Glucuronidation

Pathway network for the Glucuronidation SuperPath

Sources:

Reactome
WikiPathways
PubChem

Pathways in the Glucuronidation SuperPath

#	Name	Source	Genes
1	Glucuronidation	Reactome	ABHD10 SLC35D1 SLC35D2 UGDH UGP2 UGT1A1 UGT1A10 UGT1A3 UGT1A4 UGT1A5 UGT1A6 UGT1A7 UGT1A8 UGT1A9 UGT2A1 UGT2A2 UGT2A3 UGT2B10 UGT2B11 UGT2B15 UGT2B17 UGT2B28 UGT2B4 UGT2B7 UGT3A1 UGT3A2 UXS1 (see all 27) (see less)
2	Glucuronidation	WikiPathways	HK1 PGM1 PGM2 PGM3 PGM5 UGDH UGP2 UGT1A1 UGT1A10 UGT1A3 UGT1A4 UGT1A5 UGT1A6 UGT1A7 UGT1A8 UGT1A9 UGT2A1 UGT2A2 UGT2A3 UGT2B10 UGT2B11 UGT2B15 UGT2B17 UGT2B28 UGT2B4 UGT2B7 (see all 26) (see less)
3	Formation of the active cofactor, UDP-glucuronate	Reactome	SLC35D1 SLC35D2 UGDH UGP2 UXS1
4	UDP-α-D-glucose biosynthesis I	PubChem	PGM1 PGM2 UGP2
5	UDP-D-xylose and UDP-D-glucuronate biosynthesis	PubChem	UGDH UXS1
6	Defective SLC35D1 causes SCHBCKD	Reactome	SLC35D1
7	Defective PGM1 causes PGM1-CDG	Reactome	PGM1

Gene overlap in member pathways for Glucuronidation SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	UGDH	UDP-Glucose 6-Dehydrogenase	Protein Coding	4
2	UGP2	UDP-Glucose Pyrophosphorylase 2	Protein Coding	4
3	SLC35D1	Solute Carrier Family 35 Member D1	Protein Coding	3
4	UXS1	UDP-Glucuronate Decarboxylase 1	Protein Coding	3
5	PGM1	Phosphoglucomutase 1	Protein Coding	3
6	UGT2B11	UDP Glucuronosyltransferase Family 2 Member B11	Protein Coding	2
7	UGT2A1	UDP Glucuronosyltransferase Family 2 Member A1 Complex Locus	Protein Coding	2
8	SLC35D2	Solute Carrier Family 35 Member D2	Protein Coding	2
9	UGT2B28	UDP Glucuronosyltransferase Family 2 Member B28	Protein Coding	2
10	UGT1A10	UDP Glucuronosyltransferase Family 1 Member A10	Protein Coding	2
11	UGT1A8	UDP Glucuronosyltransferase Family 1 Member A8	Protein Coding	2
12	UGT1A7	UDP Glucuronosyltransferase Family 1 Member A7	Protein Coding	2
13	UGT1A6	UDP Glucuronosyltransferase Family 1 Member A6	Protein Coding	2
14	UGT1A5	UDP Glucuronosyltransferase Family 1 Member A5	Protein Coding	2
15	UGT1A9	UDP Glucuronosyltransferase Family 1 Member A9	Protein Coding	2
16	UGT1A4	UDP Glucuronosyltransferase Family 1 Member A4	Protein Coding	2
17	UGT1A1	UDP Glucuronosyltransferase Family 1 Member A1	Protein Coding	2
18	UGT1A3	UDP Glucuronosyltransferase Family 1 Member A3	Protein Coding	2
19	UGT2A2	UDP Glucuronosyltransferase Family 2 Member A2	Protein Coding	2
20	UGT2B4	UDP Glucuronosyltransferase Family 2 Member B4	Protein Coding	2
21	UGT2B7	UDP Glucuronosyltransferase Family 2 Member B7	Protein Coding	2
22	UGT2B10	UDP Glucuronosyltransferase Family 2 Member B10	Protein Coding	2
23	UGT2B15	UDP Glucuronosyltransferase Family 2 Member B15	Protein Coding	2
24	UGT2B17	UDP Glucuronosyltransferase Family 2 Member B17	Protein Coding	2
25	UGT2A3	UDP Glucuronosyltransferase Family 2 Member A3	Protein Coding	2
26	PGM2	Phosphoglucomutase 2	Protein Coding	2
27	UGT3A1	UDP Glycosyltransferase Family 3 Member A1	Protein Coding	1
28	UGT3A2	UDP Glycosyltransferase Family 3 Member A2	Protein Coding	1
29	ABHD10	Abhydrolase Domain Containing 10, Depalmitoylase	Protein Coding	1
30	PGM5	Phosphoglucomutase 5	Protein Coding	1
31	PGM3	Phosphoglucomutase 3	Protein Coding	1
32	HK1	Hexokinase 1	Protein Coding	1

Disorders associated with Glucuronidation SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Schneckenbecken dysplasia	Direct
2	Congenital disorder of glycosylation, type in	Direct
3	Gilbert syndrome	Enrichment	UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9	16.00
4	Crigler-najjar syndrome, type i	Enrichment	UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9	16.00
5	Hyperbilirubinemia, transient familial neonatal	Enrichment	UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9	16.00
6	Bilirubin, serum level of, quantitative trait locus 1	Enrichment	UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9	16.00
7	Crigler-najjar syndrome, type ii	Enrichment	UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9	16.00
8	Bilirubin metabolic disorder	Enrichment	UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9	16.00
9	Developmental and epileptic encephalopathy 84	Enrichment	UGDH	3.83
10	Developmental and epileptic encephalopathy 83	Enrichment	UGP2	3.66
11	Congenital disorder of glycosylation, type it	Enrichment	PGM1	3.35
12	Anemia, congenital, nonspherocytic hemolytic, 5	Enrichment	HK1	2.72
13	Bone mineral density quantitative trait locus 12	Enrichment	UGT2B17	2.72
14	Retinitis pigmentosa 79	Enrichment	HK1	2.72
15	Neuropathy, hereditary motor and sensory, russe type	Enrichment	HK1	2.72
16	Neurodevelopmental disorder with visual defects and brain anomalies	Enrichment	HK1	2.72
17	Immunodeficiency 23	Enrichment	PGM3	2.42
18	Hyper ige syndrome	Enrichment	PGM3	2.24
19	West syndrome	Enrichment	UGDH	2.19
20	Severe combined immunodeficiency	Enrichment	PGM3	1.21
21	Autism spectrum disorder	Enrichment	HK1	0.72
22	Retinitis pigmentosa	Enrichment	HK1	0.47
23	Hereditary retinal dystrophy	Enrichment	HK1	0.37
24	Fundus dystrophy	Enrichment	HK1	0.37

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Glucuronidation

Pathway network for the Glucuronidation SuperPath

Member Pathways for Glucuronidation

Pathways in the Glucuronidation SuperPath

Gene overlap in member pathways for Glucuronidation SuperPath

Associated Genes for Glucuronidation

Associated Disorders for Glucuronidation

Disorders associated with Glucuronidation SuperPath

STRING Interaction Network for Glucuronidation

Sources for Glucuronidation