Genotoxicity pathway

No Pathway Network information available for Genotoxicity pathway

Pathways in the Genotoxicity pathway SuperPath

#	Name	Source	Genes
1	Genotoxicity pathway	WikiPathways	ACTA2 AEN AMER1 B3GNT2 BLOC1S2 BRMS1L BTG2 CBLB CCP110 CDKN1A CEBPD CENPE COIL DAAM1 DCP1B DDB2 DUSP14 E2F7 E2F8 EI24 FBXO22 GADD45A GXYLT1 H1-4 H2BC10 H2BC14 H2BC15 H2BC3 H2BC4 H2BC8 H3C4 ID2 IKBIP ITPKC ITPR1 MDM2 MEX3B NLRX1 PCDH8 PHLDA3 PLK3 PPM1D PRKAB1 PRKAB2 PTGER4 RAPGEF2 RBM12B RPS27 RRM2B SEL1L SEMG2 SERTAD1 SMAD5 TIGAR TM7SF3 TNFRSF17 TOPORS TP53I3 TRIAP1 TRIM22 (see all 60) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	GXYLT1	Glucoside Xylosyltransferase 1	Protein Coding	1
2	RAPGEF2	Rap Guanine Nucleotide Exchange Factor 2	Protein Coding	1
3	TP53I3	Tumor Protein P53 Inducible Protein 3	Protein Coding	1
4	EI24	EI24 Autophagy Associated Transmembrane Protein	Protein Coding	1
5	CBLB	Cbl Proto-Oncogene B	Protein Coding	1
6	PPM1D	Protein Phosphatase, Mg2+/Mn2+ Dependent 1D	Protein Coding	1
7	H2BC4	H2B Clustered Histone 4	Protein Coding	1
8	H2BC14	H2B Clustered Histone 14	Protein Coding	1
9	H2BC8	H2B Clustered Histone 8	Protein Coding	1
10	ITPKC	Inositol-Trisphosphate 3-Kinase C	Protein Coding	1
11	E2F8	E2F Transcription Factor 8	Protein Coding	1
12	BTG2	BTG Anti-Proliferation Factor 2	Protein Coding	1
13	AEN	Apoptosis Enhancing Nuclease	Protein Coding	1
14	RPS27	Ribosomal Protein S27	Protein Coding	1
15	ACTA2	Actin Alpha 2, Smooth Muscle	Protein Coding	1
16	PTGER4	Prostaglandin E Receptor 4	Protein Coding	1
17	TIGAR	TP53 Induced Glycolysis Regulatory Phosphatase	Protein Coding	1
18	PRKAB1	Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 1	Protein Coding	1
19	PCDH8	Protocadherin 8	Protein Coding	1
20	RRM2B	Ribonucleotide Reductase Regulatory TP53 Inducible Subunit M2B	Protein Coding	1
21	MDM2	MDM2 Proto-Oncogene	Protein Coding	1
22	SMAD5	SMAD Family Member 5	Protein Coding	1
23	ITPR1	Inositol 1,4,5-Trisphosphate Receptor Type 1	Protein Coding	1
24	ID2	Inhibitor Of DNA Binding 2	Protein Coding	1
25	H1-4	H1.4 Linker Histone, Cluster Member	Protein Coding	1
26	SERTAD1	SERTA Domain Containing 1	Protein Coding	1
27	BLOC1S2	Biogenesis Of Lysosomal Organelles Complex 1 Subunit 2	Protein Coding	1
28	PHLDA3	Pleckstrin Homology Like Domain Family A Member 3	Protein Coding	1
29	DCP1B	Decapping MRNA 1B	Protein Coding	1
30	GADD45A	Growth Arrest And DNA Damage Inducible Alpha	Protein Coding	1
31	DDB2	Damage Specific DNA Binding Protein 2	Protein Coding	1
32	E2F7	E2F Transcription Factor 7	Protein Coding	1
33	AMER1	APC Membrane Recruitment Protein 1	Protein Coding	1
34	B3GNT2	UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 2	Protein Coding	1
35	CENPE	Centromere Protein E	Protein Coding	1
36	CEBPD	CCAAT Enhancer Binding Protein Delta	Protein Coding	1
37	TRIM22	Tripartite Motif Containing 22	Protein Coding	1
38	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	1
39	TOPORS	TOP1 Binding Arginine/Serine Rich Protein, E3 Ubiquitin Ligase	Protein Coding	1
40	CCP110	Centriolar Coiled-Coil Protein 110	Protein Coding	1
41	BRMS1L	BRMS1 Like Transcriptional Repressor	Protein Coding	1
42	MEX3B	Mex-3 RNA Binding Family Member B	Protein Coding	1
43	PLK3	Polo Like Kinase 3	Protein Coding	1
44	IKBIP	IKBKB Interacting Protein	Protein Coding	1
45	DUSP14	Dual Specificity Phosphatase 14	Protein Coding	1
46	H3C4	H3 Clustered Histone 4	Protein Coding	1
47	H2BC10	H2B Clustered Histone 10	Protein Coding	1
48	H2BC15	H2B Clustered Histone 15	Protein Coding	1
49	COIL	Coilin	Protein Coding	1
50	NLRX1	NLR Family Member X1	Protein Coding	1
51	SEMG2	Semenogelin 2	Protein Coding	1
52	SEL1L	SEL1L Adaptor Subunit Of SYVN1 Ubiquitin Ligase	Protein Coding	1
53	TNFRSF17	TNF Receptor Superfamily Member 17	Protein Coding	1
54	PRKAB2	Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 2	Protein Coding	1
55	TM7SF3	Transmembrane 7 Superfamily Member 3	Protein Coding	1
56	TRIAP1	TP53 Regulated Inhibitor Of Apoptosis 1	Protein Coding	1
57	RBM12B	RNA Binding Motif Protein 12B	Protein Coding	1
58	H2BC3	H2B Clustered Histone 3	Protein Coding	1
59	FBXO22	F-Box Protein 22	Protein Coding	1
60	DAAM1	Dishevelled Associated Activator Of Morphogenesis 1	Protein Coding	1

Disorders associated with Genotoxicity pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Accelerated tumor formation	Enrichment	MDM2	2.35
2	Lessel-kubisch syndrome	Enrichment	MDM2	2.35
3	Mitochondrial dna depletion syndrome 8b	Enrichment	RRM2B	2.35
4	Rahman syndrome	Enrichment	H1-4	2.35
5	Retinitis pigmentosa 31	Enrichment	TOPORS	2.35
6	Microcephaly 13, primary, autosomal recessive	Enrichment	CENPE	2.35
7	Jansen-de vries syndrome	Enrichment	PPM1D	2.35
8	Epilepsy, familial adult myoclonic, 7	Enrichment	RAPGEF2	2.35
9	Neurodevelopmental disorder with poor growth, absent speech, progressive ataxia, and dysmorphic facies	Enrichment	SEL1L	2.35
10	Tayoun-maawali syndrome	Enrichment	FBXO22	2.35
11	Trim22-related inflammatory bowel disease	Enrichment	TRIM22	2.35
12	Rrm2b mitochondrial dna maintenance defects	Enrichment	RRM2B	2.35
13	Spinocerebellar ataxia 29	Enrichment	ITPR1	2.05
14	Fanconi renotubular syndrome 1	Enrichment	RRM2B	2.05
15	Osteopathia striata with cranial sclerosis	Enrichment	AMER1	2.05
16	Rod-cone dystrophy, sensorineural deafness, and fanconi-type renal dysfunction	Enrichment	RRM2B	2.05
17	Xeroderma pigmentosum, complementation group e	Enrichment	DDB2	2.05
18	Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant 5	Enrichment	RRM2B	2.05
19	Aortic aneurysm, familial thoracic 2	Enrichment	ACTA2	2.05
20	Mitochondrial dna depletion syndrome 8a	Enrichment	RRM2B	2.05
21	Smooth muscle dysfunction syndrome	Enrichment	ACTA2	2.05
22	Aortic aneurysm, familial thoracic 6	Enrichment	ACTA2	2.05
23	Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal recessive 2	Enrichment	RRM2B	2.05
24	Moyamoya disease 5	Enrichment	ACTA2	2.05
25	Autoimmune disease, multisystem, infantile-onset, 3	Enrichment	CBLB	2.05
26	Diamond-blackfan anemia 17	Enrichment	RPS27	2.05
27	Neurodevelopmental disorder with hypotonia, poor growth, dysmorphic facies, and agammaglobulinemia	Enrichment	SEL1L	2.05
28	Xeroderma pigmentosum group e	Enrichment	DDB2	2.05
29	Gillespie syndrome	Enrichment	ITPR1	1.88
30	Dedifferentiated liposarcoma	Enrichment	MDM2	1.88
31	Idiopathic camptocormia	Enrichment	RRM2B	1.88
32	Well-differentiated liposarcoma	Enrichment	MDM2	1.88
33	Autoimmune lymphoproliferative syndrome	Enrichment	ACTA2	1.76
34	Spinocerebellar ataxia 15	Enrichment	ITPR1	1.76
35	Kearns-sayre syndrome	Enrichment	RRM2B	1.66
36	Li-fraumeni syndrome	Enrichment	MDM2	1.58
37	Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant 1	Enrichment	RRM2B	1.58
38	Moyamoya disease 1	Enrichment	ACTA2	1.58
39	Spinocerebellar ataxia, autosomal recessive 16	Enrichment	ITPR1	1.58
40	Multiple endocrine neoplasia, type i	Enrichment	CDKN1A	1.51
41	Mitochondrial neurogastrointestinal encephalomyopathy	Enrichment	RRM2B	1.41
42	Orofaciodigital syndrome vi	Enrichment	TOPORS	1.32
43	Xeroderma pigmentosum, variant type	Enrichment	DDB2	1.32
44	Multiple sclerosis	Enrichment	ITPR1	1.22
45	Lung cancer susceptibility 3	Enrichment	ACTA2	1.22
46	Seckel syndrome	Enrichment	CENPE	1.22
47	Anterior segment dysgenesis	Enrichment	ITPR1	1.19
48	Cleft palate, isolated	Enrichment	AMER1	1.14
49	Auditory neuropathy	Enrichment	H1-4	0.96
50	Bladder cancer	Enrichment	CDKN1A	0.92
51	Lung cancer	Enrichment	ACTA2	0.88
52	Primary autosomal recessive microcephaly	Enrichment	CENPE	0.88
53	Connective tissue disease	Enrichment	ACTA2	0.88
54	Diamond-blackfan anemia	Enrichment	RPS27	0.83
55	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	ACTA2	0.75
56	Hereditary breast carcinoma	Enrichment	PPM1D	0.75
57	Sensorineural hearing loss	Enrichment	RRM2B	0.72
58	Autosomal dominant non-syndromic intellectual disability	Enrichment	PPM1D	0.70
59	Spastic ataxia	Enrichment	ITPR1	0.68
60	Myeloma, multiple	Enrichment	H1-4	0.66
61	Retinitis pigmentosa	Enrichment	RRM2B, TOPORS	0.62
62	Breast cancer	Enrichment	PPM1D	0.55
63	Colorectal cancer	Enrichment	AMER1	0.49
64	Mitochondrial disease	Enrichment	RRM2B	0.49
65	Ovarian cancer	Enrichment	PPM1D	0.44
66	Hereditary retinal dystrophy	Enrichment	TOPORS	0.14
67	Fundus dystrophy	Enrichment	TOPORS	0.14

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Genotoxicity pathway

Pathway Network for Genotoxicity pathway

Member Pathways for Genotoxicity pathway

Pathways in the Genotoxicity pathway SuperPath

Associated Genes for Genotoxicity pathway

Associated Disorders for Genotoxicity pathway

Disorders associated with Genotoxicity pathway SuperPath

STRING Interaction Network for Genotoxicity pathway

Sources for Genotoxicity pathway