Gluconeogenesis

Pathway network for the Gluconeogenesis SuperPath

Sources:

Reactome
PubChem

Pathways in the Gluconeogenesis SuperPath

#	Name	Source	Genes
1	Gluconeogenesis	Reactome	ALDOA ALDOB ALDOC ENO1 ENO2 ENO3 ENO4 FBP1 FBP2 G6PC1 G6PC2 G6PC3 GAPDH GAPDHS GPI PC PCK1 PCK2 PGAM1 PGAM2 PGK1 PGK2 SLC37A1 SLC37A2 SLC37A4 TPI1 (see all 26) (see less)
2	gluconeogenesis	PubChem	ALDOA ALDOB ALDOC BPGM ENO1 ENO2 ENO3 FBP1 FBP2 G6PC1 G6PC2 G6PC3 GAPDH GAPDHS GPI MDH1 MDH2 PC PCK1 PGAM1 PGAM2 PGK1 PGK2 TPI1 (see all 24) (see less)
3	gluconeogenesis III	PubChem	ALDOA ALDOB ALDOC BPGM ENO1 ENO2 ENO3 FBP1 FBP2 G6PC1 G6PC2 G6PC3 GAPDH GAPDHS GPI MDH1 MDH2 PC PCK1 PGAM1 PGAM2 PGK1 PGK2 TPI1 (see all 24) (see less)

Gene overlap in member pathways for Gluconeogenesis SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ENO1	Enolase 1	Protein Coding	3
2	ENO2	Enolase 2	Protein Coding	3
3	ENO3	Enolase 3	Protein Coding	3
4	FBP1	Fructose-Bisphosphatase 1	Protein Coding	3
5	ALDOA	Aldolase, Fructose-Bisphosphate A	Protein Coding	3
6	ALDOB	Aldolase, Fructose-Bisphosphate B	Protein Coding	3
7	ALDOC	Aldolase, Fructose-Bisphosphate C	Protein Coding	3
8	G6PC1	Glucose-6-Phosphatase Catalytic Subunit 1	Protein Coding	3
9	GAPDH	Glyceraldehyde-3-Phosphate Dehydrogenase	Protein Coding	3
10	GAPDHS	Glyceraldehyde-3-Phosphate Dehydrogenase, Spermatogenic	Protein Coding	3
11	GPI	Glucose-6-Phosphate Isomerase	Protein Coding	3
12	PC	Pyruvate Carboxylase	Protein Coding	3
13	PCK1	Phosphoenolpyruvate Carboxykinase 1	Protein Coding	3
14	PGAM1	Phosphoglycerate Mutase 1	Protein Coding	3
15	PGAM2	Phosphoglycerate Mutase 2	Protein Coding	3
16	PGK1	Phosphoglycerate Kinase 1	Protein Coding	3
17	PGK2	Phosphoglycerate Kinase 2	Protein Coding	3
18	G6PC2	Glucose-6-Phosphatase Catalytic Subunit 2	Protein Coding	3
19	TPI1	Triosephosphate Isomerase 1	Protein Coding	3
20	FBP2	Fructose-Bisphosphatase 2	Protein Coding	3
21	G6PC3	Glucose-6-Phosphatase Catalytic Subunit 3	Protein Coding	3
22	MDH2	Malate Dehydrogenase 2	Protein Coding	2
23	BPGM	Bisphosphoglycerate Mutase	Protein Coding	2
24	MDH1	Malate Dehydrogenase 1	Protein Coding	2
25	SLC37A2	Solute Carrier Family 37 Member 2	Protein Coding	1
26	SLC37A4	Solute Carrier Family 37 Member 4	Protein Coding	1
27	ENO4	Enolase 4	Protein Coding	1
28	PCK2	Phosphoenolpyruvate Carboxykinase 2, Mitochondrial	Protein Coding	1
29	SLC37A1	Solute Carrier Family 37 Member 1	Protein Coding	1

Disorders associated with Gluconeogenesis SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Phosphoenolpyruvate carboxykinase deficiency	Enrichment	PCK1, PCK2	4.98
2	Glycogen storage disease ia	Enrichment	G6PC1, SLC37A4	4.67
3	Glycogen storage disease	Enrichment	G6PC1, SLC37A4	3.72
4	Erythrocytosis, familial, 8	Enrichment	BPGM	2.75
5	Phosphoenolpyruvate carboxykinase deficiency, cytosolic	Enrichment	PCK1	2.75
6	Fructose-1,6-bisphosphatase deficiency	Enrichment	FBP1	2.75
7	Phosphoglycerate kinase 1 deficiency	Enrichment	PGK1	2.75
8	Glycogen storage disease xiii	Enrichment	ENO3	2.75
9	Triosephosphate isomerase deficiency	Enrichment	TPI1	2.75
10	Leukodystrophy, childhood-onset, remitting	Enrichment	FBP2	2.75
11	Anemia, congenital, nonspherocytic hemolytic, 4	Enrichment	GPI	2.75
12	Developmental and epileptic encephalopathy 51	Enrichment	MDH2	2.75
13	Autosomal recessive secondary polycythemia not associated with vhl gene	Enrichment	BPGM	2.75
14	Male infertility due to obstructive azoospermia	Enrichment	PGK1	2.75
15	Glycogen storage disease ic	Enrichment	SLC37A4	2.72
16	Glycogen storage disease ib	Enrichment	SLC37A4	2.72
17	Congenital disorder of glycosylation, type iiw	Enrichment	SLC37A4	2.72
18	Glycogen storage disease due to glucose-6-phosphatase deficiency type ib	Enrichment	SLC37A4	2.72
19	Glycogen storage disease type 1 due to slc37a4 mutation	Enrichment	SLC37A4	2.72
20	Fructose intolerance, hereditary	Enrichment	ALDOB	2.45
21	Neutropenia, severe congenital, 4, autosomal recessive	Enrichment	G6PC3	2.45
22	Microcephaly 21, primary, autosomal recessive	Enrichment	GAPDH	2.45
23	Developmental and epileptic encephalopathy 88	Enrichment	MDH1	2.45
24	Glycogen storage disease xii	Enrichment	ALDOA	2.45
25	Severe congenital neutropenia 4	Enrichment	G6PC3	2.45
26	Phosphoenolpyruvate carboxykinase deficiency, mitochondrial	Enrichment	PCK2	2.42
27	Pyruvate carboxylase deficiency	Enrichment	PC	2.28
28	Glycogen storage disease x	Enrichment	PGAM2	2.15
29	Hypoglycemia	Enrichment	G6PC1	2.05
30	Hereditary spherocytosis	Enrichment	GPI	1.98
31	Hemolytic anemia	Enrichment	GPI	1.91
32	Neutropenia	Enrichment	SLC37A4	1.87
33	Immune deficiency disease	Enrichment	SLC37A4	1.68
34	Congenital disorder of glycosylation, type in	Enrichment	SLC37A4	1.49
35	Hereditary paraganglioma-pheochromocytoma syndromes	Enrichment	MDH2	1.44
36	Developmental and epileptic encephalopathy 1	Enrichment	MDH2	1.36
37	West syndrome	Enrichment	MDH2	1.12

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Gluconeogenesis

Pathway network for the Gluconeogenesis SuperPath

Member Pathways for Gluconeogenesis

Pathways in the Gluconeogenesis SuperPath

Gene overlap in member pathways for Gluconeogenesis SuperPath

Associated Genes for Gluconeogenesis

Associated Disorders for Gluconeogenesis

Disorders associated with Gluconeogenesis SuperPath

STRING Interaction Network for Gluconeogenesis

Sources for Gluconeogenesis