G13 signaling pathway

No Pathway Network information available for G13 signaling pathway

Pathways in the G13 signaling pathway SuperPath

#	Name	Source	Genes
1	G13 signaling pathway	WikiPathways	ARHGDIB ARHGDIG ARHGEF1 CALM1 CDC42 CFL1 CFL2 CIT CYFIP1 DIAPH1 GNA13 IQGAP1 IQGAP2 LIMK1 MAP3K4 MAPK10 MYBPH MYL1 PAK3 PFN1 PIK3CA PIK3CB PIK3CD PIK3R2 PIP4K2A PKN1 PPP1CB RAC1 RHOA RHPN2 ROCK1 ROCK2 RPS6KB1 RTKN SH3RF1 TNK2 WAS WASL (see all 38) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	LIMK1	LIM Domain Kinase 1	Protein Coding	1
2	CDC42	Cell Division Cycle 42	Protein Coding	1
3	ROCK2	Rho Associated Coiled-Coil Containing Protein Kinase 2	Protein Coding	1
4	WASL	WASP Like Actin Nucleation Promoting Factor	Protein Coding	1
5	IQGAP1	IQ Motif Containing GTPase Activating Protein 1	Protein Coding	1
6	RHPN2	Rhophilin Rho GTPase Binding Protein 2	Protein Coding	1
7	CALM1	Calmodulin 1	Protein Coding	1
8	WAS	WASP Actin Nucleation Promoting Factor	Protein Coding	1
9	RPS6KB1	Ribosomal Protein S6 Kinase B1	Protein Coding	1
10	ROCK1	Rho Associated Coiled-Coil Containing Protein Kinase 1	Protein Coding	1
11	RAC1	Rac Family Small GTPase 1	Protein Coding	1
12	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	1
13	PIP4K2A	Phosphatidylinositol-5-Phosphate 4-Kinase Type 2 Alpha	Protein Coding	1
14	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	1
15	PIK3CD	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta	Protein Coding	1
16	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	1
17	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
18	PFN1	Profilin 1	Protein Coding	1
19	PAK3	P21 (RAC1) Activated Kinase 3	Protein Coding	1
20	MYL1	Myosin Light Chain 1	Protein Coding	1
21	MAP3K4	Mitogen-Activated Protein Kinase Kinase Kinase 4	Protein Coding	1
22	ARHGDIB	Rho GDP Dissociation Inhibitor Beta	Protein Coding	1
23	RHOA	Ras Homolog Family Member A	Protein Coding	1
24	DIAPH1	Diaphanous Related Formin 1	Protein Coding	1
25	CIT	Citron Rho-Interacting Serine/Threonine Kinase	Protein Coding	1
26	IQGAP2	IQ Motif Containing GTPase Activating Protein 2	Protein Coding	1
27	CFL2	Cofilin 2	Protein Coding	1
28	CFL1	Cofilin 1	Protein Coding	1
29	GNA13	G Protein Subunit Alpha 13	Protein Coding	1
30	TNK2	Tyrosine Kinase Non Receptor 2	Protein Coding	1
31	ARHGEF1	Rho Guanine Nucleotide Exchange Factor 1	Protein Coding	1
32	RTKN	Rhotekin	Protein Coding	1
33	SH3RF1	SH3 Domain Containing Ring Finger 1	Protein Coding	1
34	PKN1	Protein Kinase N1	Protein Coding	1
35	PPP1CB	Protein Phosphatase 1 Catalytic Subunit Beta	Protein Coding	1
36	MYBPH	Myosin Binding Protein H	Protein Coding	1
37	ARHGDIG	Rho GDP Dissociation Inhibitor Gamma	Protein Coding	1
38	CYFIP1	Cytoplasmic FMR1 Interacting Protein 1	Protein Coding	1

Disorders associated with G13 signaling pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Immune system disease	Enrichment	CDC42, PIK3CD	5.12
2	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA, PIK3R2	4.34
3	Hemihyperplasia, isolated	Enrichment	PIK3CA, RHOA	3.94
4	Macrodactyly	Enrichment	PIK3CA	2.55
5	Thrombocytopenia 1	Enrichment	WAS	2.55
6	Intellectual developmental disorder, x-linked 30	Enrichment	PAK3	2.55
7	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.55
8	Deafness, autosomal dominant 1, with or without thrombocytopenia	Enrichment	DIAPH1	2.55
9	Cowden syndrome 5	Enrichment	PIK3CA	2.55
10	Amyotrophic lateral sclerosis 18	Enrichment	PFN1	2.55
11	Immunodeficiency 62	Enrichment	ARHGEF1	2.55
12	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.55
13	Nemaline myopathy 7	Enrichment	CFL2	2.55
14	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.55
15	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.55
16	Immunodeficiency 14b, autosomal recessive	Enrichment	PIK3CD	2.55
17	Was-related disorders	Enrichment	WAS	2.55
18	Seizures, cortical blindness, and microcephaly syndrome	Enrichment	DIAPH1	2.55
19	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.55
20	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.55
21	Noonan syndrome-like disorder with loose anagen hair 2	Enrichment	PPP1CB	2.55
22	Diaph1-related sensorineural hearing loss-thrombocytopenia syndrome	Enrichment	DIAPH1	2.55
23	Infantile-onset mesial temporal lobe epilepsy with severe cognitive regression	Enrichment	TNK2	2.55
24	Congenital myopathy 14	Enrichment	MYL1	2.55
25	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.55
26	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.55
27	Hypospadias	Enrichment	PIK3CA	2.55
28	Rare venous malformation	Enrichment	PIK3CA	2.55
29	Diaphragmatic eventration	Enrichment	PIK3CA	2.55
30	Nocarh syndrome	Enrichment	CDC42	2.55
31	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.55
32	Rare combined vascular malformation	Enrichment	PIK3CA	2.55
33	Cavernous lymphangioma	Enrichment	PIK3CA	2.55
34	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.55
35	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.55
36	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.55
37	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.55
38	Macrodactyly of toe	Enrichment	PIK3CA	2.55
39	Neutropenia, severe congenital, x-linked	Enrichment	WAS	2.25
40	Wiskott-aldrich syndrome	Enrichment	WAS	2.25
41	Ventricular tachycardia, catecholaminergic polymorphic, 4	Enrichment	CALM1	2.25
42	Keratosis, seborrheic	Enrichment	PIK3CA	2.25
43	Roifman-chitayat syndrome	Enrichment	PIK3CD	2.25
44	Noonan syndrome 8	Enrichment	PIK3CA	2.25
45	Long qt syndrome 14	Enrichment	CALM1	2.25
46	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.25
47	Noonan syndrome-like disorder with loose anagen hair	Enrichment	PPP1CB	2.25
48	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.25
49	B-lymphoblastic leukemia/lymphoma with hyperdiploidy	Enrichment	PIP4K2A	2.25
50	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.08
51	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA	2.08
52	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3CD	2.08
53	Immunodeficiency 14	Enrichment	PIK3CD	2.08
54	Microcephaly 17, primary, autosomal recessive	Enrichment	CIT	2.08
55	Keratoacanthoma	Enrichment	PIK3CA	2.08
56	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	PIK3R2	1.95
57	Cerebrovascular disease	Enrichment	PIK3CA	1.95
58	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42	1.95
59	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.95
60	Capillary malformations, congenital	Enrichment	PIK3CA	1.86
61	Hemimegalencephaly	Enrichment	PIK3CA	1.86
62	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.78
63	Cowden syndrome 1	Enrichment	PIK3CA	1.78
64	Moyamoya disease 1	Enrichment	DIAPH1	1.78
65	Pendred syndrome	Enrichment	DIAPH1	1.78
66	Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy	Enrichment	CALM1	1.78
67	Breast adenocarcinoma	Enrichment	PIK3CA	1.78
68	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.78
69	Typical nemaline myopathy	Enrichment	CFL2	1.78
70	Nevus, epidermal	Enrichment	PIK3CA	1.71
71	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	1.71
72	Gallbladder cancer	Enrichment	PIK3CA	1.71
73	Lennox-gastaut syndrome	Enrichment	MAPK10	1.65
74	Catecholaminergic polymorphic ventricular tachycardia 1	Enrichment	CALM1	1.65
75	Catecholaminergic polymorphic ventricular tachycardia	Enrichment	CALM1	1.65
76	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.60
77	Arteriovenous malformation	Enrichment	PIK3CA	1.60
78	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.60
79	Cowden syndrome	Enrichment	PIK3CA	1.60
80	Myopathy, x-linked, with excessive autophagy	Enrichment	PIK3CA	1.56
81	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3CD	1.56
82	Lung non-small cell carcinoma	Enrichment	PIK3CA	1.52
83	Meningioma	Enrichment	PIK3CA	1.48
84	Lip and oral cavity carcinoma	Enrichment	PIK3CA	1.48
85	Nk-cell enteropathy	Enrichment	PIK3CB	1.45
86	Lynch syndrome	Enrichment	PIK3CA	1.38
87	Microcephaly	Enrichment	DIAPH1, PAK3	1.33
88	Dandy-walker syndrome	Enrichment	PPP1CB	1.33
89	Parkinson's disease	Enrichment	TNK2	1.28
90	Williams-beuren syndrome	Enrichment	LIMK1	1.26
91	Endometrial cancer	Enrichment	PIK3CA	1.24
92	Centronuclear myopathy	Enrichment	CFL2	1.24
93	Hepatocellular carcinoma	Enrichment	PIK3CA	1.22
94	Noonan syndrome 1	Enrichment	PPP1CB	1.20
95	Rasopathy	Enrichment	PPP1CB	1.15
96	Auditory neuropathy	Enrichment	DIAPH1	1.15
97	Bladder cancer	Enrichment	PIK3CA	1.11
98	Prostate cancer	Enrichment	PIK3CA	1.11
99	Long qt syndrome 1	Enrichment	CALM1	1.09
100	Long qt syndrome	Enrichment	CALM1	1.08
101	Lung cancer	Enrichment	PIK3CA	1.07
102	Primary autosomal recessive microcephaly	Enrichment	CIT	1.07
103	Epilepsy	Enrichment	DIAPH1	0.97
104	Gastric cancer	Enrichment	PIK3CA	0.94
105	Hereditary breast carcinoma	Enrichment	PIK3CA	0.93
106	Thrombocytopenia	Enrichment	WAS	0.90
107	Hypertelorism	Enrichment	PIK3CA	0.87
108	Myeloma, multiple	Enrichment	PIK3R2	0.84
109	Undetermined early-onset epileptic encephalopathy	Enrichment	LIMK1	0.84
110	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	PFN1	0.82
111	Breast cancer	Enrichment	PIK3CA	0.72
112	Rare genetic deafness	Enrichment	DIAPH1	0.70
113	Colorectal cancer	Enrichment	PIK3CA	0.66
114	Ovarian cancer	Enrichment	PIK3CA	0.61
115	Complex neurodevelopmental disorder	Enrichment	PAK3	0.53

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

G13 signaling pathway

Pathway Network for G13 signaling pathway

Member Pathways for G13 signaling pathway

Pathways in the G13 signaling pathway SuperPath

Associated Genes for G13 signaling pathway

Associated Disorders for G13 signaling pathway

Disorders associated with G13 signaling pathway SuperPath

STRING Interaction Network for G13 signaling pathway

Sources for G13 signaling pathway