Glutathione conjugation

Pathway network for the Glutathione conjugation SuperPath

Sources:

Reactome
GeneGo (Thomson Reuters)
WikiPathways
PubChem

Pathways in the Glutathione conjugation SuperPath

#	Name	Source	Genes
1	Glutathione conjugation	Reactome	AKR1A1 CHAC1 CHAC2 CNDP2 ESD GCLC GCLM GGCT GGT1 GGT5 GGT6 GGT7 GSS GSTA1 GSTA2 GSTA3 GSTA4 GSTA5 GSTK1 GSTM1 GSTM2 GSTM3 GSTM4 GSTM5 GSTO1 GSTO2 GSTP1 GSTT1 GSTT2 GSTT2B GSTZ1 HPGDS MGST1 MGST2 MGST3 OPLAH (see all 36) (see less)
2	Glutathione metabolism	GeneGo (Thomson Reuters)	ANPEP GCLC GCLM GGCT GGT1 GGT7 GPX1 GPX2 GPX3 GPX4 GPX5 GPX6 GPX7 GSR GSS GSTA1 GSTA2 GSTA3 GSTA4 GSTA5 GSTK1 GSTM1 GSTM2 GSTM3 GSTM4 GSTM5 GSTO1 GSTO2 GSTP1 GSTT1 GSTT2B GSTZ1 MGST1 MGST2 MGST3 OPLAH (see all 36) (see less)
3	Glutathione metabolism	WikiPathways	ANPEP G6PD GCLC GCLM GGT1 GGT5 GPX1 GPX2 GPX3 GPX4 GSR GSS GSTA1 GSTA5 GSTM1 GSTM2 GSTT1 GSTT2 IDH1 OPLAH (see all 20) (see less)
4	Glutathione synthesis and recycling	Reactome	CHAC1 CHAC2 CNDP2 GCLC GCLM GGCT GGT1 GGT5 GGT6 GGT7 GSS OPLAH (see all 12) (see less)
5	glutathione redox reactions I	PubChem	GPX1 GPX2 GPX3 GPX4 GPX7 GSR (see all 6) (see less)
6	γ-glutamyl cycle	PubChem	GCLC GCLM GGT5 GSS OPLAH
7	glutathione-peroxide redox reactions	PubChem	GPX1 GPX2 GPX3 GPX4 GSR
8	glutathione biosynthesis	PubChem	GCLC GCLM GSS
9	Defective GCLC causes HAGGSD	Reactome	GCLC GCLM
10	Defective OPLAH causes OPLAHD	Reactome	OPLAH
11	Defective GSS causes GSS deficiency	Reactome	GSS

Gene overlap in member pathways for Glutathione conjugation SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	GCLC	Glutamate-Cysteine Ligase Catalytic Subunit	Protein Coding	7
2	GCLM	Glutamate-Cysteine Ligase Modifier Subunit	Protein Coding	7
3	GSS	Glutathione Synthetase	Protein Coding	7
4	OPLAH	5-Oxoprolinase, ATP-Hydrolysing	Protein Coding	6
5	GGT1	Gamma-Glutamyltransferase 1	Protein Coding	4
6	GGT5	Gamma-Glutamyltransferase 5	Protein Coding	4
7	GPX1	Glutathione Peroxidase 1	Protein Coding	4
8	GPX2	Glutathione Peroxidase 2	Protein Coding	4
9	GPX3	Glutathione Peroxidase 3	Protein Coding	4
10	GPX4	Glutathione Peroxidase 4	Protein Coding	4
11	GSR	Glutathione-Disulfide Reductase	Protein Coding	4
12	GSTA5	Glutathione S-Transferase Alpha 5	Protein Coding	3
13	GGT7	Gamma-Glutamyltransferase 7	Protein Coding	3
14	GSTA1	Glutathione S-Transferase Alpha 1	Protein Coding	3
15	GSTM1	Glutathione S-Transferase Mu 1	Protein Coding	3
16	GSTM2	Glutathione S-Transferase Mu 2	Protein Coding	3
17	GSTT1	Glutathione S-Transferase Theta 1	Protein Coding	3
18	GGCT	Gamma-Glutamylcyclotransferase	Protein Coding	3
19	GSTO2	Glutathione S-Transferase Omega 2	Protein Coding	2
20	GGT6	Gamma-Glutamyltransferase 6	Protein Coding	2
21	GSTA2	Glutathione S-Transferase Alpha 2	Protein Coding	2
22	GSTA3	Glutathione S-Transferase Alpha 3	Protein Coding	2
23	GSTA4	Glutathione S-Transferase Alpha 4	Protein Coding	2
24	GSTM3	Glutathione S-Transferase Mu 3	Protein Coding	2
25	GSTM4	Glutathione S-Transferase Mu 4	Protein Coding	2
26	GSTM5	Glutathione S-Transferase Mu 5	Protein Coding	2
27	GSTP1	Glutathione S-Transferase Pi 1	Protein Coding	2
28	GSTT2	Glutathione S-Transferase Theta 2 (Gene/Pseudogene)	Protein Coding	2
29	GSTZ1	Glutathione S-Transferase Zeta 1	Protein Coding	2
30	GSTK1	Glutathione S-Transferase Kappa 1	Protein Coding	2
31	MGST1	Microsomal Glutathione S-Transferase 1	Protein Coding	2
32	MGST2	Microsomal Glutathione S-Transferase 2	Protein Coding	2
33	MGST3	Microsomal Glutathione S-Transferase 3	Protein Coding	2
34	CHAC2	ChaC Glutathione Specific Gamma-Glutamylcyclotransferase 2	Protein Coding	2
35	CNDP2	Carnosine Dipeptidase 2	Protein Coding	2
36	GSTT2B	Glutathione S-Transferase Theta 2B	Protein Coding	2
37	CHAC1	ChaC Glutathione Specific Gamma-Glutamylcyclotransferase 1	Protein Coding	2
38	GSTO1	Glutathione S-Transferase Omega 1	Protein Coding	2
39	ANPEP	Alanyl Aminopeptidase, Membrane	Protein Coding	2
40	GPX7	Glutathione Peroxidase 7	Protein Coding	2
41	AKR1A1	Aldo-Keto Reductase Family 1 Member A1	Protein Coding	1
42	ESD	Esterase D	Protein Coding	1
43	HPGDS	Hematopoietic Prostaglandin D Synthase	Protein Coding	1
44	GPX5	Glutathione Peroxidase 5	Protein Coding	1
45	GPX6	Glutathione Peroxidase 6	Protein Coding	1
46	IDH1	Isocitrate Dehydrogenase (NADP(+)) 1	Protein Coding	1
47	G6PD	Glucose-6-Phosphate Dehydrogenase	Protein Coding	1

Disorders associated with Glutathione conjugation SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Hemolytic anemia	Direct
2	Inherited metabolic disorder	Direct
3	Myocardial infarction	Enrichment	GCLC, GCLM	5.12
4	Megalencephalic leukoencephalopathy with subcortical cysts 1	Enrichment	GSTT2, GSTT2B	4.17
5	Glutathione synthetase deficiency	Enrichment	GSS	3.66
6	Anemia, congenital, nonspherocytic hemolytic, 6	Enrichment	GSS	3.66
7	Anemia, congenital, nonspherocytic hemolytic, 7	Enrichment	GCLC	3.66
8	5-oxoprolinase deficiency	Enrichment	OPLAH	3.43
9	Spondylometaphyseal dysplasia, sedaghatian type	Enrichment	GPX4	3.43
10	Anemia, congenital, nonspherocytic hemolytic, 10	Enrichment	GSR	3.43
11	Glutathione peroxidase deficiency	Enrichment	GPX1	3.43
12	Pulmonary disease, chronic obstructive	Enrichment	MGST1, MGST3	3.28
13	Glutathionuria	Enrichment	GGT1	3.05
14	Metaphyseal enchondromatosis with d-2-hydroxyglutaric aciduria	Enrichment	IDH1	2.83
15	Congenital nonspherocytic hemolytic anemia	Enrichment	G6PD	2.83
16	Maleylacetoacetate isomerase deficiency	Enrichment	GSTZ1	2.58
17	Congenital hemolytic anemia	Enrichment	G6PD	2.53
18	Glucosephosphate dehydrogenase deficiency	Enrichment	G6PD	2.53
19	Cystic fibrosis	Enrichment	GCLC, GSTM3	2.49
20	Enchondromatosis	Enrichment	IDH1	2.35
21	Kala-azar 2	Enrichment	GSTP1	2.28
22	Enchondromatosis, multiple, ollier type	Enrichment	IDH1	2.13
23	Paroxysmal extreme pain disorder	Enrichment	IDH1	2.13
24	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	G6PD	2.13
25	Multiple enchondromatosis, maffucci type	Enrichment	IDH1	1.99
26	Glioma susceptibility 1	Enrichment	IDH1	1.93
27	Coronary heart disease 5	Enrichment	G6PD	1.88
28	Gliosarcoma	Enrichment	IDH1	1.63
29	Giant cell glioblastoma	Enrichment	IDH1	1.61
30	Malaria	Enrichment	G6PD	1.48
31	Leukemia, acute myeloid	Enrichment	IDH1	1.24

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Glutathione conjugation

Pathway Network for Glutathione conjugation

Pathway network for the Glutathione conjugation SuperPath

Member Pathways for Glutathione conjugation

Pathways in the Glutathione conjugation SuperPath

Gene overlap in member pathways for Glutathione conjugation SuperPath

Associated Genes for Glutathione conjugation

Associated Disorders for Glutathione conjugation

Disorders associated with Glutathione conjugation SuperPath

STRING Interaction Network for Glutathione conjugation

Sources for Glutathione conjugation