GDNF-Family Ligands and Receptor Interactions

Pathway network for the GDNF-Family Ligands and Receptor Interactions SuperPath

Sources:

QIAGEN
GeneGo (Thomson Reuters)

Pathways in the GDNF-Family Ligands and Receptor Interactions SuperPath

#	Name	Source	Genes
1	GDNF-Family Ligands and Receptor Interactions	QIAGEN	ARTN CREB1 DOK1 DOK2 DOK3 DOK4 DOK6 FOS FRS2 GAB1 GDNF GFRA1 GFRA2 GFRA3 GFRA4 GRB2 HRAS IRS1 IRS2 ITPR1 ITPR2 ITPR3 JUN KRAS MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7 MAP3K2 MAP3K3 MAP3K4 MAP3K5 MAPK1 MAPK10 MAPK3 MAPK8 MAPK9 MRAS NCK1 NRAS NRTN PAK1 PDLIM7 PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PLCG1 PLCG2 PSPN RAF1 RASA1 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA4 RPS6KA6 RRAS RRAS2 SOS1 SOS2 (see all 65) (see less)
2	Development GDNF family signaling	GeneGo (Thomson Reuters)	AKT1 AKT2 AKT3 ARTN CHUK CREB1 DOK1 FRS2 GAB2 GDNF GFRA1 GFRA2 GFRA3 GFRA4 GRB2 HRAS IKBKB IRS1 JUN MAP2K1 MAP2K2 MAP2K7 MAP3K1 MAPK1 MAPK10 MAPK3 MAPK8 MAPK9 NCK1 NFKB1 NFKB2 NFKBIA NFKBIB NFKBIE NRTN PAK1 PDLIM7 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PLCG1 PLCG2 PSPN RAF1 RASA1 REL RELA RELB RET RPS6KA1 RPS6KA2 RPS6KA3 SHC1 SOS1 SOS2 SRC (see all 58) (see less)
3	BDNF Pathway	QIAGEN	AKT1 ATF4 BAD BCL2 BCL2L1 BDNF CREB1 CREB3 CREB3L4 GAB1 GRB2 HRAS ITPR1 ITPR2 ITPR3 KRAS MAP2K1 MAP2K2 MAPK1 MAPK3 MRAS NRAS NTRK2 PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PLCG1 PLCG2 RAF1 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA4 RPS6KA6 RRAS RRAS2 SOS1 SOS2 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ (see all 46) (see less)

Gene overlap in member pathways for GDNF-Family Ligands and Receptor Interactions SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	3
2	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	3
3	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	3
4	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	3
5	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	3
6	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	3
7	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	3
8	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	3
9	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	3
10	PLCG1	Phospholipase C Gamma 1	Protein Coding	3
11	PLCG2	Phospholipase C Gamma 2	Protein Coding	3
12	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	3
13	RPS6KA1	Ribosomal Protein S6 Kinase A1	Protein Coding	3
14	RPS6KA2	Ribosomal Protein S6 Kinase A2	Protein Coding	3
15	RPS6KA3	Ribosomal Protein S6 Kinase A3	Protein Coding	3
16	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	3
17	SOS2	SOS Ras/Rho Guanine Nucleotide Exchange Factor 2	Protein Coding	3
18	ARTN	Artemin	Protein Coding	2
19	DOK1	Docking Protein 1	Protein Coding	2
20	GAB1	GRB2 Associated Binding Protein 1	Protein Coding	2
21	GDNF	Glial Cell Derived Neurotrophic Factor	Protein Coding	2
22	GFRA1	GDNF Family Receptor Alpha 1	Protein Coding	2
23	GFRA2	GDNF Family Receptor Alpha 2	Protein Coding	2
24	GFRA3	GDNF Family Receptor Alpha 3	Protein Coding	2
25	GFRA4	GDNF Family Receptor Alpha 4	Protein Coding	2
26	IRS1	Insulin Receptor Substrate 1	Protein Coding	2
27	ITPR1	Inositol 1,4,5-Trisphosphate Receptor Type 1	Protein Coding	2
28	ITPR2	Inositol 1,4,5-Trisphosphate Receptor Type 2	Protein Coding	2
29	ITPR3	Inositol 1,4,5-Trisphosphate Receptor Type 3	Protein Coding	2
30	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	2
31	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	2
32	MAP2K7	Mitogen-Activated Protein Kinase Kinase 7	Protein Coding	2
33	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	2
34	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	2
35	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	2
36	MRAS	Muscle RAS Oncogene Homolog	Protein Coding	2
37	NCK1	NCK Adaptor Protein 1	Protein Coding	2
38	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	2
39	NRTN	Neurturin	Protein Coding	2
40	PIK3R5	Phosphoinositide-3-Kinase Regulatory Subunit 5	Protein Coding	2
41	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	2
42	PDLIM7	PDZ And LIM Domain 7	Protein Coding	2
43	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	2
44	PIK3R4	Phosphoinositide-3-Kinase Regulatory Subunit 4	Protein Coding	2
45	PSPN	Persephin	Protein Coding	2
46	RASA1	RAS P21 Protein Activator 1	Protein Coding	2
47	RPS6KA4	Ribosomal Protein S6 Kinase A4	Protein Coding	2
48	RPS6KA6	Ribosomal Protein S6 Kinase A6	Protein Coding	2
49	RRAS	RAS Related	Protein Coding	2
50	RRAS2	RAS Related 2	Protein Coding	2
51	FRS2	Fibroblast Growth Factor Receptor Substrate 2	Protein Coding	2
52	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	2
53	DOK2	Docking Protein 2	Protein Coding	1
54	DOK4	Docking Protein 4	Protein Coding	1
55	DOK3	Docking Protein 3	Protein Coding	1
56	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
57	IRS2	Insulin Receptor Substrate 2	Protein Coding	1
58	MAP2K3	Mitogen-Activated Protein Kinase Kinase 3	Protein Coding	1
59	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	1
60	MAP2K5	Mitogen-Activated Protein Kinase Kinase 5	Protein Coding	1
61	MAP2K6	Mitogen-Activated Protein Kinase Kinase 6	Protein Coding	1
62	MAP3K2	Mitogen-Activated Protein Kinase Kinase Kinase 2	Protein Coding	1
63	MAP3K3	Mitogen-Activated Protein Kinase Kinase Kinase 3	Protein Coding	1
64	MAP3K4	Mitogen-Activated Protein Kinase Kinase Kinase 4	Protein Coding	1
65	MAP3K5	Mitogen-Activated Protein Kinase Kinase Kinase 5	Protein Coding	1
66	DOK6	Docking Protein 6	Protein Coding	1
67	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	1
68	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	1
69	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	1
70	MAP3K1	Mitogen-Activated Protein Kinase Kinase Kinase 1	Protein Coding	1
71	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
72	NFKB2	Nuclear Factor Kappa B Subunit 2	Protein Coding	1
73	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	1
74	NFKBIB	NFKB Inhibitor Beta	Protein Coding	1
75	NFKBIE	NFKB Inhibitor Epsilon	Protein Coding	1
76	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
77	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	1
78	PIK3CD	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta	Protein Coding	1
79	REL	REL Proto-Oncogene, NF-KB Subunit	Protein Coding	1
80	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	1
81	RELB	RELB Proto-Oncogene, NF-KB Subunit	Protein Coding	1
82	RET	Ret Proto-Oncogene	Protein Coding	1
83	SHC1	SHC Adaptor Protein 1	Protein Coding	1
84	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
85	GAB2	GRB2 Associated Binding Protein 2	Protein Coding	1
86	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	1
87	ATF4	Activating Transcription Factor 4	Protein Coding	1
88	BAD	BCL2 Associated Agonist Of Cell Death	Protein Coding	1
89	BCL2	BCL2 Apoptosis Regulator	Protein Coding	1
90	BCL2L1	BCL2 Like 1	Protein Coding	1
91	BDNF	Brain Derived Neurotrophic Factor	Protein Coding	1
92	CREB3	CAMP Responsive Element Binding Protein 3	Protein Coding	1
93	CREB3L4	CAMP Responsive Element Binding Protein 3 Like 4	Protein Coding	1
94	NTRK2	Neurotrophic Receptor Tyrosine Kinase 2	Protein Coding	1
95	YWHAB	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Beta	Protein Coding	1
96	YWHAE	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Epsilon	Protein Coding	1
97	YWHAG	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Gamma	Protein Coding	1
98	YWHAH	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Eta	Protein Coding	1
99	YWHAQ	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Theta	Protein Coding	1
100	YWHAZ	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta	Protein Coding	1

Disorders associated with GDNF-Family Ligands and Receptor Interactions SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Rasopathy	Enrichment	HRAS, KRAS, MAP2K1, MAP2K2, MRAS, NRAS, RAF1, RRAS2, SOS1, SOS2	16.00
2	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, KRAS, MAP2K1, MAP2K2, NRAS, RAF1, SOS1	11.06
3	Noonan syndrome 1	Enrichment	HRAS, KRAS, MAP2K1, MAP2K2, MRAS, NRAS, RAF1, RRAS, RRAS2, SOS1, SOS2	10.63
4	Noonan syndrome 3	Enrichment	HRAS, KRAS, RAF1, SOS1	8.40
5	Arteriovenous malformation	Enrichment	HRAS, MAP2K1, PIK3CA, RASA1	7.43
6	Lung non-small cell carcinoma	Enrichment	HRAS, KRAS, MAP2K1, NRAS	7.43
7	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, MAP2K1, PIK3CA, RASA1	7.21
8	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	6.84
9	Cardiofaciocutaneous syndrome 1	Enrichment	KRAS, MAP2K1, MAP2K2	6.84
10	Cardiofaciocutaneous syndrome	Enrichment	KRAS, MAP2K1, MAP2K2	6.84
11	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3, PIK3CA, PIK3R2	6.53
12	Nevus, epidermal	Enrichment	HRAS, KRAS, NRAS	5.90
13	Pilomyxoid astrocytoma	Enrichment	KRAS, NTRK2, RAF1	5.90
14	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, NRAS, RAF1	5.69
15	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1, PIK3CA, RASA1	5.59
16	Specific learning disability	Enrichment	MAPK1, RPS6KA3, YWHAG	5.23
17	Juvenile myelomonocytic leukemia	Enrichment	KRAS, NRAS, RRAS	5.10
18	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	4.95
19	Breast cancer	Enrichment	AKT1, JUN, PIK3CA, RET, SHC1	4.78
20	Langerhans cell histiocytosis	Enrichment	MAP2K1, NRAS	4.47
21	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	4.47
22	Colorectal cancer	Enrichment	AKT1, PIK3CA, PIK3R1, RET, SRC	4.47
23	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.27
24	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3CD, PIK3R1	4.27
25	Immunodeficiency 14	Enrichment	PIK3CD, PIK3R1	4.27
26	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	4.17
27	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3, PIK3R2	3.97
28	Differentiated thyroid carcinoma	Enrichment	HRAS, KRAS, NRAS	3.90
29	Breast adenocarcinoma	Enrichment	AKT1, KRAS	3.78
30	Capillary malformations, congenital	Enrichment	PIK3CA, RASA1	3.75
31	Hemimegalencephaly	Enrichment	AKT3, PIK3CA	3.75
32	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS, NRAS	3.63
33	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	3.63
34	Follicular thyroid carcinoma	Enrichment	HRAS, NRAS	3.63
35	Hirschsprung disease 1	Enrichment	GDNF, NRTN, RET	3.60
36	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA, RASA1	3.57
37	Common variable immunodeficiency	Enrichment	NFKB1, NFKB2	3.43
38	Congenital central hypoventilation syndrome	Enrichment	GDNF, RET	3.20
39	Cowden syndrome	Enrichment	AKT1, PIK3CA	3.20
40	Renal agenesis, bilateral	Enrichment	GFRA1, RET	3.20
41	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3CD, PIK3R1	3.10
42	Hereditary breast carcinoma	Enrichment	AKT1, PIK3CA, RET	3.06
43	Ovarian cancer	Enrichment	AKT1, MAP3K1, PIK3CA, RET	3.04
44	Meningioma	Enrichment	AKT1, PIK3CA	2.94
45	Lip and oral cavity carcinoma	Enrichment	HRAS, PIK3CA	2.94
46	Hypertelorism	Enrichment	PIK3CA, RET, RPS6KA3	2.85
47	46,xy partial gonadal dysgenesis	Enrichment	MAP3K1, SOS1	2.80
48	Anhidrosis, isolated, with normal sweat glands	Enrichment	ITPR2	2.47
49	Proteus syndrome	Enrichment	AKT1	2.47
50	Coffin-lowry syndrome	Enrichment	RPS6KA3	2.47
51	Oculoectodermal syndrome	Enrichment	KRAS	2.47
52	Deafness, autosomal recessive 26	Enrichment	GAB1	2.47
53	Noonan syndrome 5	Enrichment	RAF1	2.47
54	Noonan syndrome 4	Enrichment	SOS1	2.47
55	Melorheostosis, isolated	Enrichment	MAP2K1	2.47
56	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.47
57	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.47
58	Melanosis, neurocutaneous	Enrichment	NRAS	2.47
59	Noonan syndrome 9	Enrichment	SOS2	2.47
60	Noonan syndrome 6	Enrichment	NRAS	2.47
61	Ataxia-oculomotor apraxia 3	Enrichment	PIK3R5	2.47
62	Noonan syndrome 11	Enrichment	MRAS	2.47
63	Noonan syndrome 13	Enrichment	MAPK1	2.47
64	Developmental and epileptic encephalopathy 58	Enrichment	NTRK2	2.47
65	Charcot-marie-tooth disease, demyelinating, type 1j	Enrichment	ITPR3	2.47
66	Short syndrome	Enrichment	PIK3R1	2.47
67	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.47
68	Intellectual developmental disorder, x-linked 19	Enrichment	RPS6KA3	2.47
69	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	2.47
70	Melorheostosis	Enrichment	MAP2K1	2.47
71	Leopard syndrome 2	Enrichment	RAF1	2.47
72	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.47
73	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	2.47
74	Autoinflammation, antibody deficiency, and immune dysregulation	Enrichment	PLCG2	2.47
75	Cowden syndrome 6	Enrichment	AKT1	2.47
76	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.47
77	Obesity, hyperphagia, and developmental delay	Enrichment	NTRK2	2.47
78	Familial cold autoinflammatory syndrome 3	Enrichment	PLCG2	2.47
79	Developmental and epileptic encephalopathy 56	Enrichment	YWHAG	2.47
80	Trigonitis	Enrichment	RAF1	2.47
81	Symptomatic form of coffin-lowry syndrome in female carriers	Enrichment	RPS6KA3	2.47
82	Immunodeficiency 133 with ectodermal dysplasia with or without peripheral neuropathy	Enrichment	ITPR3	2.47
83	Congenital pulmonary airway malformation	Enrichment	KRAS	2.47
84	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.47
85	Distal 17p13.3 microdeletion syndrome	Enrichment	YWHAE	2.47
86	Neurocutaneous melanocytosis	Enrichment	NRAS	2.47
87	Hepatocellular carcinoma	Enrichment	PIK3CA, RET	2.41
88	Multiple endocrine neoplasia, type iib	Enrichment	RET	2.37
89	Macrodactyly	Enrichment	PIK3CA	2.37
90	Cystic angiomatosis of bone, diffuse	Enrichment	RASA1	2.37
91	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.37
92	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.37
93	Cowden syndrome 5	Enrichment	PIK3CA	2.37
94	Fetal encasement syndrome	Enrichment	CHUK	2.37
95	46,xy sex reversal 6	Enrichment	MAP3K1	2.37
96	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.37
97	Immunodeficiency 15b	Enrichment	IKBKB	2.37
98	Immunodeficiency 15a	Enrichment	IKBKB	2.37
99	Immunodeficiency 92	Enrichment	REL	2.37
100	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	2.37
101	Renal hypodysplasia/aplasia 4	Enrichment	GFRA1	2.37
102	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.37
103	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.37
104	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.37
105	Immunodeficiency 14b, autosomal recessive	Enrichment	PIK3CD	2.37
106	Hirschsprung disease 3	Enrichment	GDNF	2.37
107	Thrombocytopenia 6	Enrichment	SRC	2.37
108	Deficiency in anterior pituitary function - variable immunodeficiency syndrome	Enrichment	NFKB2	2.37
109	Immunodeficiency 53	Enrichment	RELB	2.37
110	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.37
111	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.37
112	Hypospadias	Enrichment	PIK3CA	2.37
113	Capillary hemangioma	Enrichment	AKT3	2.37
114	Thyroid cancer	Enrichment	RET	2.37
115	Rare venous malformation	Enrichment	PIK3CA	2.37
116	Gorham's disease	Enrichment	RASA1	2.37
117	Diaphragmatic eventration	Enrichment	PIK3CA	2.37
118	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.37
119	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.37
120	Rare combined vascular malformation	Enrichment	PIK3CA	2.37
121	Cavernous lymphangioma	Enrichment	PIK3CA	2.37
122	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.37
123	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.37
124	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.37
125	Macrodactyly of toe	Enrichment	PIK3CA	2.37
126	Gastrointestinal system disease	Enrichment	RET	2.37
127	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.37
128	Multiple endocrine neoplasia	Enrichment	RET	2.37
129	Bladder cancer	Enrichment	HRAS, KRAS	2.37
130	Cerebral cavernous malformations 5	Enrichment	MAP3K3	2.32
131	Verrucous hemangioma	Enrichment	MAP3K3	2.32
132	Non-immune hydrops fetalis	Enrichment	HRAS, KRAS	2.31
133	Spinocerebellar ataxia 29	Enrichment	ITPR1	2.17
134	Fibromatosis, gingival, 1	Enrichment	SOS1	2.17
135	Costello syndrome	Enrichment	HRAS	2.17
136	Pulmonic stenosis	Enrichment	SOS1	2.17
137	Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2	Enrichment	PIK3R5	2.17
138	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	2.17
139	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	2.17
140	Noonan syndrome 12	Enrichment	RRAS2	2.17
141	Intravascular large b-cell lymphoma	Enrichment	BCL2	2.17
142	Tafro syndrome	Enrichment	MAP2K2	2.17
143	Wooly hair nevus	Enrichment	HRAS	2.17
144	Leukemia, acute myeloid	Enrichment	KRAS, NRAS	2.09
145	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	2.07
146	Keratosis, seborrheic	Enrichment	PIK3CA	2.07
147	Roifman-chitayat syndrome	Enrichment	PIK3CD	2.07
148	Noonan syndrome 8	Enrichment	PIK3CA	2.07
149	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.07
150	Immunodeficiency, common variable, 10	Enrichment	NFKB2	2.07
151	Myopia 28, autosomal recessive	Enrichment	DOK1	2.07
152	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.07
153	Rela fusion-positive ependymoma	Enrichment	RELA	2.07
154	Senior-loken syndrome 7	Enrichment	AKT3	2.07
155	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.07
156	Medullary thyroid carcinoma	Enrichment	RET	2.07
157	Ectodermal dysplasia and immune deficiency	Enrichment	NFKBIA	2.07
158	Immune system disease	Enrichment	PIK3CD	2.07
159	Bardet-biedl syndrome 16	Enrichment	AKT3	2.07
160	Common variable immunodeficiency 12	Enrichment	NFKB1	2.07
161	Gillespie syndrome	Enrichment	ITPR1	1.99
162	Nuchal bleb, familial	Enrichment	SOS1	1.99
163	Miller-dieker lissencephaly syndrome	Enrichment	YWHAE	1.99
164	Chromosome 17p13.3, centromeric, duplication syndrome	Enrichment	YWHAE	1.99
165	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	BCL2	1.99
166	Spermatocytoma	Enrichment	HRAS	1.99
167	Melanoma of soft tissue	Enrichment	CREB1	1.99
168	Thyroid carcinoma, familial medullary	Enrichment	RET	1.89
169	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.89
170	Nasopharyngeal carcinoma	Enrichment	NFKBIA	1.89
171	Wieacker-wolff syndrome	Enrichment	RASA1	1.89
172	Gingival overgrowth	Enrichment	RET	1.89
173	Keratoacanthoma	Enrichment	PIK3CA	1.89
174	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	1.87
175	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	1.87
176	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.87
177	Spinocerebellar ataxia 15	Enrichment	ITPR1	1.87
178	Lung sarcomatoid carcinoma	Enrichment	KRAS	1.87
179	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	YWHAZ	1.87
180	Noonan syndrome with multiple lentigines	Enrichment	RAF1	1.87
181	Pilocytic astrocytoma	Enrichment	KRAS	1.87
182	Epidermolytic nevus	Enrichment	HRAS	1.87
183	Gingival fibromatosis	Enrichment	SOS1	1.87
184	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	SOS2	1.87
185	Type 2 diabetes mellitus	Enrichment	AKT2, IRS1	1.86
186	Myeloma, multiple	Enrichment	KRAS, PIK3R2	1.81
187	Undetermined early-onset epileptic encephalopathy	Enrichment	NTRK2, YWHAG	1.81
188	Follicular lymphoma	Enrichment	BCL2	1.77
189	Endometrial stromal sarcoma	Enrichment	YWHAE	1.77
190	Immunodeficiency, common variable, 1	Enrichment	NFKB2	1.77
191	Central hypoventilation syndrome, congenital, 1	Enrichment	RET	1.77
192	Cerebrovascular disease	Enrichment	PIK3CA	1.77
193	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.77
194	Haddad syndrome	Enrichment	RET	1.77
195	Congenital generalized lipodystrophy	Enrichment	FOS	1.72
196	Wilms tumor, aniridia, genitourinary anomalies, and impaired intellectual development syndrome	Enrichment	BDNF	1.70
197	Spinocerebellar ataxia, autosomal recessive 16	Enrichment	ITPR1	1.70
198	Lung squamous cell carcinoma	Enrichment	KRAS	1.70
199	Kidney clear cell sarcoma	Enrichment	YWHAE	1.70
200	Multiple endocrine neoplasia, type iia	Enrichment	RET	1.67
201	Gallbladder cancer	Enrichment	KRAS	1.63
202	Overgrowth syndrome	Enrichment	PIK3R1	1.63
203	Histiocytoid hemangioma	Enrichment	FOS	1.62
204	Cowden syndrome 1	Enrichment	PIK3CA	1.60
205	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	RASA1	1.60
206	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.60
207	Hemangioma, capillary infantile	Enrichment	RASA1	1.60
208	Basal cell carcinoma 1	Enrichment	RASA1	1.60
209	Sporadic pheochromocytoma/secreting paraganglioma	Enrichment	RET	1.60
210	Gastroesophageal reflux	Enrichment	RPS6KA3	1.57
211	Orthostatic intolerance	Enrichment	RPS6KA3	1.57
212	Myelofibrosis	Enrichment	SRC	1.53
213	Hereditary hemorrhagic telangiectasia	Enrichment	RASA1	1.53
214	Megacolon	Enrichment	AKT3	1.53
215	Ventricular septal defect	Enrichment	RPS6KA3	1.52
216	Renal hypodysplasia/aplasia 1	Enrichment	RET	1.47
217	Lennox-gastaut syndrome	Enrichment	MAPK10	1.47
218	Hypothyroidism	Enrichment	RET	1.47
219	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.42
220	Congenital long qt syndrome	Enrichment	ITPR3	1.40
221	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.38
222	Polymicrogyria	Enrichment	AKT3	1.38
223	Aortic valve disease 1	Enrichment	SOS1	1.36
224	Protein-deficiency anemia	Enrichment	NRAS	1.36
225	46,xy complete gonadal dysgenesis	Enrichment	MAP3K1	1.34
226	Multiple sclerosis	Enrichment	ITPR1	1.33
227	Lung cancer susceptibility 3	Enrichment	KRAS	1.33
228	Anterior segment dysgenesis	Enrichment	ITPR1	1.30
229	Lynch syndrome	Enrichment	KRAS	1.30
230	Renal hypodysplasia/aplasia 3	Enrichment	RET	1.30
231	Rhabdomyosarcoma	Enrichment	HRAS	1.28
232	Nk-cell enteropathy	Enrichment	PIK3CB	1.27
233	Osteoporosis	Enrichment	SRC	1.23
234	Pheochromocytoma	Enrichment	RET	1.23
235	Heart, malformation of	Enrichment	MAPK1	1.23
236	Arteriovenous malformations of the brain	Enrichment	KRAS	1.20
237	Microcephaly	Enrichment	MAPK1, YWHAG	1.19
238	Gliosarcoma	Enrichment	NFKBIA	1.18
239	Giant cell glioblastoma	Enrichment	NFKBIA	1.15
240	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	1.11
241	Pancreatic cancer	Enrichment	KRAS	1.09
242	Hydrops fetalis, nonimmune	Enrichment	HRAS	1.07
243	Endometrial cancer	Enrichment	PIK3CA	1.06
244	Hereditary paraganglioma-pheochromocytoma syndromes	Enrichment	RET	1.06
245	Long qt syndrome 1	Enrichment	ITPR3	1.01
246	Lung cancer	Enrichment	KRAS	0.99
247	Tetralogy of fallot	Enrichment	RET	0.98
248	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	0.97
249	Left ventricular noncompaction	Enrichment	RAF1	0.95
250	Non-syndromic x-linked intellectual disability	Enrichment	RPS6KA3	0.94
251	Prostate cancer	Enrichment	PIK3CA	0.93
252	Severe combined immunodeficiency	Enrichment	IKBKB	0.88
253	Gastric cancer	Enrichment	KRAS	0.87
254	West syndrome	Enrichment	NTRK2	0.86
255	Body mass index quantitative trait locus 11	Enrichment	BDNF	0.81
256	Autosomal dominant non-syndromic intellectual disability	Enrichment	YWHAZ	0.81
257	Spastic ataxia	Enrichment	ITPR1	0.78
258	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.78
259	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS	0.77
260	Sensorineural hearing loss	Enrichment	RET	0.73
261	Thrombocytopenia	Enrichment	SRC	0.73
262	Dilated cardiomyopathy	Enrichment	RAF1	0.62
263	Autism spectrum disorder	Enrichment	MAP2K1	0.51
264	Inherited cancer-predisposing syndrome	Enrichment	RET	0.36

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

GDNF-Family Ligands and Receptor Interactions

Pathway Network for GDNF-Family Ligands and Receptor Interactions

Pathway network for the GDNF-Family Ligands and Receptor Interactions SuperPath

Member Pathways for GDNF-Family Ligands and Receptor Interactions

Pathways in the GDNF-Family Ligands and Receptor Interactions SuperPath

Gene overlap in member pathways for GDNF-Family Ligands and Receptor Interactions SuperPath

Associated Genes for GDNF-Family Ligands and Receptor Interactions

Associated Disorders for GDNF-Family Ligands and Receptor Interactions

Disorders associated with GDNF-Family Ligands and Receptor Interactions SuperPath

STRING Interaction Network for GDNF-Family Ligands and Receptor Interactions

Sources for GDNF-Family Ligands and Receptor Interactions