Gain-of-function MRAS complexes activate RAF signaling

Sources:

#	Name	Source	Genes
1	Gain-of-function MRAS complexes activate RAF signaling	Reactome	ARAF BRAF MRAS PPP1CB PPP1CC RAF1 SHOC2 YWHAB (see all 8) (see less)
2	SHOC2 M1731 mutant abolishes MRAS complex function	Reactome	ARAF BRAF MRAS PPP1CB PPP1CC RAF1 SHOC2 YWHAB (see all 8) (see less)
3	Signaling by MRAS-complex mutants	Reactome	ARAF BRAF MRAS PPP1CB PPP1CC RAF1 SHOC2 YWHAB (see all 8) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	MRAS	Muscle RAS Oncogene Homolog	Protein Coding	3
2	ARAF	A-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	3
3	PPP1CB	Protein Phosphatase 1 Catalytic Subunit Beta	Protein Coding	3
4	PPP1CC	Protein Phosphatase 1 Catalytic Subunit Gamma	Protein Coding	3
5	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	3
6	BRAF	B-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	3
7	YWHAB	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Beta	Protein Coding	3
8	SHOC2	SHOC2 Leucine Rich Repeat Scaffold Protein	Protein Coding	3

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Noonan syndrome 1	Direct
2	Esophageal cancer	Direct

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Gain-of-function MRAS complexes activate RAF signaling