Gene Silencing by RNA

Pathway network for the Gene Silencing by RNA SuperPath

Sources:

Reactome
QIAGEN

Pathways in the Gene Silencing by RNA SuperPath

#	Name	Source	Genes
1	Gene Silencing by RNA	Reactome	AAAS AGO1 AGO2 AGO3 AGO4 ANG ASZ1 BCDIN3D DDX4 DGCR8 DICER1 DROSHA ELAC2 FKBP6 H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-3A H3-3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HENMT1 HSP90AA1 IPO8 MAEL MOV10L1 MYBL1 NDC1 NUP107 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP42 NUP43 NUP50 NUP54 NUP58 NUP62 NUP85 NUP88 NUP93 NUP98 PIWIL1 PIWIL2 PIWIL4 PLD6 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L POM121 PRKRA RAE1 RAN RANBP2 SEC13 SEH1L TARBP2 TDRD1 TDRD12 TDRD6 TDRD9 TDRKH TNRC6A TNRC6B TNRC6C TPR TSN TSNAX XPO5 (see all 137) (see less)
2	Mitotic Prophase	Reactome	AAAS ARPP19 BANF1 BLZF1 CCNB1 CCNB2 CDK1 CNEP1R1 CTDNEP1 EMD ENSA GOLGA2 GORASP1 GORASP2 H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-3A H3-3B H3-4 H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 KMT5A LEMD2 LEMD3 LMNA LMNB1 LPIN1 LPIN2 LPIN3 MAPK1 MAPK3 MASTL MCPH1 NCAPD3 NCAPG2 NCAPH2 NDC1 NEK6 NEK7 NEK9 NUMA1 NUP107 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP42 NUP43 NUP50 NUP54 NUP58 NUP62 NUP85 NUP88 NUP93 NUP98 PHF8 PLK1 POM121 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R2D PRKCA PRKCB RAB1A RAB1B RAB2A RAE1 RANBP2 RB1 SEC13 SEH1L SET SMC2 SMC4 TMPO TPR USO1 VRK1 VRK2 (see all 141) (see less)
3	Transcriptional regulation by small RNAs	Reactome	AAAS AGO1 AGO2 H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-3A H3-3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 IPO8 NDC1 NUP107 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP42 NUP43 NUP50 NUP54 NUP58 NUP62 NUP85 NUP88 NUP93 NUP98 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L POM121 RAE1 RAN RANBP2 SEC13 SEH1L TNRC6A TPR (see all 105) (see less)
4	Golgi Cisternae Pericentriolar Stack Reorganization	Reactome	BLZF1 CCNB1 CCNB2 CDK1 GOLGA2 GORASP1 GORASP2 MAPK1 MAPK3 PLK1 RAB1A RAB1B RAB2A USO1 (see all 14) (see less)
5	MASTL Facilitates Mitotic Progression	Reactome	ARPP19 CCNB1 CDK1 ENSA MASTL PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R2D (see all 10) (see less)
6	Small interfering RNA (siRNA) biogenesis	Reactome	AGO1 AGO2 AGO3 AGO4 DICER1 PRKRA TARBP2 TSN TSNAX (see all 9) (see less)
7	tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis	Reactome	ANG DICER1 ELAC2
8	RNAi Pathway	QIAGEN	AGO2 DICER1 TARBP2

Gene overlap in member pathways for Gene Silencing by RNA SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	DICER1	Dicer 1, Ribonuclease III	Protein Coding	4
2	AGO2	Argonaute RISC Catalytic Component 2	Protein Coding	4
3	NUP50	Nucleoporin 50	Protein Coding	3
4	NUP42	Nucleoporin 42	Protein Coding	3
5	H4C16	H4 Histone 16	Protein Coding	3
6	H3C14	H3 Clustered Histone 14	Protein Coding	3
7	H2BC26	H2B Clustered Histone 26	Protein Coding	3
8	NUP35	Nucleoporin 35	Protein Coding	3
9	NUP205	Nucleoporin 205	Protein Coding	3
10	NUP210	Nucleoporin 210	Protein Coding	3
11	NUP160	Nucleoporin 160	Protein Coding	3
12	NUP188	Nucleoporin 188	Protein Coding	3
13	NUP62	Nucleoporin 62	Protein Coding	3
14	H2BC1	H2B Clustered Histone 1	Protein Coding	3
15	AGO1	Argonaute RISC Component 1	Protein Coding	3
16	H2AC8	H2A Clustered Histone 8	Protein Coding	3
17	H2AC7	H2A Clustered Histone 7	Protein Coding	3
18	H2AX	H2A.X Variant Histone	Protein Coding	3
19	H2BC5	H2B Clustered Histone 5	Protein Coding	3
20	H2BC3	H2B Clustered Histone 3	Protein Coding	3
21	H3-3A	H3.3 Histone A	Protein Coding	3
22	H3-3B	H3.3 Histone B	Protein Coding	3
23	H3C15	H3 Clustered Histone 15	Protein Coding	3
24	NUP43	Nucleoporin 43	Protein Coding	3
25	H2AB1	H2A.B Variant Histone 1	Protein Coding	3
26	NUP88	Nucleoporin 88	Protein Coding	3
27	NUP98	Nucleoporin 98 And 96 Precursor	Protein Coding	3
28	NUP54	Nucleoporin 54	Protein Coding	3
29	H2BC12L	H2B Clustered Histone 12 Like	Protein Coding	3
30	H4C15	H4 Clustered Histone 15	Protein Coding	3
31	NDC1	NDC1 Transmembrane Nucleoporin	Protein Coding	3
32	NUP133	Nucleoporin 133	Protein Coding	3
33	H2AJ	H2A.J Histone	Protein Coding	3
34	NUP107	Nucleoporin 107	Protein Coding	3
35	RANBP2	RAN Binding Protein 2	Protein Coding	3
36	SEC13	SEC13 Homolog, Nuclear Pore And COPII Component	Protein Coding	3
37	H3C13	H3 Clustered Histone 13	Protein Coding	3
38	TARBP2	TARBP2 Subunit Of RISC Loading Complex	Protein Coding	3
39	TPR	Translocated Promoter Region, Nuclear Basket Protein	Protein Coding	3
40	H2AC19	H2A Clustered Histone 19	Protein Coding	3
41	NUP37	Nucleoporin 37	Protein Coding	3
42	NUP85	Nucleoporin 85	Protein Coding	3
43	NUP214	Nucleoporin 214	Protein Coding	3
44	AAAS	Aladin WD Repeat Nucleoporin	Protein Coding	3
45	SEH1L	SEH1 Like Nucleoporin	Protein Coding	3
46	H4C9	H4 Clustered Histone 9	Protein Coding	3
47	H2AC14	H2A Clustered Histone 14	Protein Coding	3
48	H2AC6	H2A Clustered Histone 6	Protein Coding	3
49	H2AC4	H2A Clustered Histone 4	Protein Coding	3
50	H2AC18	H2A Clustered Histone 18	Protein Coding	3
51	H2AC20	H2A Clustered Histone 20	Protein Coding	3
52	H2BC8	H2B Clustered Histone 8	Protein Coding	3
53	H2BC13	H2B Clustered Histone 13	Protein Coding	3
54	H2BC15	H2B Clustered Histone 15	Protein Coding	3
55	H2BC14	H2B Clustered Histone 14	Protein Coding	3
56	H2BC7	H2B Clustered Histone 7	Protein Coding	3
57	H2BC6	H2B Clustered Histone 6	Protein Coding	3
58	H2BC9	H2B Clustered Histone 9	Protein Coding	3
59	H2BC10	H2B Clustered Histone 10	Protein Coding	3
60	H2BC4	H2B Clustered Histone 4	Protein Coding	3
61	H2BC17	H2B Clustered Histone 17	Protein Coding	3
62	H2BC21	H2B Clustered Histone 21	Protein Coding	3
63	H3C1	H3 Clustered Histone 1	Protein Coding	3
64	H3C4	H3 Clustered Histone 4	Protein Coding	3
65	H3C3	H3 Clustered Histone 3	Protein Coding	3
66	H3C6	H3 Clustered Histone 6	Protein Coding	3
67	H3C11	H3 Clustered Histone 11	Protein Coding	3
68	H3C8	H3 Clustered Histone 8	Protein Coding	3
69	H3C12	H3 Clustered Histone 12	Protein Coding	3
70	H3C10	H3 Clustered Histone 10	Protein Coding	3
71	H3C2	H3 Clustered Histone 2	Protein Coding	3
72	H4C1	H4 Clustered Histone 1	Protein Coding	3
73	H4C4	H4 Clustered Histone 4	Protein Coding	3
74	H4C6	H4 Clustered Histone 6	Protein Coding	3
75	H4C12	H4 Clustered Histone 12	Protein Coding	3
76	H4C11	H4 Clustered Histone 11	Protein Coding	3
77	H4C3	H4 Clustered Histone 3	Protein Coding	3
78	H4C8	H4 Clustered Histone 8	Protein Coding	3
79	H4C2	H4 Clustered Histone 2	Protein Coding	3
80	H4C5	H4 Clustered Histone 5	Protein Coding	3
81	H4C13	H4 Clustered Histone 13	Protein Coding	3
82	H4C14	H4 Clustered Histone 14	Protein Coding	3
83	RAE1	Ribonucleic Acid Export 1	Protein Coding	3
84	H2BC12	H2B Clustered Histone 12	Protein Coding	3
85	H3C7	H3 Clustered Histone 7	Protein Coding	3
86	H2BC11	H2B Clustered Histone 11	Protein Coding	3
87	H2AZ2	H2A.Z Variant Histone 2	Protein Coding	3
88	NUP155	Nucleoporin 155	Protein Coding	3
89	NUP93	Nucleoporin 93	Protein Coding	3
90	NUP58	Nucleoporin 58	Protein Coding	3
91	POM121	POM121 Transmembrane Nucleoporin	Protein Coding	3
92	NUP153	Nucleoporin 153	Protein Coding	3
93	CCNB1	Cyclin B1	Protein Coding	3
94	CDK1	Cyclin Dependent Kinase 1	Protein Coding	3
95	IPO8	Importin 8	Protein Coding	2
96	AGO3	Argonaute RISC Catalytic Component 3	Protein Coding	2
97	AGO4	Argonaute RISC Component 4	Protein Coding	2
98	TNRC6A	Trinucleotide Repeat Containing Adaptor 6A	Protein Coding	2
99	ANG	Angiogenin	Protein Coding	2
100	POLR2A	RNA Polymerase II Subunit A	Protein Coding	2
101	POLR2B	RNA Polymerase II Subunit B	Protein Coding	2
102	POLR2C	RNA Polymerase II Subunit C	Protein Coding	2
103	POLR2D	RNA Polymerase II Subunit D	Protein Coding	2
104	POLR2E	RNA Polymerase II, I And III Subunit E	Protein Coding	2
105	POLR2F	RNA Polymerase II, I And III Subunit F	Protein Coding	2
106	POLR2G	RNA Polymerase II Subunit G	Protein Coding	2
107	POLR2H	RNA Polymerase II, I And III Subunit H	Protein Coding	2
108	POLR2I	RNA Polymerase II Subunit I	Protein Coding	2
109	POLR2J	RNA Polymerase II Subunit J	Protein Coding	2
110	POLR2K	RNA Polymerase II, I And III Subunit K	Protein Coding	2
111	POLR2L	RNA Polymerase II, I And III Subunit L	Protein Coding	2
112	RAN	RAN, Member RAS Oncogene Family	Protein Coding	2
113	ELAC2	ElaC Ribonuclease Z 2	Protein Coding	2
114	TSN	Translin	Protein Coding	2
115	TSNAX	Translin Associated Factor X	Protein Coding	2
116	PRKRA	Protein Activator Of Interferon Induced Protein Kinase EIF2AK2	Protein Coding	2
117	ARPP19	CAMP Regulated Phosphoprotein 19	Protein Coding	2
118	ENSA	Endosulfine Alpha	Protein Coding	2
119	GORASP2	Golgi Reassembly Stacking Protein 2	Protein Coding	2
120	GOLGA2	Golgin A2	Protein Coding	2
121	PLK1	Polo Like Kinase 1	Protein Coding	2
122	PPP2CA	Protein Phosphatase 2 Catalytic Subunit Alpha	Protein Coding	2
123	PPP2CB	Protein Phosphatase 2 Catalytic Subunit Beta	Protein Coding	2
124	PPP2R1A	Protein Phosphatase 2 Scaffold Subunit Aalpha	Protein Coding	2
125	PPP2R1B	Protein Phosphatase 2 Scaffold Subunit Abeta	Protein Coding	2
126	PPP2R2D	Protein Phosphatase 2 Regulatory Subunit Bdelta	Protein Coding	2
127	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	2
128	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	2
129	RAB1A	RAB1A, Member RAS Oncogene Family	Protein Coding	2
130	RAB2A	RAB2A, Member RAS Oncogene Family	Protein Coding	2
131	GORASP1	Golgi Reassembly Stacking Protein 1	Protein Coding	2
132	RAB1B	RAB1B, Member RAS Oncogene Family	Protein Coding	2
133	MASTL	Microtubule Associated Serine/Threonine Kinase Like	Protein Coding	2
134	BLZF1	Basic Leucine Zipper Nuclear Factor 1	Protein Coding	2
135	USO1	USO1 Vesicle Transport Factor	Protein Coding	2
136	CCNB2	Cyclin B2	Protein Coding	2
137	TDRKH	Tudor And KH Domain Containing	Protein Coding	1
138	HENMT1	HEN Methyltransferase 1	Protein Coding	1
139	TDRD9	Tudor Domain Containing 9	Protein Coding	1
140	ASZ1	Ankyrin Repeat, SAM And Basic Leucine Zipper Domain Containing 1	Protein Coding	1
141	PIWIL4	Piwi Like RNA-Mediated Gene Silencing 4	Protein Coding	1
142	BCDIN3D	BCDIN3 Domain Containing RNA Methyltransferase	Protein Coding	1
143	PLD6	Phospholipase D Family Member 6	Protein Coding	1
144	TDRD6	Tudor Domain Containing 6	Protein Coding	1
145	TNRC6B	Trinucleotide Repeat Containing Adaptor 6B	Protein Coding	1
146	DROSHA	Drosha Ribonuclease III	Protein Coding	1
147	HSP90AA1	Heat Shock Protein 90 Alpha Family Class A Member 1	Protein Coding	1
148	MYBL1	MYB Proto-Oncogene Like 1	Protein Coding	1
149	MOV10L1	Mov10 Like RNA Helicase 1	Protein Coding	1
150	DGCR8	DGCR8 Microprocessor Complex Subunit	Protein Coding	1
151	DDX4	DEAD-Box Helicase 4	Protein Coding	1
152	PIWIL2	Piwi Like RNA-Mediated Gene Silencing 2	Protein Coding	1
153	TDRD1	Tudor Domain Containing 1	Protein Coding	1
154	XPO5	Exportin 5	Protein Coding	1
155	TNRC6C	Trinucleotide Repeat Containing Adaptor 6C	Protein Coding	1
156	FKBP6	FKBP Prolyl Isomerase Family Member 6 (Inactive)	Protein Coding	1
157	MAEL	Maelstrom Spermatogenic Transposon Silencer	Protein Coding	1
158	TDRD12	Tudor Domain Containing 12	Protein Coding	1
159	PIWIL1	Piwi Like RNA-Mediated Gene Silencing 1	Protein Coding	1
160	SMC4	Structural Maintenance Of Chromosomes 4	Protein Coding	1
161	SMC2	Structural Maintenance Of Chromosomes 2	Protein Coding	1
162	NEK6	NIMA Related Kinase 6	Protein Coding	1
163	NEK7	NIMA Related Kinase 7	Protein Coding	1
164	EMD	Emerin	Protein Coding	1
165	LEMD2	LEM Domain Nuclear Envelope Protein 2	Protein Coding	1
166	PHF8	PHD Finger Protein 8	Protein Coding	1
167	LPIN1	Lipin 1	Protein Coding	1
168	NCAPD3	Non-SMC Condensin II Complex Subunit D3	Protein Coding	1
169	CTDNEP1	CTD Nuclear Envelope Phosphatase 1	Protein Coding	1
170	LEMD3	LEM Domain Containing 3	Protein Coding	1
171	CNEP1R1	CTD Nuclear Envelope Phosphatase 1 Regulatory Subunit 1	Protein Coding	1
172	NCAPH2	Non-SMC Condensin II Complex Subunit H2	Protein Coding	1
173	KMT5A	Lysine Methyltransferase 5A	Protein Coding	1
174	LMNA	Lamin A/C	Protein Coding	1
175	LMNB1	Lamin B1	Protein Coding	1
176	NUMA1	Nuclear Mitotic Apparatus Protein 1	Protein Coding	1
177	NCAPG2	Non-SMC Condensin II Complex Subunit G2	Protein Coding	1
178	PRKCA	Protein Kinase C Alpha	Protein Coding	1
179	PRKCB	Protein Kinase C Beta	Protein Coding	1
180	RB1	RB Transcriptional Corepressor 1	Protein Coding	1
181	SET	SET Nuclear Proto-Oncogene	Protein Coding	1
182	LPIN3	Lipin 3	Protein Coding	1
183	TMPO	Thymopoietin	Protein Coding	1
184	VRK1	VRK Serine/Threonine Kinase 1	Protein Coding	1
185	VRK2	VRK Serine/Threonine Kinase 2	Protein Coding	1
186	MCPH1	Microcephalin 1	Protein Coding	1
187	H3-4	H3.4 Histone, Cluster Member	Protein Coding	1
188	BANF1	Barrier To Autointegration Nuclear Assembly Factor 1	Protein Coding	1
189	NEK9	NIMA Related Kinase 9	Protein Coding	1
190	LPIN2	Lipin 2	Protein Coding	1

Disorders associated with Gene Silencing by RNA SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Male infertility	Enrichment	FKBP6, MAEL, MOV10L1, PIWIL1, PLD6, TDRD1, TDRD12, TDRD9	8.89
2	Genetic steroid-resistant nephrotic syndrome	Enrichment	NUP107, NUP133, NUP160, NUP205, NUP37, NUP85, NUP93	8.21
3	Tessadori-bicknell-van haaften neurodevelopmental syndrome 4	Enrichment	H2BC12, H4C1, H4C9	6.35
4	Azoospermia	Enrichment	HENMT1, MOV10L1, TDRD9, TDRKH	4.37
5	Tessadori-bicknell-van haaften neurodevelopmental syndrome 1	Enrichment	H4C1, H4C3	4.23
6	Tessadori-bicknell-van haaften neurodevelopmental syndrome 2	Enrichment	H4C1, H4C11	4.23
7	Bryant-li-bhoj neurodevelopmental syndrome 2	Enrichment	H3-3A, H3-3B	4.23
8	Pineoblastoma	Enrichment	DICER1, DROSHA	3.99
9	Ovarian cancer	Enrichment	DICER1, ELAC2	3.79
10	Tessadori-bicknell-van haaften neurodevelopmental syndrome 3	Enrichment	H4C1, H4C5	3.75
11	Rhabdomyosarcoma, embryonal, 2	Enrichment	DICER1	3.66
12	Dicer1 syndrome	Enrichment	DICER1	3.66
13	Pleuropulmonary blastoma	Enrichment	DICER1	3.66
14	Global developmental delay, lung cysts, overgrowth, and wilms tumor	Enrichment	DICER1	3.66
15	Prostate cancer, hereditary, 2	Enrichment	ELAC2	3.66
16	Combined oxidative phosphorylation deficiency 17	Enrichment	ELAC2	3.66
17	Malignant sertoli-leydig cell tumor of ovary	Enrichment	DICER1	3.66
18	Supratentorial primitive neuroectodermal tumor	Enrichment	DICER1	3.66
19	Gynandroblastoma	Enrichment	DICER1	3.66
20	Dicer1 tumor predisposition	Enrichment	DICER1	3.66
21	Familial infantile bilateral striatal necrosis	Enrichment	NUP54, NUP62	3.45
22	Goiter, multinodular 1, with or without sertoli-leydig cell tumors	Enrichment	DICER1	3.35
23	Vertebral anomalies and variable endocrine and t-cell dysfunction	Enrichment	DICER1	3.35
24	Malignant granulosa cell tumor of the ovary	Enrichment	DICER1	3.35
25	Premature ovarian failure 3	Enrichment	AGO2	3.35
26	Emery-dreifuss muscular dystrophy 1, x-linked	Enrichment	EMD, LMNA	3.20
27	Emery-dreifuss muscular dystrophy	Enrichment	EMD, LMNA	3.20
28	Amyotrophic lateral sclerosis 9	Enrichment	ANG	3.18
29	Lessel-kreienkamp syndrome	Enrichment	AGO2	3.18
30	Houge-janssens syndrome 2	Enrichment	PPP2R1A	3.13
31	Ppp2r1a-related neurodevelopmental disorder	Enrichment	PPP2R1A	3.13
32	Neuromuscular disease	Enrichment	EMD, GOLGA2, LMNA	3.10
33	Embryonal rhabdomyosarcoma	Enrichment	DICER1	3.05
34	Noonan syndrome 13	Enrichment	MAPK1	2.99
35	Developmental delay with hypotonia, myopathy, and brain abnormalities	Enrichment	GOLGA2	2.99
36	Dystonia 16	Enrichment	PRKRA	2.88
37	Neurodevelopmental disorder with language delay and behavioral abnormalities, with or without seizures	Enrichment	AGO1	2.88
38	Houge-janssens syndrome 3	Enrichment	PPP2CA	2.83
39	Complex neurodevelopmental disorder	Enrichment	AGO1, AGO2, H4C3, H4C5, H4C9, TNRC6B	2.80
40	Glioma susceptibility 1	Enrichment	H3-3A, H3C1	2.79
41	Frontotemporal dementia 1	Enrichment	ANG	2.61
42	Galloway-mowat syndrome	Enrichment	NUP107, NUP133	2.59
43	Rhabdomyosarcoma	Enrichment	DICER1	2.45
44	Autosomal thrombocytopenia with normal platelets	Enrichment	MASTL	2.43
45	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	2.38
46	Primary autosomal recessive microcephaly	Enrichment	MCPH1, NCAPD3, NUP37	2.36
47	Prostate cancer	Enrichment	ELAC2	2.19
48	Fetal akinesia deformation sequence 4	Enrichment	NUP88	2.11
49	Neurodevelopmental disorder with achalasia, polyneuropathy, and alacrima	Enrichment	NDC1	2.11
50	Atrial fibrillation, familial, 15	Enrichment	NUP155	2.11
51	Dystonia 37, early-onset, with striatal lesions	Enrichment	NUP54	2.11
52	Nephrotic syndrome, type 19	Enrichment	NUP160	2.11
53	Galloway-mowat syndrome 8	Enrichment	NUP133	2.11
54	Nephrotic syndrome, type 13	Enrichment	NUP205	2.11
55	Microcephaly 24, primary, autosomal recessive	Enrichment	NUP37	2.11
56	Galloway-mowat syndrome 7	Enrichment	NUP107	2.11
57	Nephrotic syndrome, type 12	Enrichment	NUP93	2.11
58	Nephrotic syndrome, type 11	Enrichment	NUP107	2.11
59	Epilepsy, familial adult myoclonic, 6	Enrichment	TNRC6A	2.11
60	Encephalopathy, acute, infection-induced 9	Enrichment	NUP214	2.11
61	Bryant-li-bhoj neurodevelopmental syndrome 1	Enrichment	H3-3A	2.11
62	Sandestig-stefanova syndrome	Enrichment	NUP188	2.11
63	Ovarian dysgenesis 6	Enrichment	NUP107	2.11
64	Intellectual developmental disorder, autosomal recessive 79	Enrichment	TPR	2.11
65	Nephrotic syndrome, type 18	Enrichment	NUP133	2.11
66	Familial acute necrotizing encephalopathy	Enrichment	RANBP2	2.11
67	Global developmental delay with speech and behavioral abnormalities	Enrichment	TNRC6B	2.00
68	Spermatogenic failure 73	Enrichment	MOV10L1	2.00
69	Spermatogenic failure 77	Enrichment	FKBP6	2.00
70	Spermatogenic failure 30	Enrichment	TDRD9	2.00
71	Leukodystrophy, demyelinating, adult-onset, autosomal dominant, typical	Enrichment	LMNB1	1.98
72	Buschke-ollendorff syndrome	Enrichment	LEMD3	1.98
73	Intellectual developmental disorder, x-linked, syndromic, siderius type	Enrichment	PHF8	1.98
74	Teeth, supernumerary	Enrichment	LEMD2	1.98
75	Arthrogryposis, perthes disease, and upward gaze palsy	Enrichment	NEK9	1.98
76	Nevus comedonicus	Enrichment	NEK9	1.98
77	Khan-khan-katsanis syndrome	Enrichment	NCAPG2	1.98
78	Syndromic x-linked intellectual disability siderius type	Enrichment	PHF8	1.98
79	Marbach-rustad progeroid syndrome	Enrichment	LEMD2	1.98
80	Adult onset demyelinating leukodystrophy	Enrichment	LMNB1	1.98
81	Majeed syndrome	Enrichment	LPIN2	1.98
82	Nestor-guillermo progeria syndrome	Enrichment	BANF1	1.98
83	Microcephaly 26, primary, autosomal dominant	Enrichment	LMNB1	1.98
84	Lethal congenital contracture syndrome 10	Enrichment	NEK9	1.98
85	Atypical werner syndrome	Enrichment	LMNA	1.98
86	Microcephaly 22, primary, autosomal recessive	Enrichment	NCAPD3	1.98
87	Neuronopathy, distal hereditary motor, autosomal recessive 10	Enrichment	VRK1	1.98
88	Melorheostosis with osteopoikilosis	Enrichment	LEMD3	1.98
89	Trilateral retinoblastoma	Enrichment	RB1	1.98
90	Mandibuloacral dysplasia	Enrichment	LMNA	1.98
91	Atrioventricular block	Enrichment	LMNA	1.98
92	Lmna-related cardiocutaneous progeria syndrome	Enrichment	LMNA	1.98
93	Isolated osteopoikilosis	Enrichment	LEMD3	1.98
94	Autosomal semi-dominant severe lipodystrophic laminopathy	Enrichment	LMNA	1.98
95	Microcephaly-complex motor and sensory axonal neuropathy syndrome	Enrichment	VRK1	1.98
96	Autosomal recessive axonal hereditary motor and sensory neuropathy	Enrichment	LMNA	1.98
97	Laminopathy	Enrichment	LMNA	1.98
98	Lung oat cell carcinoma	Enrichment	RB1	1.98
99	Specific learning disability	Enrichment	MAPK1	1.95
100	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	ANG	1.89
101	Camptodactyly-arthropathy-coxa vara-pericarditis syndrome	Enrichment	TPR	1.81
102	Striatonigral degeneration, infantile	Enrichment	NUP62	1.81
103	Waardenburg syndrome, type 4c	Enrichment	POLR2F	1.81
104	Duane-radial ray syndrome	Enrichment	IPO8	1.81
105	Nephrotic syndrome, type 17	Enrichment	NUP85	1.81
106	Peripheral demyelinating neuropathy, central dysmyelination, waardenburg syndrome, and hirschsprung disease	Enrichment	POLR2F	1.81
107	Acute myeloid leukemia with t(6;9) (p23;q34.1)	Enrichment	NUP214	1.81
108	Acute necrotizing encephalopathy of childhood	Enrichment	RANBP2	1.81
109	Neuropathy, hereditary motor and sensory, okinawa type	Enrichment	EMD, LMNA	1.79
110	Heart, malformation of	Enrichment	MAPK1	1.73
111	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	ASZ1, MOV10L1, TDRD9	1.72
112	Cataract 46, juvenile-onset, with or without arrhythmic cardiomyopathy	Enrichment	LEMD2	1.68
113	Mandibuloacral dysplasia with type a lipodystrophy	Enrichment	LMNA	1.68
114	Myopathy, x-linked, with postural muscle atrophy	Enrichment	EMD	1.68
115	Heart-hand syndrome, slovenian type	Enrichment	LMNA	1.68
116	Pontocerebellar hypoplasia, type 1a	Enrichment	VRK1	1.68
117	Charcot-marie-tooth disease, axonal, type 2b1	Enrichment	LMNA	1.68
118	Cardiomyopathy, dilated, with hypergonadotropic hypogonadism	Enrichment	LMNA	1.68
119	Chromosome 13q14 deletion syndrome	Enrichment	RB1	1.68
120	Cardiomyopathy, dilated, 1d	Enrichment	LMNA	1.68
121	Restrictive dermopathy 2	Enrichment	LMNA	1.68
122	Emery-dreifuss muscular dystrophy 3, autosomal recessive	Enrichment	LMNA	1.68
123	Myopia 6	Enrichment	NCAPH2	1.68
124	Cataract 46 juvenile-onset	Enrichment	LEMD2	1.68
125	Lipodystrophy, familial partial, type 1	Enrichment	LMNA	1.68
126	Osteopoikilosis	Enrichment	LEMD3	1.68
127	Autosomal dominant primary microcephaly	Enrichment	LMNB1	1.68
128	Congenital pontocerebellar hypoplasia type 1	Enrichment	VRK1	1.68
129	Lymphatic malformation 10	Enrichment	MCPH1	1.68
130	Intellectual developmental disorder, autosomal dominant 58	Enrichment	SET	1.68
131	Familial partial lipodystrophy	Enrichment	LMNA	1.68
132	12q14 microdeletion syndrome	Enrichment	LEMD3	1.68
133	Familial retinoblastoma	Enrichment	RB1	1.68
134	Charcot-marie-tooth disease type 2b1	Enrichment	LMNA	1.68
135	X-linked emery-dreifuss muscular dystrophy	Enrichment	EMD	1.68
136	Hirschsprung disease 1	Enrichment	NUP98, POLR2F	1.68
137	Waardenburg syndrome, type 2a	Enrichment	POLR2F	1.64
138	Ectodermal dysplasia 11b, hypohidrotic/hair/tooth type, autosomal recessive	Enrichment	RANBP2	1.64
139	Viss syndrome	Enrichment	IPO8	1.64
140	Lung cancer	Enrichment	PPP2R1B	1.63
141	Precursor t-cell acute lymphoblastic leukemia	Enrichment	NUP214, SET	1.63
142	Inherited cancer-predisposing syndrome	Enrichment	DICER1	1.54
143	Adenoid cystic carcinoma	Enrichment	MYBL1	1.52
144	Ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive	Enrichment	RANBP2	1.51
145	Achalasia-addisonianism-alacrima syndrome	Enrichment	AAAS	1.51
146	Neurodevelopmental disorder with hypotonia and variable intellectual and behavioral abnormalities	Enrichment	POLR2A	1.51
147	Ectodermal dysplasia	Enrichment	RANBP2	1.51
148	Retinoblastoma	Enrichment	RB1	1.51
149	Restrictive dermopathy 1	Enrichment	LMNA	1.51
150	Myoglobinuria, acute recurrent, autosomal recessive	Enrichment	LPIN1	1.51
151	Mitochondrial complex iv deficiency, nuclear type 2	Enrichment	NCAPH2	1.51
152	Osteogenic sarcoma	Enrichment	RB1	1.51
153	Lipodystrophy, familial partial, type 2	Enrichment	LMNA	1.51
154	Woolly hair, autosomal recessive 3	Enrichment	RB1	1.51
155	Muscular dystrophy, congenital, lmna-related	Enrichment	LMNA	1.51
156	Pontocerebellar hypoplasia, type 1b	Enrichment	VRK1	1.51
157	Hypotrichosis 8	Enrichment	RB1	1.51
158	Squamous cell carcinoma	Enrichment	RB1	1.51
159	Bone osteosarcoma	Enrichment	RB1	1.51
160	Restrictive dermopathy	Enrichment	LMNA	1.51
161	Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant	Enrichment	RANBP2	1.42
162	Hypogonadotropic hypogonadism 1 with or without anosmia	Enrichment	POLR2F	1.42
163	Autosomal recessive hypohidrotic ectodermal dysplasia syndrome	Enrichment	RANBP2	1.42
164	Charcot-marie-tooth hereditary neuropathy	Enrichment	TDRKH	1.40
165	Hutchinson-gilford progeria syndrome	Enrichment	LMNA	1.39
166	Small cell cancer of the lung	Enrichment	RB1	1.39
167	Microtia-anotia	Enrichment	LMNA	1.39
168	Lynch syndrome 4	Enrichment	RB1	1.39
169	Hereditary recurrent myoglobinuria	Enrichment	LPIN1	1.39
170	Sick sinus syndrome	Enrichment	LMNA	1.39
171	Waardenburg syndrome, type 4a	Enrichment	POLR2F	1.34
172	Inflammatory myofibroblastic tumor	Enrichment	RANBP2	1.34
173	Waardenburg syndrome	Enrichment	POLR2F	1.34
174	Dilated cardiomyopathy	Enrichment	EMD, LMNA, NCAPH2	1.30
175	Cataract 6, multiple types	Enrichment	LEMD2	1.29
176	Microcephaly 1, primary, autosomal recessive	Enrichment	MCPH1	1.29
177	Goldberg-shprintzen syndrome	Enrichment	NEK9	1.29
178	Autosomal recessive limb-girdle muscular dystrophy type 2b	Enrichment	LMNA	1.29
179	Spinal muscular atrophy	Enrichment	VRK1	1.29
180	Histiocytoid hemangioma	Enrichment	LMNA	1.29
181	Waardenburg syndrome, type 1	Enrichment	POLR2F	1.28
182	Mitochondrial dna depletion syndrome 4a	Enrichment	RANBP2	1.28
183	Waardenburg syndrome, type 2e	Enrichment	POLR2F	1.28
184	Mitochondrial dna depletion syndrome 4b	Enrichment	RANBP2	1.22
185	Emery-dreifuss muscular dystrophy 2, autosomal dominant	Enrichment	LMNA	1.22
186	Pontocerebellar hypoplasia, type 1e	Enrichment	VRK1	1.22
187	Loeys-dietz syndrome	Enrichment	IPO8	1.17
188	Bethlem myopathy 1a	Enrichment	LMNA	1.15
189	Congenital muscular dystrophy	Enrichment	LMNA	1.10
190	Myocarditis	Enrichment	LMNA	1.10
191	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	TNRC6B	1.06
192	46 xx gonadal dysgenesis	Enrichment	NUP107	1.05
193	Arrhythmogenic right ventricular dysplasia, familial, 9	Enrichment	LMNA	1.05
194	Juvenile amyotrophic lateral sclerosis	Enrichment	VRK1	1.05
195	Seckel syndrome	Enrichment	NUP85	0.99
196	Familial isolated dilated cardiomyopathy	Enrichment	LMNA, TMPO	0.98
197	Cardiac conduction defect	Enrichment	LMNA	0.93
198	Muscular dystrophy, limb-girdle, autosomal recessive 2	Enrichment	LMNA	0.93
199	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant	Enrichment	LMNA	0.93
200	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant	Enrichment	LMNA	0.93
201	Lip and oral cavity carcinoma	Enrichment	RB1	0.93
202	Microcephaly	Enrichment	MAPK1	0.92
203	Acute promyelocytic leukemia	Enrichment	NUMA1	0.90
204	Lung cancer susceptibility 3	Enrichment	RB1	0.87
205	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	LMNA	0.87
206	Esophageal atresia/tracheoesophageal fistula	Enrichment	POLR2B	0.86
207	Focal segmental glomerulosclerosis	Enrichment	NUP93	0.84
208	Arrhythmogenic right ventricular cardiomyopathy	Enrichment	LMNA	0.81
209	Isolated congenital microcephaly	Enrichment	MCPH1	0.81
210	Tooth agenesis	Enrichment	RANBP2	0.80
211	Cardiomyopathy, dilated, 1e	Enrichment	LMNA	0.79
212	Cataract 44	Enrichment	LEMD2	0.79
213	Kallmann syndrome	Enrichment	POLR2F	0.79
214	Familial atrial fibrillation	Enrichment	NUP155	0.77
215	Pontocerebellar hypoplasia	Enrichment	VRK1	0.77
216	Arteriovenous malformations of the brain	Enrichment	LEMD3	0.74
217	Williams-beuren syndrome	Enrichment	FKBP6	0.74
218	Cardiomyopathy, dilated, 1a	Enrichment	LMNA	0.71
219	Differentiated thyroid carcinoma	Enrichment	TPR	0.69
220	Cardiomyopathy, familial hypertrophic, 1	Enrichment	LMNA	0.65
221	Autoinflammatory disease	Enrichment	LPIN2	0.65
222	Muscular dystrophy	Enrichment	LMNA	0.65
223	Brugada syndrome	Enrichment	LMNA	0.62
224	Fetal akinesia deformation sequence 1	Enrichment	NUP88	0.60
225	Bladder cancer	Enrichment	RB1	0.58
226	Leukemia, acute myeloid	Enrichment	NUP214	0.57
227	Long qt syndrome	Enrichment	LMNA	0.56
228	Nephrotic syndrome	Enrichment	NUP93	0.55
229	Peripheral nervous system disease	Enrichment	LMNA	0.55
230	Neuropathy	Enrichment	LMNA	0.55
231	Congenital nervous system abnormality	Enrichment	AAAS, MCPH1	0.52
232	Nervous system disease	Enrichment	AAAS, MCPH1	0.52
233	Left ventricular noncompaction	Enrichment	LMNA	0.51
234	Myopathy	Enrichment	EMD	0.47
235	Charcot-marie-tooth disease	Enrichment	LMNA	0.46
236	Myeloma, multiple	Enrichment	H3C1	0.45
237	Autosomal recessive non-syndromic intellectual disability	Enrichment	TPR	0.44
238	Autosomal dominant non-syndromic intellectual disability	Enrichment	SET	0.39
239	Hereditary breast ovarian cancer syndrome	Enrichment	DROSHA	0.37
240	Rare genetic deafness	Enrichment	POLR2F	0.34
241	Autism spectrum disorder	Enrichment	TNRC6B	0.17

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Gene Silencing by RNA

Pathway Network for Gene Silencing by RNA

Pathway network for the Gene Silencing by RNA SuperPath

Member Pathways for Gene Silencing by RNA

Pathways in the Gene Silencing by RNA SuperPath

Gene overlap in member pathways for Gene Silencing by RNA SuperPath

Associated Genes for Gene Silencing by RNA

Associated Disorders for Gene Silencing by RNA

Disorders associated with Gene Silencing by RNA SuperPath

STRING Interaction Network for Gene Silencing by RNA

Sources for Gene Silencing by RNA