GDP-glucose biosynthesis II

Pathway network for the GDP-glucose biosynthesis II SuperPath

Sources:

PubChem
WikiPathways
Reactome

Pathways in the GDP-glucose biosynthesis II SuperPath

#	Name	Source	Genes
1	GDP-glucose biosynthesis II	PubChem	GCK HK1 HK2 HK3 HKDC1 PGM1 PGM2 (see all 7) (see less)
2	UDP-derived sugars synthesis in fibroblasts	WikiPathways	GALE GCK GFPT1 GPI HK1 HK2 HK3 PGM1 PGM3 UGDH UXS1 (see all 11) (see less)
3	UDP-N-acetyl-D-glucosamine biosynthesis II	PubChem	GCK GFPT1 GPI HK1 HK2 HK3 PGM3 (see all 7) (see less)
4	GDP-glucose biosynthesis	PubChem	GCK HK1 HK2 HK3 PGM1 PGM2 (see all 6) (see less)
5	trehalose degradation	PubChem	GCK HK1 HK2 HK3 TREH
6	Defective GCK causes maturity-onset diabetes of the young 2 (MODY2)	Reactome	GCK
7	Defective GFPT1 causes CMSTA1	Reactome	GFPT1
8	Defective HK1 causes hexokinase deficiency (HK deficiency)	Reactome	HK1

Gene overlap in member pathways for GDP-glucose biosynthesis II SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	HK1	Hexokinase 1	Protein Coding	6
2	GCK	Glucokinase	Protein Coding	6
3	HK3	Hexokinase 3	Protein Coding	5
4	HK2	Hexokinase 2	Protein Coding	5
5	PGM1	Phosphoglucomutase 1	Protein Coding	3
6	GFPT1	Glutamine--Fructose-6-Phosphate Transaminase 1	Protein Coding	3
7	PGM2	Phosphoglucomutase 2	Protein Coding	2
8	PGM3	Phosphoglucomutase 3	Protein Coding	2
9	GPI	Glucose-6-Phosphate Isomerase	Protein Coding	2
10	HKDC1	Hexokinase Domain Containing 1	Protein Coding	1
11	UXS1	UDP-Glucuronate Decarboxylase 1	Protein Coding	1
12	UGDH	UDP-Glucose 6-Dehydrogenase	Protein Coding	1
13	GALE	UDP-Galactose-4-Epimerase	Protein Coding	1
14	TREH	Trehalase	Protein Coding	1

Disorders associated with GDP-glucose biosynthesis II SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Maturity-onset diabetes of the young	Direct
2	Developmental and epileptic encephalopathy 36	Direct
3	Congenital nonspherocytic hemolytic anemia	Direct
4	Anemia, congenital, nonspherocytic hemolytic, 5	Enrichment	HK1	3.43
5	Trehalase deficiency	Enrichment	TREH	3.43
6	Maturity-onset diabetes of the young, type 2	Enrichment	GCK	3.43
7	Retinitis pigmentosa 79	Enrichment	HK1	3.43
8	Hyperinsulinemic hypoglycemia, familial, 3	Enrichment	GCK	3.43
9	Neuropathy, hereditary motor and sensory, russe type	Enrichment	HK1	3.43
10	Neurodevelopmental disorder with visual defects and brain anomalies	Enrichment	HK1	3.43
11	Gestational diabetes	Enrichment	GCK	3.43
12	Anemia, congenital, nonspherocytic hemolytic, 4	Enrichment	GPI	3.29
13	Maturity-onset diabetes of the young, type 1	Enrichment	GCK	3.13
14	Diabetes mellitus, permanent neonatal, 1	Enrichment	GCK	3.13
15	Bone marrow failure syndrome 2	Enrichment	GCK	3.13
16	Galactosemia iii	Enrichment	GALE	3.09
17	Developmental and epileptic encephalopathy 84	Enrichment	UGDH	3.09
18	Thrombocytopenia 13, syndromic	Enrichment	GALE	3.09
19	Congenital disorder of glycosylation, type it	Enrichment	PGM1	3.05
20	Myasthenic syndrome, congenital, 12	Enrichment	GFPT1	2.99
21	Immunodeficiency 23	Enrichment	PGM3	2.99
22	Nijmegen breakage syndrome	Enrichment	GCK	2.96
23	Maturity-onset diabetes of the young, type 3	Enrichment	GCK	2.83
24	Retinitis pigmentosa 92	Enrichment	HKDC1	2.81
25	Hyper ige syndrome	Enrichment	PGM3	2.81
26	Hyperinsulinemic hypoglycemia, familial, 1	Enrichment	GCK	2.66
27	Nonsyndromic genetic hyperinsulinism	Enrichment	GCK	2.66
28	Congenital myasthenic syndromes with glycosylation defect	Enrichment	GFPT1	2.59
29	Permanent neonatal diabetes mellitus	Enrichment	GCK	2.53
30	Hereditary spherocytosis	Enrichment	GPI	2.51
31	Hemolytic anemia	Enrichment	GPI	2.44
32	Diabetes mellitus	Enrichment	GCK	2.39
33	Orofacial cleft 1	Enrichment	HKDC1	2.33
34	Myasthenic syndrome, congenital, 4c, associated with acetylcholine receptor deficiency	Enrichment	GFPT1	2.29
35	Congenital myasthenic syndrome	Enrichment	GFPT1	2.14
36	Congenital disorder of glycosylation, type in	Enrichment	PGM1	2.13
37	Type 2 diabetes mellitus	Enrichment	GCK	1.81
38	Severe combined immunodeficiency	Enrichment	PGM3	1.77
39	West syndrome	Enrichment	UGDH	1.45
40	Autism spectrum disorder	Enrichment	HK1	1.40
41	Retinitis pigmentosa	Enrichment	HK1	1.12
42	Hereditary retinal dystrophy	Enrichment	HK1	0.99
43	Fundus dystrophy	Enrichment	HK1	0.99

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

GDP-glucose biosynthesis II

Pathway Network for GDP-glucose biosynthesis II

Pathway network for the GDP-glucose biosynthesis II SuperPath

Member Pathways for GDP-glucose biosynthesis II

Pathways in the GDP-glucose biosynthesis II SuperPath

Gene overlap in member pathways for GDP-glucose biosynthesis II SuperPath

Associated Genes for GDP-glucose biosynthesis II

Associated Disorders for GDP-glucose biosynthesis II

Disorders associated with GDP-glucose biosynthesis II SuperPath

STRING Interaction Network for GDP-glucose biosynthesis II

Sources for GDP-glucose biosynthesis II