GDNF signaling

No Pathway Network information available for GDNF signaling

Pathways in the GDNF signaling SuperPath

#	Name	Source	Genes
1	GDNF signaling	WikiPathways	AGRN AKT1 AKT3 AP2M1 APP BCAR1 BCL2 BCL2L2 BRAF CALR CAMK2A CBLC CCNA2 CCNB1 CD2AP CDH2 CEBPB CHUK CREB1 CRK DOK1 DOK4 DOK6 DSG2 ESR1 ETV5 EZR FAT4 FOXO1 FRS2 FYN GAB1 GAB2 GAD1 GAD2 GFRA1 GFRA2 GFRA3 GRB2 GRB7 GSK3B IKBKB ITGA3 ITGA5 ITGA6 ITGB1 ITGB3 ITPR1 ITPR2 KCND2 LHX1 LRIG1 LYN MAP2K1 MAP2K5 MAP3K14 MAP3K3 MAPK1 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MET MYC NCAM1 NCK1 NCS1 NFKB2 NFKBIA NRAS PCDHA4 PCDHGB7 PDLIM7 PDPK1 PIK3CB PIK3R1 PLCG1 PLCG2 PRKAR2A PTEN PTK2 PXN RABEP1 RAC1 RAF1 RAP1A RAP1GAP RASA1 RHOA ROCK1 ROCK2 RPS6KB1 RPTOR S1PR3 SH2B2 SLC6A3 SMAD2 SMAD3 SORL1 SP1 SPHK1 SPRY2 SRC ST3GAL1 SYP TGFBR1 VAV2 VEGFA YES1 YWHAZ (see all 111) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	SPRY2	Sprouty RTK Signaling Antagonist 2	Protein Coding	1
2	BCL2L2	BCL2 Like 2	Protein Coding	1
3	CAMK2A	Calcium/Calmodulin Dependent Protein Kinase II Alpha	Protein Coding	1
4	ITGA5	Integrin Subunit Alpha 5	Protein Coding	1
5	NFKB2	Nuclear Factor Kappa B Subunit 2	Protein Coding	1
6	ST3GAL1	ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 1	Protein Coding	1
7	DOK1	Docking Protein 1	Protein Coding	1
8	ITGB1	Integrin Subunit Beta 1	Protein Coding	1
9	CRK	CRK Proto-Oncogene, Adaptor Protein	Protein Coding	1
10	ETV5	ETS Variant Transcription Factor 5	Protein Coding	1
11	RAP1GAP	RAP1 GTPase Activating Protein	Protein Coding	1
12	MAPK7	Mitogen-Activated Protein Kinase 7	Protein Coding	1
13	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	1
14	YWHAZ	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta	Protein Coding	1
15	FOXO1	Forkhead Box O1	Protein Coding	1
16	GAD2	Glutamate Decarboxylase 2	Protein Coding	1
17	LRIG1	Leucine Rich Repeats And Immunoglobulin Like Domains 1	Protein Coding	1
18	RPS6KB1	Ribosomal Protein S6 Kinase B1	Protein Coding	1
19	BCAR1	BCAR1 Scaffold Protein, Cas Family Member	Protein Coding	1
20	ITGB3	Integrin Subunit Beta 3	Protein Coding	1
21	PCDHA4	Protocadherin Alpha 4	Protein Coding	1
22	RABEP1	Rabaptin, RAB GTPase Binding Effector Protein 1	Protein Coding	1
23	NCAM1	Neural Cell Adhesion Molecule 1	Protein Coding	1
24	MAP2K5	Mitogen-Activated Protein Kinase Kinase 5	Protein Coding	1
25	GFRA1	GDNF Family Receptor Alpha 1	Protein Coding	1
26	PTK2	Protein Tyrosine Kinase 2	Protein Coding	1
27	AP2M1	Adaptor Related Protein Complex 2 Subunit Mu 1	Protein Coding	1
28	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	1
29	RAC1	Rac Family Small GTPase 1	Protein Coding	1
30	LHX1	LIM Homeobox 1	Protein Coding	1
31	CEBPB	CCAAT Enhancer Binding Protein Beta	Protein Coding	1
32	RASA1	RAS P21 Protein Activator 1	Protein Coding	1
33	SMAD2	SMAD Family Member 2	Protein Coding	1
34	SP1	Sp1 Transcription Factor	Protein Coding	1
35	CALR	Calreticulin	Protein Coding	1
36	SYP	Synaptophysin	Protein Coding	1
37	CDH2	Cadherin 2	Protein Coding	1
38	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
39	AGRN	Agrin	Protein Coding	1
40	CCNB1	Cyclin B1	Protein Coding	1
41	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	1
42	PLCG1	Phospholipase C Gamma 1	Protein Coding	1
43	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	1
44	APP	Amyloid Beta Precursor Protein	Protein Coding	1
45	NCS1	Neuronal Calcium Sensor 1	Protein Coding	1
46	ITGA3	Integrin Subunit Alpha 3	Protein Coding	1
47	SH2B2	SH2B Adaptor Protein 2	Protein Coding	1
48	DOK6	Docking Protein 6	Protein Coding	1
49	CBLC	Cbl Proto-Oncogene C	Protein Coding	1
50	PRKAR2A	Protein Kinase CAMP-Dependent Type II Regulatory Subunit Alpha	Protein Coding	1
51	RAP1A	RAP1A, Member Of RAS Oncogene Family	Protein Coding	1
52	FAT4	FAT Atypical Cadherin 4	Protein Coding	1
53	ITGA6	Integrin Subunit Alpha 6	Protein Coding	1
54	PCDHGB7	Protocadherin Gamma Subfamily B, 7	Protein Coding	1
55	ITPR1	Inositol 1,4,5-Trisphosphate Receptor Type 1	Protein Coding	1
56	PXN	Paxillin	Protein Coding	1
57	GFRA3	GDNF Family Receptor Alpha 3	Protein Coding	1
58	GFRA2	GDNF Family Receptor Alpha 2	Protein Coding	1
59	GAB1	GRB2 Associated Binding Protein 1	Protein Coding	1
60	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
61	NCK1	NCK Adaptor Protein 1	Protein Coding	1
62	GRB7	Growth Factor Receptor Bound Protein 7	Protein Coding	1
63	SPHK1	Sphingosine Kinase 1	Protein Coding	1
64	DOK4	Docking Protein 4	Protein Coding	1
65	VAV2	Vav Guanine Nucleotide Exchange Factor 2	Protein Coding	1
66	TGFBR1	Transforming Growth Factor Beta Receptor 1	Protein Coding	1
67	CD2AP	CD2 Associated Protein	Protein Coding	1
68	RHOA	Ras Homolog Family Member A	Protein Coding	1
69	GAB2	GRB2 Associated Binding Protein 2	Protein Coding	1
70	SORL1	Sortilin Related Receptor 1	Protein Coding	1
71	FRS2	Fibroblast Growth Factor Receptor Substrate 2	Protein Coding	1
72	RPTOR	Regulatory Associated Protein Of MTOR Complex 1	Protein Coding	1
73	KCND2	Potassium Voltage-Gated Channel Subfamily D Member 2	Protein Coding	1
74	ITPR2	Inositol 1,4,5-Trisphosphate Receptor Type 2	Protein Coding	1
75	PDLIM7	PDZ And LIM Domain 7	Protein Coding	1
76	EZR	Ezrin	Protein Coding	1
77	DSG2	Desmoglein 2	Protein Coding	1
78	MAP3K3	Mitogen-Activated Protein Kinase Kinase Kinase 3	Protein Coding	1
79	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	1
80	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	1
81	SMAD3	SMAD Family Member 3	Protein Coding	1
82	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	1
83	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
84	ROCK2	Rho Associated Coiled-Coil Containing Protein Kinase 2	Protein Coding	1
85	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	1
86	LYN	LYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
87	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	1
88	MAP3K14	Mitogen-Activated Protein Kinase Kinase Kinase 14	Protein Coding	1
89	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	1
90	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	1
91	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
92	CCNA2	Cyclin A2	Protein Coding	1
93	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
94	PLCG2	Phospholipase C Gamma 2	Protein Coding	1
95	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
96	MET	MET Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	1
97	GAD1	Glutamate Decarboxylase 1	Protein Coding	1
98	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
99	BRAF	B-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
100	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	1
101	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
102	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
103	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	1
104	BCL2	BCL2 Apoptosis Regulator	Protein Coding	1
105	ROCK1	Rho Associated Coiled-Coil Containing Protein Kinase 1	Protein Coding	1
106	SLC6A3	Solute Carrier Family 6 Member 3	Protein Coding	1
107	ESR1	Estrogen Receptor 1	Protein Coding	1
108	YES1	YES Proto-Oncogene 1, Src Family Tyrosine Kinase	Protein Coding	1
109	S1PR3	Sphingosine-1-Phosphate Receptor 3	Protein Coding	1
110	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
111	PTEN	Phosphatase And Tensin Homolog	Protein Coding	1

Disorders associated with GDNF signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Langerhans cell histiocytosis	Enrichment	BRAF, MAP2K1, NRAS	6.27
2	Noonan syndrome and noonan-related syndrome	Enrichment	BRAF, MAP2K1, NRAS, RAF1	5.27
3	Thyroid cancer, nonmedullary, 2	Enrichment	BRAF, NRAS, PTEN	4.74
4	Follicular thyroid carcinoma	Enrichment	BRAF, NRAS, PTEN	4.74
5	Melanocytic nevus syndrome, congenital	Enrichment	BRAF, NRAS, RAF1	4.54
6	Noonan syndrome 1	Enrichment	BRAF, MAP2K1, NRAS, RAF1	4.48
7	Loeys-dietz syndrome	Enrichment	SMAD2, SMAD3, TGFBR1	4.36
8	Rasopathy	Enrichment	BRAF, MAP2K1, NRAS, RAF1	4.26
9	Colorectal cancer	Enrichment	AKT1, BRAF, MET, NRAS, PIK3R1, SRC	4.11
10	Lung non-small cell carcinoma	Enrichment	BRAF, MAP2K1, NRAS	4.08
11	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	BCL2, MYC	3.70
12	Loeys-dietz syndrome 1	Enrichment	SMAD2, TGFBR1	3.70
13	Cardiofaciocutaneous syndrome 1	Enrichment	BRAF, MAP2K1	3.40
14	Cardiofaciocutaneous syndrome	Enrichment	BRAF, MAP2K1	3.40
15	Aortic aneurysm	Enrichment	SMAD3, TGFBR1	3.40
16	Noonan syndrome with multiple lentigines	Enrichment	BRAF, RAF1	3.40
17	Diffuse large b-cell lymphoma	Enrichment	BRAF, FOXO1, PTEN	3.33
18	Hemimegalencephaly	Enrichment	AKT3, PTEN	3.19
19	Myelofibrosis	Enrichment	CALR, SRC	2.87
20	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1, RASA1	2.87
21	Pilomyxoid astrocytoma	Enrichment	BRAF, RAF1	2.87
22	Early-onset autosomal dominant alzheimer disease	Enrichment	APP, SORL1	2.87
23	Arteriovenous malformation	Enrichment	MAP2K1, RASA1	2.64
24	Cowden syndrome	Enrichment	AKT1, PTEN	2.64
25	Myopathy, x-linked, with excessive autophagy	Enrichment	MAP2K1, RASA1	2.54
26	Melanoma	Enrichment	BRAF, PTEN	2.54
27	Meningioma	Enrichment	AKT1, PTEN	2.38
28	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	SMAD2, SMAD3, TGFBR1	2.26
29	Hereditary breast carcinoma	Enrichment	AKT1, ESR1, PTEN	2.26
30	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	CDH2, DSG2	2.25
31	Anhidrosis, isolated, with normal sweat glands	Enrichment	ITPR2	2.09
32	Proteus syndrome	Enrichment	AKT1	2.09
33	Cystic angiomatosis of bone, diffuse	Enrichment	RASA1	2.09
34	Vacterl association with hydrocephalus	Enrichment	PTEN	2.09
35	Deafness, autosomal recessive 26	Enrichment	GAB1	2.09
36	Noonan syndrome 5	Enrichment	RAF1	2.09
37	Melorheostosis, isolated	Enrichment	MAP2K1	2.09
38	Noonan syndrome 7	Enrichment	BRAF	2.09
39	Leopard syndrome 3	Enrichment	BRAF	2.09
40	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.09
41	Multiple self-healing squamous epithelioma	Enrichment	TGFBR1	2.09
42	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.09
43	Melanosis, neurocutaneous	Enrichment	NRAS	2.09
44	Iga nephropathy 3	Enrichment	SPRY2	2.09
45	Noonan syndrome 6	Enrichment	NRAS	2.09
46	Fetal encasement syndrome	Enrichment	CHUK	2.09
47	Immunodeficiency 15b	Enrichment	IKBKB	2.09
48	Noonan syndrome 13	Enrichment	MAPK1	2.09
49	Immunodeficiency 15a	Enrichment	IKBKB	2.09
50	Intellectual developmental disorder, autosomal recessive 63	Enrichment	CAMK2A	2.09
51	Short syndrome	Enrichment	PIK3R1	2.09
52	Developmental and epileptic encephalopathy 89	Enrichment	GAD1	2.09
53	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.09
54	Osteofibrous dysplasia	Enrichment	MET	2.09
55	Agenesis of corpus callosum, cardiac, ocular, and genital syndrome	Enrichment	CDH2	2.09
56	Renal hypodysplasia/aplasia 4	Enrichment	GFRA1	2.09
57	Papillary tumor of the pineal region	Enrichment	PTEN	2.09
58	Deafness, autosomal recessive 97	Enrichment	MET	2.09
59	Microvascular complications of diabetes 1	Enrichment	VEGFA	2.09
60	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.09
61	Lymphangioma	Enrichment	BRAF	2.09
62	Phace association	Enrichment	BRAF	2.09
63	Cerebral amyloid angiopathy, app-related	Enrichment	APP	2.09
64	Parkinsonism-dystonia 1, infantile-onset	Enrichment	SLC6A3	2.09
65	Melorheostosis	Enrichment	MAP2K1	2.09
66	Autism 9	Enrichment	MET	2.09
67	Focal segmental glomerulosclerosis 3	Enrichment	CD2AP	2.09
68	Arrhythmogenic right ventricular dysplasia, familial, 14	Enrichment	CDH2	2.09
69	Leopard syndrome 2	Enrichment	RAF1	2.09
70	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.09
71	Autoinflammation, antibody deficiency, and immune dysregulation	Enrichment	PLCG2	2.09
72	Cowden syndrome 6	Enrichment	AKT1	2.09
73	Van maldergem syndrome 2	Enrichment	FAT4	2.09
74	Hennekam lymphangiectasia-lymphedema syndrome 2	Enrichment	FAT4	2.09
75	Loeys-dietz syndrome 6	Enrichment	SMAD2	2.09
76	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.09
77	Glioma susceptibility 2	Enrichment	PTEN	2.09
78	Familial cold autoinflammatory syndrome 3	Enrichment	PLCG2	2.09
79	Thrombocytopenia 6	Enrichment	SRC	2.09
80	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.09
81	Deficiency in anterior pituitary function - variable immunodeficiency syndrome	Enrichment	NFKB2	2.09
82	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.09
83	Autoinflammatory disease, systemic, with vasculitis	Enrichment	LYN	2.09
84	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.09
85	Van maldergem syndrome	Enrichment	FAT4	2.09
86	Intellectual developmental disorder, autosomal dominant 53	Enrichment	CAMK2A	2.09
87	Trigonitis	Enrichment	RAF1	2.09
88	Congenital heart defects, multiple types, 8, with or without heterotaxy	Enrichment	SMAD2	2.09
89	Attention deficit-hyperactivity disorder 8	Enrichment	CDH2	2.09
90	Arthrogryposis, distal, type 11	Enrichment	MET	2.09
91	Classic dopamine transporter deficiency syndrome	Enrichment	SLC6A3	2.09
92	Capillary hemangioma	Enrichment	AKT3	2.09
93	Immunodeficiency 112	Enrichment	MAP3K14	2.09
94	Cerebral cavernous malformations 5	Enrichment	MAP3K3	2.09
95	Gorham's disease	Enrichment	RASA1	2.09
96	Syringocystadenoma papilliferum	Enrichment	BRAF	2.09
97	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.09
98	Ganglioglioma	Enrichment	BRAF	2.09
99	Nongerminomatous germ cell tumor	Enrichment	BRAF	2.09
100	Phace syndrome	Enrichment	BRAF	2.09
101	Parkinsonism-dystonia, infantile	Enrichment	SLC6A3	2.09
102	Segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome	Enrichment	PTEN	2.09
103	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.09
104	Classic hairy cell leukemia	Enrichment	BRAF	2.09
105	Verrucous hemangioma	Enrichment	MAP3K3	2.09
106	Neurocutaneous melanocytosis	Enrichment	NRAS	2.09
107	Nik deficiency	Enrichment	MAP3K14	2.09
108	Arteriovenous malformations of the brain	Enrichment	BRAF, CDH2	1.98
109	Myocardial infarction	Enrichment	ESR1, ITGB3	1.86
110	Spinocerebellar ataxia 29	Enrichment	ITPR1	1.79
111	Cerebral amyloid angiopathy, cst3-related	Enrichment	APP	1.79
112	Burkitt lymphoma	Enrichment	MYC	1.79
113	Scoliosis, isolated 1	Enrichment	MAPK7	1.79
114	Van maldergem syndrome 1	Enrichment	FAT4	1.79
115	Pulmonic stenosis	Enrichment	BRAF	1.79
116	Alzheimer disease 9	Enrichment	SORL1	1.79
117	Loeys-dietz syndrome 2	Enrichment	TGFBR1	1.79
118	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	1.79
119	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	1.79
120	Ras-associated autoimmune leukoproliferative disorder	Enrichment	NRAS	1.79
121	Immunodeficiency, common variable, 10	Enrichment	NFKB2	1.79
122	Loeys-dietz syndrome 3	Enrichment	SMAD3	1.79
123	Cardiomyopathy, dilated, 1bb	Enrichment	DSG2	1.79
124	Myopia 28, autosomal recessive	Enrichment	DOK1	1.79
125	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	1.79
126	Intravascular large b-cell lymphoma	Enrichment	BCL2	1.79
127	Epidermolysis bullosa, junctional 7, with interstitial lung disease and nephrotic syndrome	Enrichment	ITGA3	1.79
128	Childhood hepatocellular carcinoma	Enrichment	MET	1.79
129	Senior-loken syndrome 7	Enrichment	AKT3	1.79
130	Papillary renal cell carcinoma	Enrichment	MET	1.79
131	Ectodermal dysplasia and immune deficiency	Enrichment	NFKBIA	1.79
132	Intellectual developmental disorder, autosomal dominant 60, with seizures	Enrichment	AP2M1	1.79
133	Bardet-biedl syndrome 16	Enrichment	AKT3	1.79
134	Vacterl with hydrocephalus	Enrichment	PTEN	1.79
135	Juvenile polyposis of infancy	Enrichment	PTEN	1.79
136	Differentiated thyroid carcinoma	Enrichment	BRAF, NRAS	1.63
137	Breast cancer	Enrichment	AKT1, ESR1, PTEN	1.63
138	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	ITGB3	1.61
139	Ataxia-telangiectasia	Enrichment	BRAF	1.61
140	Bleeding disorder, platelet-type, 16	Enrichment	ITGB3	1.61
141	Thrombocythemia 1	Enrichment	CALR	1.61
142	Gillespie syndrome	Enrichment	ITPR1	1.61
143	Intellectual developmental disorder, x-linked 96	Enrichment	SYP	1.61
144	Nasopharyngeal carcinoma	Enrichment	NFKBIA	1.61
145	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3R1	1.61
146	Estrogen resistance	Enrichment	ESR1	1.61
147	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	1.61
148	Chromosome 17q12 deletion syndrome	Enrichment	LHX1	1.61
149	Epidermolysis bullosa, junctional 6, with pyloric atresia	Enrichment	ITGA6	1.61
150	Tethered spinal cord syndrome	Enrichment	BRAF	1.61
151	Large congenital melanocytic nevus	Enrichment	NRAS	1.61
152	Wieacker-wolff syndrome	Enrichment	RASA1	1.61
153	Hennekam syndrome	Enrichment	FAT4	1.61
154	Immunodeficiency 14	Enrichment	PIK3R1	1.61
155	Migraine without aura	Enrichment	ESR1	1.61
156	Laryngeal squamous cell carcinoma	Enrichment	PTEN	1.61
157	Bleeding disorder, platelet-type, 24	Enrichment	ITGB3	1.61
158	Melanoma of soft tissue	Enrichment	CREB1	1.61
159	Renal cell carcinoma	Enrichment	MET	1.61
160	Dilated cardiomyopathy	Enrichment	BRAF, DSG2, RAF1	1.56
161	Lung cancer	Enrichment	BRAF, MET	1.55
162	Schimmelpenning-feuerstein-mims syndrome	Enrichment	NRAS	1.49
163	Thyroid cancer, nonmedullary, 1	Enrichment	BRAF	1.49
164	Budd-chiari syndrome	Enrichment	CALR	1.49
165	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3	1.49
166	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.49
167	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3	1.49
168	Immunodeficiency, common variable, 1	Enrichment	NFKB2	1.49
169	Spinocerebellar ataxia 15	Enrichment	ITPR1	1.49
170	Arrhythmogenic right ventricular dysplasia, familial, 10	Enrichment	DSG2	1.49
171	Tobacco addiction	Enrichment	SLC6A3	1.49
172	Neurodevelopmental disorder with progressive spasticity and brain white matter abnormalities	Enrichment	GAD1	1.49
173	Arthrogryposis multiplex congenita 3, myogenic type	Enrichment	ESR1	1.49
174	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	NRAS	1.49
175	Craniopharyngioma	Enrichment	BRAF	1.49
176	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	YWHAZ	1.49
177	Spastic quadriplegic cerebral palsy	Enrichment	GAD1	1.49
178	Newborn respiratory distress syndrome	Enrichment	BRAF	1.49
179	Complex hereditary spastic paraplegia	Enrichment	SORL1	1.49
180	Glioma	Enrichment	PTEN	1.49
181	Capillary malformations, congenital	Enrichment	RASA1	1.40
182	Rhabdomyosarcoma 2	Enrichment	FOXO1	1.40
183	Macrocephaly/autism syndrome	Enrichment	PTEN	1.40
184	Myasthenic syndrome, congenital, 8	Enrichment	AGRN	1.40
185	Glanzmann thrombasthenia 2	Enrichment	ITGB3	1.40
186	Follicular lymphoma	Enrichment	BCL2	1.40
187	Epidermolysis bullosa	Enrichment	ITGA6	1.40
188	Hemangioma	Enrichment	PTEN	1.40
189	Acute megakaryocytic leukemia	Enrichment	PTEN	1.40
190	Klippel-trenaunay-weber syndrome	Enrichment	RASA1	1.32
191	Cowden syndrome 1	Enrichment	PTEN	1.32
192	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	RASA1	1.32
193	Hemihyperplasia, isolated	Enrichment	RHOA	1.32
194	Epidermolysis bullosa, junctional 5b, with pyloric atresia	Enrichment	ITGA6	1.32
195	Wilms tumor 5	Enrichment	BRAF	1.32
196	Hemangioma, capillary infantile	Enrichment	RASA1	1.32
197	Basal cell carcinoma 1	Enrichment	RASA1	1.32
198	Spinocerebellar ataxia, autosomal recessive 16	Enrichment	ITPR1	1.32
199	Early myoclonic encephalopathy	Enrichment	KCND2	1.32
200	Fetomaternal alloimmune thrombocytopenia 1	Enrichment	ITGB3	1.32
201	Breast adenocarcinoma	Enrichment	AKT1	1.32
202	Classic ehlers-danlos syndrome	Enrichment	TGFBR1	1.32
203	Ovarian cancer	Enrichment	AKT1, MET, PTEN	1.30
204	Nevus, epidermal	Enrichment	NRAS	1.25
205	Squamous cell carcinoma, head and neck	Enrichment	PTEN	1.25
206	Glanzmann thrombasthenia 1	Enrichment	ITGB3	1.25
207	Leukemia, chronic myeloid	Enrichment	NRAS	1.25
208	Renal cell carcinoma, papillary, 1	Enrichment	MET	1.25
209	Noonan syndrome 3	Enrichment	RAF1	1.25
210	Alzheimer's disease 1	Enrichment	APP	1.25
211	Essential thrombocythemia	Enrichment	CALR	1.25
212	Gallbladder cancer	Enrichment	BRAF	1.25
213	Hereditary hemorrhagic telangiectasia	Enrichment	RASA1	1.25
214	Megacolon	Enrichment	AKT3	1.25
215	Common variable immunodeficiency	Enrichment	NFKB2	1.25
216	Overgrowth syndrome	Enrichment	PIK3R1	1.25
217	Thrombocytopenia	Enrichment	ITGB3, SRC	1.23
218	Autosomal dominant non-syndromic intellectual disability	Enrichment	CAMK2A, YWHAZ	1.20
219	Arthrogryposis, distal, type 1a	Enrichment	MET	1.20
220	Lymphoma, non-hodgkin, familial	Enrichment	BRAF	1.20
221	Familial isolated dilated cardiomyopathy	Enrichment	DSG2, RAF1	1.16
222	Cardiomyopathy, familial hypertrophic, 4	Enrichment	BRAF	1.15
223	Arrhythmogenic right ventricular dysplasia, familial, 9	Enrichment	DSG2	1.15
224	Myoclonic-atonic epilepsy	Enrichment	AP2M1	1.15
225	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.15
226	Junctional epidermolysis bullosa	Enrichment	ITGA6	1.15
227	Primary hyperaldosteronism	Enrichment	BRAF	1.15
228	Ventricular septal defect	Enrichment	BRAF	1.15
229	Familial isolated arrhythmogenic right ventricular dysplasia	Enrichment	DSG2	1.15
230	Familial thoracic aortic aneurysm and dissection	Enrichment	SMAD3	1.15
231	Renal agenesis, bilateral	Enrichment	GFRA1	1.15
232	Hereditary breast ovarian cancer syndrome	Enrichment	BCAR1, PTEN	1.13
233	Marfan syndrome	Enrichment	TGFBR1	1.10
234	Polymicrogyria	Enrichment	AKT3	1.10
235	Autosomal dominant macrothrombocytopenia	Enrichment	ITGB3	1.10
236	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.10
237	Migraine with or without aura 1	Enrichment	ESR1	1.06
238	Pectus excavatum	Enrichment	TGFBR1	1.06
239	Meningioma, familial	Enrichment	PTEN	1.06
240	Uterine corpus cancer	Enrichment	PTEN	1.06
241	Specific learning disability	Enrichment	MAPK1	1.06
242	Presynaptic congenital myasthenic syndromes	Enrichment	AGRN	1.06
243	Cardiac conduction defect	Enrichment	DSG2	1.03
244	Juvenile myelomonocytic leukemia	Enrichment	NRAS	1.03
245	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant	Enrichment	DSG2	1.03
246	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant	Enrichment	DSG2	1.03
247	Lip and oral cavity carcinoma	Enrichment	BRAF	1.03
248	Postsynaptic congenital myasthenic syndromes	Enrichment	AGRN	1.03
249	Neural tube defects	Enrichment	ITGB1	0.99
250	Alzheimer's disease	Enrichment	APP	0.99
251	Protein-deficiency anemia	Enrichment	NRAS	0.99
252	Nk-cell enteropathy	Enrichment	PIK3CB	0.99
253	Multiple sclerosis	Enrichment	ITPR1	0.96
254	Osteoporosis	Enrichment	SRC	0.96
255	Aortic aneurysm, familial thoracic 1	Enrichment	SMAD3	0.96
256	Lung cancer susceptibility 3	Enrichment	BRAF	0.96
257	Congenital myasthenic syndrome	Enrichment	AGRN	0.96
258	Renal cell carcinoma, nonpapillary	Enrichment	MET	0.94
259	Wilms tumor 1	Enrichment	BRAF	0.94
260	Corpus callosum, agenesis of	Enrichment	CDH2	0.94
261	Anterior segment dysgenesis	Enrichment	ITPR1	0.94
262	Isolated corpus callosum agenesis	Enrichment	CDH2	0.94
263	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CDH2	0.94
264	Arrhythmogenic right ventricular cardiomyopathy	Enrichment	DSG2	0.91
265	Rhabdomyosarcoma	Enrichment	PTEN	0.91
266	Gliosarcoma	Enrichment	NFKBIA	0.91
267	Alzheimer disease, familial, 1	Enrichment	APP	0.88
268	Melanoma, cutaneous malignant 1	Enrichment	BRAF	0.88
269	Dandy-walker syndrome	Enrichment	BRAF	0.88
270	Giant cell glioblastoma	Enrichment	NFKBIA	0.88
271	Heart, malformation of	Enrichment	MAPK1	0.86
272	Ehlers-danlos syndrome	Enrichment	SMAD3	0.84
273	Endometrial cancer	Enrichment	PTEN	0.80
274	Hepatocellular carcinoma	Enrichment	MET	0.78
275	Neurodevelopmental disorder with poor growth and skeletal anomalies	Enrichment	PCDHGB7	0.78
276	Precursor t-cell acute lymphoblastic leukemia	Enrichment	MYC	0.76
277	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	0.75
278	Auditory neuropathy	Enrichment	CDH2	0.72
279	Bladder cancer	Enrichment	PTEN	0.67
280	Prostate cancer	Enrichment	PTEN	0.67
281	Autism spectrum disorder	Enrichment	MAP2K1, PTEN	0.65
282	Long qt syndrome	Enrichment	DSG2	0.65
283	Connective tissue disease	Enrichment	SMAD3	0.64
284	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	0.62
285	Severe combined immunodeficiency	Enrichment	IKBKB	0.62
286	Cakut	Enrichment	FAT4	0.61
287	Genetic steroid-resistant nephrotic syndrome	Enrichment	CD2AP	0.61
288	Left ventricular noncompaction	Enrichment	RAF1	0.60
289	Non-syndromic x-linked intellectual disability	Enrichment	SYP	0.59
290	Leukemia, acute myeloid	Enrichment	NRAS	0.55
291	Inherited cancer-predisposing syndrome	Enrichment	MET, PTEN	0.53
292	Gastric cancer	Enrichment	PTEN	0.53
293	Nephrotic syndrome	Enrichment	ITGA3	0.53
294	Spastic ataxia	Enrichment	ITPR1	0.45
295	Myeloma, multiple	Enrichment	BRAF	0.43
296	Autosomal recessive non-syndromic intellectual disability	Enrichment	EZR	0.42
297	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	MET	0.28
298	Congenital nervous system abnormality	Enrichment	PTEN	0.23
299	Nervous system disease	Enrichment	PTEN	0.23
300	Microcephaly	Enrichment	MAPK1	0.20

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

GDNF signaling

Pathway Network for GDNF signaling

Member Pathways for GDNF signaling

Pathways in the GDNF signaling SuperPath

Associated Genes for GDNF signaling

Associated Disorders for GDNF signaling

Disorders associated with GDNF signaling SuperPath

STRING Interaction Network for GDNF signaling

Sources for GDNF signaling