GADD45 Pathway

No Pathway Network information available for GADD45 Pathway

Pathways in the GADD45 Pathway SuperPath

#	Name	Source	Genes
1	GADD45 Pathway	QIAGEN	ATM ATR BRCA1 CCNA1 CCNA2 CCNB1 CCNB2 CCNC CCND1 CCND2 CCND3 CCNE1 CCNF CCNG1 CCNT1 CDK1 CDK10 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDKN1A GADD45A GADD45B GADD45G MAP3K1 PCNA TP53 (see all 32) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ATM	ATM Serine/Threonine Kinase	Protein Coding	1
2	ATR	ATR Checkpoint Kinase	Protein Coding	1
3	BRCA1	BRCA1 DNA Repair Associated	Protein Coding	1
4	CCNA1	Cyclin A1	Protein Coding	1
5	CCNA2	Cyclin A2	Protein Coding	1
6	CCNB1	Cyclin B1	Protein Coding	1
7	CCNB2	Cyclin B2	Protein Coding	1
8	CCNC	Cyclin C	Protein Coding	1
9	CCND1	Cyclin D1	Protein Coding	1
10	CCND2	Cyclin D2	Protein Coding	1
11	CCND3	Cyclin D3	Protein Coding	1
12	CCNE1	Cyclin E1	Protein Coding	1
13	CCNF	Cyclin F	Protein Coding	1
14	CCNG1	Cyclin G1	Protein Coding	1
15	CCNT1	Cyclin T1	Protein Coding	1
16	CDK1	Cyclin Dependent Kinase 1	Protein Coding	1
17	CDK10	Cyclin Dependent Kinase 10	Protein Coding	1
18	CDK2	Cyclin Dependent Kinase 2	Protein Coding	1
19	CDK3	Cyclin Dependent Kinase 3	Protein Coding	1
20	CDK4	Cyclin Dependent Kinase 4	Protein Coding	1
21	CDK5	Cyclin Dependent Kinase 5	Protein Coding	1
22	CDK6	Cyclin Dependent Kinase 6	Protein Coding	1
23	CDK7	Cyclin Dependent Kinase 7	Protein Coding	1
24	CDK8	Cyclin Dependent Kinase 8	Protein Coding	1
25	CDK9	Cyclin Dependent Kinase 9	Protein Coding	1
26	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	1
27	GADD45A	Growth Arrest And DNA Damage Inducible Alpha	Protein Coding	1
28	GADD45B	Growth Arrest And DNA Damage Inducible Beta	Protein Coding	1
29	GADD45G	Growth Arrest And DNA Damage Inducible Gamma	Protein Coding	1
30	MAP3K1	Mitogen-Activated Protein Kinase Kinase Kinase 1	Protein Coding	1
31	PCNA	Proliferating Cell Nuclear Antigen	Protein Coding	1
32	TP53	Tumor Protein P53	Protein Coding	1

Disorders associated with GADD45 Pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Bladder cancer	Enrichment	ATM, BRCA1, CDKN1A, TP53	6.24
2	Leukemia, chronic lymphocytic	Enrichment	ATM, CCND1, TP53	5.85
3	Gastric cancer	Enrichment	ATM, BRCA1, CDK4, TP53	5.53
4	Adenocarcinoma	Enrichment	ATM, TP53	4.79
5	Pancreatic cancer	Enrichment	ATM, BRCA1, TP53	4.58
6	Mantle cell lymphoma	Enrichment	ATM, CCND1	4.49
7	Prostate cancer	Enrichment	ATM, BRCA1, TP53	4.38
8	Colorectal cancer	Enrichment	ATM, BRCA1, CCND1, TP53	4.31
9	Ovarian cancer	Enrichment	ATM, BRCA1, MAP3K1, TP53	4.05
10	Hereditary breast carcinoma	Enrichment	ATM, BRCA1, TP53	3.83
11	Inherited cancer-predisposing syndrome	Enrichment	ATM, BRCA1, CDK4, TP53	3.60
12	Hereditary breast ovarian cancer syndrome	Enrichment	ATM, BRCA1, TP53	3.54
13	Uterine corpus cancer	Enrichment	ATM, BRCA1	3.53
14	Myeloma, multiple	Enrichment	ATM, CCND1, TP53	3.52
15	Breast-ovarian cancer, familial 1	Enrichment	ATM, BRCA1	3.38
16	Rhabdomyosarcoma	Enrichment	BRCA1, TP53	3.20
17	Gliosarcoma	Enrichment	ATM, TP53	3.20
18	Giant cell glioblastoma	Enrichment	ATM, TP53	3.14
19	Breast cancer	Enrichment	ATM, BRCA1, TP53	3.14
20	Endometrial cancer	Enrichment	ATM, BRCA1	2.96
21	Palmoplantar keratoderma, punctate type ii	Enrichment	BRCA1	2.63
22	Melanoma, cutaneous malignant 3	Enrichment	CDK4	2.63
23	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3	Enrichment	CCND2	2.63
24	Seckel syndrome 1	Enrichment	ATR	2.63
25	Microcephaly 12, primary, autosomal recessive	Enrichment	CDK6	2.63
26	46,xy sex reversal 6	Enrichment	MAP3K1	2.63
27	Lissencephaly 7 with cerebellar hypoplasia	Enrichment	CDK5	2.63
28	Bone marrow failure syndrome 5	Enrichment	TP53	2.63
29	Frontotemporal dementia and/or amyotrophic lateral sclerosis 5	Enrichment	CCNF	2.63
30	Papilloma of choroid plexus	Enrichment	TP53	2.63
31	Basal cell carcinoma 7	Enrichment	TP53	2.63
32	Anaplastic thyroid carcinoma	Enrichment	TP53	2.63
33	Infant-type hemispheric glioma	Enrichment	BRCA1	2.63
34	Cutaneous telangiectasia and cancer syndrome, familial	Enrichment	ATR	2.63
35	Ataxia-telangiectasia-like disorder 2	Enrichment	PCNA	2.63
36	Endometrial serous adenocarcinoma	Enrichment	ATM	2.63
37	Ductal carcinoma in situ	Enrichment	TP53	2.63
38	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.63
39	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.63
40	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.63
41	B-cell non-hodgkin lymphoma	Enrichment	ATM	2.63
42	Choroid plexus cancer	Enrichment	TP53	2.63
43	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.63
44	Familial cutaneous telangiectasia and oropharyngeal predisposition cancer syndrome	Enrichment	ATR	2.63
45	Primary peritoneal carcinoma	Enrichment	BRCA1	2.63
46	Adrenocortical carcinoma, hereditary	Enrichment	TP53	2.33
47	Ebstein anomaly	Enrichment	CDK8	2.33
48	Cervical cancer	Enrichment	TP53	2.33
49	Lymphoma, hodgkin, classic	Enrichment	TP53	2.33
50	Fanconi anemia, complementation group s	Enrichment	BRCA1	2.33
51	Cardiac valvular dysplasia, x-linked	Enrichment	ATM	2.33
52	Pancreatic cancer 4	Enrichment	BRCA1	2.33
53	Al kaissi syndrome	Enrichment	CDK10	2.33
54	Congenital fibrosarcoma	Enrichment	TP53	2.33
55	High grade glioma	Enrichment	ATM	2.33
56	Li-fraumeni syndrome 1	Enrichment	TP53	2.33
57	Sarcoma	Enrichment	TP53	2.33
58	Cervix carcinoma	Enrichment	TP53	2.33
59	Hodgkin's lymphoma	Enrichment	TP53	2.33
60	T-cell prolymphocytic leukemia	Enrichment	ATM	2.33
61	Inflammatory breast carcinoma	Enrichment	BRCA1	2.33
62	Intellectual developmental disorder with hypotonia and behavioral abnormalities	Enrichment	CDK8	2.33
63	Peritoneum cancer	Enrichment	BRCA1	2.33
64	Bilateral breast cancer	Enrichment	BRCA1	2.33
65	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	2.33
66	Ataxia-telangiectasia	Enrichment	ATM	2.15
67	Polycythemia vera	Enrichment	ATM	2.15
68	Osteogenic sarcoma	Enrichment	TP53	2.15
69	Nasopharyngeal carcinoma	Enrichment	TP53	2.15
70	Koolen-de vries syndrome	Enrichment	ATM	2.15
71	Dedifferentiated liposarcoma	Enrichment	CDK4	2.15
72	Atypical teratoid rhabdoid tumor	Enrichment	TP53	2.15
73	Anaplastic astrocytoma	Enrichment	TP53	2.15
74	Squamous cell carcinoma	Enrichment	TP53	2.15
75	Bone osteosarcoma	Enrichment	TP53	2.15
76	Well-differentiated liposarcoma	Enrichment	CDK4	2.15
77	Small cell cancer of the lung	Enrichment	TP53	2.03
78	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	2.03
79	Polyposis syndrome, hereditary mixed, 1	Enrichment	BRCA1	2.03
80	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	CCND2	2.03
81	Cholangiocarcinoma	Enrichment	BRCA1	2.03
82	Lung sarcomatoid carcinoma	Enrichment	TP53	2.03
83	Embryonal rhabdomyosarcoma	Enrichment	TP53	2.03
84	Oculomotor apraxia	Enrichment	ATM	2.03
85	Von hippel-lindau syndrome	Enrichment	CCND1	1.93
86	Rhabdomyosarcoma 2	Enrichment	TP53	1.93
87	Breast-ovarian cancer, familial 2	Enrichment	BRCA1	1.93
88	Lymphoma	Enrichment	TP53	1.93
89	Glioblastoma	Enrichment	ATM	1.93
90	Acute megakaryocytic leukemia	Enrichment	TP53	1.93
91	Li-fraumeni syndrome	Enrichment	TP53	1.85
92	Adrenocortical carcinoma	Enrichment	TP53	1.85
93	Clear cell renal cell carcinoma	Enrichment	ATM	1.85
94	Breast adenocarcinoma	Enrichment	TP53	1.85
95	Esophageal cancer	Enrichment	TP53	1.79
96	Multiple endocrine neoplasia, type i	Enrichment	CDKN1A	1.79
97	Squamous cell carcinoma, head and neck	Enrichment	TP53	1.79
98	Renal cell carcinoma, papillary, 1	Enrichment	ATM	1.79
99	Essential thrombocythemia	Enrichment	TP53	1.79
100	Gallbladder cancer	Enrichment	TP53	1.79
101	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	1.79
102	Glioma susceptibility 1	Enrichment	TP53	1.73
103	Lymphoma, non-hodgkin, familial	Enrichment	TP53	1.73
104	Adult hepatocellular carcinoma	Enrichment	TP53	1.68
105	Primary hyperaldosteronism	Enrichment	TP53	1.68
106	Colonic benign neoplasm	Enrichment	ATM	1.68
107	Lynch syndrome 1	Enrichment	ATM	1.63
108	Familial colorectal cancer	Enrichment	TP53	1.63
109	Immune deficiency disease	Enrichment	ATM	1.59
110	Myelodysplastic syndrome	Enrichment	TP53	1.59
111	46,xy complete gonadal dysgenesis	Enrichment	MAP3K1	1.59
112	Familial colorectal cancer type x	Enrichment	ATM	1.59
113	Lip and oral cavity carcinoma	Enrichment	TP53	1.55
114	Diaphragmatic hernia, congenital	Enrichment	CDK8	1.52
115	Lung cancer susceptibility 3	Enrichment	TP53	1.49
116	Periventricular nodular heterotopia	Enrichment	BRCA1	1.49
117	Seckel syndrome	Enrichment	ATR	1.49
118	46,xy partial gonadal dysgenesis	Enrichment	MAP3K1	1.49
119	Renal cell carcinoma, nonpapillary	Enrichment	ATM	1.46
120	Hydrocephalus, congenital, 1	Enrichment	CDK8	1.43
121	Melanoma, cutaneous malignant 1	Enrichment	CDK4	1.40
122	Heart, malformation of	Enrichment	CDK8	1.38
123	Diffuse large b-cell lymphoma	Enrichment	TP53	1.36
124	Hepatoblastoma	Enrichment	TP53	1.31
125	Hepatocellular carcinoma	Enrichment	TP53	1.30
126	Diamond-blackfan anemia 1	Enrichment	TP53	1.28
127	Lung cancer	Enrichment	BRCA1	1.14
128	Primary autosomal recessive microcephaly	Enrichment	CDK6	1.14
129	Fanconi anemia, complementation group a	Enrichment	BRCA1	1.10
130	Diamond-blackfan anemia	Enrichment	TP53	1.09
131	Leukemia, acute myeloid	Enrichment	TP53	1.04
132	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	CCNF	0.89
133	Complex neurodevelopmental disorder	Enrichment	CDK8	0.59

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for GADD45 Pathway

Member Pathways for GADD45 Pathway

Pathways in the GADD45 Pathway SuperPath

Associated Genes for GADD45 Pathway

Associated Disorders for GADD45 Pathway

Disorders associated with GADD45 Pathway SuperPath

STRING Interaction Network for GADD45 Pathway

Sources for GADD45 Pathway