Glycosaminoglycan-protein linkage region biosynthesis

Pathway network for the Glycosaminoglycan-protein linkage region biosynthesis SuperPath

Sources:

Reactome

Pathways in the Glycosaminoglycan-protein linkage region biosynthesis SuperPath

#	Name	Source	Genes
1	Glycosaminoglycan-protein linkage region biosynthesis	Reactome	AGRN B3GALT6 B3GAT1 B3GAT2 B3GAT3 B4GALT7 BCAN BGN CSPG4 CSPG5 DCN FAM20B GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 HSPG2 NCAN PXYLP1 SDC1 SDC2 SDC3 SDC4 UXS1 VCAN XYLT1 XYLT2 (see all 29) (see less)
2	Diseases associated with glycosaminoglycan metabolism	Reactome	ACAN AGRN B3GALT6 B3GAT3 B4GALT1 B4GALT7 BCAN BGN CHST14 CHST3 CHST6 CHSY1 CSPG4 CSPG5 DCN EXT1 EXT2 FMOD GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 HEXA HEXB HSPG2 KERA LUM NCAN OGN OMD PAPSS2 PRELP SDC1 SDC2 SDC3 SDC4 SLC26A2 ST3GAL3 VCAN (see all 41) (see less)
3	Defective B4GALT7 causes EDS, progeroid type	Reactome	AGRN B4GALT7 BCAN BGN CSPG4 CSPG5 DCN GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 HSPG2 NCAN SDC1 SDC2 SDC3 SDC4 VCAN (see all 20) (see less)
4	Defective B3GAT3 causes JDSSDHD	Reactome	AGRN B3GAT3 BCAN BGN CSPG4 CSPG5 DCN GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 HSPG2 NCAN SDC1 SDC2 SDC3 SDC4 VCAN (see all 20) (see less)
5	Defective B3GALT6 causes EDSP2 and SEMDJL1	Reactome	AGRN B3GALT6 BCAN BGN CSPG4 CSPG5 DCN GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 HSPG2 NCAN SDC1 SDC2 SDC3 SDC4 VCAN (see all 20) (see less)

Gene overlap in member pathways for Glycosaminoglycan-protein linkage region biosynthesis SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	GPC6	Glypican 6	Protein Coding	5
2	CSPG5	Chondroitin Sulfate Proteoglycan 5	Protein Coding	5
3	VCAN	Versican	Protein Coding	5
4	NCAN	Neurocan	Protein Coding	5
5	CSPG4	Chondroitin Sulfate Proteoglycan 4	Protein Coding	5
6	DCN	Decorin	Protein Coding	5
7	GPC2	Glypican 2	Protein Coding	5
8	GPC4	Glypican 4	Protein Coding	5
9	GPC5	Glypican 5	Protein Coding	5
10	GPC3	Glypican 3	Protein Coding	5
11	GPC1	Glypican 1	Protein Coding	5
12	HSPG2	Heparan Sulfate Proteoglycan 2	Protein Coding	5
13	AGRN	Agrin	Protein Coding	5
14	BGN	Biglycan	Protein Coding	5
15	SDC1	Syndecan 1	Protein Coding	5
16	BCAN	Brevican	Protein Coding	5
17	SDC2	Syndecan 2	Protein Coding	5
18	SDC4	Syndecan 4	Protein Coding	5
19	SDC3	Syndecan 3	Protein Coding	5
20	B4GALT7	Beta-1,4-Galactosyltransferase 7	Protein Coding	3
21	B3GALT6	Beta-1,3-Galactosyltransferase 6	Protein Coding	3
22	B3GAT3	Beta-1,3-Glucuronyltransferase 3	Protein Coding	3
23	B3GAT2	Beta-1,3-Glucuronyltransferase 2	Protein Coding	1
24	B3GAT1	Beta-1,3-Glucuronyltransferase 1	Protein Coding	1
25	XYLT1	Xylosyltransferase 1	Protein Coding	1
26	XYLT2	Xylosyltransferase 2	Protein Coding	1
27	UXS1	UDP-Glucuronate Decarboxylase 1	Protein Coding	1
28	PXYLP1	2-Phosphoxylose Phosphatase 1	Protein Coding	1
29	FAM20B	FAM20B Glycosaminoglycan Xylosylkinase	Protein Coding	1
30	KERA	Keratocan	Protein Coding	1
31	CHST14	Carbohydrate Sulfotransferase 14	Protein Coding	1
32	ACAN	Aggrecan	Protein Coding	1
33	SLC26A2	Solute Carrier Family 26 Member 2	Protein Coding	1
34	EXT1	Exostosin Glycosyltransferase 1	Protein Coding	1
35	EXT2	Exostosin Glycosyltransferase 2	Protein Coding	1
36	CHSY1	Chondroitin Sulfate Synthase 1	Protein Coding	1
37	FMOD	Fibromodulin	Protein Coding	1
38	B4GALT1	Beta-1,4-Galactosyltransferase 1	Protein Coding	1
39	HEXA	Hexosaminidase Subunit Alpha	Protein Coding	1
40	HEXB	Hexosaminidase Subunit Beta	Protein Coding	1
41	LUM	Lumican	Protein Coding	1
42	CHST6	Carbohydrate Sulfotransferase 6	Protein Coding	1
43	OMD	Osteomodulin	Protein Coding	1
44	OGN	Osteoglycin	Protein Coding	1
45	PRELP	Proline And Arginine Rich End Leucine Rich Repeat Protein	Protein Coding	1
46	ST3GAL3	ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 3	Protein Coding	1
47	PAPSS2	3''-Phosphoadenosine 5''-Phosphosulfate Synthase 2	Protein Coding	1
48	CHST3	Carbohydrate Sulfotransferase 3	Protein Coding	1

Disorders associated with Glycosaminoglycan-protein linkage region biosynthesis SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Congenital disorder of glycosylation, type in	Direct
2	Ehlers-danlos syndrome	Direct
3	Heart disease	Direct
4	Larsen syndrome	Direct
5	Spondyloepimetaphyseal dysplasia	Direct
6	Spondyloepiphyseal dysplasia with congenital joint dislocations	Enrichment	B3GALT6, B3GAT3, B4GALT7	6.76
7	Ehlers-danlos syndrome, spondylodysplastic type, 2	Enrichment	B3GALT6, B4GALT7	5.36
8	Simpson-golabi-behmel syndrome, type 1	Enrichment	GPC3, GPC4	4.88
9	Multiple joint dislocations, short stature, and craniofacial dysmorphism with or without congenital heart defects	Enrichment	B3GAT3, B4GALT7	4.88
10	Larsen-like syndrome b3gat3 type	Enrichment	B3GAT3, B4GALT7	4.88
11	Pseudoxanthoma elasticum	Enrichment	XYLT1, XYLT2	4.18
12	Al-gazali syndrome	Enrichment	B3GALT6	2.67
13	Ehlers-danlos syndrome, spondylodysplastic type, 1	Enrichment	B4GALT7	2.67
14	Spondyloepimetaphyseal dysplasia with joint laxity, type 1, with or without fractures	Enrichment	B3GALT6	2.67
15	Keipert syndrome	Enrichment	GPC4	2.67
16	Meester-loeys syndrome	Enrichment	BGN	2.67
17	Spondyloocular syndrome	Enrichment	XYLT2	2.67
18	Spondylodysplastic ehlers-danlos syndrome	Enrichment	B4GALT7	2.67
19	Spondyloepimetaphyseal dysplasia with joint laxity	Enrichment	B3GALT6	2.67
20	Xylt1-congenital disorder of glycosylation	Enrichment	XYLT1	2.67
21	Wagner vitreoretinopathy	Enrichment	VCAN	2.37
22	Spondyloepimetaphyseal dysplasia, x-linked	Enrichment	BGN	2.37
23	Omodysplasia 1	Enrichment	GPC6	2.37
24	Corneal dystrophy, congenital stromal	Enrichment	DCN	2.37
25	Schwartz-jampel syndrome, type 1	Enrichment	HSPG2	2.37
26	Wagner disease	Enrichment	VCAN	2.37
27	Dyssegmental dysplasia, silverman-handmaker type	Enrichment	HSPG2	2.19
28	Desbuquois dysplasia 2	Enrichment	XYLT1	2.19
29	Myasthenic syndrome, congenital, 8	Enrichment	AGRN	1.97
30	Desbuquois dysplasia 1	Enrichment	XYLT1	1.89
31	Stickler syndrome	Enrichment	VCAN	1.67
32	Presynaptic congenital myasthenic syndromes	Enrichment	AGRN	1.63
33	Postsynaptic congenital myasthenic syndromes	Enrichment	AGRN	1.60
34	Chromosome 1p36 deletion syndrome	Enrichment	HSPG2	1.56
35	Congenital myasthenic syndrome	Enrichment	AGRN	1.53
36	Wilms tumor 1	Enrichment	GPC3	1.50
37	Craniosynostosis	Enrichment	GPC4	1.38
38	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	BGN	1.05
39	Body mass index quantitative trait locus 11	Enrichment	SDC3	0.99
40	Hereditary retinal dystrophy	Enrichment	VCAN	0.33
41	Fundus dystrophy	Enrichment	VCAN	0.33

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Glycosaminoglycan-protein linkage region biosynthesis

Pathway Network for Glycosaminoglycan-protein linkage region biosynthesis

Pathway network for the Glycosaminoglycan-protein linkage region biosynthesis SuperPath

Member Pathways for Glycosaminoglycan-protein linkage region biosynthesis

Pathways in the Glycosaminoglycan-protein linkage region biosynthesis SuperPath

Gene overlap in member pathways for Glycosaminoglycan-protein linkage region biosynthesis SuperPath

Associated Genes for Glycosaminoglycan-protein linkage region biosynthesis

Associated Disorders for Glycosaminoglycan-protein linkage region biosynthesis

Disorders associated with Glycosaminoglycan-protein linkage region biosynthesis SuperPath

STRING Interaction Network for Glycosaminoglycan-protein linkage region biosynthesis

Sources for Glycosaminoglycan-protein linkage region biosynthesis