Glycogen metabolism

Pathway network for the Glycogen metabolism SuperPath

Sources:

Reactome
WikiPathways

Pathways in the Glycogen metabolism SuperPath

#	Name	Source	Genes
1	Glycogen metabolism	Reactome	AGL AKR1E2 CALM1 CALM2 CALM3 EPM2A GAA GBE1 GYG1 GYG2 GYS1 GYS2 NHLRC1 PGM1 PHKA1 PHKA2 PHKB PHKG1 PHKG2 PPP1R3C PYGB PYGL PYGM RPS27A UBA52 UBB UBC UGP2 (see all 28) (see less)
2	Glycogen synthesis and degradation	WikiPathways	AGL CALM1 CALM2 CALM3 GBE1 GSK3A GSK3B GYG1 GYG2 GYS1 GYS2 HK1 HK2 HK3 HKDC1 PGM1 PHKA1 PHKA2 PHKB PHKG1 PHKG2 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R2A PPP2R2B PPP2R2C PPP2R3A PPP2R3B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PTPA PYGB PYGL PYGM UGP2 (see all 40) (see less)
3	Glycogen breakdown (glycogenolysis)	Reactome	AGL AKR1E2 CALM1 CALM2 CALM3 GAA GYG1 GYG2 PGM1 PHKA1 PHKA2 PHKB PHKG1 PHKG2 PYGB PYGL PYGM (see all 17) (see less)
4	Glycogen synthesis	Reactome	EPM2A GBE1 GYG1 GYG2 GYS1 GYS2 NHLRC1 PGM1 PPP1R3C RPS27A UBA52 UBB UBC UGP2 (see all 14) (see less)
5	Myoclonic epilepsy of Lafora	Reactome	EPM2A GYG1 GYS1 NHLRC1 PPP1R3C RPS27A UBA52 UBB UBC (see all 9) (see less)

Gene overlap in member pathways for Glycogen metabolism SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	GYG1	Glycogenin 1	Protein Coding	5
2	GYS1	Glycogen Synthase 1	Protein Coding	4
3	PGM1	Phosphoglucomutase 1	Protein Coding	4
4	GYG2	Glycogenin 2	Protein Coding	4
5	AGL	Amylo-Alpha-1,6-Glucosidase And 4-Alpha-Glucanotransferase	Protein Coding	3
6	GBE1	1,4-Alpha-Glucan Branching Enzyme 1	Protein Coding	3
7	GYS2	Glycogen Synthase 2	Protein Coding	3
8	NHLRC1	NHL Repeat Containing E3 Ubiquitin Protein Ligase 1	Protein Coding	3
9	PHKA1	Phosphorylase Kinase Regulatory Subunit Alpha 1	Protein Coding	3
10	PHKA2	Phosphorylase Kinase Regulatory Subunit Alpha 2	Protein Coding	3
11	PHKB	Phosphorylase Kinase Regulatory Subunit Beta	Protein Coding	3
12	PHKG1	Phosphorylase Kinase Catalytic Subunit Gamma 1	Protein Coding	3
13	PHKG2	Phosphorylase Kinase Catalytic Subunit Gamma 2	Protein Coding	3
14	PPP1R3C	Protein Phosphatase 1 Regulatory Subunit 3C	Protein Coding	3
15	PYGB	Glycogen Phosphorylase B	Protein Coding	3
16	PYGL	Glycogen Phosphorylase L	Protein Coding	3
17	PYGM	Glycogen Phosphorylase, Muscle Associated	Protein Coding	3
18	RPS27A	Ribosomal Protein S27a	Protein Coding	3
19	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	3
20	UBB	Ubiquitin B	Protein Coding	3
21	UBC	Ubiquitin C	Protein Coding	3
22	UGP2	UDP-Glucose Pyrophosphorylase 2	Protein Coding	3
23	EPM2A	EPM2A Glucan Phosphatase, Laforin	Protein Coding	3
24	CALM1	Calmodulin 1	Protein Coding	3
25	CALM2	Calmodulin 2	Protein Coding	3
26	CALM3	Calmodulin 3	Protein Coding	3
27	GAA	Alpha Glucosidase	Protein Coding	2
28	AKR1E2	Aldo-Keto Reductase Family 1 Member E2	Protein Coding	2
29	HKDC1	Hexokinase Domain Containing 1	Protein Coding	1
30	HK3	Hexokinase 3	Protein Coding	1
31	HK2	Hexokinase 2	Protein Coding	1
32	HK1	Hexokinase 1	Protein Coding	1
33	PPP2R5E	Protein Phosphatase 2 Regulatory Subunit B''Epsilon	Protein Coding	1
34	PPP2R5D	Protein Phosphatase 2 Regulatory Subunit B''Delta	Protein Coding	1
35	PPP2R5C	Protein Phosphatase 2 Regulatory Subunit B''Gamma	Protein Coding	1
36	PPP2R5A	Protein Phosphatase 2 Regulatory Subunit B''Alpha	Protein Coding	1
37	PTPA	Protein Phosphatase 2 Phosphatase Activator	Protein Coding	1
38	PPP2R3A	Protein Phosphatase 2 Regulatory Subunit B''''Alpha	Protein Coding	1
39	PPP2R2C	Protein Phosphatase 2 Regulatory Subunit Bgamma	Protein Coding	1
40	PPP2R2B	Protein Phosphatase 2 Regulatory Subunit Bbeta	Protein Coding	1
41	PPP2R2A	Protein Phosphatase 2 Regulatory Subunit Balpha	Protein Coding	1
42	PPP2R1B	Protein Phosphatase 2 Scaffold Subunit Abeta	Protein Coding	1
43	PPP2R1A	Protein Phosphatase 2 Scaffold Subunit Aalpha	Protein Coding	1
44	PPP2CA	Protein Phosphatase 2 Catalytic Subunit Alpha	Protein Coding	1
45	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
46	GSK3A	Glycogen Synthase Kinase 3 Alpha	Protein Coding	1
47	PPP2R5B	Protein Phosphatase 2 Regulatory Subunit B''Beta	Protein Coding	1
48	PPP2CB	Protein Phosphatase 2 Catalytic Subunit Beta	Protein Coding	1
49	PPP2R3B	Protein Phosphatase 2 Regulatory Subunit B''''Beta~Name Same As:- HGNC:9310	Protein Coding	1

Disorders associated with Glycogen metabolism SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Glycogen storage disease	Direct
2	Phosphorylase kinase deficiency	Enrichment	PHKA1, PHKA2, PHKB, PHKG2	11.77
3	Catecholaminergic polymorphic ventricular tachycardia	Enrichment	CALM1, CALM2, CALM3	7.04
4	Glycogen storage disease due to liver phosphorylase kinase deficiency	Enrichment	PHKA2, PHKG2	5.83
5	Glycogen storage disease ixd	Enrichment	PHKA1, PHKG1	5.35
6	Myoclonic epilepsy of lafora 1	Enrichment	EPM2A, NHLRC1	5.23
7	Long qt syndrome 1	Enrichment	CALM1, CALM2, CALM3	5.19
8	Glycogen storage disease iv	Enrichment	GAA, GBE1	4.91
9	Long qt syndrome	Enrichment	CALM1, CALM2	3.17
10	Polyglucosan body neuropathy, adult form	Enrichment	GBE1	2.99
11	Myoclonic epilepsy of lafora 2	Enrichment	NHLRC1	2.99
12	Adult polyglucosan body disease	Enrichment	GBE1	2.99
13	Developmental and epileptic encephalopathy 83	Enrichment	UGP2	2.99
14	Glycogen storage disease vi	Enrichment	PYGL	2.90
15	Glycoprotein storage disease	Enrichment	GAA	2.90
16	Glycogen storage disease v	Enrichment	PYGM	2.90
17	Glycogen storage disease ixc	Enrichment	PHKG2	2.90
18	Long qt syndrome 16	Enrichment	CALM3	2.90
19	Long qt syndrome 15	Enrichment	CALM2	2.90
20	Pompe disease, late-onset	Enrichment	GAA	2.90
21	Glycogen storage disease 0, liver	Enrichment	GYS2	2.69
22	Osteogenesis imperfecta, type xv	Enrichment	GBE1	2.69
23	Glycogen storage disease xv	Enrichment	GYG1	2.69
24	Congenital disorder of glycosylation, type it	Enrichment	PGM1	2.69
25	Polyglucosan body myopathy 2	Enrichment	GYG1	2.69
26	Glycogen storage disease 0, muscle	Enrichment	GYS1	2.69
27	Glycogen storage disorder due to hepatic glycogen synthase deficiency	Enrichment	GYS2	2.69
28	Glycogen storage disease due to muscle and heart glycogen synthase deficiency	Enrichment	GYS1	2.69
29	Submucosal cleft palate	Enrichment	UBB	2.69
30	Cleft hard palate	Enrichment	UBB	2.69
31	Glycogen storage disease ixa1	Enrichment	PHKA2	2.60
32	Ventricular tachycardia, catecholaminergic polymorphic, 4	Enrichment	CALM1	2.60
33	Glycogen storage disease iii	Enrichment	AGL	2.60
34	Long qt syndrome 14	Enrichment	CALM1	2.60
35	Glycogen storage disease viii	Enrichment	PHKA2	2.60
36	Anemia, congenital, nonspherocytic hemolytic, 5	Enrichment	HK1	2.53
37	Spinocerebellar ataxia 12	Enrichment	PPP2R2B	2.53
38	Retinitis pigmentosa 79	Enrichment	HK1	2.53
39	Parkinson disease 25, autosomal recessive early-onset, with impaired intellectual development	Enrichment	PTPA	2.53
40	Houge-janssens syndrome 4	Enrichment	PPP2R5C	2.53
41	Houge-janssens syndrome 2	Enrichment	PPP2R1A	2.53
42	Neuropathy, hereditary motor and sensory, russe type	Enrichment	HK1	2.53
43	Neurodevelopmental disorder with visual defects and brain anomalies	Enrichment	HK1	2.53
44	Ppp2r1a-related neurodevelopmental disorder	Enrichment	PPP2R1A	2.53
45	Uvula, bifid	Enrichment	UBB	2.51
46	Cleft soft palate	Enrichment	UBB	2.51
47	Cutis laxa, autosomal recessive, type ib	Enrichment	GBE1	2.51
48	Glycogen storage disease ixb	Enrichment	PHKB	2.43
49	Pompe disease, infantile-onset	Enrichment	GAA	2.43
50	Glycogen storage disease ia	Enrichment	GAA	2.30
51	Aland island eye disease	Enrichment	PHKA2	2.30
52	Houge-janssens syndrome 1	Enrichment	PPP2R5D	2.23
53	Houge-janssens syndrome 3	Enrichment	PPP2CA	2.23
54	Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy	Enrichment	CALM1	2.13
55	Retinitis pigmentosa 92	Enrichment	HKDC1	2.05
56	Catecholaminergic polymorphic ventricular tachycardia 1	Enrichment	CALM1	2.00
57	Progressive myoclonus epilepsy	Enrichment	EPM2A	1.99
58	Myoclonic epilepsy of unverricht and lundborg	Enrichment	EPM2A	1.84
59	Congenital disorder of glycosylation, type in	Enrichment	PGM1	1.76
60	Creatine phosphokinase, elevated serum	Enrichment	GAA	1.70
61	Isolated elevated serum creatine phosphokinase levels	Enrichment	GAA	1.70
62	Sudden infant death syndrome	Enrichment	CALM2	1.68
63	Orofacial cleft 1	Enrichment	HKDC1	1.58
64	Fetal akinesia deformation sequence 1	Enrichment	GBE1	1.43
65	Benign epilepsy with centrotemporal spikes	Enrichment	EPM2A	1.38
66	Distal arthrogryposis	Enrichment	GBE1	1.37
67	Centralopathic epilepsy	Enrichment	EPM2A	1.36
68	Myopathy	Enrichment	GAA	1.31
69	Lung cancer	Enrichment	PPP2R1B	1.04
70	Rare genetic deafness	Enrichment	GAA	1.02
71	Congenital nervous system abnormality	Enrichment	EPM2A	0.98
72	Nervous system disease	Enrichment	EPM2A	0.98
73	Autism spectrum disorder	Enrichment	HK1	0.56
74	Complex neurodevelopmental disorder	Enrichment	PPP2CA	0.51
75	Retinitis pigmentosa	Enrichment	HK1	0.33
76	Hereditary retinal dystrophy	Enrichment	HK1	0.24
77	Fundus dystrophy	Enrichment	HK1	0.24

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Glycogen metabolism

Pathway Network for Glycogen metabolism

Pathway network for the Glycogen metabolism SuperPath

Member Pathways for Glycogen metabolism

Pathways in the Glycogen metabolism SuperPath

Gene overlap in member pathways for Glycogen metabolism SuperPath

Associated Genes for Glycogen metabolism

Associated Disorders for Glycogen metabolism

Disorders associated with Glycogen metabolism SuperPath

STRING Interaction Network for Glycogen metabolism

Sources for Glycogen metabolism