GLP1 receptor agonists and DPP4 inhibitors, Pharmacodynamics

No Pathway Network information available for GLP1 receptor agonists and DPP4 inhibitors, Pharmacodynamics

Pathways in the GLP1 receptor agonists and DPP4 inhibitors, Pharmacodynamics SuperPath

#	Name	Source	Genes
1	GLP1 receptor agonists and DPP4 inhibitors, Pharmacodynamics	PharmGKB	ARRB1 CDKAL1 CNR1 CTRB1 CTRB2 DPP4 GCG GIP GIPR GLP1R IL6 KCNJ11 KCNQ1 PNPLA3 PRKD1 SORCS1 TCF7L2 (see all 17) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PNPLA3	Patatin Like Domain 3, 1-Acylglycerol-3-Phosphate O-Acyltransferase	Protein Coding	1
2	TCF7L2	Transcription Factor 7 Like 2	Protein Coding	1
3	ARRB1	Arrestin Beta 1	Protein Coding	1
4	KCNJ11	Potassium Inwardly Rectifying Channel Subfamily J Member 11	Protein Coding	1
5	KCNQ1	Potassium Voltage-Gated Channel Subfamily Q Member 1	Protein Coding	1
6	GCG	Glucagon	Protein Coding	1
7	GLP1R	Glucagon Like Peptide 1 Receptor	Protein Coding	1
8	IL6	Interleukin 6	Protein Coding	1
9	DPP4	Dipeptidyl Peptidase 4	Protein Coding	1
10	CTRB1	Chymotrypsinogen B1	Protein Coding	1
11	CNR1	Cannabinoid Receptor 1	Protein Coding	1
12	GIP	Gastric Inhibitory Polypeptide	Protein Coding	1
13	GIPR	Gastric Inhibitory Polypeptide Receptor	Protein Coding	1
14	PRKD1	Protein Kinase D1	Protein Coding	1
15	SORCS1	Sortilin Related VPS10 Domain Containing Receptor 1	Protein Coding	1
16	CDKAL1	CDKAL1 Threonylcarbamoyladenosine TRNA Methylthiotransferase	Protein Coding	1
17	CTRB2	Chymotrypsinogen B2	Protein Coding	1

Disorders associated with GLP1 receptor agonists and DPP4 inhibitors, Pharmacodynamics SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Type 2 diabetes mellitus	Enrichment	IL6, KCNJ11, TCF7L2	4.74
2	Hyperinsulinemic hypoglycemia, familial, 2	Enrichment	KCNJ11	2.90
3	Diabetes mellitus, transient neonatal, 3	Enrichment	KCNJ11	2.90
4	Diabetes mellitus, permanent neonatal, 2	Enrichment	KCNJ11	2.90
5	Maturity-onset diabetes of the young, type 13	Enrichment	KCNJ11	2.90
6	Congenital heart defects and ectodermal dysplasia	Enrichment	PRKD1	2.90
7	Intermediate dend syndrome	Enrichment	KCNJ11	2.90
8	Malignant epithelial tumor of salivary glands	Enrichment	PRKD1	2.90
9	Diazoxide-resistant focal hyperinsulinism due to kir6.2 deficiency	Enrichment	KCNJ11	2.90
10	Autosomal dominant hyperinsulinism due to kir6.2 deficiency	Enrichment	KCNJ11	2.90
11	Autosomal recessive hyperinsulinism due to kir6.2 deficiency	Enrichment	KCNJ11	2.90
12	Alzheimer disease 6	Enrichment	SORCS1	2.60
13	Diabetes mellitus, permanent neonatal, 1	Enrichment	KCNJ11	2.60
14	Cardiovascular system disease	Enrichment	KCNQ1	2.60
15	Hyperinsulinism	Enrichment	KCNJ11	2.60
16	Jervell-lange nielsen syndrome	Enrichment	KCNQ1	2.60
17	Atrial fibrillation, familial, 3	Enrichment	KCNQ1	2.43
18	Short qt syndrome 2	Enrichment	KCNQ1	2.43
19	Dend syndrome	Enrichment	KCNJ11	2.43
20	Kaposi sarcoma	Enrichment	IL6	2.30
21	Jervell and lange-nielsen syndrome 1	Enrichment	KCNQ1	2.30
22	Dermatitis, atopic	Enrichment	KCNJ11	2.30
23	Long qt syndrome 2	Enrichment	KCNQ1	2.30
24	Atrial fibrillation	Enrichment	KCNQ1	2.30
25	Neonatal diabetes mellitus	Enrichment	KCNJ11	2.30
26	Pregnancy loss, recurrent 1	Enrichment	KCNQ1	2.30
27	Systemic-onset juvenile idiopathic arthritis	Enrichment	IL6	2.30
28	Rheumatoid arthritis, systemic juvenile	Enrichment	IL6	2.20
29	Transient neonatal diabetes mellitus	Enrichment	KCNJ11	2.20
30	Hypoglycemia	Enrichment	KCNJ11	2.20
31	Congenital short qt syndrome	Enrichment	KCNQ1	2.20
32	Hyperinsulinemic hypoglycemia, familial, 1	Enrichment	KCNJ11	2.13
33	Type 1 diabetes mellitus	Enrichment	IL6	2.13
34	Hypertrichosis	Enrichment	KCNJ11	2.13
35	Nonsyndromic genetic hyperinsulinism	Enrichment	KCNJ11	2.13
36	Silver-russell syndrome 1	Enrichment	KCNQ1	2.06
37	Permanent neonatal diabetes mellitus	Enrichment	KCNJ11	2.00
38	Inflammatory bowel disease 1	Enrichment	IL6	1.95
39	Diabetes mellitus	Enrichment	KCNJ11	1.86
40	Congenital long qt syndrome	Enrichment	KCNQ1	1.83
41	Wolff-parkinson-white syndrome	Enrichment	KCNQ1	1.70
42	Sudden infant death syndrome	Enrichment	KCNQ1	1.68
43	Beckwith-wiedemann syndrome	Enrichment	KCNQ1	1.65
44	Arteriovenous malformations of the brain	Enrichment	IL6	1.63
45	Maturity-onset diabetes of the young	Enrichment	KCNJ11	1.61
46	Ear malformation	Enrichment	KCNQ1	1.53
47	Familial atrial fibrillation	Enrichment	KCNQ1	1.53
48	Long qt syndrome 1	Enrichment	KCNQ1	1.43
49	Long qt syndrome	Enrichment	KCNQ1	1.42
50	Body mass index quantitative trait locus 11	Enrichment	CDKAL1	1.22
51	Autism	Enrichment	TCF7L2	1.06
52	Rare genetic deafness	Enrichment	KCNQ1	1.02
53	Complex neurodevelopmental disorder	Enrichment	TCF7L2	0.84

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

GLP1 receptor agonists and DPP4 inhibitors, Pharmacodynamics

Pathway Network for GLP1 receptor agonists and DPP4 inhibitors, Pharmacodynamics

Member Pathways for GLP1 receptor agonists and DPP4 inhibitors, Pharmacodynamics

Pathways in the GLP1 receptor agonists and DPP4 inhibitors, Pharmacodynamics SuperPath

Associated Genes for GLP1 receptor agonists and DPP4 inhibitors, Pharmacodynamics

Associated Disorders for GLP1 receptor agonists and DPP4 inhibitors, Pharmacodynamics

Disorders associated with GLP1 receptor agonists and DPP4 inhibitors, Pharmacodynamics SuperPath

STRING Interaction Network for GLP1 receptor agonists and DPP4 inhibitors, Pharmacodynamics

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