome 1	Enrichment	HRAS, KRAS, MAP2K1, MAP2K2, MRAS, NRAS, RAF1, RRAS, RRAS2	10.97
2	Rasopathy	Enrichment	HRAS, KRAS, MAP2K1, MAP2K2, MRAS, NRAS, RAF1, RRAS2	10.43
3	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, KRAS, MAP2K1, MAP2K2, NRAS, RAF1	8.64
4	Colorectal cancer	Enrichment	AKT1, APC, CDH1, CTNNB1, FZD3, NRAS, PIK3R1, SRC	5.93
5	Lung non-small cell carcinoma	Enrichment	HRAS, KRAS, MAP2K1, NRAS	5.69
6	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	5.54
7	Cardiofaciocutaneous syndrome 1	Enrichment	KRAS, MAP2K1, MAP2K2	5.54
8	Cardiofaciocutaneous syndrome	Enrichment	KRAS, MAP2K1, MAP2K2	5.54
9	Robinow syndrome, autosomal dominant 2	Enrichment	CHN1, DVL1, FZD2	5.14
10	Nevus, epidermal	Enrichment	HRAS, KRAS, NRAS	4.61
11	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, MAP2K1, RASA1	4.61
12	Noonan syndrome 3	Enrichment	HRAS, KRAS, RAF1	4.61
13	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, NRAS, RAF1	4.40
14	Arteriovenous malformation	Enrichment	HRAS, MAP2K1, RASA1	4.23
15	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	4.09
16	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG, NFKBIA	4.09
17	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, MAP2K1, RASA1	4.08
18	Juvenile myelomonocytic leukemia	Enrichment	KRAS, NRAS, RRAS	3.82
19	Desmoid disease, hereditary	Enrichment	APC, CTNNB1	3.61
20	Langerhans cell histiocytosis	Enrichment	MAP2K1, NRAS	3.61
21	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	3.61
22	Desmoid tumor	Enrichment	APC, CTNNB1	3.61
23	Ovarian cancer	Enrichment	AKT1, APC, CDH1, CTNNB1, KRAS, RRAS2	3.51
24	Diffuse gastric and lobular breast cancer syndrome	Enrichment	CDH1, KRAS	3.32
25	Robinow syndrome, autosomal dominant 1	Enrichment	DVL1, FZD2	3.32
26	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3, PIK3R2	3.32
27	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3, PIK3R2	3.32
28	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	3.32
29	Craniopharyngioma	Enrichment	APC, CTNNB1	3.32
30	Autosomal dominant robinow syndrome	Enrichment	DVL1, FZD2	3.32
31	Breast cancer	Enrichment	AKT1, APC, CDH1, JUN, KRAS	3.23
32	Hereditary breast carcinoma	Enrichment	AKT1, APC, CDH1, KRAS	3.18
33	Exudative vitreoretinopathy 1	Enrichment	CTNNB1, FZD4	3.10
34	Robinow syndrome, autosomal recessive 1	Enrichment	DVL1, FZD2	3.10
35	Hepatocellular carcinoma	Enrichment	APC, AXIN1, CTNNB1	3.01
36	Autosomal recessive robinow syndrome	Enrichment	DVL1, FZD2	2.92
37	Breast adenocarcinoma	Enrichment	AKT1, KRAS	2.92
38	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS, NRAS	2.78
39	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	2.78
40	Gallbladder cancer	Enrichment	CTNNB1, KRAS	2.78
41	Pilomyxoid astrocytoma	Enrichment	KRAS, RAF1	2.78
42	Follicular thyroid carcinoma	Enrichment	HRAS, NRAS	2.78
43	Exudative vitreoretinopathy	Enrichment	CTNNB1, FZD4	2.66
44	Bladder cancer	Enrichment	CTNNB1, HRAS, KRAS	2.65
45	Differentiated thyroid carcinoma	Enrichment	HRAS, KRAS, NRAS	2.65
46	Non-immune hydrops fetalis	Enrichment	FZD6, HRAS, KRAS	2.57
47	Adult hepatocellular carcinoma	Enrichment	AXIN1, CTNNB1	2.55
48	Gastric cancer	Enrichment	APC, CDH1, KRAS	2.16
49	Osteoporosis	Enrichment	SRC, WNT1	2.16
50	Medulloblastoma	Enrichment	APC, CTNNB1	2.16
51	Proteus syndrome	Enrichment	AKT1	2.04
52	Nail disorder, nonsyndromic congenital, 1	Enrichment	FZD6	2.04
53	Cystic angiomatosis of bone, diffuse	Enrichment	RASA1	2.04
54	Ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome	Enrichment	CDH3	2.04
55	Elsahy-waters syndrome	Enrichment	CDH11	2.04
56	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.04
57	Oculoectodermal syndrome	Enrichment	KRAS	2.04
58	Incontinentia pigmenti	Enrichment	IKBKG	2.04
59	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	2.04
60	Noonan syndrome 5	Enrichment	RAF1	2.04
61	Immunodeficiency 73a with defective neutrophil chemotaxis and leukocytosis	Enrichment	RAC2	2.04
62	Intellectual developmental disorder, autosomal dominant 3	Enrichment	CDH15	2.04
63	Mitral valve prolapse 2	Enrichment	DCHS1	2.04
64	Melorheostosis, isolated	Enrichment	MAP2K1	2.04
65	Prothrombin deficiency, congenital	Enrichment	F2	2.04
66	Omodysplasia 2	Enrichment	FZD2	2.04
67	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.04
68	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.04
69	Lichtenstein-knorr syndrome	Enrichment	SLC9A1	2.04
70	Melanosis, neurocutaneous	Enrichment	NRAS	2.04
71	Caudal duplication anomaly	Enrichment	AXIN1	2.04
72	Noonan syndrome 6	Enrichment	NRAS	2.04
73	Fetal encasement syndrome	Enrichment	CHUK	2.04
74	Ataxia-oculomotor apraxia 3	Enrichment	PIK3R5	2.04
75	Transient erythroblastopenia of childhood	Enrichment	TEC	2.04
76	Immunodeficiency 62	Enrichment	ARHGEF1	2.04
77	Noonan syndrome 11	Enrichment	MRAS	2.04
78	Immunodeficiency 15b	Enrichment	IKBKB	2.04
79	Teebi hypertelorism syndrome 2	Enrichment	CDH11	2.04
80	Noonan syndrome 13	Enrichment	MAPK1	2.04
81	Immunodeficiency 15a	Enrichment	IKBKB	2.04
82	Neurodevelopmental disorder with structural brain anomalies and dysmorphic facies	Enrichment	RAC3	2.04
83	Short syndrome	Enrichment	PIK3R1	2.04
84	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	2.04
85	Bleeding disorder, platelet-type, 13	Enrichment	TBXA2R	2.04
86	Isolated growth hormone deficiency type iii	Enrichment	BTK	2.04
87	Agenesis of corpus callosum, cardiac, ocular, and genital syndrome	Enrichment	CDH2	2.04
88	Immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia	Enrichment	RAC2	2.04
89	Neurodevelopmental disorder with hypotonia, stereotypic hand movements, and impaired language	Enrichment	MEF2C	2.04
90	Bone mineral density quantitative trait locus 16	Enrichment	WNT1	2.04
91	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	2.04
92	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.04
93	Hypotrichosis	Enrichment	CDH3	2.04
94	Coronary artery disease, autosomal dominant, 1	Enrichment	MEF2A	2.04
95	Melorheostosis	Enrichment	MAP2K1	2.04
96	Arrhythmogenic right ventricular dysplasia, familial, 14	Enrichment	CDH2	2.04
97	Leopard syndrome 2	Enrichment	RAF1	2.04
98	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.04
99	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	2.04
100	Cowden syndrome 6	Enrichment	AKT1	2.04
101	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.04
102	Microphthalmia/coloboma 11	Enrichment	FZD5	2.04
103	Pregnancy loss, recurrent 2	Enrichment	F2	2.04
104	Thrombocytopenia 6	Enrichment	SRC	2.04
105	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.04
106	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.04
107	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.04
108	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.04
109	Immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia	Enrichment	RAC2	2.04
110	Trigonitis	Enrichment	RAF1	2.04
111	Craniometadiaphyseal osteosclerosis with hip dysplasia	Enrichment	AXIN1	2.04
112	Tsh producing pituitary tumor	Enrichment	CDH23	2.04
113	Attention deficit-hyperactivity disorder 8	Enrichment	CDH2	2.04
114	Adenoid ameloblastoma	Enrichment	CTNNB1	2.04
115	Capillary hemangioma	Enrichment	AKT3	2.04
116	Prothrombin deficiency	Enrichment	F2	2.04
117	Breast lobular carcinoma	Enrichment	CDH1	2.04
118	5q14.3 microdeletion syndrome	Enrichment	MEF2C	2.04
119	Congenital pulmonary airway malformation	Enrichment	KRAS	2.04
120	Familial adenomatous polyposis	Enrichment	APC	2.04
121	Gorham's disease	Enrichment	RASA1	2.04
122	Complete atrioventricular septal defect without ventricular hypoplasia	Enrichment	MEF2C	2.04
123	Infantile lad-like disease due to rac2 deficiency	Enrichment	RAC2	2.04
124	Reticular dysgenesis-like severe combined immunodeficiency	Enrichment	RAC2	2.04
125	Nocarh syndrome	Enrichment	CDC42	2.04
126	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.04
127	Bleeding diathesis due to thromboxane synthesis deficiency	Enrichment	TBXA2R	2.04
128	Gardner syndrome	Enrichment	APC	2.04
129	5q22 microdeletion syndrome	Enrichment	APC	2.04
130	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.04
131	Mef2c-related disorder	Enrichment	MEF2C	2.04
132	Attenuated familial adenomatous polyposis	Enrichment	APC	2.04
133	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.04
134	Rac2-related combined immunodeficiency-bronchiectasis-cancer-predisposing syndrome	Enrichment	RAC2	2.04
135	Neurocutaneous melanocytosis	Enrichment	NRAS	2.04
136	Microcystic stromal tumor	Enrichment	CTNNB1	2.04
137	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.04
138	Arteriovenous malformations of the brain	Enrichment	CDH2, KRAS	1.90
139	Hepatoblastoma	Enrichment	APC, CTNNB1	1.82
140	Blepharocheilodontic syndrome 1	Enrichment	CDH1	1.74
141	Mitral valve prolapse 1	Enrichment	DCHS1	1.74
142	Scoliosis, isolated 1	Enrichment	MAPK7	1.74
143	Costello syndrome	Enrichment	HRAS	1.74
144	Bladder exstrophy and epispadias complex	Enrichment	WNT3	1.74
145	Osteopathia striata with cranial sclerosis	Enrichment	CTNNB1	1.74
146	Van maldergem syndrome 1	Enrichment	DCHS1	1.74
147	Hypotrichosis, congenital, with juvenile macular dystrophy	Enrichment	CDH3	1.74
148	Immunodeficiency 33	Enrichment	IKBKG	1.74
149	Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2	Enrichment	PIK3R5	1.74
150	Isolated growth hormone deficiency, type iii, with agammaglobulinemia	Enrichment	BTK	1.74
151	Tetraamelia syndrome 1	Enrichment	WNT3	1.74
152	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	1.74
153	Osteogenesis imperfecta, type xv	Enrichment	WNT1	1.74
154	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	1.74
155	Duane retraction syndrome 2	Enrichment	CHN1	1.74
156	Robinow syndrome, autosomal dominant 3	Enrichment	FZD2	1.74
157	Deafness, autosomal recessive 84a	Enrichment	CDH23	1.74
158	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	1.74
159	Diarrhea 8, secretory sodium, congenital	Enrichment	SLC9A3	1.74
160	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	1.74
161	Agammaglobulinemia, x-linked	Enrichment	BTK	1.74
162	Noonan syndrome 12	Enrichment	RRAS2	1.74
163	Childhood hepatocellular carcinoma	Enrichment	CTNNB1	1.74
164	Combined saposin deficiency	Enrichment	CDH23	1.74
165	Senior-loken syndrome 7	Enrichment	AKT3	1.74
166	Periampullary adenoma	Enrichment	APC	1.74
167	Gastric adenocarcinoma and proximal polyposis of the stomach	Enrichment	APC	1.74
168	Immune system disease	Enrichment	CDC42	1.74
169	Bardet-biedl syndrome 16	Enrichment	AKT3	1.74
170	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	1.74
171	Combined psap deficiency	Enrichment	CDH23	1.74
172	Megacystis-microcolon-intestinal hypoperistalsis syndrome 4	Enrichment	MYL9	1.74
173	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	1.74
174	Teratoma	Enrichment	CTNNB1	1.74
175	Bladder exstrophy-epispadias-cloacal exstrophy complex	Enrichment	WNT3	1.74
176	Common variable immunodeficiency 12	Enrichment	NFKB1	1.74
177	Familial isolated pituitary adenoma	Enrichment	CDH23	1.74
178	Tafro syndrome	Enrichment	MAP2K2	1.74
179	Wooly hair nevus	Enrichment	HRAS	1.74
180	Hydrops fetalis, nonimmune	Enrichment	FZD6, HRAS	1.64
181	Diarrhea 3, secretory sodium, congenital, with or without other congenital anomalies	Enrichment	SLC9A3	1.57
182	Agammaglobulinemia 1, autosomal recessive	Enrichment	BTK	1.57
183	Osteoporosis, juvenile	Enrichment	WNT1	1.57
184	Nasopharyngeal carcinoma	Enrichment	NFKBIA	1.57
185	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3R1	1.57
186	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	1.57
187	Cenani-lenz syndactyly syndrome	Enrichment	APC	1.57
188	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	1.57
189	Anus, imperforate	Enrichment	CTNNB1	1.57
190	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	1.57
191	Agammaglobulinemia 1	Enrichment	BTK	1.57
192	Wieacker-wolff syndrome	Enrichment	RASA1	1.57
193	Nail disease	Enrichment	FZD6	1.57
194	Immunodeficiency 14	Enrichment	PIK3R1	1.57
195	Duane retraction syndrome	Enrichment	CHN1	1.57
196	Spermatocytoma	Enrichment	HRAS	1.57
197	Tetraamelia syndrome	Enrichment	WNT3	1.57
198	Colon adenocarcinoma	Enrichment	APC	1.57
199	Cerebral sinovenous thrombosis	Enrichment	F2	1.57
200	Apc-associated polyposis conditions	Enrichment	APC	1.57
201	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	1.45
202	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.45
203	Pilomatrixoma	Enrichment	CTNNB1	1.45
204	Pituitary adenoma 5, multiple types	Enrichment	CDH23	1.45
205	Alazami syndrome	Enrichment	CTNNB1	1.45
206	Lung sarcomatoid carcinoma	Enrichment	KRAS	1.45
207	Retinopathy of prematurity	Enrichment	FZD4	1.45
208	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42	1.45
209	Noonan syndrome with multiple lentigines	Enrichment	RAF1	1.45
210	Pilocytic astrocytoma	Enrichment	KRAS	1.45
211	Prolactinoma	Enrichment	CDH23	1.45
212	Epidermolytic nevus	Enrichment	HRAS	1.45
213	Eyelid coloboma	Enrichment	FZD5	1.45
214	Vacterl association	Enrichment	CDH13	1.45
215	Lens coloboma	Enrichment	FZD5	1.45
216	Capillary malformations, congenital	Enrichment	RASA1	1.35
217	Moebius syndrome	Enrichment	CHN1	1.35
218	Martsolf syndrome 1	Enrichment	ARHGAP5	1.35
219	Vater/vacterl association	Enrichment	CDH13	1.35
220	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	1.35
221	Norrie disease	Enrichment	FZD4	1.35
222	Familial adenomatous polyposis 1	Enrichment	APC	1.35
223	Persistent hyperplastic primary vitreous	Enrichment	FZD4	1.35
224	Hemimegalencephaly	Enrichment	AKT3	1.35
225	Coloboma of choroid and retina	Enrichment	FZD5	1.35
226	Leukemia, acute myeloid	Enrichment	KRAS, NRAS	1.29
227	Klippel-trenaunay-weber syndrome	Enrichment	RASA1	1.27
228	Coloboma of optic nerve	Enrichment	FZD5	1.27
229	Weyers acrofacial dysostosis	Enrichment	CTNNB1	1.27
230	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	RASA1	1.27
231	Hemihyperplasia, isolated	Enrichment	RHOA	1.27
232	Usher syndrome, type id	Enrichment	CDH23	1.27
233	Hemangioma, capillary infantile	Enrichment	RASA1	1.27
234	Deafness, autosomal recessive 12	Enrichment	CDH23	1.27
235	Basal cell carcinoma 1	Enrichment	RASA1	1.27
236	Adrenocortical carcinoma	Enrichment	CTNNB1	1.27
237	Lung squamous cell carcinoma	Enrichment	KRAS	1.27
238	Multicystic kidney dysplasia	Enrichment	FZD3	1.27
239	Syndromic rod-cone dystrophy	Enrichment	CDH23	1.27
240	Cleft lip with or without cleft palate	Enrichment	CDH1	1.27
241	Multicystic dysplastic kidney	Enrichment	FZD3	1.27
242	Meniere disease	Enrichment	CDH23	1.21
243	Thrombophilia due to thrombin defect	Enrichment	F2	1.21
244	Myelofibrosis	Enrichment	SRC	1.21
245	Coats disease	Enrichment	FZD4	1.21
246	Usher syndrome, type iia	Enrichment	CDH23	1.21
247	Hereditary hemorrhagic telangiectasia	Enrichment	RASA1	1.21
248	Megacolon	Enrichment	AKT3	1.21
249	Common variable immunodeficiency	Enrichment	NFKB1	1.21
250	Overgrowth syndrome	Enrichment	PIK3R1	1.21
251	Coronary heart disease 5	Enrichment	IKBKG	1.10
252	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.10
253	Primary hyperaldosteronism	Enrichment	CDH23	1.10
254	Colonic benign neoplasm	Enrichment	APC	1.10
255	Cowden syndrome	Enrichment	AKT1	1.10
256	Hypotrichosis simplex	Enrichment	CDH3	1.10
257	Cat eye syndrome	Enrichment	FZD5	1.06
258	Stroke, ischemic	Enrichment	F2	1.06
259	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.06
260	Polymicrogyria	Enrichment	AKT3	1.06
261	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.06
262	Myeloma, multiple	Enrichment	KRAS, PIK3R2	1.04
263	Usher syndrome type 2	Enrichment	CDH23	1.02
264	Specific learning disability	Enrichment	MAPK1	1.02
265	Meningioma	Enrichment	AKT1	0.98
266	Lip and oral cavity carcinoma	Enrichment	HRAS	0.98
267	Microphthalmia/coloboma 12	Enrichment	FZD5	0.95
268	Osteogenesis imperfecta, type iv	Enrichment	WNT1	0.95
269	Protein-deficiency anemia	Enrichment	NRAS	0.95
270	Lung cancer susceptibility 3	Enrichment	KRAS	0.92
271	Cleft lip/palate	Enrichment	CDH1	0.92
272	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	CDH2	0.92
273	Coloboma of macula	Enrichment	FZD5	0.89
274	Corpus callosum, agenesis of	Enrichment	CDH2	0.89
275	Osteogenesis imperfecta, type iii	Enrichment	WNT1	0.89
276	Usher syndrome, type i	Enrichment	CDH23	0.89
277	Hydrocephalus	Enrichment	FZD3	0.89
278	Lynch syndrome	Enrichment	KRAS	0.89
279	Isolated corpus callosum agenesis	Enrichment	CDH2	0.89
280	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CDH2	0.89
281	Rhabdomyosarcoma	Enrichment	HRAS	0.87
282	Gliosarcoma	Enrichment	NFKBIA	0.87
283	Polycystic liver disease	Enrichment	CTNNB1	0.84
284	Giant cell glioblastoma	Enrichment	NFKBIA	0.84
285	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1	0.84
286	Heart, malformation of	Enrichment	MAPK1	0.82
287	Diffuse large b-cell lymphoma	Enrichment	BTK	0.80
288	Endometrial cancer	Enrichment	CDH1	0.76
289	Brittle bone disorder	Enrichment	WNT1	0.72
290	Malaria	Enrichment	IKBKG	0.72
291	Ear malformation	Enrichment	CDH23	0.71
292	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	0.71
293	Pancreatic cancer	Enrichment	KRAS	0.69
294	Auditory neuropathy	Enrichment	CDH2	0.68
295	Prostate cancer	Enrichment	CDH1	0.63
296	Lung cancer	Enrichment	KRAS	0.60
297	Cystic fibrosis	Enrichment	SLC9A3	0.60
298	Usher syndrome	Enrichment	CDH23	0.59
299	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	0.59
300	Severe combined immunodeficiency	Enrichment	IKBKB	0.59
301	Autism spectrum disorder	Enrichment	MAP2K1, MEF2C	0.59
302	Left ventricular noncompaction	Enrichment	RAF1	0.56
303	Non-syndromic genetic deafness	Enrichment	CDH23	0.55
304	Cerebral palsy	Enrichment	F2	0.52
305	Microcephaly	Enrichment	CTNNB1, MAPK1	0.51
306	Type 2 diabetes mellitus	Enrichment	AKT2	0.50
307	Distal arthrogryposis	Enrichment	FZD3	0.50
308	Nonsyndromic hearing loss	Enrichment	CDH23	0.50
309	Inherited cancer-predisposing syndrome	Enrichment	APC, CDH1	0.47
310	Sensorineural hearing loss	Enrichment	CDH23	0.45
311	Thrombocytopenia	Enrichment	SRC	0.45
312	Autosomal dominant non-syndromic intellectual disability	Enrichment	CDH15	0.44
313	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.42
314	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS	0.40
315	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	MEF2C	0.39
316	Deafness, autosomal recessive	Enrichment	CDH23	0.36
317	Autosomal recessive nonsyndromic deafness	Enrichment	CDH23	0.35
318	Hereditary retinal dystrophy	Enrichment	CDH23, CDH3, FZD4	0.31
319	Fundus dystrophy	Enrichment	CDH23, CDH3, FZD4	0.31
320	Rare genetic deafness	Enrichment	CDH23	0.29
321	Dilated cardiomyopathy	Enrichment	RAF1	0.29
322	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	CDH23	0.25
323	Retinitis pigmentosa	Enrichment	CDH23, CDH3	0.24
324	Congenital nervous system abnormality	Enrichment	CTNNB1	0.21
325	Nervous system disease	Enrichment	CTNNB1	0.21
326	Complex neurodevelopmental disorder	Enrichment	RAC3	0.17

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

G12-G13 in Cellular Signaling

Pathway Network for G12-G13 in Cellular Signaling

Member Pathways for G12-G13 in Cellular Signaling

Pathways in the G12-G13 in Cellular Signaling SuperPath

Associated Genes for G12-G13 in Cellular Signaling

Associated Disorders for G12-G13 in Cellular Signaling

Disorders associated with G12-G13 in Cellular Signaling SuperPath

STRING Interaction Network for G12-G13 in Cellular Signaling

Sources for G12-G13 in Cellular Signaling