Glycolysis (REACTOME)

Pathway network for the Glycolysis (REACTOME) SuperPath

Sources:

Reactome

Pathways in the Glycolysis (REACTOME) SuperPath

#	Name	Source	Genes
1	Glucose metabolism	Reactome	AAAS ADPGK ALDOA ALDOB ALDOC BPGM ENO1 ENO2 ENO3 ENO4 FBP1 FBP2 G6PC1 G6PC2 G6PC3 GAPDH GAPDHS GCK GCKR GNPDA1 GNPDA2 GPI HK1 HK2 HK3 HKDC1 NDC1 NUP107 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP42 NUP43 NUP50 NUP54 NUP58 NUP62 NUP85 NUP88 NUP93 NUP98 PC PCK1 PCK2 PFKFB1 PFKFB2 PFKFB3 PFKFB4 PFKL PFKM PFKP PGAM1 PGAM2 PGK1 PGK2 PGM2L1 PKLR PKM POM121 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PRKACA PRKACB PRKACG RAE1 RANBP2 SEC13 SEH1L SLC37A1 SLC37A2 SLC37A4 TPI1 TPR (see all 83) (see less)
2	Glycolysis	Reactome	AAAS ADPGK ALDOA ALDOB ALDOC BPGM ENO1 ENO2 ENO3 ENO4 GAPDH GAPDHS GCK GCKR GNPDA1 GNPDA2 GPI HK1 HK2 HK3 HKDC1 NDC1 NUP107 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP42 NUP43 NUP50 NUP54 NUP58 NUP62 NUP85 NUP88 NUP93 NUP98 PFKFB1 PFKFB2 PFKFB3 PFKFB4 PFKL PFKM PFKP PGAM1 PGAM2 PGK1 PGK2 PGM2L1 PKLR PKM POM121 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PRKACA PRKACB PRKACG RAE1 RANBP2 SEC13 SEH1L TPI1 TPR (see all 72) (see less)
3	Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	Reactome	PFKFB1 PFKFB2 PFKFB3 PFKFB4 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PRKACA PRKACB PRKACG (see all 12) (see less)

Gene overlap in member pathways for Glycolysis (REACTOME) SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PFKFB1	6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 1	Protein Coding	3
2	PFKFB2	6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 2	Protein Coding	3
3	PFKFB3	6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3	Protein Coding	3
4	PFKFB4	6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 4	Protein Coding	3
5	PPP2CA	Protein Phosphatase 2 Catalytic Subunit Alpha	Protein Coding	3
6	PPP2CB	Protein Phosphatase 2 Catalytic Subunit Beta	Protein Coding	3
7	PPP2R1A	Protein Phosphatase 2 Scaffold Subunit Aalpha	Protein Coding	3
8	PPP2R1B	Protein Phosphatase 2 Scaffold Subunit Abeta	Protein Coding	3
9	PPP2R5D	Protein Phosphatase 2 Regulatory Subunit B''Delta	Protein Coding	3
10	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	3
11	PRKACB	Protein Kinase CAMP-Activated Catalytic Subunit Beta	Protein Coding	3
12	PRKACG	Protein Kinase CAMP-Activated Catalytic Subunit Gamma	Protein Coding	3
13	GNPDA1	Glucosamine-6-Phosphate Deaminase 1	Protein Coding	2
14	NUP50	Nucleoporin 50	Protein Coding	2
15	NUP42	Nucleoporin 42	Protein Coding	2
16	NUP35	Nucleoporin 35	Protein Coding	2
17	GNPDA2	Glucosamine-6-Phosphate Deaminase 2	Protein Coding	2
18	ENO1	Enolase 1	Protein Coding	2
19	ENO2	Enolase 2	Protein Coding	2
20	ENO3	Enolase 3	Protein Coding	2
21	ALDOA	Aldolase, Fructose-Bisphosphate A	Protein Coding	2
22	ALDOB	Aldolase, Fructose-Bisphosphate B	Protein Coding	2
23	ALDOC	Aldolase, Fructose-Bisphosphate C	Protein Coding	2
24	NUP205	Nucleoporin 205	Protein Coding	2
25	NUP210	Nucleoporin 210	Protein Coding	2
26	NUP160	Nucleoporin 160	Protein Coding	2
27	NUP188	Nucleoporin 188	Protein Coding	2
28	NUP62	Nucleoporin 62	Protein Coding	2
29	GAPDH	Glyceraldehyde-3-Phosphate Dehydrogenase	Protein Coding	2
30	GAPDHS	Glyceraldehyde-3-Phosphate Dehydrogenase, Spermatogenic	Protein Coding	2
31	GCK	Glucokinase	Protein Coding	2
32	GCKR	Glucokinase Regulator	Protein Coding	2
33	GPI	Glucose-6-Phosphate Isomerase	Protein Coding	2
34	PGM2L1	Phosphoglucomutase 2 Like 1	Protein Coding	2
35	HK1	Hexokinase 1	Protein Coding	2
36	HK2	Hexokinase 2	Protein Coding	2
37	HK3	Hexokinase 3	Protein Coding	2
38	NUP43	Nucleoporin 43	Protein Coding	2
39	ENO4	Enolase 4	Protein Coding	2
40	NUP88	Nucleoporin 88	Protein Coding	2
41	NUP98	Nucleoporin 98 And 96 Precursor	Protein Coding	2
42	PFKL	Phosphofructokinase, Liver Type	Protein Coding	2
43	PFKM	Phosphofructokinase, Muscle	Protein Coding	2
44	PFKP	Phosphofructokinase, Platelet	Protein Coding	2
45	PGAM1	Phosphoglycerate Mutase 1	Protein Coding	2
46	PGAM2	Phosphoglycerate Mutase 2	Protein Coding	2
47	PGK1	Phosphoglycerate Kinase 1	Protein Coding	2
48	PGK2	Phosphoglycerate Kinase 2	Protein Coding	2
49	PKLR	Pyruvate Kinase L/R	Protein Coding	2
50	PKM	Pyruvate Kinase M1/2	Protein Coding	2
51	NUP54	Nucleoporin 54	Protein Coding	2
52	NDC1	NDC1 Transmembrane Nucleoporin	Protein Coding	2
53	NUP133	Nucleoporin 133	Protein Coding	2
54	NUP107	Nucleoporin 107	Protein Coding	2
55	RANBP2	RAN Binding Protein 2	Protein Coding	2
56	SEC13	SEC13 Homolog, Nuclear Pore And COPII Component	Protein Coding	2
57	BPGM	Bisphosphoglycerate Mutase	Protein Coding	2
58	TPI1	Triosephosphate Isomerase 1	Protein Coding	2
59	TPR	Translocated Promoter Region, Nuclear Basket Protein	Protein Coding	2
60	NUP37	Nucleoporin 37	Protein Coding	2
61	NUP85	Nucleoporin 85	Protein Coding	2
62	HKDC1	Hexokinase Domain Containing 1	Protein Coding	2
63	NUP214	Nucleoporin 214	Protein Coding	2
64	AAAS	Aladin WD Repeat Nucleoporin	Protein Coding	2
65	SEH1L	SEH1 Like Nucleoporin	Protein Coding	2
66	ADPGK	ADP Dependent Glucokinase	Protein Coding	2
67	RAE1	Ribonucleic Acid Export 1	Protein Coding	2
68	NUP155	Nucleoporin 155	Protein Coding	2
69	NUP93	Nucleoporin 93	Protein Coding	2
70	NUP58	Nucleoporin 58	Protein Coding	2
71	POM121	POM121 Transmembrane Nucleoporin	Protein Coding	2
72	NUP153	Nucleoporin 153	Protein Coding	2
73	SLC37A2	Solute Carrier Family 37 Member 2	Protein Coding	1
74	FBP1	Fructose-Bisphosphatase 1	Protein Coding	1
75	G6PC1	Glucose-6-Phosphatase Catalytic Subunit 1	Protein Coding	1
76	SLC37A4	Solute Carrier Family 37 Member 4	Protein Coding	1
77	PC	Pyruvate Carboxylase	Protein Coding	1
78	PCK1	Phosphoenolpyruvate Carboxykinase 1	Protein Coding	1
79	PCK2	Phosphoenolpyruvate Carboxykinase 2, Mitochondrial	Protein Coding	1
80	SLC37A1	Solute Carrier Family 37 Member 1	Protein Coding	1
81	G6PC2	Glucose-6-Phosphatase Catalytic Subunit 2	Protein Coding	1
82	FBP2	Fructose-Bisphosphatase 2	Protein Coding	1
83	G6PC3	Glucose-6-Phosphatase Catalytic Subunit 3	Protein Coding	1

Disorders associated with Glycolysis (REACTOME) SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Genetic steroid-resistant nephrotic syndrome	Enrichment	NUP107, NUP133, NUP160, NUP205, NUP37, NUP85, NUP93	9.35
2	Ellis-van creveld syndrome	Enrichment	PRKACA, PRKACB	4.59
3	Glycogen storage disease	Enrichment	G6PC1, PFKM, SLC37A4	4.45
4	Phosphoenolpyruvate carboxykinase deficiency	Enrichment	PCK1, PCK2	3.96
5	Familial infantile bilateral striatal necrosis	Enrichment	NUP54, NUP62	3.78
6	Glycogen storage disease ia	Enrichment	G6PC1, SLC37A4	3.66
7	Hemolytic anemia	Enrichment	GPI, PKLR	3.24
8	Cardioacrofacial dysplasia 2	Enrichment	PRKACB	3.05
9	Houge-janssens syndrome 2	Enrichment	PPP2R1A	3.05
10	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	3.05
11	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	3.05
12	Ppp2r1a-related neurodevelopmental disorder	Enrichment	PPP2R1A	3.05
13	Galloway-mowat syndrome	Enrichment	NUP107, NUP133	2.91
14	Bleeding disorder, platelet-type, 19	Enrichment	PRKACG	2.75
15	Houge-janssens syndrome 1	Enrichment	PPP2R5D	2.75
16	Fibrolamellar carcinoma	Enrichment	PRKACA	2.75
17	Houge-janssens syndrome 3	Enrichment	PPP2CA	2.75
18	Adenosine triphosphate, elevated, of erythrocytes	Enrichment	PKLR	2.28
19	Erythrocytosis, familial, 8	Enrichment	BPGM	2.28
20	Anemia, congenital, nonspherocytic hemolytic, 5	Enrichment	HK1	2.28
21	Anemia, congenital, nonspherocytic hemolytic, 2	Enrichment	PKLR	2.28
22	Phosphoglycerate kinase 1 deficiency	Enrichment	PGK1	2.28
23	Glycogen storage disease xiii	Enrichment	ENO3	2.28
24	Maturity-onset diabetes of the young, type 2	Enrichment	GCK	2.28
25	Triosephosphate isomerase deficiency	Enrichment	TPI1	2.28
26	Retinitis pigmentosa 79	Enrichment	HK1	2.28
27	Fetal akinesia deformation sequence 4	Enrichment	NUP88	2.28
28	Neurodevelopmental disorder with achalasia, polyneuropathy, and alacrima	Enrichment	NDC1	2.28
29	Atrial fibrillation, familial, 15	Enrichment	NUP155	2.28
30	Dystonia 37, early-onset, with striatal lesions	Enrichment	NUP54	2.28
31	Nephrotic syndrome, type 19	Enrichment	NUP160	2.28
32	Neurodevelopmental disorder with hypotonia, dysmorphic facies, and skin abnormalities	Enrichment	PGM2L1	2.28
33	Galloway-mowat syndrome 8	Enrichment	NUP133	2.28
34	Nephrotic syndrome, type 13	Enrichment	NUP205	2.28
35	Hyperinsulinemic hypoglycemia, familial, 3	Enrichment	GCK	2.28
36	Neuropathy, hereditary motor and sensory, russe type	Enrichment	HK1	2.28
37	Microcephaly 24, primary, autosomal recessive	Enrichment	NUP37	2.28
38	Galloway-mowat syndrome 7	Enrichment	NUP107	2.28
39	Neurodevelopmental disorder with visual defects and brain anomalies	Enrichment	HK1	2.28
40	Nephrotic syndrome, type 12	Enrichment	NUP93	2.28
41	Anemia, congenital, nonspherocytic hemolytic, 4	Enrichment	GPI	2.28
42	Fasting plasma glucose level quantitative trait locus 5	Enrichment	GCKR	2.28
43	Nephrotic syndrome, type 11	Enrichment	NUP107	2.28
44	Encephalopathy, acute, infection-induced 9	Enrichment	NUP214	2.28
45	Sandestig-stefanova syndrome	Enrichment	NUP188	2.28
46	Ovarian dysgenesis 6	Enrichment	NUP107	2.28
47	Intellectual developmental disorder, autosomal recessive 79	Enrichment	TPR	2.28
48	Nephrotic syndrome, type 18	Enrichment	NUP133	2.28
49	Gestational diabetes	Enrichment	GCK	2.28
50	Autosomal recessive secondary polycythemia not associated with vhl gene	Enrichment	BPGM	2.28
51	Familial acute necrotizing encephalopathy	Enrichment	RANBP2	2.28
52	Male infertility due to obstructive azoospermia	Enrichment	PGK1	2.28
53	Phosphoenolpyruvate carboxykinase deficiency, cytosolic	Enrichment	PCK1	2.21
54	Fructose-1,6-bisphosphatase deficiency	Enrichment	FBP1	2.21
55	Glycogen storage disease ic	Enrichment	SLC37A4	2.21
56	Glycogen storage disease ib	Enrichment	SLC37A4	2.21
57	Congenital disorder of glycosylation, type iiw	Enrichment	SLC37A4	2.21
58	Leukodystrophy, childhood-onset, remitting	Enrichment	FBP2	2.21
59	Glycogen storage disease due to glucose-6-phosphatase deficiency type ib	Enrichment	SLC37A4	2.21
60	Glycogen storage disease type 1 due to slc37a4 mutation	Enrichment	SLC37A4	2.21
61	Maturity-onset diabetes of the young, type 1	Enrichment	GCK	1.98
62	Fructose intolerance, hereditary	Enrichment	ALDOB	1.98
63	Glycogen storage disease vii	Enrichment	PFKM	1.98
64	Camptodactyly-arthropathy-coxa vara-pericarditis syndrome	Enrichment	TPR	1.98
65	Striatonigral degeneration, infantile	Enrichment	NUP62	1.98
66	Diabetes mellitus, permanent neonatal, 1	Enrichment	GCK	1.98
67	Bone marrow failure syndrome 2	Enrichment	GCK	1.98
68	Microcephaly 21, primary, autosomal recessive	Enrichment	GAPDH	1.98
69	Nephrotic syndrome, type 17	Enrichment	NUP85	1.98
70	Glycogen storage disease xii	Enrichment	ALDOA	1.98
71	Acute myeloid leukemia with t(6;9) (p23;q34.1)	Enrichment	NUP214	1.98
72	Acute necrotizing encephalopathy of childhood	Enrichment	RANBP2	1.98
73	Phosphoenolpyruvate carboxykinase deficiency, mitochondrial	Enrichment	PCK2	1.91
74	Neutropenia, severe congenital, 4, autosomal recessive	Enrichment	G6PC3	1.91
75	Severe congenital neutropenia 4	Enrichment	G6PC3	1.91
76	Nijmegen breakage syndrome	Enrichment	GCK	1.80
77	Ectodermal dysplasia 11b, hypohidrotic/hair/tooth type, autosomal recessive	Enrichment	RANBP2	1.80
78	Retinitis pigmentosa 92	Enrichment	HKDC1	1.80
79	Pyruvate carboxylase deficiency	Enrichment	PC	1.74
80	Ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive	Enrichment	RANBP2	1.68
81	Achalasia-addisonianism-alacrima syndrome	Enrichment	AAAS	1.68
82	Maturity-onset diabetes of the young, type 3	Enrichment	GCK	1.68
83	Glycogen storage disease x	Enrichment	PGAM2	1.68
84	Ectodermal dysplasia	Enrichment	RANBP2	1.68
85	Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant	Enrichment	RANBP2	1.58
86	Autosomal recessive hypohidrotic ectodermal dysplasia syndrome	Enrichment	RANBP2	1.58
87	Lung cancer	Enrichment	PPP2R1B	1.55
88	Hypoglycemia	Enrichment	G6PC1	1.52
89	Hyperinsulinemic hypoglycemia, familial, 1	Enrichment	GCK	1.50
90	Inflammatory myofibroblastic tumor	Enrichment	RANBP2	1.50
91	Hereditary spherocytosis	Enrichment	GPI	1.50
92	Nonsyndromic genetic hyperinsulinism	Enrichment	GCK	1.50
93	Mitochondrial dna depletion syndrome 4a	Enrichment	RANBP2	1.44
94	Mitochondrial dna depletion syndrome 4b	Enrichment	RANBP2	1.38
95	Permanent neonatal diabetes mellitus	Enrichment	GCK	1.38
96	Neutropenia	Enrichment	SLC37A4	1.38
97	Orofacial cleft 1	Enrichment	HKDC1	1.33
98	Diabetes mellitus	Enrichment	GCK	1.25
99	46 xx gonadal dysgenesis	Enrichment	NUP107	1.21
100	Immune deficiency disease	Enrichment	SLC37A4	1.19
101	Seckel syndrome	Enrichment	NUP85	1.14
102	Congenital disorder of glycosylation, type in	Enrichment	SLC37A4	1.00
103	Maturity-onset diabetes of the young	Enrichment	GCK	1.00
104	Focal segmental glomerulosclerosis	Enrichment	NUP93	1.00
105	Complex neurodevelopmental disorder	Enrichment	PPP2CA	0.98
106	Tooth agenesis	Enrichment	RANBP2	0.96
107	Precursor t-cell acute lymphoblastic leukemia	Enrichment	NUP214	0.94
108	Familial atrial fibrillation	Enrichment	NUP155	0.92
109	Hirschsprung disease 1	Enrichment	NUP98	0.84
110	Differentiated thyroid carcinoma	Enrichment	TPR	0.84
111	Primary autosomal recessive microcephaly	Enrichment	NUP37	0.80
112	Fetal akinesia deformation sequence 1	Enrichment	NUP88	0.75
113	Leukemia, acute myeloid	Enrichment	NUP214	0.72
114	Type 2 diabetes mellitus	Enrichment	GCK	0.70
115	Nephrotic syndrome	Enrichment	NUP93	0.69
116	Autosomal recessive non-syndromic intellectual disability	Enrichment	TPR	0.58
117	Congenital nervous system abnormality	Enrichment	AAAS	0.36
118	Nervous system disease	Enrichment	AAAS	0.36
119	Autism spectrum disorder	Enrichment	HK1	0.36
120	Microcephaly	Enrichment	NUP188	0.32
121	Retinitis pigmentosa	Enrichment	HK1	0.17
122	Hereditary retinal dystrophy	Enrichment	HK1	0.10
123	Fundus dystrophy	Enrichment	HK1	0.10

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Glycolysis (REACTOME)

Pathway Network for Glycolysis (REACTOME)

Pathway network for the Glycolysis (REACTOME) SuperPath

Member Pathways for Glycolysis (REACTOME)

Pathways in the Glycolysis (REACTOME) SuperPath

Gene overlap in member pathways for Glycolysis (REACTOME) SuperPath

Associated Genes for Glycolysis (REACTOME)

Associated Disorders for Glycolysis (REACTOME)

Disorders associated with Glycolysis (REACTOME) SuperPath

STRING Interaction Network for Glycolysis (REACTOME)

Sources for Glycolysis (REACTOME)