Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation

Pathway network for the Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation SuperPath

Sources:

Reactome
PubChem

Pathways in the Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation SuperPath

#	Name	Source	Genes
1	Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	Reactome	ARSA ARSB ARSD ARSF ARSG ARSH ARSI ARSJ ARSK ARSL ASPH BGLAP DHPS DNAJC24 DOHH DPH1 DPH2 DPH3 DPH5 DPH6 DPH7 DRG1 DRG2 EEF2 EIF5A EIF5A2 ETF1 F10 F2 F7 F8 F9 FN3K FN3KRP FURIN GAS6 GGCX ICMT JMJD4 JMJD6 JMJD7 KDM8 OGFOD1 PROC PROS1 PROZ RCCD1 RIOX1 RIOX2 RPL27A RPL8 RPS23 RPS6 RWDD1 STS SUMF1 SUMF2 TPST1 TPST2 U2AF2 ZC3H15 (see all 61) (see less)
2	Protein hydroxylation	Reactome	ASPH DRG1 DRG2 ETF1 F9 JMJD4 JMJD6 JMJD7 KDM8 OGFOD1 RCCD1 RIOX1 RIOX2 RPL27A RPL8 RPS23 RPS6 RWDD1 U2AF2 ZC3H15 (see all 20) (see less)
3	Gamma-carboxylation, transport, and amino-terminal cleavage of proteins	Reactome	BGLAP F10 F2 F7 F9 FURIN GAS6 GGCX PROC PROS1 PROZ (see all 11) (see less)
4	Removal of aminoterminal propeptides from gamma-carboxylated proteins	Reactome	BGLAP F10 F2 F7 F9 FURIN GAS6 PROC PROS1 PROZ (see all 10) (see less)
5	Gamma-carboxylation of protein precursors	Reactome	BGLAP F10 F2 F7 F9 GAS6 GGCX PROC PROS1 PROZ (see all 10) (see less)
6	Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus	Reactome	BGLAP F10 F2 F7 F9 GAS6 PROC PROS1 PROZ (see all 9) (see less)
7	Synthesis of diphthamide-EEF2	Reactome	DNAJC24 DPH1 DPH2 DPH3 DPH5 DPH6 DPH7 EEF2 (see all 8) (see less)
8	Hypusine synthesis from eIF5A-lysine	Reactome	DHPS DOHH EIF5A EIF5A2
9	hypusine biosynthesis	PubChem	DOHH
10	diphthamide biosynthesis	PubChem	DPH6

Gene overlap in member pathways for Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	F9	Coagulation Factor IX	Protein Coding	6
2	F2	Coagulation Factor II, Thrombin	Protein Coding	5
3	F7	Coagulation Factor VII	Protein Coding	5
4	F10	Coagulation Factor X	Protein Coding	5
5	GAS6	Growth Arrest Specific 6	Protein Coding	5
6	PROC	Protein C, Inactivator Of Coagulation Factors Va And VIIIa	Protein Coding	5
7	PROS1	Protein S	Protein Coding	5
8	BGLAP	Bone Gamma-Carboxyglutamate Protein	Protein Coding	5
9	PROZ	Protein Z, Vitamin K Dependent Plasma Glycoprotein	Protein Coding	5
10	GGCX	Gamma-Glutamyl Carboxylase	Protein Coding	3
11	FURIN	Furin, Paired Basic Amino Acid Cleaving Enzyme	Protein Coding	3
12	DOHH	Deoxyhypusine Hydroxylase	Protein Coding	3
13	DPH6	Diphthamine Biosynthesis 6	Protein Coding	3
14	JMJD7	Jumonji Domain Containing 7	Protein Coding	2
15	U2AF2	U2 Small Nuclear RNA Auxiliary Factor 2	Protein Coding	2
16	DNAJC24	DnaJ Heat Shock Protein Family (Hsp40) Member C24	Protein Coding	2
17	DHPS	Deoxyhypusine Synthase	Protein Coding	2
18	DPH1	Diphthamide Biosynthesis 1	Protein Coding	2
19	DPH2	Diphthamide Biosynthesis 2	Protein Coding	2
20	DRG2	Developmentally Regulated GTP Binding Protein 2	Protein Coding	2
21	EEF2	Eukaryotic Translation Elongation Factor 2	Protein Coding	2
22	EIF5A	Eukaryotic Translation Initiation Factor 5A	Protein Coding	2
23	ETF1	Eukaryotic Translation Termination Factor 1	Protein Coding	2
24	JMJD6	Jumonji Domain Containing 6, Arginine Demethylase And Lysine Hydroxylase	Protein Coding	2
25	DPH3	Diphthamide Biosynthesis 3	Protein Coding	2
26	ASPH	Aspartate Beta-Hydroxylase	Protein Coding	2
27	DRG1	Developmentally Regulated GTP Binding Protein 1	Protein Coding	2
28	RWDD1	RWD Domain Containing 1	Protein Coding	2
29	DPH5	Diphthamide Biosynthesis 5	Protein Coding	2
30	OGFOD1	2-Oxoglutarate And Iron Dependent Oxygenase Domain Containing 1	Protein Coding	2
31	ZC3H15	Zinc Finger CCCH-Type Containing 15	Protein Coding	2
32	EIF5A2	Eukaryotic Translation Initiation Factor 5A2	Protein Coding	2
33	RPL8	Ribosomal Protein L8	Protein Coding	2
34	RPL27A	Ribosomal Protein L27a	Protein Coding	2
35	RPS6	Ribosomal Protein S6	Protein Coding	2
36	RPS23	Ribosomal Protein S23	Protein Coding	2
37	JMJD4	Jumonji Domain Containing 4	Protein Coding	2
38	RIOX1	Ribosomal Oxygenase 1	Protein Coding	2
39	KDM8	Lysine Demethylase 8	Protein Coding	2
40	RIOX2	Ribosomal Oxygenase 2	Protein Coding	2
41	RCCD1	RCC1 Domain Containing 1	Protein Coding	2
42	DPH7	Diphthamide Biosynthesis 7	Protein Coding	2
43	ARSK	Arylsulfatase Family Member K	Protein Coding	1
44	F8	Coagulation Factor VIII	Protein Coding	1
45	ARSG	Arylsulfatase G	Protein Coding	1
46	ICMT	Isoprenylcysteine Carboxyl Methyltransferase	Protein Coding	1
47	SUMF2	Sulfatase Modifying Factor 2	Protein Coding	1
48	SUMF1	Sulfatase Modifying Factor 1	Protein Coding	1
49	ARSI	Arylsulfatase Family Member I	Protein Coding	1
50	ARSH	Arylsulfatase Family Member H	Protein Coding	1
51	ARSA	Arylsulfatase A	Protein Coding	1
52	ARSB	Arylsulfatase B	Protein Coding	1
53	STS	Steroid Sulfatase	Protein Coding	1
54	ARSD	Arylsulfatase D	Protein Coding	1
55	ARSL	Arylsulfatase L	Protein Coding	1
56	ARSF	Arylsulfatase F	Protein Coding	1
57	FN3K	Fructosamine 3 Kinase	Protein Coding	1
58	ARSJ	Arylsulfatase Family Member J	Protein Coding	1
59	FN3KRP	Fructosamine 3 Kinase Related Protein	Protein Coding	1
60	TPST2	Tyrosylprotein Sulfotransferase 2	Protein Coding	1
61	TPST1	Tyrosylprotein Sulfotransferase 1	Protein Coding	1

Disorders associated with Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Diphthamide deficiency syndrome	Enrichment	DPH1, DPH2	6.04
2	Cerebral sinovenous thrombosis	Enrichment	F2, PROZ	5.93
3	Hemophilia b	Enrichment	F8, F9	4.70
4	Multiple sulfatase deficiency	Enrichment	SUMF1, SUMF2	4.23
5	Neurodevelopmental disorder with microcephaly, cerebral atrophy, and visual impairment	Enrichment	DOHH	4.13
6	Hemophilia a	Enrichment	F8, F9	3.93
7	Factor viii deficiency	Enrichment	F8, F9	3.93
8	Cerebral palsy	Enrichment	F2, PROC	3.54
9	Faundes-banka syndrome	Enrichment	EIF5A	3.53
10	Metachromatic leukodystrophy	Enrichment	ARSA, ARSB	3.53
11	Thrombocytopenia	Enrichment	F10, PROS1	3.36
12	Complex neurodevelopmental disorder	Enrichment	DOHH, EIF5A	3.31
13	Neurodevelopmental disorder with seizures and speech and walking impairment	Enrichment	DHPS	3.23
14	Spinocerebellar ataxia 26	Enrichment	EEF2	3.23
15	Developmental delay with short stature, dysmorphic facial features, and sparse hair 1	Enrichment	DPH1	3.23
16	Thrombophilia due to protein c deficiency, autosomal dominant	Enrichment	PROC	3.18
17	Factor vii deficiency	Enrichment	F7	3.18
18	Warfarin sensitivity, x-linked	Enrichment	F9	3.18
19	Prothrombin deficiency, congenital	Enrichment	F2	3.18
20	Thrombophilia due to protein s deficiency, autosomal dominant	Enrichment	PROS1	3.18
21	Thrombophilia due to protein s deficiency, autosomal recessive	Enrichment	PROS1	3.18
22	Protein z deficiency	Enrichment	PROZ	3.18
23	Thrombophilia, x-linked, due to factor ix defect	Enrichment	F9	3.18
24	Thrombophilia due to protein c deficiency, autosomal recessive	Enrichment	PROC	3.18
25	Pregnancy loss, recurrent 2	Enrichment	F2	3.18
26	Protein s deficiency	Enrichment	PROS1	3.18
27	Prothrombin deficiency	Enrichment	F2	3.18
28	Severe hereditary thrombophilia due to congenital protein c deficiency	Enrichment	PROC	3.18
29	Protein c deficiency	Enrichment	PROC	3.18
30	Hemophilia b leyden	Enrichment	F9	3.18
31	Hereditary thrombophilia due to congenital protein s deficiency	Enrichment	PROS1	3.18
32	Congenital factor vii deficiency	Enrichment	F7	3.18
33	Pseudoxanthoma elasticum-like disorder with multiple coagulation factor deficiency	Enrichment	GGCX	3.13
34	Vitamin k-dependent clotting factors, combined deficiency of, 1	Enrichment	GGCX	3.13
35	Body skin hyperlaxity due to vitamin k-dependent coagulation factor deficiency	Enrichment	GGCX	3.13
36	Pseudoxanthoma elasticum-like skin manifestations with retinitis pigmentosa	Enrichment	GGCX	3.13
37	Developmental delay with short stature, dysmorphic facial features, and sparse hair 2	Enrichment	DPH2	2.93
38	Neurodevelopmental disorder with short stature, prominent forehead, and feeding difficulties	Enrichment	DPH5	2.93
39	Hereditary combined deficiency of vitamin k-dependent clotting factors	Enrichment	GGCX	2.83
40	Traboulsi syndrome	Enrichment	ASPH	2.83
41	Developmental delay, dysmorphic facies, and brain anomalies	Enrichment	U2AF2	2.83
42	Tan-almurshedi syndrome	Enrichment	DRG1	2.83
43	Brachycephaly, trichomegaly, and developmental delay	Enrichment	RPS23	2.83
44	Factor x deficiency	Enrichment	F10	2.70
45	Congenital factor x deficiency	Enrichment	F10	2.70
46	Exercise-induced malignant hyperthermia	Enrichment	ASPH	2.53
47	Leukodystrophy	Enrichment	ARSA, U2AF2	2.45
48	Thrombophilia, x-linked, due to factor viii defect	Enrichment	F8	2.35
49	Chondrodysplasia punctata, brachytelephalangic, autosomal	Enrichment	ARSL	2.35
50	Chondrodysplasia punctata 1, x-linked recessive	Enrichment	ARSL	2.35
51	Mucopolysaccharidosis, type x	Enrichment	ARSK	2.35
52	X-linked chondrodysplasia punctata 1	Enrichment	ARSL	2.35
53	Syndromic recessive x-linked ichthyosis	Enrichment	STS	2.35
54	Autosomal recessive spastic paraplegia type 66	Enrichment	ARSI	2.35
55	Thrombophilia due to thrombin defect	Enrichment	F2	2.33
56	Malignant hyperthermia	Enrichment	ASPH	2.23
57	Stroke, ischemic	Enrichment	F2	2.18
58	Hydrocephalus	Enrichment	DPH1	2.05
59	Usher syndrome, type iv	Enrichment	ARSG	2.05
60	Ichthyosis, x-linked	Enrichment	STS	2.05
61	Surfactant metabolism dysfunction, pulmonary, 3	Enrichment	F8	2.05
62	Dandy-walker syndrome	Enrichment	DPH1	2.00
63	Mucopolysaccharidosis, type vi	Enrichment	ARSB	1.87
64	Neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset 2	Enrichment	ARSA	1.87
65	Myocardial infarction	Enrichment	F7	1.84
66	Spinocerebellar ataxia 15	Enrichment	SUMF1	1.75
67	Spinocerebellar ataxia, autosomal recessive 16	Enrichment	SUMF1	1.57
68	Usher syndrome, type iiia	Enrichment	ARSG	1.51
69	Rett syndrome, congenital variant	Enrichment	ARSJ	1.45
70	Diamond-blackfan anemia	Enrichment	RPL8	1.29
71	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	ASPH	1.20
72	Coffin-siris syndrome 1	Enrichment	ARSL	1.18
73	Usher syndrome	Enrichment	ARSG	0.86
74	Spastic ataxia	Enrichment	ARSA	0.67
75	Congenital nervous system abnormality	Enrichment	ARSA	0.42
76	Nervous system disease	Enrichment	ARSA	0.42

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation

Pathway Network for Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation

Pathway network for the Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation SuperPath

Member Pathways for Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation

Pathways in the Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation SuperPath

Gene overlap in member pathways for Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation SuperPath

Associated Genes for Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation

Associated Disorders for Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation

Disorders associated with Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation SuperPath

STRING Interaction Network for Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation

Sources for Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation