Gemtuzumab ozogamicin Pathway, Pharmacokinetics/Pharmacodynamics

No Pathway Network information available for Gemtuzumab ozogamicin Pathway, Pharmacokinetics/Pharmacodynamics

Pathways in the Gemtuzumab ozogamicin Pathway, Pharmacokinetics/Pharmacodynamics SuperPath

#	Name	Source	Genes
1	Gemtuzumab ozogamicin Pathway, Pharmacokinetics/Pharmacodynamics	PharmGKB	ABCB1 ABCC1 ABCC2 AKT1 ATM ATR BAD BAK1 BAX BCL2 BCL2L1 CASP3 CASP9 CCNB1 CD33 CHEK1 CHEK2 CYCS GADD45A H2AX PARP1 PRKDC XRCC4 (see all 23) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	BCL2	BCL2 Apoptosis Regulator	Protein Coding	1
2	BCL2L1	BCL2 Like 1	Protein Coding	1
3	BAD	BCL2 Associated Agonist Of Cell Death	Protein Coding	1
4	BAX	BCL2 Associated X, Apoptosis Regulator	Protein Coding	1
5	XRCC4	X-Ray Repair Cross Complementing 4	Protein Coding	1
6	CHEK1	Checkpoint Kinase 1	Protein Coding	1
7	PRKDC	Protein Kinase, DNA-Activated, Catalytic Subunit	Protein Coding	1
8	ATR	ATR Checkpoint Kinase	Protein Coding	1
9	ATM	ATM Serine/Threonine Kinase	Protein Coding	1
10	CCNB1	Cyclin B1	Protein Coding	1
11	CASP3	Caspase 3	Protein Coding	1
12	CASP9	Caspase 9	Protein Coding	1
13	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
14	GADD45A	Growth Arrest And DNA Damage Inducible Alpha	Protein Coding	1
15	BAK1	BCL2 Antagonist/Killer 1	Protein Coding	1
16	ABCC1	ATP Binding Cassette Subfamily C Member 1 (ABCC1 Blood Group)	Protein Coding	1
17	H2AX	H2A.X Variant Histone	Protein Coding	1
18	ABCB1	ATP Binding Cassette Subfamily B Member 1	Protein Coding	1
19	PARP1	Poly(ADP-Ribose) Polymerase 1	Protein Coding	1
20	ABCC2	ATP Binding Cassette Subfamily C Member 2	Protein Coding	1
21	CHEK2	Checkpoint Kinase 2	Protein Coding	1
22	CD33	CD33 Molecule	Protein Coding	1
23	CYCS	Cytochrome C, Somatic	Protein Coding	1

Disorders associated with Gemtuzumab ozogamicin Pathway, Pharmacokinetics/Pharmacodynamics SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Colorectal cancer	Enrichment	AKT1, ATM, BAX, CHEK2	4.90
2	Hereditary breast carcinoma	Enrichment	AKT1, ATM, CHEK2	4.27
3	Colonic benign neoplasm	Enrichment	ATM, CHEK2	4.01
4	Lynch syndrome 1	Enrichment	ATM, CHEK2	3.91
5	Uterine corpus cancer	Enrichment	ATM, CHEK2	3.82
6	Familial colorectal cancer type x	Enrichment	ATM, CHEK2	3.82
7	Breast-ovarian cancer, familial 1	Enrichment	ATM, CHEK2	3.67
8	Breast cancer	Enrichment	AKT1, ATM, CHEK2	3.58
9	Endometrial cancer	Enrichment	ATM, CHEK2	3.25
10	Ovarian cancer	Enrichment	AKT1, ATM, CHEK2	3.20
11	Pancreatic cancer	Enrichment	ATM, CHEK2	3.09
12	Prostate cancer	Enrichment	ATM, CHEK2	2.96
13	Proteus syndrome	Enrichment	AKT1	2.77
14	Colchicine resistance	Enrichment	ABCB1	2.77
15	Seckel syndrome 1	Enrichment	ATR	2.77
16	Encephalopathy, acute transient	Enrichment	ABCB1	2.77
17	Deafness, autosomal dominant 77	Enrichment	ABCC1	2.77
18	Tumor predisposition syndrome 4	Enrichment	CHEK2	2.77
19	Thrombocytopenia 4	Enrichment	CYCS	2.77
20	Inflammatory bowel disease 13	Enrichment	ABCB1	2.77
21	Cutaneous telangiectasia and cancer syndrome, familial	Enrichment	ATR	2.77
22	Immunodeficiency 26 with or without neurologic abnormalities	Enrichment	PRKDC	2.77
23	Cowden syndrome 6	Enrichment	AKT1	2.77
24	Endometrial serous adenocarcinoma	Enrichment	ATM	2.77
25	Leiomyosarcoma	Enrichment	CHEK2	2.77
26	Oocyte/zygote/embryo maturation arrest 21	Enrichment	CHEK1	2.77
27	B-cell non-hodgkin lymphoma	Enrichment	ATM	2.77
28	Familial cutaneous telangiectasia and oropharyngeal predisposition cancer syndrome	Enrichment	ATR	2.77
29	Gastric cancer	Enrichment	ATM, CHEK2	2.62
30	Lig4 syndrome	Enrichment	XRCC4	2.47
31	Congenital heart defects, multiple types, 3	Enrichment	CHEK2	2.47
32	Cardiac valvular dysplasia, x-linked	Enrichment	ATM	2.47
33	Intravascular large b-cell lymphoma	Enrichment	BCL2	2.47
34	Short stature, microcephaly, and endocrine dysfunction	Enrichment	XRCC4	2.47
35	High grade glioma	Enrichment	ATM	2.47
36	Li-fraumeni syndrome 1	Enrichment	CHEK2	2.47
37	Sarcoma	Enrichment	CHEK2	2.47
38	T-cell prolymphocytic leukemia	Enrichment	ATM	2.47
39	Microcephalic primordial dwarfism-insulin resistance syndrome	Enrichment	XRCC4	2.47
40	Hereditary breast ovarian cancer syndrome	Enrichment	ATM, CHEK2	2.41
41	Ataxia-telangiectasia	Enrichment	ATM	2.29
42	Dubin-johnson syndrome	Enrichment	ABCC2	2.29
43	Polycythemia vera	Enrichment	ATM	2.29
44	Osteogenic sarcoma	Enrichment	CHEK2	2.29
45	Koolen-de vries syndrome	Enrichment	ATM	2.29
46	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	BCL2	2.29
47	T-cell acute lymphoblastic leukemia	Enrichment	BAX	2.29
48	Adenocarcinoma	Enrichment	ATM	2.29
49	Bone osteosarcoma	Enrichment	CHEK2	2.29
50	Mantle cell lymphoma	Enrichment	ATM	2.17
51	Hemoglobin c disease	Enrichment	CHEK2	2.17
52	Oculomotor apraxia	Enrichment	ATM	2.17
53	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	CHEK1	2.17
54	Follicular lymphoma	Enrichment	BCL2	2.07
55	Glioblastoma	Enrichment	ATM	2.07
56	Autosomal thrombocytopenia with normal platelets	Enrichment	CYCS	2.07
57	Li-fraumeni syndrome	Enrichment	CHEK2	1.99
58	Pseudoxanthoma elasticum	Enrichment	ABCC2	1.99
59	Wilms tumor 5	Enrichment	CHEK2	1.99
60	Clear cell renal cell carcinoma	Enrichment	ATM	1.99
61	Breast adenocarcinoma	Enrichment	AKT1	1.99
62	Renal cell carcinoma, papillary, 1	Enrichment	ATM	1.93
63	Isolated growth hormone deficiency, type ia	Enrichment	XRCC4	1.87
64	Cowden syndrome	Enrichment	AKT1	1.82
65	Leukemia, chronic lymphocytic	Enrichment	ATM	1.77
66	Melanoma	Enrichment	CHEK2	1.77
67	Immune deficiency disease	Enrichment	ATM	1.73
68	Epilepsy, idiopathic generalized	Enrichment	ABCB1	1.73
69	Meningioma	Enrichment	AKT1	1.70
70	Inherited cancer-predisposing syndrome	Enrichment	ATM, CHEK2	1.68
71	Nk-cell enteropathy	Enrichment	CHEK2	1.66
72	Seckel syndrome	Enrichment	ATR	1.63
73	Renal cell carcinoma, nonpapillary	Enrichment	ATM	1.60
74	Wilms tumor 1	Enrichment	CHEK2	1.60
75	Lynch syndrome	Enrichment	CHEK2	1.60
76	Gliosarcoma	Enrichment	ATM	1.57
77	Giant cell glioblastoma	Enrichment	ATM	1.55
78	Diffuse large b-cell lymphoma	Enrichment	CHEK2	1.50
79	Bladder cancer	Enrichment	ATM	1.32
80	Lung cancer	Enrichment	CHEK2	1.28
81	Thrombocytopenia	Enrichment	CYCS	1.11
82	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	ABCC1	1.07
83	Myeloma, multiple	Enrichment	ATM	1.04
84	Primary ovarian insufficiency	Enrichment	CHEK2	1.02

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Gemtuzumab ozogamicin Pathway, Pharmacokinetics/Pharmacodynamics

Pathway Network for Gemtuzumab ozogamicin Pathway, Pharmacokinetics/Pharmacodynamics

Member Pathways for Gemtuzumab ozogamicin Pathway, Pharmacokinetics/Pharmacodynamics

Pathways in the Gemtuzumab ozogamicin Pathway, Pharmacokinetics/Pharmacodynamics SuperPath

Associated Genes for Gemtuzumab ozogamicin Pathway, Pharmacokinetics/Pharmacodynamics

Associated Disorders for Gemtuzumab ozogamicin Pathway, Pharmacokinetics/Pharmacodynamics

Disorders associated with Gemtuzumab ozogamicin Pathway, Pharmacokinetics/Pharmacodynamics SuperPath

STRING Interaction Network for Gemtuzumab ozogamicin Pathway, Pharmacokinetics/Pharmacodynamics

Sources for Gemtuzumab ozogamicin Pathway, Pharmacokinetics/Pharmacodynamics