Glycerophospholipid biosynthetic pathway

Pathway network for the Glycerophospholipid biosynthetic pathway SuperPath

Sources:

WikiPathways
PubChem
Reactome

Pathways in the Glycerophospholipid biosynthetic pathway SuperPath

#	Name	Source	Genes
1	Glycerophospholipid biosynthetic pathway	WikiPathways	AGPS CDIPT CDS2 CEPT1 CHKB CHPT1 CRLS1 GK GNPAT GPAM GPAT2 GPAT3 GPAT4 GPD1 IPMK LPIN1 LPIN2 MOGAT3 PCYT2 PEMT PGS1 PI4K2A PIK3CA PIK3CB PIK3CD PIK3CG PIP5K1A PLA2G2A PTDSS1 PTPMT1 (see all 30) (see less)
2	cardiolipin biosynthesis	PubChem	CRLS1 PGS1 PTPMT1
3	Synthesis of CL	Reactome	CRLS1
4	cardiolipin biosynthesis II	PubChem	PGS1

Gene overlap in member pathways for Glycerophospholipid biosynthetic pathway SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CRLS1	Cardiolipin Synthase 1	Protein Coding	3
2	PGS1	Phosphatidylglycerophosphate Synthase 1	Protein Coding	3
3	PTPMT1	Protein Tyrosine Phosphatase Mitochondrial 1	Protein Coding	2
4	GK	Glycerol Kinase	Protein Coding	1
5	PI4K2A	Phosphatidylinositol 4-Kinase Type 2 Alpha	Protein Coding	1
6	GPAT2	Glycerol-3-Phosphate Acyltransferase 2, Mitochondrial	Protein Coding	1
7	GPAT3	Glycerol-3-Phosphate Acyltransferase 3	Protein Coding	1
8	MOGAT3	Monoacylglycerol O-Acyltransferase 3	Protein Coding	1
9	PIP5K1A	Phosphatidylinositol-4-Phosphate 5-Kinase Type 1 Alpha	Protein Coding	1
10	AGPS	Alkylglycerone Phosphate Synthase	Protein Coding	1
11	CHPT1	Choline Phosphotransferase 1	Protein Coding	1
12	LPIN2	Lipin 2	Protein Coding	1
13	CDIPT	CDP-Diacylglycerol--Inositol 3-Phosphatidyltransferase	Protein Coding	1
14	GNPAT	Glyceronephosphate O-Acyltransferase	Protein Coding	1
15	GPAT4	Glycerol-3-Phosphate Acyltransferase 4	Protein Coding	1
16	CHKB	Choline Kinase Beta	Protein Coding	1
17	IPMK	Inositol Polyphosphate Multikinase	Protein Coding	1
18	PIK3CG	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma	Protein Coding	1
19	PIK3CD	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta	Protein Coding	1
20	PEMT	Phosphatidylethanolamine N-Methyltransferase	Protein Coding	1
21	PCYT2	Phosphate Cytidylyltransferase 2, Ethanolamine	Protein Coding	1
22	PTDSS1	Phosphatidylserine Synthase 1	Protein Coding	1
23	CEPT1	Choline/Ethanolamine Phosphotransferase 1	Protein Coding	1
24	CDS2	CDP-Diacylglycerol Synthase 2	Protein Coding	1
25	GPD1	Glycerol-3-Phosphate Dehydrogenase 1	Protein Coding	1
26	LPIN1	Lipin 1	Protein Coding	1
27	GPAM	Glycerol-3-Phosphate Acyltransferase, Mitochondrial	Protein Coding	1
28	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	1
29	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
30	PLA2G2A	Phospholipase A2 Group IIA	Protein Coding	1

Disorders associated with Glycerophospholipid biosynthetic pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Rhizomelic chondrodysplasia punctata	Enrichment	AGPS, GNPAT	4.55
2	Combined oxidative phosphorylation deficiency 57	Enrichment	CRLS1	4.13
3	Neurodevelopmental disorder with ataxia and brain abnormalities	Enrichment	PTPMT1	3.66
4	Macrodactyly	Enrichment	PIK3CA	2.66
5	Lenz-majewski hyperostotic dwarfism	Enrichment	PTDSS1	2.66
6	Rhizomelic chondrodysplasia punctata, type 2	Enrichment	GNPAT	2.66
7	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.66
8	Cowden syndrome 5	Enrichment	PIK3CA	2.66
9	Hypertriglyceridemia, transient infantile	Enrichment	GPD1	2.66
10	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.66
11	Rhizomelic chondrodysplasia punctata, type 3	Enrichment	AGPS	2.66
12	Proximal myopathy with focal depletion of mitochondria	Enrichment	CHKB	2.66
13	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.66
14	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.66
15	Majeed syndrome	Enrichment	LPIN2	2.66
16	Immunodeficiency 14b, autosomal recessive	Enrichment	PIK3CD	2.66
17	Immunodeficiency 97 with autoinflammation	Enrichment	PIK3CG	2.66
18	Hereditary neuroendocrine tumor of small intestine	Enrichment	IPMK	2.66
19	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.66
20	Hypospadias	Enrichment	PIK3CA	2.66
21	Rare venous malformation	Enrichment	PIK3CA	2.66
22	Diaphragmatic eventration	Enrichment	PIK3CA	2.66
23	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.66
24	Rare combined vascular malformation	Enrichment	PIK3CA	2.66
25	Cavernous lymphangioma	Enrichment	PIK3CA	2.66
26	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.66
27	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.66
28	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.66
29	Macrodactyly of toe	Enrichment	PIK3CA	2.66
30	Glycerol kinase deficiency	Enrichment	GK	2.35
31	Keratosis, seborrheic	Enrichment	PIK3CA	2.35
32	Roifman-chitayat syndrome	Enrichment	PIK3CD	2.35
33	Noonan syndrome 8	Enrichment	PIK3CA	2.35
34	Spastic paraplegia 82, autosomal recessive	Enrichment	PCYT2	2.35
35	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.35
36	Intellectual developmental disorder, autosomal dominant 60, with seizures	Enrichment	PIP5K1A	2.35
37	Immune system disease	Enrichment	PIK3CD	2.35
38	Neurodevelopmental disorder with hyperkinetic movements, seizures, and structural brain abnormalities	Enrichment	PI4K2A	2.35
39	Transient infantile hypertriglyceridemia and hepatosteatosis	Enrichment	GPD1	2.35
40	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.18
41	Myoglobinuria, acute recurrent, autosomal recessive	Enrichment	LPIN1	2.18
42	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA	2.18
43	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3CD	2.18
44	Immunodeficiency 14	Enrichment	PIK3CD	2.18
45	Keratoacanthoma	Enrichment	PIK3CA	2.18
46	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	2.05
47	Muscular dystrophy, congenital, megaconial type	Enrichment	CHKB	2.05
48	Cerebrovascular disease	Enrichment	PIK3CA	2.05
49	Hereditary recurrent myoglobinuria	Enrichment	LPIN1	2.05
50	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.05
51	Capillary malformations, congenital	Enrichment	PIK3CA	1.96
52	Hemimegalencephaly	Enrichment	PIK3CA	1.96
53	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.88
54	Cowden syndrome 1	Enrichment	PIK3CA	1.88
55	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.88
56	Breast adenocarcinoma	Enrichment	PIK3CA	1.88
57	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.88
58	Nevus, epidermal	Enrichment	PIK3CA	1.81
59	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	1.81
60	Gallbladder cancer	Enrichment	PIK3CA	1.81
61	Colorectal cancer	Enrichment	PIK3CA, PLA2G2A	1.80
62	Arteriovenous malformation	Enrichment	PIK3CA	1.70
63	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.70
64	Cowden syndrome	Enrichment	PIK3CA	1.70
65	Myopathy, x-linked, with excessive autophagy	Enrichment	PIK3CA	1.66
66	Familial colorectal cancer	Enrichment	PLA2G2A	1.66
67	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3CD	1.66
68	Lung non-small cell carcinoma	Enrichment	PIK3CA	1.62
69	Meningioma	Enrichment	PIK3CA	1.58
70	Lip and oral cavity carcinoma	Enrichment	PIK3CA	1.58
71	Nk-cell enteropathy	Enrichment	PIK3CB	1.55
72	Lynch syndrome	Enrichment	PIK3CA	1.49
73	Endometrial cancer	Enrichment	PIK3CA	1.34
74	Hepatocellular carcinoma	Enrichment	PIK3CA	1.32
75	Autoinflammatory disease	Enrichment	LPIN2	1.29
76	Muscular dystrophy	Enrichment	CHKB	1.29
77	Bladder cancer	Enrichment	PIK3CA	1.21
78	Prostate cancer	Enrichment	PIK3CA	1.21
79	Lung cancer	Enrichment	PIK3CA	1.16
80	Male infertility	Enrichment	GPAT2	1.14
81	Gastric cancer	Enrichment	PIK3CA	1.04
82	Hereditary breast carcinoma	Enrichment	PIK3CA	1.03
83	Hypertelorism	Enrichment	PIK3CA	0.96
84	Breast cancer	Enrichment	PIK3CA	0.81
85	Ovarian cancer	Enrichment	PIK3CA	0.70

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Glycerophospholipid biosynthetic pathway

Pathway Network for Glycerophospholipid biosynthetic pathway

Pathway network for the Glycerophospholipid biosynthetic pathway SuperPath

Member Pathways for Glycerophospholipid biosynthetic pathway

Pathways in the Glycerophospholipid biosynthetic pathway SuperPath

Gene overlap in member pathways for Glycerophospholipid biosynthetic pathway SuperPath

Associated Genes for Glycerophospholipid biosynthetic pathway

Associated Disorders for Glycerophospholipid biosynthetic pathway

Disorders associated with Glycerophospholipid biosynthetic pathway SuperPath

STRING Interaction Network for Glycerophospholipid biosynthetic pathway

Sources for Glycerophospholipid biosynthetic pathway