Genes controlling nephrogenesis

No Pathway Network information available for Genes controlling nephrogenesis

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

Disorders associated with Genes controlling nephrogenesis SuperPath

according to GeneCards Suite gene sharing
#DisorderTypeGenesScore
1Focal segmental glomerulosclerosisEnrichmentEYA1, NPHS1, NPHS2, PAX2, WT18.37
2Nephrotic syndromeEnrichmentITGA3, LAMB2, LMX1B, NPHS1, NPHS2, PAX28.34
3CakutEnrichmentETV4, FOXC1, HNF1B, PAX2, SLIT27.13
4Genetic steroid-resistant nephrotic syndromeEnrichmentCD2AP, NPHS1, NPHS2, PAX2, WT17.13
5Renal agenesis, bilateralEnrichmentEYA1, ITGA8, RET5.58
6Branchiootic syndromeEnrichmentEYA1, SIX14.99
7Branchiootic syndrome 1EnrichmentEYA1, SIX14.99
8Kidney diseaseEnrichmentLAMB2, NPHS1, WT14.85
9Mullerian duct aplasia, unilateral renal agenesis, and cervicothoracic somite anomaliesEnrichmentHNF1B, WNT44.51
10Chromosome 17q12 deletion syndromeEnrichmentHNF1B, LHX14.51
11SchizencephalyEnrichmentEMX2, SHH4.21
12Hirschsprung disease 1EnrichmentGDNF, GLI3, RET3.96
13Branchiootorenal syndrome 1EnrichmentEYA1, SIX13.82
14Branchiootorenal syndromeEnrichmentEYA1, SIX13.67
15Basal ganglia calcification, idiopathic, 1EnrichmentPDGFB, PDGFRB3.55
16Renal hypodysplasia/aplasia 1EnrichmentITGA8, RET3.55
17Ovarian cancerEnrichmentCTNNB1, HNF1B, RET, WT13.50
18Nephrotic syndrome, type 1EnrichmentNPHS1, NPHS23.44
19Congenital central hypoventilation syndromeEnrichmentGDNF, RET3.44
20Primary ovarian insufficiencyEnrichmentKDR, NOTCH2, WT13.04
21HydrocephalusEnrichmentFGFR2, PDGFRB2.98
22Septopreoptic holoprosencephalyEnrichmentFGF8, SHH2.98
23Midline interhemispheric variant of holoprosencephalyEnrichmentFGF8, SHH2.98
24Microform holoprosencephalyEnrichmentFGF8, SHH2.92
25Lobar holoprosencephalyEnrichmentFGF8, SHH2.92
26Alobar holoprosencephalyEnrichmentFGF8, SHH2.87
27Semilobar holoprosencephalyEnrichmentFGF8, SHH2.82
28CraniosynostosisEnrichmentFGFR2, GLI32.73
29Hepatocellular carcinomaEnrichmentCTNNB1, RET2.64
30Colorectal cancerEnrichmentCTNNB1, FGFR2, RET2.55
31Tetralogy of fallotEnrichmentKDR, RET2.50
32Holoprosencephaly 3EnrichmentSHH2.49
33Multiple endocrine neoplasia, type iibEnrichmentRET2.49
34Pallister-hall syndromeEnrichmentGLI32.49
35Beare-stevenson cutis gyrata syndromeEnrichmentFGFR22.49
36Greig cephalopolysyndactyly syndromeEnrichmentGLI32.49
37Mullerian aplasia and hyperandrogenismEnrichmentWNT42.49
38Focal segmental glomerulosclerosis 10EnrichmentLMX1B2.49
39Hypertelorism and tetralogy of fallotEnrichmentFOXC12.49
40Premature aging syndrome, penttinen typeEnrichmentPDGFRB2.49
41Vesicoureteral reflux 2EnrichmentROBO22.49
42Coronary heart disease 7EnrichmentCD362.49
4346,xx sex reversal with dysgenesis of kidneys, adrenals, and lungsEnrichmentWNT42.49
44Polydactyly, preaxial ivEnrichmentGLI32.49
45Scaphocephaly, maxillary retrusion, and impaired intellectual developmentEnrichmentFGFR22.49
46Apert syndromeEnrichmentFGFR22.49
47Hajdu-cheney syndromeEnrichmentNOTCH22.49
48Alagille syndrome 2EnrichmentNOTCH22.49
49Basal ganglia calcification, idiopathic, 5EnrichmentPDGFB2.49
50Nail-patella syndromeEnrichmentLMX1B2.49
51Microphthalmia/coloboma 5EnrichmentSHH2.49
52Otofaciocervical syndrome 1EnrichmentEYA12.49
53Prostate cancer, hereditary, 11EnrichmentHNF1B2.49
54Myofibromatosis, infantile, 1EnrichmentPDGFRB2.49
55Whim syndrome 1EnrichmentCXCR42.49
56Bent bone dysplasia syndrome 1EnrichmentFGFR22.49
57Deafness, autosomal dominant 23EnrichmentSIX12.49
58Radioulnar synostosis with amegakaryocytic thrombocytopenia 1EnrichmentHOXA112.49
59Microvascular complications of diabetes 1EnrichmentVEGFA2.49
60Platelet glycoprotein iv deficiencyEnrichmentCD362.49
61Meacham syndromeEnrichmentWT12.49
62Focal segmental glomerulosclerosis 3EnrichmentCD2AP2.49
63Basal ganglia calcification, idiopathic, 4EnrichmentPDGFRB2.49
64Myeloid and lymphoid neoplasms associated with pdgfrb rearrangementEnrichmentPDGFRB2.49
65Hirschsprung disease 3EnrichmentGDNF2.49
66Hypogonadotropic hypogonadism 6 with or without anosmiaEnrichmentFGF82.49
67Kosaki overgrowth syndromeEnrichmentPDGFRB2.49
68Lipoid nephrosisEnrichmentLMX1B2.49
69Ocular pterygium-digital keloid dysplasia syndromeEnrichmentPDGFRB2.49
70Tufted angioma of skinEnrichmentKDR2.49
71Adenoid ameloblastomaEnrichmentCTNNB12.49
72Thyroid cancerEnrichmentRET2.49
73Familial nephrotic syndromeEnrichmentNPHS12.49
74Pax2-related disorderEnrichmentPAX22.49
75Medullary sponge kidneyEnrichmentHNF1B2.49
76Autosomal dominant nonsyndromic hearing loss 23EnrichmentSIX12.49
77Renal dysplasia, bilateralEnrichmentHNF1B2.49
78Unilateral multicystic dysplastic kidneyEnrichmentHNF1B2.49
79Renal dysplasia, unilateralEnrichmentHNF1B2.49
80Non-syndromic unicoronal craniosynostosisEnrichmentFGFR22.49
81Microcystic stromal tumorEnrichmentCTNNB12.49
82Gastrointestinal system diseaseEnrichmentRET2.49
83Autosomal dominant preaxial polydactyly-upperback hypertrichosis syndromeEnrichmentSHH2.49
84Multiple endocrine neoplasiaEnrichmentRET2.49
85Tubulointerstitial kidney disease, autosomal dominant 1EnrichmentHNF1B2.19
86Papillorenal syndromeEnrichmentPAX22.19
87Renal cysts and diabetes syndromeEnrichmentHNF1B2.19
88Congenital anomalies of kidney and urinary tract 2EnrichmentHNF1B2.19
89Deafness, unilateralEnrichmentSIX12.19
90Myeloproliferative disorder, chronic, with eosinophiliaEnrichmentPDGFRB2.19
91Denys-drash syndromeEnrichmentWT12.19
92Myasthenic syndrome, congenital, 5EnrichmentLAMB22.19
93Osteopathia striata with cranial sclerosisEnrichmentCTNNB12.19
94Nephrotic syndrome, type 2EnrichmentNPHS22.19
95Dermatofibrosarcoma protuberansEnrichmentPDGFB2.19
96Axenfeld-rieger syndrome, type 3EnrichmentFOXC12.19
97Nephrotic syndrome, type 4EnrichmentWT12.19
98Genitourinary tract anomaliesEnrichmentHOXA112.19
99Axenfeld-rieger anomaly with partially absent eye muscles, distinctive face, hydrocephaly, and skeletal abnormalitiesEnrichmentFOXC12.19
100Branchiootic syndrome 3EnrichmentSIX12.19
101Lymphedema-distichiasis syndromeEnrichmentFOXC22.19
102Aural atresia, congenitalEnrichmentFGFR22.19
103Pfeiffer syndromeEnrichmentFGFR22.19
104Jackson-weiss syndromeEnrichmentFGFR22.19
105Solitary median maxillary central incisorEnrichmentSHH2.19
106Frasier syndromeEnrichmentWT12.19
107Angioma, tuftedEnrichmentKDR2.19
108Pierson syndromeEnrichmentLAMB22.19
109Antley-bixler syndrome without genital anomalies or disordered steroidogenesisEnrichmentFGFR22.19
110Anterior segment dysgenesis 3EnrichmentFOXC12.19
111Infantile myofibromatosisEnrichmentPDGFRB2.19
112Nephrotic syndrome, type 5, with or without ocular abnormalitiesEnrichmentLAMB22.19
113Hyperuricemic nephropathy, familial juvenile, 3EnrichmentHNF1B2.19
114Tibial hemimeliaEnrichmentGLI32.19
115Epidermolysis bullosa, junctional 7, with interstitial lung disease and nephrotic syndromeEnrichmentITGA32.19
116Childhood hepatocellular carcinomaEnrichmentCTNNB12.19
117Focal segmental glomerulosclerosis 7EnrichmentPAX22.19
118Split hand-foot malformationEnrichmentFGFR22.19
119SynpolydactylyEnrichmentGLI32.19
120Medullary thyroid carcinomaEnrichmentRET2.19
1219q33.3q34.11 microdeletion syndromeEnrichmentLMX1B2.19
122Nephrotic syndrome, type 23EnrichmentKIRREL12.19
123Juvenile nasopharyngeal angiofibromaEnrichmentCTNNB12.19
124Otofaciocervical syndromeEnrichmentEYA12.19
125Axenfeld-rieger syndromeEnrichmentFOXC12.19
126Postaxial polydactyly type bEnrichmentGLI32.19
127Autosomal dominant nonsyndromic deafnessEnrichmentFGFR22.19
128Congenital hypogonadotropic hypogonadismEnrichmentEMX22.19
129TeratomaEnrichmentCTNNB12.19
130Renal hypoplasia, bilateralEnrichmentPAX22.19
131Genetic nephrotic syndromeEnrichmentNPHS22.19
132Isolated radial hemimeliaEnrichmentSHH2.19
133Idiopathic nephrotic syndromeEnrichmentNPHS22.19
134Desmoplastic small round cell tumorEnrichmentWT12.19
135Radio-ulnar synostosis-amegakaryocytic thrombocytopenia syndromeEnrichmentHOXA112.19
136Crouzon syndromeEnrichmentFGFR22.01
137Desmoid disease, hereditaryEnrichmentCTNNB12.01
138Lacrimoauriculodentodigital syndrome 1EnrichmentFGFR22.01
139Thyroid carcinoma, familial medullaryEnrichmentRET2.01
140Mesothelioma, malignantEnrichmentWT12.01
141Acrocallosal syndromeEnrichmentGLI32.01
142Syndactyly, type ivEnrichmentSHH2.01
143Aarskog-scott syndromeEnrichmentGLI32.01
144Neurodevelopmental disorder with spastic diplegia and visual defectsEnrichmentCTNNB12.01
145Anus, imperforateEnrichmentCTNNB12.01
146Exudative vitreoretinopathy 7EnrichmentCTNNB12.01
147Nephrotic syndrome, type 24EnrichmentNPHS22.01
148Umbilical herniaEnrichmentGLI32.01
149Desmoid tumorEnrichmentCTNNB12.01
150Gingival overgrowthEnrichmentRET2.01
151Hypoplastic or aplastic tibia with polydactylyEnrichmentSHH2.01
152Chromophobe renal cell carcinomaEnrichmentHNF1B2.01
153Familial vesicoureteral refluxEnrichmentROBO22.01
154KeratoacanthomaEnrichmentNOTCH22.01
155HypertelorismEnrichmentFGFR2, RET1.91
156Aniridia 1EnrichmentWT11.89
157Branchiooculofacial syndromeEnrichmentEYA11.89
158Polydactyly, preaxial iiEnrichmentSHH1.89
159Developmental and epileptic encephalopathy 4EnrichmentLMX1B1.89
160Saethre-chotzen syndromeEnrichmentFGFR21.89
161PilomatrixomaEnrichmentCTNNB11.89
162Alazami syndromeEnrichmentCTNNB11.89
163Central hypoventilation syndrome, congenital, 1EnrichmentRET1.89
164CraniopharyngiomaEnrichmentCTNNB11.89
165Blood platelet diseaseEnrichmentCD361.89
166Cerebral malariaEnrichmentCD361.89
167GliomaEnrichmentFGFR21.89
168Haddad syndromeEnrichmentRET1.89
169Hemifacial hyperplasiaEnrichmentFGFR21.79
170Exudative vitreoretinopathy 1EnrichmentCTNNB11.79
171Multiple endocrine neoplasia, type iiaEnrichmentRET1.79
172Leber congenital amaurosis 10EnrichmentWT11.79
173HoloprosencephalyEnrichmentFGF81.79
174Juvenile glaucomaEnrichmentFOXC11.79
175AniridiaEnrichmentFOXC11.79
176Primary hypereosinophilic syndromeEnrichmentPDGFRB1.79
177Weyers acrofacial dysostosisEnrichmentCTNNB11.71
178Split-hand/foot malformation 1EnrichmentFGFR21.71
179Wilms tumor, aniridia, genitourinary anomalies, and impaired intellectual development syndromeEnrichmentWT11.71
180Holoprosencephaly 1EnrichmentFGF81.71
181Wilms tumor 5EnrichmentWT11.71
182Hemangioma, capillary infantileEnrichmentKDR1.71
183Congenital anomalies of kidney and urinary tract 1EnrichmentPAX21.71
184Renal hypoplasiaEnrichmentPAX21.71
185Adrenocortical carcinomaEnrichmentCTNNB11.71
186Sporadic pheochromocytoma/secreting paragangliomaEnrichmentRET1.71
187Gallbladder cancerEnrichmentCTNNB11.65
188Ewing sarcomaEnrichmentETV41.59
189Exudative vitreoretinopathyEnrichmentCTNNB11.59
190HypothyroidismEnrichmentRET1.59
191Difference of sex developmentEnrichmentWT11.59
192Leukemia, acute lymphoblastic 3EnrichmentWT11.54
193Adult hepatocellular carcinomaEnrichmentCTNNB11.54
194Cystic kidney diseaseEnrichmentPAX21.54
195Meier-gorlin syndrome 1EnrichmentFGFR21.50
196Peters-plus syndromeEnrichmentFOXC11.50
197Meningioma, familialEnrichmentPDGFB1.45
19846,xy complete gonadal dysgenesisEnrichmentWT11.45
199Septooptic dysplasiaEnrichmentSHH1.42
200Renal hypodysplasia/aplasia 3EnrichmentRET1.42
201MeningiomaEnrichmentPDGFB1.42
202Microphthalmia/coloboma 12EnrichmentPAX21.38
203Diaphragmatic hernia, congenitalEnrichmentGLI31.38
204Neural tube defectsEnrichmentITGB11.38
205Chronic kidney diseaseEnrichmentNPHS21.38
206MedulloblastomaEnrichmentCTNNB11.35
207PheochromocytomaEnrichmentRET1.35
20846,xy partial gonadal dysgenesisEnrichmentWT11.35
209Coloboma of maculaEnrichmentPAX21.32
210Renal cell carcinoma, nonpapillaryEnrichmentHNF1B1.32
211Polydactyly, postaxial, type a1EnrichmentGLI31.32
212Wilms tumor 1EnrichmentWT11.32
213Anterior segment dysgenesisEnrichmentFOXC11.32
214Dandy-walker syndromeEnrichmentPDGFRB1.27
215Polycystic liver diseaseEnrichmentCTNNB11.27
216Autosomal dominant polycystic liver diseaseEnrichmentCTNNB11.27
217Human immunodeficiency virus type 1EnrichmentCXCL121.25
218Normosmic congenital hypogonadotropic hypogonadismEnrichmentFGF81.25
219Macs syndromeEnrichmentSHH1.20
220Maturity-onset diabetes of the youngEnrichmentHNF1B1.20
221Endometrial cancerEnrichmentFGFR21.18
222HepatoblastomaEnrichmentCTNNB11.18
223Hereditary paraganglioma-pheochromocytoma syndromesEnrichmentRET1.18
224Inherited cancer-predisposing syndromeEnrichmentRET, WT11.17
225MalariaEnrichmentCD361.14
226Kallmann syndromeEnrichmentFGF81.14
227Hydrops fetalis, nonimmuneEnrichmentFOXC21.09
228Bladder cancerEnrichmentCTNNB11.05
229Prostate cancerEnrichmentHNF1B1.05
230Differentiated thyroid carcinomaEnrichmentRET1.05
231Non-immune hydrops fetalisEnrichmentFOXC21.02
232Cerebral palsyEnrichmentPDGFRB0.92
233Type 2 diabetes mellitusEnrichmentHNF1B0.89
234Gastric cancerEnrichmentFGFR20.88
235Hereditary breast carcinomaEnrichmentRET0.87
236Sensorineural hearing lossEnrichmentRET0.84
237Rare autosomal dominant non-syndromic sensorineural deafness type dfnaEnrichmentSIX10.81
238Male infertility with azoospermia or oligozoospermia due to single gene mutationEnrichmentFGF80.78
239AutismEnrichmentSHH0.68
240Breast cancerEnrichmentRET0.66
241Rare genetic deafnessEnrichmentEYA10.64
242Congenital nervous system abnormalityEnrichmentCTNNB10.53
243Nervous system diseaseEnrichmentCTNNB10.53
244MicrocephalyEnrichmentCTNNB10.48
245Hereditary retinal dystrophyEnrichmentPAX20.21
246Fundus dystrophyEnrichmentPAX20.21

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