Glutamate and glutamine metabolism

Pathway network for the Glutamate and glutamine metabolism SuperPath

Sources:

Reactome
PubChem

Pathways in the Glutamate and glutamine metabolism SuperPath

#	Name	Source	Genes
1	Glutamate and glutamine metabolism	Reactome	ALDH18A1 GLS GLS2 GLUD1 GLUD2 GLUL GOT2 KYAT1 OAT PYCR1 PYCR2 PYCR3 RIMKLA RIMKLB (see all 14) (see less)
2	L-ornithine biosynthesis II	PubChem	ALDH18A1 GLUD1 GLUD2 OAT
3	proline biosynthesis	PubChem	ALDH18A1 PYCR1 PYCR2
4	L-glutamate and L-glutamine biosynthesis	PubChem	GLUD1 GLUD2 GLUL
5	ornithine de novo biosynthesis	PubChem	ALDH18A1 GLUD1 GLUD2
6	L-proline biosynthesis I	PubChem	ALDH18A1 PYCR1

Gene overlap in member pathways for Glutamate and glutamine metabolism SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ALDH18A1	Aldehyde Dehydrogenase 18 Family Member A1	Protein Coding	5
2	GLUD1	Glutamate Dehydrogenase 1	Protein Coding	4
3	GLUD2	Glutamate Dehydrogenase 2	Protein Coding	4
4	PYCR1	Pyrroline-5-Carboxylate Reductase 1	Protein Coding	3
5	GLUL	Glutamate-Ammonia Ligase	Protein Coding	2
6	PYCR2	Pyrroline-5-Carboxylate Reductase 2	Protein Coding	2
7	OAT	Ornithine Aminotransferase	Protein Coding	2
8	GLS2	Glutaminase 2	Protein Coding	1
9	GLS	Glutaminase	Protein Coding	1
10	GOT2	Glutamic-Oxaloacetic Transaminase 2	Protein Coding	1
11	RIMKLA	Ribosomal Modification Protein RimK Like Family Member A	Protein Coding	1
12	RIMKLB	Ribosomal Modification Protein RimK Like Family Member B	Protein Coding	1
13	PYCR3	Pyrroline-5-Carboxylate Reductase 3	Protein Coding	1
14	KYAT1	Kynurenine Aminotransferase 1	Protein Coding	1

Disorders associated with Glutamate and glutamine metabolism SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Spastic paraplegia 9a, autosomal dominant	Enrichment	ALDH18A1	3.83
2	Cutis laxa, autosomal recessive, type iiia	Enrichment	ALDH18A1	3.83
3	Cutis laxa, autosomal recessive, type iiib	Enrichment	PYCR1	3.83
4	Spastic paraplegia 9b, autosomal recessive	Enrichment	ALDH18A1	3.83
5	Cutis laxa, autosomal dominant 3	Enrichment	ALDH18A1	3.83
6	Autosomal recessive cutis laxa type iii	Enrichment	ALDH18A1	3.83
7	Cutis laxa, autosomal recessive, type iib	Enrichment	PYCR1	3.83
8	Autosomal dominant complex spastic paraplegia type 9b	Enrichment	ALDH18A1	3.83
9	Leukodystrophy, hypomyelinating, 10	Enrichment	PYCR2	3.66
10	Pycr2-related microcephaly-progressive leukoencephalopathy	Enrichment	PYCR2	3.66
11	Hyperinsulinemic hypoglycemia, familial, 6	Enrichment	GLUD1	3.66
12	Developmental and epileptic encephalopathy 116	Enrichment	GLUL	3.66
13	Spastic paraplegia 5a, autosomal recessive	Enrichment	ALDH18A1	3.53
14	Choroid disease	Enrichment	OAT	3.53
15	Glutamine deficiency, congenital	Enrichment	GLUL	3.35
16	Developmental and epileptic encephalopathy 16	Enrichment	GLUL	3.35
17	Congenital brain dysgenesis due to glutamine synthetase deficiency	Enrichment	GLUL	3.35
18	Geroderma osteodysplasticum	Enrichment	PYCR1	3.35
19	Autosomal dominant cutis laxa	Enrichment	ALDH18A1	3.35
20	Gyrate atrophy of choroid and retina	Enrichment	OAT	3.05
21	Casgid syndrome	Enrichment	GLS	2.99
22	Developmental and epileptic encephalopathy 71	Enrichment	GLS	2.99
23	Spastic ataxia-dysarthria due to glutaminase deficiency	Enrichment	GLS	2.99
24	Hyperinsulinemic hypoglycemia, familial, 1	Enrichment	GLUD1	2.88
25	Nonsyndromic genetic hyperinsulinism	Enrichment	GLUD1	2.88
26	Pain disorder	Enrichment	OAT	2.75
27	Cutis laxa	Enrichment	PYCR1	2.75
28	Global developmental delay, progressive ataxia, and elevated glutamine	Enrichment	GLS	2.69
29	Developmental and epileptic encephalopathy 82	Enrichment	GOT2	2.69
30	Leukodystrophy	Enrichment	PYCR2	2.35
31	Connective tissue disease	Enrichment	PYCR1	2.33
32	Hereditary spastic paraplegia	Enrichment	ALDH18A1	2.21
33	Primary autosomal recessive microcephaly	Enrichment	PYCR2	2.15
34	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	GLUD2	1.91
35	Optic atrophy plus syndrome	Enrichment	OAT	1.89
36	Congenital nervous system abnormality	Enrichment	ALDH18A1	1.81
37	Nervous system disease	Enrichment	ALDH18A1	1.81
38	Esophageal atresia/tracheoesophageal fistula	Enrichment	GLS	1.71
39	Developmental and epileptic encephalopathy	Enrichment	GOT2	1.44
40	Hereditary retinal dystrophy	Enrichment	OAT	1.08
41	Fundus dystrophy	Enrichment	OAT	1.08

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Glutamate and glutamine metabolism

Pathway Network for Glutamate and glutamine metabolism

Pathway network for the Glutamate and glutamine metabolism SuperPath

Member Pathways for Glutamate and glutamine metabolism

Pathways in the Glutamate and glutamine metabolism SuperPath

Gene overlap in member pathways for Glutamate and glutamine metabolism SuperPath

Associated Genes for Glutamate and glutamine metabolism

Associated Disorders for Glutamate and glutamine metabolism

Disorders associated with Glutamate and glutamine metabolism SuperPath

STRING Interaction Network for Glutamate and glutamine metabolism

Sources for Glutamate and glutamine metabolism