GABA B receptor activation

Pathway network for the GABA B receptor activation SuperPath

Sources:

Reactome

Pathways in the GABA B receptor activation SuperPath

#	Name	Source	Genes
1	GABA B receptor activation	Reactome	ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 GABBR1 GABBR2 GNAI1 GNAI2 GNAI3 GNAL GNAT3 GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 KCNJ10 KCNJ12 KCNJ15 KCNJ16 KCNJ2 KCNJ3 KCNJ4 KCNJ5 KCNJ6 KCNJ9 (see all 43) (see less)
2	GABA receptor activation	Reactome	ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ARHGEF9 GABBR1 GABBR2 GABRA1 GABRA2 GABRA3 GABRA4 GABRA5 GABRA6 GABRB1 GABRB2 GABRB3 GABRG2 GABRG3 GABRQ GABRR1 GABRR2 GABRR3 GNAI1 GNAI2 GNAI3 GNAL GNAT3 GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 KCNJ10 KCNJ12 KCNJ15 KCNJ16 KCNJ2 KCNJ3 KCNJ4 KCNJ5 KCNJ6 KCNJ9 NPTN (see all 60) (see less)
3	Activation of GABAB receptors	Reactome	ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 GABBR1 GABBR2 GNAI1 GNAI2 GNAI3 GNAL GNAT3 GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 KCNJ10 KCNJ12 KCNJ15 KCNJ16 KCNJ2 KCNJ3 KCNJ4 KCNJ5 KCNJ6 KCNJ9 (see all 43) (see less)
4	Adenylate cyclase inhibitory pathway	Reactome	ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 GNAI1 GNAI2 GNAI3 GNAL GNAT3 (see all 14) (see less)
5	Adenylate cyclase activating pathway	Reactome	ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 GNAL (see all 10) (see less)

Gene overlap in member pathways for GABA B receptor activation SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ADCY1	Adenylate Cyclase 1	Protein Coding	5
2	ADCY2	Adenylate Cyclase 2	Protein Coding	5
3	ADCY3	Adenylate Cyclase 3	Protein Coding	5
4	ADCY5	Adenylate Cyclase 5	Protein Coding	5
5	ADCY6	Adenylate Cyclase 6	Protein Coding	5
6	ADCY7	Adenylate Cyclase 7	Protein Coding	5
7	ADCY8	Adenylate Cyclase 8	Protein Coding	5
8	ADCY9	Adenylate Cyclase 9	Protein Coding	5
9	ADCY4	Adenylate Cyclase 4	Protein Coding	5
10	GNAL	G Protein Subunit Alpha L	Protein Coding	5
11	GNAI1	G Protein Subunit Alpha I1	Protein Coding	4
12	GNAI2	G Protein Subunit Alpha I2	Protein Coding	4
13	GNAI3	G Protein Subunit Alpha I3	Protein Coding	4
14	GNAT3	G Protein Subunit Alpha Transducin 3	Protein Coding	4
15	GNB5	G Protein Subunit Beta 5	Protein Coding	3
16	GABBR1	Gamma-Aminobutyric Acid Type B Receptor Subunit 1	Protein Coding	3
17	GNB1	G Protein Subunit Beta 1	Protein Coding	3
18	GNB2	G Protein Subunit Beta 2	Protein Coding	3
19	GNB3	G Protein Subunit Beta 3	Protein Coding	3
20	GNG3	G Protein Subunit Gamma 3	Protein Coding	3
21	GNG4	G Protein Subunit Gamma 4	Protein Coding	3
22	GNG5	G Protein Subunit Gamma 5	Protein Coding	3
23	GNG7	G Protein Subunit Gamma 7	Protein Coding	3
24	GNG10	G Protein Subunit Gamma 10	Protein Coding	3
25	GNG11	G Protein Subunit Gamma 11	Protein Coding	3
26	GNGT1	G Protein Subunit Gamma Transducin 1	Protein Coding	3
27	GNGT2	G Protein Subunit Gamma Transducin 2	Protein Coding	3
28	KCNJ2	Potassium Inwardly Rectifying Channel Subfamily J Member 2	Protein Coding	3
29	KCNJ3	Potassium Inwardly Rectifying Channel Subfamily J Member 3	Protein Coding	3
30	KCNJ4	Potassium Inwardly Rectifying Channel Subfamily J Member 4	Protein Coding	3
31	KCNJ5	Potassium Inwardly Rectifying Channel Subfamily J Member 5	Protein Coding	3
32	KCNJ6	Potassium Inwardly Rectifying Channel Subfamily J Member 6	Protein Coding	3
33	KCNJ9	Potassium Inwardly Rectifying Channel Subfamily J Member 9	Protein Coding	3
34	KCNJ10	Potassium Inwardly Rectifying Channel Subfamily J Member 10	Protein Coding	3
35	KCNJ12	Potassium Inwardly Rectifying Channel Subfamily J Member 12	Protein Coding	3
36	KCNJ15	Potassium Inwardly Rectifying Channel Subfamily J Member 15	Protein Coding	3
37	KCNJ16	Potassium Inwardly Rectifying Channel Subfamily J Member 16	Protein Coding	3
38	GNG13	G Protein Subunit Gamma 13	Protein Coding	3
39	GNG2	G Protein Subunit Gamma 2	Protein Coding	3
40	GNG12	G Protein Subunit Gamma 12	Protein Coding	3
41	GNB4	G Protein Subunit Beta 4	Protein Coding	3
42	GNG8	G Protein Subunit Gamma 8	Protein Coding	3
43	GABBR2	Gamma-Aminobutyric Acid Type B Receptor Subunit 2	Protein Coding	3
44	GABRR3	Gamma-Aminobutyric Acid Type A Receptor Subunit Rho3	Protein Coding	1
45	ARHGEF9	Cdc42 Guanine Nucleotide Exchange Factor 9	Protein Coding	1
46	GABRA1	Gamma-Aminobutyric Acid Type A Receptor Subunit Alpha1	Protein Coding	1
47	GABRA2	Gamma-Aminobutyric Acid Type A Receptor Subunit Alpha2	Protein Coding	1
48	GABRA3	Gamma-Aminobutyric Acid Type A Receptor Subunit Alpha3	Protein Coding	1
49	GABRA4	Gamma-Aminobutyric Acid Type A Receptor Subunit Alpha4	Protein Coding	1
50	GABRA5	Gamma-Aminobutyric Acid Type A Receptor Subunit Alpha5	Protein Coding	1
51	GABRA6	Gamma-Aminobutyric Acid Type A Receptor Subunit Alpha6	Protein Coding	1
52	GABRB1	Gamma-Aminobutyric Acid Type A Receptor Subunit Beta1	Protein Coding	1
53	GABRB2	Gamma-Aminobutyric Acid Type A Receptor Subunit Beta2	Protein Coding	1
54	GABRB3	Gamma-Aminobutyric Acid Type A Receptor Subunit Beta3	Protein Coding	1
55	GABRG2	Gamma-Aminobutyric Acid Type A Receptor Subunit Gamma2	Protein Coding	1
56	GABRG3	Gamma-Aminobutyric Acid Type A Receptor Subunit Gamma3	Protein Coding	1
57	GABRR1	Gamma-Aminobutyric Acid Type A Receptor Subunit Rho1	Protein Coding	1
58	GABRR2	Gamma-Aminobutyric Acid Type A Receptor Subunit Rho2	Protein Coding	1
59	NPTN	Neuroplastin	Protein Coding	1
60	GABRQ	Gamma-Aminobutyric Acid Type A Receptor Subunit Theta	Protein Coding	1

Disorders associated with GABA B receptor activation SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Childhood absence epilepsy	Enrichment	GABRA1, GABRB3, GABRG2	5.79
2	Undetermined early-onset epileptic encephalopathy	Enrichment	GABBR2, GABRA2, GABRA5, GABRB2, GABRG2	5.34
3	Andersen cardiodysrhythmic periodic paralysis	Enrichment	KCNJ2, KCNJ5	5.01
4	Familial atrial fibrillation	Enrichment	KCNJ2, KCNJ3, KCNJ5	4.24
5	Lennox-gastaut syndrome	Enrichment	GABRB3, GABRG2	3.28
6	Dyskinesia with orofacial involvement, autosomal dominant	Enrichment	ADCY5	3.13
7	Deafness, autosomal recessive 44	Enrichment	ADCY1	3.13
8	Neurodevelopmental disorder with hyperkinetic movements and dyskinesia	Enrichment	ADCY5	3.13
9	Dyskinesia with orofacial involvement, autosomal recessive	Enrichment	ADCY5	3.13
10	Dystonia 25	Enrichment	GNAL	3.13
11	Dravet syndrome	Enrichment	GABRA1, GABRG2	3.07
12	Ventricular tachycardia, familial	Enrichment	GNAI2	2.99
13	Neurodevelopmental disorder with hypotonia, impaired speech, and behavioral abnormalities	Enrichment	GNAI1	2.99
14	Lethal congenital contracture syndrome 8	Enrichment	ADCY6	2.83
15	Body mass index quantitative trait locus 19	Enrichment	ADCY3	2.83
16	Pituitary adenoma 4, acth-secreting	Enrichment	GNAI2	2.69
17	Hypopituitarism	Enrichment	GNAI2	2.69
18	Hypomyelination neuropathy-arthrogryposis syndrome	Enrichment	ADCY6	2.66
19	Chorea, benign hereditary	Enrichment	ADCY5	2.53
20	Long qt syndrome 13	Enrichment	KCNJ5	2.50
21	Short qt syndrome 3	Enrichment	KCNJ2	2.50
22	Neurodevelopmental disorder with hypotonia and dysmorphic facies	Enrichment	GNB2	2.50
23	Hypokalemic tubulopathy and deafness	Enrichment	KCNJ16	2.50
24	Neurodevelopmental disorder with poor language and loss of hand skills	Enrichment	GABBR2	2.50
25	Developmental and epileptic encephalopathy 59	Enrichment	GABBR2	2.50
26	Hyperaldosteronism, familial, type iii	Enrichment	KCNJ5	2.50
27	Seizures, sensorineural deafness, ataxia, impaired intellectual development, and electrolyte imbalance	Enrichment	KCNJ10	2.50
28	Lodder-merla syndrome, type 2, with developmental delay and with or without cardiac arrhythmia	Enrichment	GNB5	2.50
29	Charcot-marie-tooth disease, dominant intermediate f	Enrichment	GNB4	2.50
30	Atrial fibrillation, familial, 9	Enrichment	KCNJ2	2.50
31	Intellectual developmental disorder, autosomal dominant 42	Enrichment	GNB1	2.50
32	Sick sinus syndrome 4	Enrichment	GNB2	2.50
33	Neurodevelopmental disorder with language delay and variable cognitive abnormalities	Enrichment	GABBR1	2.50
34	Rare renal tubular disease	Enrichment	KCNJ10	2.50
35	Auriculocondylar syndrome 1	Enrichment	GNAI3	2.38
36	Achromatopsia 4	Enrichment	GNAI3	2.38
37	Developmental and epileptic encephalopathy 8	Enrichment	ARHGEF9	2.35
38	Febrile seizures, familial, 8	Enrichment	GABRG2	2.35
39	Epilepsy, idiopathic generalized 13	Enrichment	GABRA1	2.35
40	Developmental and epileptic encephalopathy 74	Enrichment	GABRG2	2.35
41	Developmental and epileptic encephalopathy 79	Enrichment	GABRA5	2.35
42	Epilepsy, x-linked 2, with or without impaired intellectual development and dysmorphic features	Enrichment	GABRA3	2.35
43	Developmental and epileptic encephalopathy 19	Enrichment	GABRA1	2.35
44	Epilepsy, childhood absence 5	Enrichment	GABRB3	2.35
45	Developmental and epileptic encephalopathy 92	Enrichment	GABRB2	2.35
46	Developmental and epileptic encephalopathy 43	Enrichment	GABRB3	2.35
47	Developmental and epileptic encephalopathy 45	Enrichment	GABRB1	2.35
48	Dystonia	Enrichment	GNAL, GNB1	2.26
49	Keppen-lubinsky syndrome	Enrichment	KCNJ6	2.20
50	Night blindness, congenital stationary, type 1h	Enrichment	GNB3	2.20
51	Lodder-merla syndrome, type 1, with impaired intellectual development and cardiac arrhythmia	Enrichment	GNB5	2.20
52	Cerebral visual impairment	Enrichment	GNB1	2.20
53	Developmental and epileptic encephalopathy 78	Enrichment	GABRA2	2.05
54	Autosomal dominant non-syndromic intellectual disability	Enrichment	GABBR1, GNB1	1.96
55	Episodic kinesigenic dyskinesia 1	Enrichment	KCNJ10	1.90
56	Spastic paraplegia 17, autosomal dominant	Enrichment	GNG3	1.90
57	Lipodystrophy, congenital generalized, type 2	Enrichment	GNG3	1.90
58	Tobacco addiction	Enrichment	GABBR2	1.90
59	Familial sick sinus syndrome	Enrichment	GNB2	1.90
60	Thyrotoxic periodic paralysis	Enrichment	GABRA3	1.88
61	Epilepsy	Enrichment	GABRA1, GABRB3	1.87
62	Deafness, autosomal recessive 4, with enlarged vestibular aqueduct	Enrichment	KCNJ10	1.80
63	Spastic diplegia	Enrichment	KCNJ10	1.80
64	Congenital short qt syndrome	Enrichment	KCNJ2	1.80
65	Autosomal dominant nocturnal frontal lobe epilepsy	Enrichment	GABRG2	1.76
66	Pendred syndrome	Enrichment	KCNJ10	1.72
67	Rett syndrome	Enrichment	GABBR2	1.66
68	Rett syndrome, congenital variant	Enrichment	GABBR2	1.60
69	Hypothyroidism	Enrichment	GNB1	1.60
70	Angelman syndrome	Enrichment	GABRG3	1.58
71	Alcohol dependence	Enrichment	GABRA2	1.58
72	Epilepsy, childhood absence 1	Enrichment	GABRB3	1.58
73	Neurofibromatosis, type i	Enrichment	GABBR1	1.55
74	Leukemia, acute lymphoblastic	Enrichment	GNB1	1.46
75	Myelodysplastic syndrome	Enrichment	GNB1	1.46
76	Body mass index quantitative trait locus 11	Enrichment	ADCY3	1.44
77	Congenital nervous system abnormality	Enrichment	GNB5, KCNJ10	1.35
78	Nervous system disease	Enrichment	GNB5, KCNJ10	1.35
79	Epilepsy, myoclonic juvenile	Enrichment	GABRA1	1.32
80	Epilepsy, idiopathic generalized	Enrichment	GABRA1	1.32
81	Hypertension, essential	Enrichment	GNB3	1.28
82	Cleft palate, isolated	Enrichment	GNB1	1.28
83	Microcephaly	Enrichment	GNB1, KCNJ10	1.24
84	Generalized epilepsy with febrile seizures plus	Enrichment	GABRG2	1.22
85	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	ADCY1	1.20
86	Attention deficit-hyperactivity disorder	Enrichment	GNB5	1.17
87	Congenital stationary night blindness	Enrichment	GNB3	1.15
88	Strabismus	Enrichment	GNB1	1.08
89	Long qt syndrome 1	Enrichment	KCNJ5	1.04
90	Long qt syndrome	Enrichment	KCNJ5	1.03
91	Cerebral palsy	Enrichment	GNB1	0.93
92	Benign epilepsy with centrotemporal spikes	Enrichment	GABRG2	0.78
93	Centralopathic epilepsy	Enrichment	GABRG2	0.76
94	Breast cancer	Enrichment	GNG3	0.67
95	Schizophrenia	Enrichment	GABRB2	0.64
96	Autism spectrum disorder	Enrichment	GNB1	0.53
97	Complex neurodevelopmental disorder	Enrichment	GNB2	0.49

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

GABA B receptor activation

Pathway Network for GABA B receptor activation

Pathway network for the GABA B receptor activation SuperPath

Member Pathways for GABA B receptor activation

Pathways in the GABA B receptor activation SuperPath

Gene overlap in member pathways for GABA B receptor activation SuperPath

Associated Genes for GABA B receptor activation

Associated Disorders for GABA B receptor activation

Disorders associated with GABA B receptor activation SuperPath

STRING Interaction Network for GABA B receptor activation

Sources for GABA B receptor activation