Gap junction trafficking

Pathway network for the Gap junction trafficking SuperPath

Sources:

Reactome
GeneGo (Thomson Reuters)

Pathways in the Gap junction trafficking SuperPath

#	Name	Source	Genes
1	Gap junction trafficking	Reactome	ACTB ACTG1 AP2M1 CLTA CLTB CLTC CLTCL1 DAB2 DNM1 DNM2 GJA1 GJA10 GJA3 GJA4 GJA5 GJA8 GJA9 GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 GJC1 GJC2 GJD2 GJD3 GJD4 MYO6 TUBA1A TUBA1B TUBA1C TUBA3C TUBA3D TUBA3E TUBA4A TUBA4B TUBA8 TUBAL3 TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBB8 TUBB8B (see all 49) (see less)
2	Cell adhesion Gap junctions	GeneGo (Thomson Reuters)	ACTA1 ACTA2 ACTB ACTC1 ACTG1 ACTG2 CAV1 CGN GJA1 GJA3 GJA4 GJA5 GJA8 GJB1 GJB2 GJB3 GJC1 GJD2 OCLN PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCI PRKCQ PRKCZ PRKD1 PRKD2 PRKD3 SRC TJP1 TJP2 TJP3 TUBA1A TUBA1B TUBA1C TUBA3C TUBA3D TUBA3E TUBA4A TUBA4B TUBA8 TUBAL3 TUBB TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBB7P TUBB8 (see all 55) (see less)
3	Gap junction trafficking and regulation	Reactome	ACTB ACTG1 AP2M1 CLTA CLTB CLTC CLTCL1 DAB2 DNM1 DNM2 GJA1 GJA10 GJA3 GJA4 GJA5 GJA8 GJA9 GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 GJC1 GJC2 GJD2 GJD3 GJD4 MYO6 SRC TJP1 TUBA1A TUBA1B TUBA1C TUBA3C TUBA3D TUBA3E TUBA4A TUBA4B TUBA8 TUBAL3 TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBB8 TUBB8B (see all 51) (see less)
4	Gap junction assembly	Reactome	GJA1 GJA10 GJA3 GJA4 GJA5 GJA8 GJA9 GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 GJC1 GJC2 GJD2 GJD3 GJD4 TUBA1A TUBA1B TUBA1C TUBA3C TUBA3D TUBA3E TUBA4A TUBA4B TUBA8 TUBAL3 TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBB8 TUBB8B (see all 38) (see less)
5	Gap junction degradation	Reactome	ACTB ACTG1 AP2M1 CLTA CLTB CLTC CLTCL1 DAB2 DNM1 DNM2 GJA1 MYO6 (see all 12) (see less)
6	Formation of annular gap junctions	Reactome	ACTB ACTG1 AP2M1 CLTA CLTB CLTC CLTCL1 DAB2 DNM1 DNM2 GJA1 (see all 11) (see less)
7	Regulation of gap junction activity	Reactome	GJA1 SRC TJP1
8	Entry of Influenza Virion into Host Cell via Endocytosis	Reactome	CLTA CLTC

Gene overlap in member pathways for Gap junction trafficking SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	GJA1	Gap Junction Protein Alpha 1	Protein Coding	7
2	CLTA	Clathrin Light Chain A	Protein Coding	5
3	CLTC	Clathrin Heavy Chain	Protein Coding	5
4	ACTB	Actin Beta	Protein Coding	5
5	ACTG1	Actin Gamma 1	Protein Coding	5
6	GJC1	Gap Junction Protein Gamma 1	Protein Coding	4
7	TUBA1B	Tubulin Alpha 1b	Protein Coding	4
8	TUBB3	Tubulin Beta 3 Class III	Protein Coding	4
9	TUBB4A	Tubulin Beta 4A Class IVa	Protein Coding	4
10	TUBB4B	Tubulin Beta 4B Class IVb	Protein Coding	4
11	TUBA3E	Tubulin Alpha 3e	Protein Coding	4
12	TUBA3D	Tubulin Alpha 3d	Protein Coding	4
13	AP2M1	Adaptor Related Protein Complex 2 Subunit Mu 1	Protein Coding	4
14	CLTB	Clathrin Light Chain B	Protein Coding	4
15	DAB2	DAB Adaptor Protein 2	Protein Coding	4
16	DNM1	Dynamin 1	Protein Coding	4
17	DNM2	Dynamin 2	Protein Coding	4
18	GJA3	Gap Junction Protein Alpha 3	Protein Coding	4
19	GJA4	Gap Junction Protein Alpha 4	Protein Coding	4
20	GJA5	Gap Junction Protein Alpha 5	Protein Coding	4
21	GJA8	Gap Junction Protein Alpha 8	Protein Coding	4
22	GJB1	Gap Junction Protein Beta 1	Protein Coding	4
23	GJB2	Gap Junction Protein Beta 2	Protein Coding	4
24	GJB3	Gap Junction Protein Beta 3	Protein Coding	4
25	TUBB8	Tubulin Beta 8 Class VIII	Protein Coding	4
26	TUBB2B	Tubulin Beta 2B Class IIb	Protein Coding	4
27	TUBA8	Tubulin Alpha 8	Protein Coding	4
28	GJD2	Gap Junction Protein Delta 2	Protein Coding	4
29	TUBA4A	Tubulin Alpha 4a	Protein Coding	4
30	TUBA3C	Tubulin Alpha 3c	Protein Coding	4
31	TUBB2A	Tubulin Beta 2A Class IIa	Protein Coding	4
32	TUBA1A	Tubulin Alpha 1a	Protein Coding	4
33	TUBAL3	Tubulin Alpha Like 3	Protein Coding	4
34	TUBA4B	Tubulin Alpha 4b	Protein Coding	4
35	TUBB1	Tubulin Beta 1 Class VI	Protein Coding	4
36	CLTCL1	Clathrin Heavy Chain Like 1	Protein Coding	4
37	TUBB6	Tubulin Beta 6 Class V	Protein Coding	4
38	TUBA1C	Tubulin Alpha 1c	Protein Coding	4
39	GJB6	Gap Junction Protein Beta 6	Protein Coding	3
40	GJD3	Gap Junction Protein Delta 3	Protein Coding	3
41	GJB4	Gap Junction Protein Beta 4	Protein Coding	3
42	GJD4	Gap Junction Protein Delta 4	Protein Coding	3
43	TUBB8B	Tubulin Beta 8B	Protein Coding	3
44	GJB5	Gap Junction Protein Beta 5	Protein Coding	3
45	GJB7	Gap Junction Protein Beta 7	Protein Coding	3
46	MYO6	Myosin VI	Protein Coding	3
47	GJC2	Gap Junction Protein Gamma 2	Protein Coding	3
48	GJA9	Gap Junction Protein Alpha 9	Protein Coding	3
49	GJA10	Gap Junction Protein Alpha 10	Protein Coding	3
50	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	3
51	TJP1	Tight Junction Protein 1	Protein Coding	3
52	ACTA1	Actin Alpha 1, Skeletal Muscle	Protein Coding	1
53	ACTA2	Actin Alpha 2, Smooth Muscle	Protein Coding	1
54	ACTC1	Actin Alpha Cardiac Muscle 1	Protein Coding	1
55	ACTG2	Actin Gamma 2, Smooth Muscle	Protein Coding	1
56	CAV1	Caveolin 1	Protein Coding	1
57	PRKCA	Protein Kinase C Alpha	Protein Coding	1
58	PRKCB	Protein Kinase C Beta	Protein Coding	1
59	PRKCD	Protein Kinase C Delta	Protein Coding	1
60	PRKCE	Protein Kinase C Epsilon	Protein Coding	1
61	PRKCG	Protein Kinase C Gamma	Protein Coding	1
62	PRKCH	Protein Kinase C Eta	Protein Coding	1
63	PRKCI	Protein Kinase C Iota	Protein Coding	1
64	PRKD1	Protein Kinase D1	Protein Coding	1
65	PRKCQ	Protein Kinase C Theta	Protein Coding	1
66	PRKCZ	Protein Kinase C Zeta	Protein Coding	1
67	TJP2	Tight Junction Protein 2	Protein Coding	1
68	PRKD3	Protein Kinase D3	Protein Coding	1
69	PRKD2	Protein Kinase D2	Protein Coding	1
70	TJP3	Tight Junction Protein 3	Protein Coding	1
71	TUBB7P	Tubulin Beta 7 Pseudogene	Pseudogene	1
72	CGN	Cingulin	Protein Coding	1
73	TUBB	Tubulin Beta Class I	Protein Coding	1
74	OCLN	Occludin	Protein Coding	1

Disorders associated with Gap junction trafficking SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Influenza	Direct
2	Lissencephaly	Enrichment	ACTG1, TUBA1A, TUBA3E, TUBB, TUBB2B, TUBB3	9.74
3	Tubulinopathy-associated dysgyria	Enrichment	TUBA1A, TUBB2B, TUBB3	7.69
4	Deafness, autosomal recessive 1a	Enrichment	GJB2, GJB3, GJB6	7.09
5	Tubulinopathy	Enrichment	TUBA1A, TUBB2A, TUBB2B	7.09
6	Gjb2-related autosomal recessive nonsyndromic hearing loss	Enrichment	GJB2, GJB3, GJB6	7.09
7	Nonsyndromic hearing loss	Enrichment	ACTG1, GJB2, GJB3, GJB6, MYO6	6.42
8	Congenital fibrosis of the extraocular muscles	Enrichment	TUBA1A, TUBB2B, TUBB3	6.39
9	Baraitser-winter cerebrofrontofacial syndrome	Enrichment	ACTB, ACTG1	6.22
10	Erythrokeratodermia variabilis et progressiva 1	Enrichment	GJA1, GJB3, GJB4	5.95
11	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	ACTG1, GJB2, GJB3, GJB6, MYO6	5.94
12	Deafness, autosomal recessive 1b	Enrichment	GJB2, GJB6	5.12
13	Keratitis ichthyosis and deafness syndrome	Enrichment	GJB2, GJB6	5.12
14	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	GJA1, GJB2, GJB3, GJB6, MYO6	4.78
15	Deafness, x-linked 2	Enrichment	GJB2, GJB6	4.64
16	X-linked mixed hearing loss with perilymphatic gusher	Enrichment	GJB2, GJB6	4.64
17	Polymicrogyria, bilateral perisylvian, x-linked	Enrichment	TUBA1A, TUBB2B	3.80
18	Palmoplantar keratoderma and congenital alopecia 1	Enrichment	GJA1	3.66
19	Hypoplastic left heart syndrome 1	Enrichment	GJA1	3.66
20	Oculodentodigital dysplasia	Enrichment	GJA1	3.66
21	Craniometaphyseal dysplasia, autosomal recessive	Enrichment	GJA1	3.66
22	Oculodentodigital dysplasia, autosomal recessive	Enrichment	GJA1	3.66
23	Thrombocytopenia 6	Enrichment	SRC	3.66
24	Erythrokeratodermia variabilis et progressiva 3	Enrichment	GJA1	3.66
25	Bilateral perisylvian polymicrogyria	Enrichment	TUBA1A, TUBB2B	3.57
26	Non-syndromic genetic deafness	Enrichment	ACTG1, GJB2, MYO6	3.54
27	Cataract 30, multiple types	Enrichment	GJA3, GJA8	3.47
28	Autosomal dominant macrothrombocytopenia	Enrichment	TUBA8, TUBB1	3.47
29	Hallermann-streiff syndrome	Enrichment	GJA1	3.35
30	Syndactyly, type iii	Enrichment	GJA1	3.35
31	Syndactyly, type v	Enrichment	GJA1	3.35
32	Craniometaphyseal dysplasia	Enrichment	GJA1	3.35
33	Baraitser-winter syndrome 1	Enrichment	ACTB	3.09
34	Charcot-marie-tooth disease, dominant intermediate b	Enrichment	DNM2	3.09
35	Congenital smooth muscle hamartoma, with or without hemihypertrophy	Enrichment	ACTB	3.09
36	Becker nevus syndrome	Enrichment	ACTB	3.09
37	Dystonia-deafness syndrome 1	Enrichment	ACTB	3.09
38	Lethal congenital contracture syndrome 5	Enrichment	DNM2	3.09
39	Thrombocytopenia 8, with dysmorphic features and developmental delay	Enrichment	ACTB	3.09
40	Baraitser-winter syndrome	Enrichment	ACTB	3.09
41	Congenital insensitivity to pain with severe intellectual disability	Enrichment	CLTCL1	3.09
42	Autosomal dominant charcot-marie-tooth disease type 2m	Enrichment	DNM2	3.09
43	Congenital smooth muscle hamartoma	Enrichment	ACTB	3.09
44	Developmental malformations-deafness-dystonia syndrome	Enrichment	ACTB	3.09
45	Deafness, autosomal dominant 22	Enrichment	MYO6	3.05
46	Deafness, autosomal recessive 37	Enrichment	MYO6	3.05
47	Progressive sensorineural hearing loss-hypertrophic cardiomyopathy syndrome	Enrichment	MYO6	3.05
48	Autosomal dominant nonsyndromic hearing loss 22	Enrichment	MYO6	3.05
49	Undetermined early-onset epileptic encephalopathy	Enrichment	CLTC, DNM1	3.05
50	Cleft upper lip	Enrichment	GJA1	2.96
51	Early-onset nuclear cataract	Enrichment	GJA3, GJA8	2.94
52	Myelofibrosis	Enrichment	SRC	2.81
53	Deafness, autosomal dominant 20	Enrichment	ACTG1	2.79
54	Baraitser-winter syndrome 2	Enrichment	ACTG1	2.79
55	Intellectual developmental disorder, autosomal dominant 60, with seizures	Enrichment	AP2M1	2.79
56	Hypoplastic left heart syndrome	Enrichment	GJA1	2.75
57	Isolated congenital microcephaly	Enrichment	OCLN, TUBA3E	2.73
58	Rare genetic deafness	Enrichment	ACTG1, MYO6	2.67
59	Myopathy, centronuclear, x-linked	Enrichment	DNM2	2.61
60	Intellectual developmental disorder, autosomal dominant 56	Enrichment	CLTC	2.61
61	Developmental and epileptic encephalopathy 31b	Enrichment	DNM1	2.61
62	Bart-pumphrey syndrome	Enrichment	GJB2	2.55
63	Clouston syndrome	Enrichment	GJB6	2.55
64	Vohwinkel syndrome	Enrichment	GJB2	2.55
65	Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement	Enrichment	TUBB3	2.55
66	Cataract 14, multiple types	Enrichment	GJA3	2.55
67	Deafness, autosomal dominant 3a	Enrichment	GJB2	2.55
68	Lymphatic malformation 3	Enrichment	GJC2	2.55
69	Keratitis-ichthyosis-deafness syndrome, autosomal dominant	Enrichment	GJB2	2.55
70	Deafness, autosomal dominant 3b	Enrichment	GJB6	2.55
71	Cataract 1, multiple types	Enrichment	GJA8	2.55
72	Macrothrombocytopenia, isolated, 1, autosomal dominant	Enrichment	TUBB1	2.55
73	Deafness, autosomal dominant 2b	Enrichment	GJB3	2.55
74	Leber congenital amaurosis with early-onset deafness	Enrichment	TUBB4B	2.55
75	Oocyte/zygote/embryo maturation arrest 24	Enrichment	TUBA1C	2.55
76	Ichthyosis, hystrix-like, with deafness	Enrichment	GJB2	2.55
77	Spastic paraplegia 44, autosomal recessive	Enrichment	GJC2	2.55
78	Cortical dysplasia, complex, with other brain malformations 7	Enrichment	TUBB2B	2.55
79	Oocyte/zygote/embryo maturation arrest 23	Enrichment	TUBA4A	2.55
80	Frontotemporal dementia and/or amyotrophic lateral sclerosis 9	Enrichment	TUBA4A	2.55
81	Hemangioma of liver	Enrichment	GJA4	2.55
82	Erythrokeratodermia variabilis et progressiva 2	Enrichment	GJB4	2.55
83	Facial palsy, congenital, with ptosis and velopharyngeal dysfunction	Enrichment	TUBB6	2.55
84	Gjc2-related late-onset primary lymphedema	Enrichment	GJC2	2.55
85	Neuropathy with hearing impairment	Enrichment	GJB3	2.55
86	Macrothrombocytopenia, isolated, 2, autosomal dominant	Enrichment	TUBA8	2.55
87	Lissencephaly due to tuba1a mutation	Enrichment	TUBA1A	2.55
88	Congenital myopathy 26	Enrichment	TUBA4A	2.55
89	Spastic ataxia 11, autosomal dominant	Enrichment	TUBA4A	2.55
90	Amyotrophic lateral sclerosis type 22	Enrichment	TUBA4A	2.55
91	Porokeratotic eccrine ostial and dermal duct nevus	Enrichment	GJB2	2.55
92	Autosomal dominant nonsyndromic hearing loss 3a	Enrichment	GJB2	2.55
93	Polymicrogyria with optic nerve hypoplasia	Enrichment	TUBA8	2.55
94	Skin hemangioma	Enrichment	GJA4	2.55
95	Osteoporosis	Enrichment	SRC	2.51
96	Congenital nervous system abnormality	Enrichment	GJC2, TUBA1A, TUBB4A	2.49
97	Nervous system disease	Enrichment	GJC2, TUBA1A, TUBB4A	2.49
98	Aminoacylase 1 deficiency	Enrichment	ACTB	2.49
99	Neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset 1	Enrichment	CLTC	2.49
100	Pseudomyogenic hemangioendothelioma	Enrichment	ACTB	2.49
101	Ear malformation	Enrichment	GJB2, MYO6	2.47
102	Developmental and epileptic encephalopathy 31a	Enrichment	DNM1	2.39
103	Coloboma of choroid and retina	Enrichment	ACTG1	2.39
104	Skin creases, congenital symmetric circumferential, 1	Enrichment	TUBB	2.39
105	Pseudo-torch syndrome 1	Enrichment	OCLN	2.39
106	Lipodystrophy, congenital generalized, type 3	Enrichment	CAV1	2.39
107	Deafness, autosomal dominant 51	Enrichment	TJP2	2.39
108	Congenital myopathy 2a, typical, autosomal dominant	Enrichment	ACTA1	2.39
109	Cortical dysplasia, complex, with other brain malformations 6	Enrichment	TUBB	2.39
110	Myopathy, scapulohumeroperoneal	Enrichment	ACTA1	2.39
111	Pulmonary hypertension, primary, 3	Enrichment	CAV1	2.39
112	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	2.39
113	Megacystis-microcolon-intestinal hypoperistalsis syndrome 5	Enrichment	ACTG2	2.39
114	Lipodystrophy, familial partial, type 7	Enrichment	CAV1	2.39
115	Spinocerebellar ataxia 14	Enrichment	PRKCG	2.39
116	Visceral neuropathy, familial, 3, autosomal dominant	Enrichment	ACTG2	2.39
117	Congenital myopathy 2b, severe infantile, autosomal recessive	Enrichment	ACTA1	2.39
118	Autosomal dominant familial visceral neuropathy	Enrichment	ACTG2	2.39
119	Congenital heart defects and ectodermal dysplasia	Enrichment	PRKD1	2.39
120	Congenital myopathy 2c, severe infantile, autosomal dominant	Enrichment	ACTA1	2.39
121	Zebra body myopathy	Enrichment	ACTA1	2.39
122	Actin-accumulation myopathy	Enrichment	ACTA1	2.39
123	Malignant epithelial tumor of salivary glands	Enrichment	PRKD1	2.39
124	Myopathic intestinal pseudoobstruction	Enrichment	ACTG2	2.39
125	Actg2 visceral myopathy	Enrichment	ACTG2	2.39
126	Microcephaly	Enrichment	ACTB, ACTG1	2.37
127	Myopathy, centronuclear, 1	Enrichment	DNM2	2.31
128	Inflammatory myofibroblastic tumor	Enrichment	CLTC	2.31
129	Epidermolysis bullosa, junctional 5b, with pyloric atresia	Enrichment	MYO6	2.28
130	Cerebral palsy	Enrichment	TUBA1A, TUBB4A	2.28
131	Atrial standstill 1	Enrichment	GJA5	2.25
132	Dystonia 4, torsion, autosomal dominant	Enrichment	TUBB4A	2.25
133	Spinocerebellar ataxia, x-linked 1	Enrichment	GJB1	2.25
134	Congenital cataracts, facial dysmorphism, and neuropathy	Enrichment	GJA3	2.25
135	Muscular dystrophy, limb-girdle, autosomal recessive 3	Enrichment	TUBA1A	2.25
136	Atrial fibrillation, familial, 11	Enrichment	GJA5	2.25
137	Deafness, autosomal recessive 104	Enrichment	GJB2	2.25
138	Keratoconus 9	Enrichment	TUBA3D	2.25
139	Autosomal recessive limb-girdle muscular dystrophy type 2d	Enrichment	TUBA1A	2.25
140	Lissencephaly 3	Enrichment	TUBA1A	2.25
141	Cortical dysplasia, complex, with other brain malformations 1	Enrichment	TUBB3	2.25
142	Torsion dystonia 4	Enrichment	TUBB4A	2.25
143	Hereditary palmoplantar keratoderma	Enrichment	GJB2	2.25
144	Continuous spikes and waves during sleep	Enrichment	TUBA1A	2.25
145	Noonan syndrome 3	Enrichment	CLTC	2.25
146	Renal cell carcinoma with mit translocations	Enrichment	CLTC	2.25
147	Lennox-gastaut syndrome	Enrichment	DNM1	2.19
148	Myoclonic-atonic epilepsy	Enrichment	AP2M1	2.14
149	Cat eye syndrome	Enrichment	ACTG1	2.09
150	Aortic aneurysm, familial thoracic 2	Enrichment	ACTA2	2.09
151	Cardiomyopathy, dilated, 1r	Enrichment	ACTC1	2.09
152	Cardiomyopathy, familial hypertrophic, 11	Enrichment	ACTC1	2.09
153	Smooth muscle dysfunction syndrome	Enrichment	ACTA2	2.09
154	Aortic aneurysm, familial thoracic 6	Enrichment	ACTA2	2.09
155	Cholestasis, progressive familial intrahepatic, 4	Enrichment	TJP2	2.09
156	Moyamoya disease 5	Enrichment	ACTA2	2.09
157	Atrial septal defect 5	Enrichment	ACTC1	2.09
158	Multiple benign circumferential skin creases on limbs	Enrichment	TUBB	2.09
159	Intestinal obstruction	Enrichment	ACTG2	2.09
160	Macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss	Enrichment	TUBB1	2.08
161	Keratoderma, palmoplantar, with deafness	Enrichment	GJB2	2.08
162	Pelizaeus-merzbacher disease	Enrichment	GJC2	2.08
163	Ifap syndrome 1, with or without bresheck syndrome	Enrichment	GJB2	2.08
164	Charcot-marie-tooth disease, x-linked dominant, 1	Enrichment	GJB1	2.08
165	Leukodystrophy, hypomyelinating, 6	Enrichment	TUBB4A	2.08
166	Leukodystrophy, hypomyelinating, 2	Enrichment	GJC2	2.08
167	Oocyte/zygote/embryo maturation arrest 2	Enrichment	TUBB8	2.08
168	Cortical dysplasia, complex, with other brain malformations 5	Enrichment	TUBB2A	2.08
169	Sclerocornea	Enrichment	GJA8	2.08
170	Pelizeaus-merzbacher spectrum disorder	Enrichment	GJC2	2.08
171	Charcot-marie-tooth disease	Enrichment	DNM2, GJB1	2.02
172	Spastic ataxia	Enrichment	GJC2, TUBB3	2.02
173	Fetal akinesia deformation sequence 1	Enrichment	ACTA1, TUBA1A	2.01
174	Stereotypic movement disorder	Enrichment	DNM1	1.98
175	Thrombocytopenia	Enrichment	SRC	1.98
176	West syndrome	Enrichment	DNM1, TUBA1A	1.96
177	Hypercholanemia, familial 1	Enrichment	TJP2	1.92
178	Distal arthrogryposis	Enrichment	ACTA1, ACTC1	1.90
179	Hypertrophic neuropathy of dejerine-sottas	Enrichment	GJB1	1.86
180	Female infertility due to oocyte meiotic arrest	Enrichment	TUBB8	1.86
181	Sensory peripheral neuropathy	Enrichment	GJB1	1.86
182	Nemaline myopathy 2	Enrichment	ACTA1	1.79
183	Megacystis-microcolon-intestinal hypoperistalsis syndrome 1	Enrichment	ACTG2	1.79
184	Autoimmune lymphoproliferative syndrome	Enrichment	ACTA2	1.79
185	Hereditary ataxia	Enrichment	PRKCG	1.79
186	Intermediate nemaline myopathy	Enrichment	ACTA1	1.79
187	Cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 1	Enrichment	TUBB2B	1.78
188	Deafness, autosomal recessive 12	Enrichment	GJB2	1.78
189	Pain disorder	Enrichment	GJB1	1.78
190	Early myoclonic encephalopathy	Enrichment	TUBA1A	1.78
191	Early-onset sutural cataract	Enrichment	GJA8	1.78
192	Centronuclear myopathy	Enrichment	DNM2	1.77
193	Colorectal cancer	Enrichment	SRC	1.72
194	Visceral myopathy 1	Enrichment	ACTG2	1.70
195	Congenital myopathy 3 with rigid spine	Enrichment	ACTA1	1.70
196	Diffuse cutaneous systemic sclerosis	Enrichment	CAV1	1.70
197	Severe congenital nemaline myopathy	Enrichment	ACTA1	1.70
198	Cryptorchidism	Enrichment	TUBA1A	1.65
199	Cataract - microcornea syndrome	Enrichment	GJA8	1.65
200	Early-onset posterior polar cataract	Enrichment	GJA3	1.65
201	Branchiootorenal syndrome 1	Enrichment	TJP2	1.62
202	Moyamoya disease 1	Enrichment	ACTA2	1.62
203	Intestinal pseudo-obstruction	Enrichment	ACTG2	1.62
204	Limited scleroderma	Enrichment	CAV1	1.62
205	Familial hypercholanemia	Enrichment	TJP2	1.62
206	Typical nemaline myopathy	Enrichment	ACTA1	1.62
207	Cryptorchidism, unilateral or bilateral	Enrichment	TUBA1A	1.60
208	Cakut	Enrichment	ACTG1	1.56
209	Branchiootorenal syndrome	Enrichment	TJP2	1.55
210	Childhood-onset nemaline myopathy	Enrichment	ACTA1	1.55
211	Myopathy	Enrichment	DNM2	1.50
212	Congenital hypothyroidism	Enrichment	TUBB1	1.48
213	Inflammatory bowel disease 1	Enrichment	PRKCQ	1.44
214	Primary biliary cholangitis	Enrichment	TJP2	1.44
215	Autosomal dominant non-syndromic intellectual disability	Enrichment	CLTC	1.40
216	Stroke, ischemic	Enrichment	PRKCH	1.40
217	Nemaline myopathy	Enrichment	ACTA1	1.40
218	Corpus callosum, agenesis of	Enrichment	TUBA1A	1.38
219	Anterior segment dysgenesis	Enrichment	GJA8	1.38
220	Isolated corpus callosum agenesis	Enrichment	TUBA1A	1.38
221	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	TUBA1A	1.38
222	Dilated cardiomyopathy	Enrichment	ACTA1, ACTC1	1.38
223	Heritable pulmonary arterial hypertension	Enrichment	CAV1	1.36
224	Dandy-walker syndrome	Enrichment	TUBA1A	1.33
225	Cataract 44	Enrichment	GJA8	1.33
226	Chromosome 1p36 deletion syndrome	Enrichment	PRKCZ	1.29
227	Lung cancer susceptibility 3	Enrichment	ACTA2	1.26
228	Congenital myopathy 4a, autosomal dominant	Enrichment	ACTA1	1.23
229	Microphthalmia	Enrichment	GJA8	1.22
230	Noonan syndrome 1	Enrichment	GJB2	1.20
231	Hydrocephalus, congenital, 1	Enrichment	TUBB	1.20
232	Familial atrial fibrillation	Enrichment	GJA5	1.19
233	Tetralogy of fallot	Enrichment	GJA5	1.15
234	Auditory neuropathy	Enrichment	TUBB4A	1.15
235	Neuromuscular disease	Enrichment	ACTA1	1.15
236	Patent foramen ovale	Enrichment	ACTC1	1.15
237	Congenital myopathy	Enrichment	ACTA1	1.13
238	Peripheral nervous system disease	Enrichment	GJB1	1.07
239	Neuropathy	Enrichment	GJB1	1.07
240	Dystonia	Enrichment	GJC2	1.03
241	Hydrops fetalis, nonimmune	Enrichment	ACTA1	1.00
242	Optic atrophy plus syndrome	Enrichment	TUBB6	0.93
243	Non-immune hydrops fetalis	Enrichment	ACTA1	0.93
244	Lung cancer	Enrichment	ACTA2	0.91
245	Connective tissue disease	Enrichment	ACTA2	0.91
246	Familial hypertrophic cardiomyopathy	Enrichment	ACTC1	0.90
247	Sensorineural hearing loss	Enrichment	GJB2	0.90
248	Left ventricular noncompaction	Enrichment	ACTC1	0.88
249	Hypertrophic cardiomyopathy	Enrichment	ACTC1	0.79
250	Deafness, autosomal recessive	Enrichment	GJB2	0.79
251	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	ACTA2	0.79
252	Autosomal recessive nonsyndromic deafness	Enrichment	GJB2	0.78
253	Familial isolated dilated cardiomyopathy	Enrichment	ACTC1	0.71
254	Leber plus disease	Enrichment	TUBB4B	0.63
255	Autism spectrum disorder	Enrichment	GJB2	0.58

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Gap junction trafficking

Pathway Network for Gap junction trafficking

Pathway network for the Gap junction trafficking SuperPath

Member Pathways for Gap junction trafficking

Pathways in the Gap junction trafficking SuperPath

Gene overlap in member pathways for Gap junction trafficking SuperPath

Associated Genes for Gap junction trafficking

Associated Disorders for Gap junction trafficking

Disorders associated with Gap junction trafficking SuperPath

STRING Interaction Network for Gap junction trafficking

Sources for Gap junction trafficking