Gastrin signaling pathway

No Pathway Network information available for Gastrin signaling pathway

Pathways in the Gastrin signaling pathway SuperPath

#	Name	Source	Genes
1	Gastrin signaling pathway	WikiPathways	AKT1 ANXA2 ARHGEF28 ARRB1 ARRB2 ATF2 BAD BCAR1 BCL2L1 BIRC2 BIRC3 BIRC5 BMP2 CASP3 CCKBR CCND1 CD44 CDC42 CDH1 CDKN1A CDKN1B CDKN2A CHGA CHUK CLDN1 CREB1 CRK CTNNB1 CXCL8 EGFR EGR1 EIF4EBP1 ELK1 FOS FOXO1 FOXO3 FYN GAST GNAQ GRB2 GSK3B HDAC7 HDC HRAS IKBKB IL2 IRS1 ITGB1 JAG1 JAK2 JUN KAT5 KIT KLF4 KRAS LAMTOR3 MAP2K1 MAP3K11 MAPK1 MAPK14 MAPK3 MAPK8 MAPK9 MEF2B MEF2C MEF2D MMP7 MYC NFKB1 NFKBIA PAK1 PIK3CA PIK3R1 PIK3R2 PIK3R3 PLCG1 PPARG PRKACA PRKCA PRKCD PRKCE PRKCH PRKCQ PRKD1 PRKD2 PTGS2 PTK2 PTPN11 PXN RAC1 RAF1 RELA RHOA RHOB RHOD ROCK1 RPS6 RPS6KB1 SERPINB2 SERPINE1 SHC1 SLC9A1 SLC9A3 SOS1 SP1 SRC STAT3 TCF4 TFF2 TJP1 VEGFA YES1 (see all 112) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	HDAC7	Histone Deacetylase 7	Protein Coding	1
2	CDH1	Cadherin 1	Protein Coding	1
3	CDC42	Cell Division Cycle 42	Protein Coding	1
4	CD44	CD44 Molecule (IN Blood Group)	Protein Coding	1
5	BCAR1	BCAR1 Scaffold Protein, Cas Family Member	Protein Coding	1
6	KLF4	KLF Transcription Factor 4	Protein Coding	1
7	CLDN1	Claudin 1	Protein Coding	1
8	CCKBR	Cholecystokinin B Receptor	Protein Coding	1
9	CASP3	Caspase 3	Protein Coding	1
10	YES1	YES Proto-Oncogene 1, Src Family Tyrosine Kinase	Protein Coding	1
11	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	1
12	TJP1	Tight Junction Protein 1	Protein Coding	1
13	TFF2	Trefoil Factor 2	Protein Coding	1
14	TCF4	Transcription Factor 4	Protein Coding	1
15	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
16	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
17	SP1	Sp1 Transcription Factor	Protein Coding	1
18	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	1
19	SLC9A3	Solute Carrier Family 9 Member A3	Protein Coding	1
20	SLC9A1	Solute Carrier Family 9 Member A1	Protein Coding	1
21	BMP2	Bone Morphogenetic Protein 2	Protein Coding	1
22	SHC1	SHC Adaptor Protein 1	Protein Coding	1
23	RPS6KB1	Ribosomal Protein S6 Kinase B1	Protein Coding	1
24	RPS6	Ribosomal Protein S6	Protein Coding	1
25	ROCK1	Rho Associated Coiled-Coil Containing Protein Kinase 1	Protein Coding	1
26	BCL2L1	BCL2 Like 1	Protein Coding	1
27	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	1
28	CCND1	Cyclin D1	Protein Coding	1
29	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
30	RAC1	Rac Family Small GTPase 1	Protein Coding	1
31	PXN	Paxillin	Protein Coding	1
32	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	1
33	PTK2	Protein Tyrosine Kinase 2	Protein Coding	1
34	PTGS2	Prostaglandin-Endoperoxide Synthase 2	Protein Coding	1
35	BAD	BCL2 Associated Agonist Of Cell Death	Protein Coding	1
36	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	1
37	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	1
38	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
39	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
40	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
41	PRKCQ	Protein Kinase C Theta	Protein Coding	1
42	PRKD1	Protein Kinase D1	Protein Coding	1
43	PRKCH	Protein Kinase C Eta	Protein Coding	1
44	PRKCE	Protein Kinase C Epsilon	Protein Coding	1
45	PRKCD	Protein Kinase C Delta	Protein Coding	1
46	PRKCA	Protein Kinase C Alpha	Protein Coding	1
47	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	1
48	PPARG	Peroxisome Proliferator Activated Receptor Gamma	Protein Coding	1
49	PLCG1	Phospholipase C Gamma 1	Protein Coding	1
50	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	1
51	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
52	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
53	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	1
54	SERPINB2	Serpin Family B Member 2	Protein Coding	1
55	SERPINE1	Serpin Family E Member 1	Protein Coding	1
56	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	1
57	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
58	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	1
59	MMP7	Matrix Metallopeptidase 7	Protein Coding	1
60	MEF2D	Myocyte Enhancer Factor 2D	Protein Coding	1
61	MEF2C	Myocyte Enhancer Factor 2C	Protein Coding	1
62	ARRB2	Arrestin Beta 2	Protein Coding	1
63	ARRB1	Arrestin Beta 1	Protein Coding	1
64	RHOB	Ras Homolog Family Member B	Protein Coding	1
65	RHOA	Ras Homolog Family Member A	Protein Coding	1
66	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	1
67	KIT	KIT Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	1
68	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
69	JAK2	Janus Kinase 2	Protein Coding	1
70	ITGB1	Integrin Subunit Beta 1	Protein Coding	1
71	IRS1	Insulin Receptor Substrate 1	Protein Coding	1
72	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	1
73	IL2	Interleukin 2	Protein Coding	1
74	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	1
75	BIRC5	Baculoviral IAP Repeat Containing 5	Protein Coding	1
76	BIRC3	Baculoviral IAP Repeat Containing 3	Protein Coding	1
77	BIRC2	Baculoviral IAP Repeat Containing 2	Protein Coding	1
78	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	1
79	HDC	Histidine Decarboxylase	Protein Coding	1
80	ANXA2	Annexin A2	Protein Coding	1
81	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
82	GNAQ	G Protein Subunit Alpha Q	Protein Coding	1
83	PRKD2	Protein Kinase D2	Protein Coding	1
84	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
85	GAST	Gastrin	Protein Coding	1
86	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
87	FOXO3	Forkhead Box O3	Protein Coding	1
88	FOXO1	Forkhead Box O1	Protein Coding	1
89	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
90	EIF4EBP1	Eukaryotic Translation Initiation Factor 4E Binding Protein 1	Protein Coding	1
91	EGR1	Early Growth Response 1	Protein Coding	1
92	EGFR	Epidermal Growth Factor Receptor	Protein Coding	1
93	JAG1	Jagged Canonical Notch Ligand 1	Protein Coding	1
94	CTNNB1	Catenin Beta 1	Protein Coding	1
95	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
96	CRK	CRK Proto-Oncogene, Adaptor Protein	Protein Coding	1
97	ATF2	Activating Transcription Factor 2	Protein Coding	1
98	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	1
99	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	1
100	CHGA	Chromogranin A	Protein Coding	1
101	KAT5	Lysine Acetyltransferase 5	Protein Coding	1
102	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	1
103	CDKN1B	Cyclin Dependent Kinase Inhibitor 1B	Protein Coding	1
104	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	1
105	LAMTOR3	Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 3	Protein Coding	1
106	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	1
107	ARHGEF28	Rho Guanine Nucleotide Exchange Factor 28	Protein Coding	1
108	MAP3K11	Mitogen-Activated Protein Kinase Kinase Kinase 11	Protein Coding	1
109	RHOD	Ras Homolog Family Member D	Protein Coding	1
110	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	1
111	ELK1	ETS Transcription Factor ELK1	Protein Coding	1
112	MEF2B	Myocyte Enhancer Factor 2B	Protein Coding	1

Disorders associated with Gastrin signaling pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Noonan syndrome 3	Enrichment	HRAS, KRAS, PTPN11, RAF1, SOS1	9.11
2	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, KRAS, MAP2K1, PTPN11, RAF1, SOS1	8.88
3	Bladder cancer	Enrichment	CDKN1A, CDKN2A, CTNNB1, EGFR, HRAS, KRAS, PIK3CA	8.53
4	Lung non-small cell carcinoma	Enrichment	EGFR, HRAS, KRAS, MAP2K1, PIK3CA	7.81
5	Noonan syndrome 1	Enrichment	HRAS, KRAS, MAP2K1, PTPN11, RAF1, SOS1	7.60
6	Lip and oral cavity carcinoma	Enrichment	CDKN2A, EGFR, HRAS, KIT, PIK3CA	7.58
7	Rasopathy	Enrichment	HRAS, KRAS, MAP2K1, PTPN11, RAF1, SOS1	7.25
8	Lung squamous cell carcinoma	Enrichment	CDKN2A, EGFR, KRAS, PIK3CA	7.19
9	Ovarian cancer	Enrichment	AKT1, CDH1, CDKN1B, CDKN2A, CTNNB1, EGFR, KIT, KRAS, PIK3CA	6.85
10	Colorectal cancer	Enrichment	AKT1, CCND1, CDH1, CTNNB1, PIK3CA, PIK3R1, PPARG, SRC	6.24
11	Breast cancer	Enrichment	AKT1, CDH1, IL2, JUN, KRAS, PIK3CA, SHC1	5.57
12	Breast adenocarcinoma	Enrichment	AKT1, KRAS, PIK3CA	4.97
13	Nevus, epidermal	Enrichment	HRAS, KRAS, PIK3CA	4.73
14	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, MAP2K1, PIK3CA	4.73
15	Gallbladder cancer	Enrichment	CTNNB1, KRAS, PIK3CA	4.73
16	Arteriovenous malformation	Enrichment	HRAS, MAP2K1, PIK3CA	4.35
17	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, MAP2K1, PIK3CA	4.20
18	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	3.70
19	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK2, STAT3	3.70
20	Gliosarcoma	Enrichment	EGFR, NFKBIA, PPARG	3.55
21	Giant cell glioblastoma	Enrichment	EGFR, NFKBIA, PPARG	3.47
22	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS	3.40
23	Cardiofaciocutaneous syndrome 1	Enrichment	KRAS, MAP2K1	3.40
24	Diffuse gastric and lobular breast cancer syndrome	Enrichment	CDH1, KRAS	3.40
25	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA, PIK3R2	3.40
26	Congenital generalized lipodystrophy	Enrichment	FOS, PPARG	3.40
27	Cardiofaciocutaneous syndrome	Enrichment	KRAS, MAP2K1	3.40
28	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42, PTPN11	3.40
29	Noonan syndrome with multiple lentigines	Enrichment	PTPN11, RAF1	3.40
30	Gastric cancer	Enrichment	CDH1, CDKN2A, KRAS, PIK3CA	3.37
31	Hereditary breast carcinoma	Enrichment	AKT1, CDH1, KRAS, PIK3CA	3.33
32	Capillary malformations, congenital	Enrichment	GNAQ, PIK3CA	3.18
33	Inherited cancer-predisposing syndrome	Enrichment	CDH1, CDKN1B, CDKN2A, EGFR, KIT, PTPN11	3.11
34	Klippel-trenaunay-weber syndrome	Enrichment	GNAQ, PIK3CA	3.00
35	Cowden syndrome 1	Enrichment	EGFR, PIK3CA	3.00
36	Hemihyperplasia, isolated	Enrichment	PIK3CA, RHOA	3.00
37	Adrenocortical carcinoma	Enrichment	CDKN2A, CTNNB1	3.00
38	Multiple endocrine neoplasia, type i	Enrichment	CDKN1A, CDKN1B	2.86
39	Myelofibrosis	Enrichment	JAK2, SRC	2.86
40	Pilomyxoid astrocytoma	Enrichment	KRAS, RAF1	2.86
41	Differentiated thyroid carcinoma	Enrichment	HRAS, KRAS, PPARG	2.77
42	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, RAF1	2.74
43	Non-immune hydrops fetalis	Enrichment	HRAS, KRAS, PTPN11	2.68
44	Lung cancer	Enrichment	EGFR, KRAS, PIK3CA	2.64
45	Adult hepatocellular carcinoma	Enrichment	CTNNB1, PIK3CA	2.63
46	Cowden syndrome	Enrichment	AKT1, PIK3CA	2.63
47	Specific learning disability	Enrichment	MAPK1, PTPN11	2.45
48	Epicanthus	Enrichment	PTPN11, TCF4	2.37
49	Juvenile myelomonocytic leukemia	Enrichment	KRAS, PTPN11	2.37
50	Meningioma	Enrichment	AKT1, PIK3CA	2.37
51	Leukemia, acute myeloid	Enrichment	JAK2, KIT, KRAS	2.36
52	Lung cancer susceptibility 3	Enrichment	EGFR, KRAS	2.24
53	Lynch syndrome	Enrichment	KRAS, PIK3CA	2.18
54	Macrodactyly	Enrichment	PIK3CA	2.08
55	Proteus syndrome	Enrichment	AKT1	2.08
56	Metachondromatosis	Enrichment	PTPN11	2.08
57	Oculoectodermal syndrome	Enrichment	KRAS	2.08
58	Noonan syndrome 5	Enrichment	RAF1	2.08
59	Noonan syndrome 4	Enrichment	SOS1	2.08
60	Mastocytosis, cutaneous	Enrichment	KIT	2.08
61	Melorheostosis, isolated	Enrichment	MAP2K1	2.08
62	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.08
63	Leopard syndrome 1	Enrichment	PTPN11	2.08
64	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.08
65	Cowden syndrome 5	Enrichment	PIK3CA	2.08
66	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.08
67	Lichtenstein-knorr syndrome	Enrichment	SLC9A1	2.08
68	Fetal encasement syndrome	Enrichment	CHUK	2.08
69	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	2.08
70	Sturge-weber syndrome	Enrichment	GNAQ	2.08
71	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.08
72	Charcot-marie-tooth disease, axonal, type 2hh	Enrichment	JAG1	2.08
73	Immunodeficiency 15b	Enrichment	IKBKB	2.08
74	Noonan syndrome 13	Enrichment	MAPK1	2.08
75	Immunodeficiency 15a	Enrichment	IKBKB	2.08
76	Short syndrome	Enrichment	PIK3R1	2.08
77	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	2.08
78	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.08
79	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.08
80	Plasminogen activator inhibitor-1 deficiency	Enrichment	SERPINE1	2.08
81	Neurodevelopmental disorder with hypotonia, stereotypic hand movements, and impaired language	Enrichment	MEF2C	2.08
82	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	2.08
83	Microvascular complications of diabetes 1	Enrichment	VEGFA	2.08
84	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.08
85	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.08
86	Melorheostosis	Enrichment	MAP2K1	2.08
87	Neuroendocrine tumor	Enrichment	CDKN1B	2.08
88	Leopard syndrome 2	Enrichment	RAF1	2.08
89	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.08
90	Cowden syndrome 6	Enrichment	AKT1	2.08
91	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	2.08
92	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.08
93	Corneal dystrophy, fuchs endothelial, 3	Enrichment	TCF4	2.08
94	Congenital heart defects and ectodermal dysplasia	Enrichment	PRKD1	2.08
95	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.08
96	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	2.08
97	20p12.3 microdeletion syndrome	Enrichment	BMP2	2.08
98	Thrombocytopenia 6	Enrichment	SRC	2.08
99	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.08
100	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.08
101	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.08
102	Deafness, congenital heart defects, and posterior embryotoxon	Enrichment	JAG1	2.08
103	Short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies 1	Enrichment	BMP2	2.08
104	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.08
105	Chronic mast cell leukemia	Enrichment	KIT	2.08
106	Trigonitis	Enrichment	RAF1	2.08
107	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.08
108	Adenoid ameloblastoma	Enrichment	CTNNB1	2.08
109	Cdkn2a cancer predisposition	Enrichment	CDKN2A	2.08
110	Pparg-associated congenital generalized lipodystrophy	Enrichment	PPARG	2.08
111	Hypospadias	Enrichment	PIK3CA	2.08
112	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.08
113	Breast lobular carcinoma	Enrichment	CDH1	2.08
114	5q14.3 microdeletion syndrome	Enrichment	MEF2C	2.08
115	Isolated bone marrow mastocytosis	Enrichment	KIT	2.08
116	Congenital pulmonary airway malformation	Enrichment	KRAS	2.08
117	Smoldering systemic mastocytosis	Enrichment	KIT	2.08
118	Rare venous malformation	Enrichment	PIK3CA	2.08
119	Diaphragmatic eventration	Enrichment	PIK3CA	2.08
120	Complete atrioventricular septal defect without ventricular hypoplasia	Enrichment	MEF2C	2.08
121	Nocarh syndrome	Enrichment	CDC42	2.08
122	Mastocytosis	Enrichment	KIT	2.08
123	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.08
124	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.08
125	Rare combined vascular malformation	Enrichment	PIK3CA	2.08
126	Cavernous lymphangioma	Enrichment	PIK3CA	2.08
127	Congenital plasminogen activator inhibitor type 1 deficiency	Enrichment	SERPINE1	2.08
128	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.08
129	Cutaneous mastocytoma	Enrichment	KIT	2.08
130	Typical urticaria pigmentosa	Enrichment	KIT	2.08
131	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.08
132	Mef2c-related disorder	Enrichment	MEF2C	2.08
133	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.08
134	Nodular urticaria pigmentosa	Enrichment	KIT	2.08
135	Malignant epithelial tumor of salivary glands	Enrichment	PRKD1	2.08
136	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.08
137	Pseudoxanthomatous diffuse cutaneous mastocytosis	Enrichment	KIT	2.08
138	Telangiectasia macularis eruptiva perstans	Enrichment	KIT	2.08
139	Acute mast cell leukemia	Enrichment	KIT	2.08
140	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.08
141	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.08
142	Plaque-form urticaria pigmentosa	Enrichment	KIT	2.08
143	Macrodactyly of toe	Enrichment	PIK3CA	2.08
144	Bullous diffuse cutaneous mastocytosis	Enrichment	KIT	2.08
145	Microcystic stromal tumor	Enrichment	CTNNB1	2.08
146	Malignant astrocytoma	Enrichment	PTPN11	2.08
147	Testis seminoma	Enrichment	KIT	2.08
148	Heart, malformation of	Enrichment	JAG1, MAPK1	2.02
149	Arteriovenous malformations of the brain	Enrichment	EGFR, KRAS	1.98
150	Diffuse large b-cell lymphoma	Enrichment	FOXO1, STAT3	1.98
151	Myeloma, multiple	Enrichment	CCND1, KRAS, PIK3R2	1.96
152	Autism spectrum disorder	Enrichment	MAP2K1, MEF2C, PTPN11, TCF4	1.90
153	Endometrial cancer	Enrichment	CDH1, PIK3CA	1.89
154	Hepatoblastoma	Enrichment	CTNNB1, JAG1	1.89
155	Hepatocellular carcinoma	Enrichment	CTNNB1, PIK3CA	1.85
156	Precursor t-cell acute lymphoblastic leukemia	Enrichment	CDKN2A, MYC	1.82
157	Gilles de la tourette syndrome	Enrichment	HDC	1.78
158	Blepharocheilodontic syndrome 1	Enrichment	CDH1	1.78
159	Melanoma-astrocytoma syndrome	Enrichment	CDKN2A	1.78
160	Burkitt lymphoma	Enrichment	MYC	1.78
161	Fibromatosis, gingival, 1	Enrichment	SOS1	1.78
162	Costello syndrome	Enrichment	HRAS	1.78
163	Osteopathia striata with cranial sclerosis	Enrichment	CTNNB1	1.78
164	Carotid intimal medial thickness 1	Enrichment	PPARG	1.78
165	Pulmonic stenosis	Enrichment	SOS1	1.78
166	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	1.78
167	Ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis	Enrichment	CLDN1	1.78
168	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	1.78
169	Piebald trait	Enrichment	KIT	1.78
170	Keratosis, seborrheic	Enrichment	PIK3CA	1.78
171	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	1.78
172	Melanoma, cutaneous malignant 2	Enrichment	CDKN2A	1.78
173	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS	1.78
174	Noonan syndrome 8	Enrichment	PIK3CA	1.78
175	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	1.78
176	Thrombocythemia 3	Enrichment	JAK2	1.78
177	Multiple endocrine neoplasia, type iv	Enrichment	CDKN1B	1.78
178	Diarrhea 8, secretory sodium, congenital	Enrichment	SLC9A3	1.78
179	Neurodevelopmental disorder with dysmorphic facies, sleep disturbance, and brain abnormalities	Enrichment	KAT5	1.78
180	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	1.78
181	Werner syndrome	Enrichment	PTPN11	1.78
182	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	1.78
183	Childhood hepatocellular carcinoma	Enrichment	CTNNB1	1.78
184	Rela fusion-positive ependymoma	Enrichment	RELA	1.78
185	Melanoma-pancreatic cancer syndrome	Enrichment	CDKN2A	1.78
186	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	1.78
187	Fibrolamellar carcinoma	Enrichment	PRKACA	1.78
188	Ectodermal dysplasia and immune deficiency	Enrichment	NFKBIA	1.78
189	Immune system disease	Enrichment	CDC42	1.78
190	Polycythemia	Enrichment	JAK2	1.78
191	Craniosynostosis 7	Enrichment	BMP2	1.78
192	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	1.78
193	Familial partial lipodystrophy	Enrichment	PPARG	1.78
194	Hypereosinophilic syndrome	Enrichment	JAK2	1.78
195	Teratoma	Enrichment	CTNNB1	1.78
196	B-lymphoblastic leukemia/lymphoma with t	Enrichment	KIT	1.78
197	Common variable immunodeficiency 12	Enrichment	NFKB1	1.78
198	Phakomatosis cesioflammea	Enrichment	GNAQ	1.78
199	Wooly hair nevus	Enrichment	HRAS	1.78
200	Pancreatic cancer	Enrichment	CDKN2A, KRAS	1.75
201	Microcephaly	Enrichment	CTNNB1, MAPK1, PTPN11, TCF4	1.72
202	Hydrops fetalis, nonimmune	Enrichment	HRAS, PTPN11	1.71
203	Prostate cancer	Enrichment	CDH1, PIK3CA	1.62
204	Desmoid disease, hereditary	Enrichment	CTNNB1	1.61
205	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	1.61
206	Alagille syndrome 1	Enrichment	JAG1	1.61
207	Polycythemia vera	Enrichment	JAK2	1.61
208	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.61
209	Diarrhea 3, secretory sodium, congenital, with or without other congenital anomalies	Enrichment	SLC9A3	1.61
210	Nuchal bleb, familial	Enrichment	SOS1	1.61
211	Langerhans cell histiocytosis	Enrichment	MAP2K1	1.61
212	Transposition of the great arteries, dextro-looped	Enrichment	BMP2	1.61
213	Nasopharyngeal carcinoma	Enrichment	NFKBIA	1.61
214	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	1.61
215	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	1.61
216	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	1.61
217	Anus, imperforate	Enrichment	CTNNB1	1.61
218	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	1.61
219	Large congenital melanocytic nevus	Enrichment	HRAS	1.61
220	Desmoid tumor	Enrichment	CTNNB1	1.61
221	Hyper ige syndrome	Enrichment	STAT3	1.61
222	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	MYC	1.61
223	Testicular germ cell cancer	Enrichment	KIT	1.61
224	Immunodeficiency 14	Enrichment	PIK3R1	1.61
225	Spermatocytoma	Enrichment	HRAS	1.61
226	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	1.61
227	Melanoma of soft tissue	Enrichment	CREB1	1.61
228	Tricuspid valve insufficiency	Enrichment	PTPN11	1.61
229	Anastomosing haemangioma	Enrichment	GNAQ	1.61
230	Keratoacanthoma	Enrichment	PIK3CA	1.61
231	Erythrocytosis, familial, 1	Enrichment	JAK2	1.49
232	Brachydactyly, type a2	Enrichment	BMP2	1.49
233	Budd-chiari syndrome	Enrichment	JAK2	1.49
234	Lipodystrophy, familial partial, type 3	Enrichment	PPARG	1.49
235	Pitt-hopkins syndrome	Enrichment	TCF4	1.49
236	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.49
237	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	PIK3R2	1.49
238	Pilomatrixoma	Enrichment	CTNNB1	1.49
239	Leptin deficiency or dysfunction	Enrichment	PPARG	1.49
240	Alazami syndrome	Enrichment	CTNNB1	1.49
241	Mantle cell lymphoma	Enrichment	CCND1	1.49
242	Lung sarcomatoid carcinoma	Enrichment	KRAS	1.49
243	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS	1.49
244	Cerebrovascular disease	Enrichment	PIK3CA	1.49
245	Craniopharyngioma	Enrichment	CTNNB1	1.49
246	Pilocytic astrocytoma	Enrichment	KRAS	1.49
247	Epidermolytic nevus	Enrichment	HRAS	1.49
248	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.49
249	Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)	Enrichment	KIT	1.49
250	Primary hyperparathyroidism	Enrichment	CDKN1B	1.49
251	Systemic mastocytosis with associated hematologic neoplasm	Enrichment	KIT	1.49
252	Middle aortic syndrome	Enrichment	JAG1	1.49
253	Gingival fibromatosis	Enrichment	SOS1	1.49
254	Pseudomyogenic hemangioendothelioma	Enrichment	SERPINE1	1.49
255	Lymphoma, mucosa-associated lymphoid type	Enrichment	BIRC3	1.39
256	Exudative vitreoretinopathy 1	Enrichment	CTNNB1	1.39
257	Von hippel-lindau syndrome	Enrichment	CCND1	1.39
258	Rhabdomyosarcoma 2	Enrichment	FOXO1	1.39
259	Ventricular septal defect 1	Enrichment	BMP2	1.39
260	Cholangitis, primary sclerosing	Enrichment	TCF4	1.39
261	Fuchs' endothelial dystrophy	Enrichment	TCF4	1.39
262	Lymphoma	Enrichment	PTPN11	1.39
263	Acute myeloid leukemia with maturation	Enrichment	KIT	1.39
264	Myeloproliferative neoplasm	Enrichment	JAK2	1.39
265	Histiocytoid hemangioma	Enrichment	FOS	1.39
266	Hemimegalencephaly	Enrichment	PIK3CA	1.39
267	Acute myeloid leukemia with t(8;21)(q22;q22) translocation	Enrichment	KIT	1.39
268	Type 2 diabetes mellitus	Enrichment	IRS1, PPARG	1.33
269	Atrial septal defect 1	Enrichment	BMP2	1.31
270	Li-fraumeni syndrome	Enrichment	CDKN2A	1.31
271	Melanoma, uveal	Enrichment	GNAQ	1.31
272	Weyers acrofacial dysostosis	Enrichment	CTNNB1	1.31
273	Testicular germ cell tumor	Enrichment	KIT	1.31
274	Patent ductus arteriosus	Enrichment	PTPN11	1.31
275	Cleft lip with or without cleft palate	Enrichment	CDH1	1.31
276	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS	1.25
277	Squamous cell carcinoma, head and neck	Enrichment	EGFR	1.25
278	Gastrointestinal stromal tumor	Enrichment	KIT	1.25
279	Leukemia, chronic myeloid	Enrichment	KRAS	1.25
280	Essential thrombocythemia	Enrichment	JAK2	1.25
281	Common variable immunodeficiency	Enrichment	NFKB1	1.25
282	Follicular thyroid carcinoma	Enrichment	HRAS	1.25
283	Overgrowth syndrome	Enrichment	PIK3R1	1.25
284	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	CDKN2A	1.25
285	Thrombocytopenia	Enrichment	PTPN11, SRC	1.22
286	Spastic paraplegia 4, autosomal dominant	Enrichment	TCF4	1.19
287	Hemochromatosis, type 1	Enrichment	BMP2	1.19
288	Exudative vitreoretinopathy	Enrichment	CTNNB1	1.19
289	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.19
290	Ellis-van creveld syndrome	Enrichment	PRKACA	1.14
291	Inflammatory bowel disease 1	Enrichment	PRKCQ	1.14
292	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	1.14
293	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.14
294	Hereditary breast ovarian cancer syndrome	Enrichment	BCAR1, KRAS	1.12
295	Leukemia, chronic lymphocytic	Enrichment	CCND1	1.10
296	Stroke, ischemic	Enrichment	PRKCH	1.10
297	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.10
298	Melanoma	Enrichment	CDKN2A	1.10
299	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.10
300	Pectus excavatum	Enrichment	PTPN11	1.06
301	Leukemia, acute lymphoblastic	Enrichment	CDKN2A	1.06
302	Congenital long qt syndrome	Enrichment	PTPN11	1.02
303	Aortic valve disease 1	Enrichment	SOS1	0.99
304	Neural tube defects	Enrichment	ITGB1	0.99
305	Acute promyelocytic leukemia	Enrichment	STAT3	0.99
306	Stereotypic movement disorder	Enrichment	TCF4	0.99
307	Osteoporosis	Enrichment	SRC	0.96
308	Medulloblastoma	Enrichment	CTNNB1	0.96
309	Cleft lip/palate	Enrichment	CDH1	0.96
310	46,xy partial gonadal dysgenesis	Enrichment	SOS1	0.96
311	Rhabdomyosarcoma	Enrichment	HRAS	0.91
312	Melanoma, cutaneous malignant 1	Enrichment	CDKN2A	0.88
313	Polycystic liver disease	Enrichment	CTNNB1	0.88
314	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1	0.88
315	Patent foramen ovale	Enrichment	PTPN11	0.86
316	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	0.74
317	Scoliosis	Enrichment	PTPN11	0.74
318	Tetralogy of fallot	Enrichment	JAG1	0.71
319	Strabismus	Enrichment	PTPN11	0.70
320	Long qt syndrome 1	Enrichment	PTPN11	0.66
321	Cystic fibrosis	Enrichment	SLC9A3	0.63
322	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	0.62
323	Severe combined immunodeficiency	Enrichment	IKBKB	0.62
324	Left ventricular noncompaction	Enrichment	RAF1	0.60
325	Hypertrophic cardiomyopathy	Enrichment	PTPN11	0.52
326	Body mass index quantitative trait locus 11	Enrichment	PPARG	0.47
327	Autosomal dominant non-syndromic intellectual disability	Enrichment	TCF4	0.47
328	Hypertelorism	Enrichment	PIK3CA	0.46
329	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.45
330	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	0.43
331	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	MEF2C	0.42
332	Primary ovarian insufficiency	Enrichment	JAK2	0.41
333	Dilated cardiomyopathy	Enrichment	RAF1	0.31
334	Congenital nervous system abnormality	Enrichment	CTNNB1	0.23
335	Nervous system disease	Enrichment	CTNNB1	0.23
336	Hereditary retinal dystrophy	Enrichment	JAG1	0.04
337	Fundus dystrophy	Enrichment	JAG1	0.04

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Gastrin signaling pathway

Pathway Network for Gastrin signaling pathway

Member Pathways for Gastrin signaling pathway

Pathways in the Gastrin signaling pathway SuperPath

Associated Genes for Gastrin signaling pathway

Associated Disorders for Gastrin signaling pathway

Disorders associated with Gastrin signaling pathway SuperPath

STRING Interaction Network for Gastrin signaling pathway

Sources for Gastrin signaling pathway