Gastrin-CREB signalling pathway via PKC and MAPK

No Pathway Network information available for Gastrin-CREB signalling pathway via PKC and MAPK

Pathways in the Gastrin-CREB signalling pathway via PKC and MAPK SuperPath

#	Name	Source	Genes
1	Gastrin-CREB signalling pathway via PKC and MAPK	Reactome	CCKBR CREB1 EGFR GAST GRB2 HBEGF HRAS KRAS MAPK1 MAPK3 MAPK7 MMP3 NRAS PRKCA RPS6KA1 RPS6KA2 RPS6KA3 SOS1 (see all 18) (see less)
2	EGFR Transactivation by Gastrin	Reactome	EGFR GRB2 HBEGF HRAS KRAS MMP3 NRAS PRKCA SOS1 (see all 9) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	HBEGF	Heparin Binding EGF Like Growth Factor	Protein Coding	2
2	EGFR	Epidermal Growth Factor Receptor	Protein Coding	2
3	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	2
4	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	2
5	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	2
6	MMP3	Matrix Metallopeptidase 3	Protein Coding	2
7	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	2
8	PRKCA	Protein Kinase C Alpha	Protein Coding	2
9	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	2
10	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	1
11	GAST	Gastrin	Protein Coding	1
12	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
13	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
14	MAPK7	Mitogen-Activated Protein Kinase 7	Protein Coding	1
15	RPS6KA1	Ribosomal Protein S6 Kinase A1	Protein Coding	1
16	RPS6KA2	Ribosomal Protein S6 Kinase A2	Protein Coding	1
17	RPS6KA3	Ribosomal Protein S6 Kinase A3	Protein Coding	1
18	CCKBR	Cholecystokinin B Receptor	Protein Coding	1

Disorders associated with Gastrin-CREB signalling pathway via PKC and MAPK SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Lung non-small cell carcinoma	Enrichment	EGFR, HRAS, KRAS, NRAS	10.30
2	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, KRAS, NRAS, SOS1	9.89
3	Noonan syndrome 1	Enrichment	HRAS, KRAS, NRAS, SOS1	9.09
4	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	9.08
5	Rasopathy	Enrichment	HRAS, KRAS, NRAS, SOS1	8.88
6	Nevus, epidermal	Enrichment	HRAS, KRAS, NRAS	8.15
7	Noonan syndrome 3	Enrichment	HRAS, KRAS, SOS1	8.15
8	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	6.41
9	Bladder cancer	Enrichment	EGFR, HRAS, KRAS	6.14
10	Differentiated thyroid carcinoma	Enrichment	HRAS, KRAS, NRAS	6.14
11	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	5.93
12	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	5.63
13	Lung squamous cell carcinoma	Enrichment	EGFR, KRAS	5.23
14	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS, NRAS	5.09
15	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	5.09
16	Follicular thyroid carcinoma	Enrichment	HRAS, NRAS	5.09
17	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, NRAS	4.96
18	Juvenile myelomonocytic leukemia	Enrichment	KRAS, NRAS	4.59
19	Lip and oral cavity carcinoma	Enrichment	EGFR, HRAS	4.59
20	Lung cancer susceptibility 3	Enrichment	EGFR, KRAS	4.45
21	Arteriovenous malformations of the brain	Enrichment	EGFR, KRAS	4.18
22	Specific learning disability	Enrichment	MAPK1, RPS6KA3	4.04
23	Non-immune hydrops fetalis	Enrichment	HRAS, KRAS	3.74
24	Lung cancer	Enrichment	EGFR, KRAS	3.72
25	Leukemia, acute myeloid	Enrichment	KRAS, NRAS	3.52
26	Oculoectodermal syndrome	Enrichment	KRAS	3.18
27	Noonan syndrome 4	Enrichment	SOS1	3.18
28	Melanosis, neurocutaneous	Enrichment	NRAS	3.18
29	Noonan syndrome 6	Enrichment	NRAS	3.18
30	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	3.18
31	Coronary heart disease 6	Enrichment	MMP3	3.18
32	Congenital pulmonary airway malformation	Enrichment	KRAS	3.18
33	Phakomatosis pigmentokeratotica	Enrichment	HRAS	3.18
34	Neurocutaneous melanocytosis	Enrichment	NRAS	3.18
35	Fibromatosis, gingival, 1	Enrichment	SOS1	2.88
36	Costello syndrome	Enrichment	HRAS	2.88
37	Pulmonic stenosis	Enrichment	SOS1	2.88
38	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	2.88
39	Wooly hair nevus	Enrichment	HRAS	2.88
40	Coffin-lowry syndrome	Enrichment	RPS6KA3	2.88
41	Noonan syndrome 13	Enrichment	MAPK1	2.88
42	Intellectual developmental disorder, x-linked 19	Enrichment	RPS6KA3	2.88
43	Symptomatic form of coffin-lowry syndrome in female carriers	Enrichment	RPS6KA3	2.88
44	Ovarian cancer	Enrichment	EGFR, KRAS	2.72
45	Nuchal bleb, familial	Enrichment	SOS1	2.70
46	Langerhans cell histiocytosis	Enrichment	NRAS	2.70
47	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	2.70
48	Spermatocytoma	Enrichment	HRAS	2.70
49	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	2.70
50	Cardiofaciocutaneous syndrome 1	Enrichment	KRAS	2.58
51	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	2.58
52	Cardiofaciocutaneous syndrome	Enrichment	KRAS	2.58
53	Lung sarcomatoid carcinoma	Enrichment	KRAS	2.58
54	Pilocytic astrocytoma	Enrichment	KRAS	2.58
55	Epidermolytic nevus	Enrichment	HRAS	2.58
56	Gingival fibromatosis	Enrichment	SOS1	2.58
57	Scoliosis, isolated 1	Enrichment	MAPK7	2.58
58	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	2.58
59	Cowden syndrome 1	Enrichment	EGFR	2.40
60	Breast adenocarcinoma	Enrichment	KRAS	2.40
61	Melanoma of soft tissue	Enrichment	CREB1	2.40
62	Squamous cell carcinoma, head and neck	Enrichment	EGFR	2.33
63	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS	2.33
64	Gallbladder cancer	Enrichment	KRAS	2.33
65	Pilomyxoid astrocytoma	Enrichment	KRAS	2.33
66	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	2.28
67	Arteriovenous malformation	Enrichment	HRAS	2.22
68	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS	2.18
69	Aortic valve disease 1	Enrichment	SOS1	2.07
70	Protein-deficiency anemia	Enrichment	NRAS	2.07
71	46,xy partial gonadal dysgenesis	Enrichment	SOS1	2.03
72	Lynch syndrome	Enrichment	KRAS	2.00
73	Rhabdomyosarcoma	Enrichment	HRAS	1.98
74	Gliosarcoma	Enrichment	EGFR	1.98
75	Gastroesophageal reflux	Enrichment	RPS6KA3	1.98
76	Orthostatic intolerance	Enrichment	RPS6KA3	1.98
77	Giant cell glioblastoma	Enrichment	EGFR	1.95
78	Ventricular septal defect	Enrichment	RPS6KA3	1.93
79	Pancreatic cancer	Enrichment	KRAS	1.78
80	Hydrops fetalis, nonimmune	Enrichment	HRAS	1.77
81	Heart, malformation of	Enrichment	MAPK1	1.63
82	Gastric cancer	Enrichment	KRAS	1.55
83	Hereditary breast carcinoma	Enrichment	KRAS	1.54
84	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS	1.44
85	Myeloma, multiple	Enrichment	KRAS	1.44
86	Non-syndromic x-linked intellectual disability	Enrichment	RPS6KA3	1.33
87	Breast cancer	Enrichment	KRAS	1.31
88	Colorectal cancer	Enrichment	NRAS	1.25
89	Hypertelorism	Enrichment	RPS6KA3	1.17
90	Inherited cancer-predisposing syndrome	Enrichment	EGFR	1.07
91	Microcephaly	Enrichment	MAPK1	0.82

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Gastrin-CREB signalling pathway via PKC and MAPK

Pathway Network for Gastrin-CREB signalling pathway via PKC and MAPK

Member Pathways for Gastrin-CREB signalling pathway via PKC and MAPK

Pathways in the Gastrin-CREB signalling pathway via PKC and MAPK SuperPath

Associated Genes for Gastrin-CREB signalling pathway via PKC and MAPK

Associated Disorders for Gastrin-CREB signalling pathway via PKC and MAPK

Disorders associated with Gastrin-CREB signalling pathway via PKC and MAPK SuperPath

STRING Interaction Network for Gastrin-CREB signalling pathway via PKC and MAPK

Sources for Gastrin-CREB signalling pathway via PKC and MAPK