Glycosaminoglycan metabolism

Pathway network for the Glycosaminoglycan metabolism SuperPath

Sources:

Reactome
WikiPathways

Pathways in the Glycosaminoglycan metabolism SuperPath

#	Name	Source	Genes
1	Glycosaminoglycan metabolism	Reactome	ABCC5 ACAN AGRN ARSB B3GALT6 B3GAT1 B3GAT2 B3GAT3 B3GNT2 B3GNT3 B3GNT4 B3GNT7 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 B4GALT7 B4GAT1 BCAN BGN CD44 CEMIP CHP1 CHPF CHPF2 CHST1 CHST11 CHST12 CHST13 CHST14 CHST15 CHST2 CHST3 CHST5 CHST6 CHST7 CHST9 CHSY1 CHSY3 CSGALNACT1 CSGALNACT2 CSPG4 CSPG5 CTSL DCN DSE DSEL EXT1 EXT2 EXTL2 EXTL3 FAM20B FMOD GALNS GLB1 GLB1L GLB1L2 GLB1L3 GLCE GNS GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 GUSB HAS1 HAS2 HAS3 HEXA HEXB HGSNAT HMMR HPSE HPSE2 HS2ST1 HS3ST1 HS3ST2 HS3ST3A1 HS3ST3B1 HS3ST4 HS3ST5 HS3ST6 HS6ST1 HS6ST2 HS6ST3 HSPG2 HYAL1 HYAL2 HYAL3 HYAL4 IDS IDUA KERA LUM LYVE1 NAGLU NCAN NDST1 NDST2 NDST3 NDST4 OGN OMD PAPSS1 PAPSS2 PRELP PXYLP1 SDC1 SDC2 SDC3 SDC4 SGSH SLC17A5 SLC26A1 SLC26A11 SLC26A2 SLC35B2 SLC35B3 SLC35D2 SLC9A1 SPAM1 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL6 STAB2 UST UXS1 VCAN XYLT1 XYLT2 (see all 136) (see less)
2	Metabolism of carbohydrates and carbohydrate derivatives	Reactome	AAAS ABCC5 ABO ACAN ADPGK AGL AGRN AKR1A1 AKR1B1 AKR1E2 ALDH1A1 ALDOA ALDOB ALDOC ARSB B3GALT1 B3GALT2 B3GALT4 B3GALT5 B3GALT6 B3GAT1 B3GAT2 B3GAT3 B3GNT2 B3GNT3 B3GNT4 B3GNT7 B4GALNT2 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 B4GALT7 B4GAT1 BCAN BGN BPGM CALM1 CALM2 CALM3 CD44 CEMIP CHP1 CHPF CHPF2 CHST1 CHST11 CHST12 CHST13 CHST14 CHST15 CHST2 CHST3 CHST5 CHST6 CHST7 CHST9 CHSY1 CHSY3 CRYL1 CSGALNACT1 CSGALNACT2 CSPG4 CSPG5 CTSL DCN DCXR DERA DSE DSEL ENO1 ENO2 ENO3 ENO4 EPM2A EXT1 EXT2 EXTL2 EXTL3 FAM20B FBP1 FBP2 FMOD FUT1 FUT2 FUT3 FUT4 FUT5 FUT6 FUT7 FUT9 G6PC1 G6PC2 G6PC3 G6PD GAA GALE GALK1 GALM GALNS GALT GAPDH GAPDHS GBE1 GCK GCKR GLB1 GLB1L GLB1L2 GLB1L3 GLCE GLYCTK GNPDA1 GNPDA2 GNS GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 GPI GUSB GYG1 GYG2 GYS1 GYS2 HAS1 HAS2 HAS3 HEXA HEXB HGSNAT HK1 HK2 HK3 HKDC1 HMMR HPSE HPSE2 HS2ST1 HS3ST1 HS3ST2 HS3ST3A1 HS3ST3B1 HS3ST4 HS3ST5 HS3ST6 HS6ST1 HS6ST2 HS6ST3 HSPG2 HYAL1 HYAL2 HYAL3 HYAL4 IDS IDUA KERA KHK LALBA LUM LYVE1 MAN2B1 MAN2B2 MAN2C1 MANBA NAGLU NCAN NDC1 NDST1 NDST2 NDST3 NDST4 NHLRC1 NUP107 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP42 NUP43 NUP50 NUP54 NUP58 NUP62 NUP85 NUP88 NUP93 NUP98 OGN OMD PAPSS1 PAPSS2 PC PCK1 PCK2 PFKFB1 PFKFB2 PFKFB3 PFKFB4 PFKL PFKM PFKP PGAM1 PGAM2 PGD PGK1 PGK2 PGLS PGM1 PGM2 PGM2L1 PHKA1 PHKA2 PHKB PHKG1 PHKG2 PKLR PKM POM121 PPP1R3C PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PRELP PRKACA PRKACB PRKACG PRPS1 PRPS1L1 PRPS2 PXYLP1 PYGB PYGL PYGM RAE1 RANBP2 RBKS RHCE RHD RPE RPEL1 RPIA RPS27A SDC1 SDC2 SDC3 SDC4 SEC13 SEH1L SGSH SHPK SLC17A5 SLC26A1 SLC26A11 SLC26A2 SLC2A1 SLC35B2 SLC35B3 SLC35D2 SLC37A1 SLC37A2 SLC37A4 SLC9A1 SORD SPAM1 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL6 ST6GALNAC6 STAB2 TALDO1 TKFC TKT TPI1 TPR UBA52 UBB UBC UGP2 UST UXS1 VCAN XYLB XYLT1 XYLT2 (see all 299) (see less)
3	Hyaluronan metabolism	Reactome	ABCC5 CD44 CEMIP CHP1 GUSB HAS1 HAS2 HAS3 HEXA HEXB HMMR HYAL1 HYAL2 HYAL3 HYAL4 LYVE1 SLC17A5 SLC9A1 SPAM1 STAB2 (see all 20) (see less)
4	Glycosaminoglycan degradation	WikiPathways	ARSB GALNS GLB1 GNS GUSB HEXA HEXB HGSNAT HPSE HPSE2 HYAL1 HYAL2 HYAL4 IDS IDUA NAGLU SGSH (see all 17) (see less)
5	Hyaluronan degradation	Reactome	CD44 CEMIP CHP1 GUSB HEXA HEXB HMMR HYAL1 HYAL2 HYAL3 HYAL4 LYVE1 SLC17A5 SLC9A1 SPAM1 STAB2 (see all 16) (see less)
6	Mucopolysaccharidoses	Reactome	ARSB GALNS GLB1 GNS GUSB HGSNAT HYAL1 IDS IDUA NAGLU SGSH (see all 11) (see less)
7	Transport and metabolism of PAPS	Reactome	PAPSS1 PAPSS2 SLC26A1 SLC26A11 SLC26A2 SLC35B2 SLC35B3 (see all 7) (see less)
8	Defective SLC26A2 causes chondrodysplasias	Reactome	SLC26A2
9	MPS IIIA - Sanfilippo syndrome A	Reactome	SGSH
10	MPS VI - Maroteaux-Lamy syndrome	Reactome	ARSB
11	MPS IIID - Sanfilippo syndrome D	Reactome	GNS
12	MPS IIIB - Sanfilippo syndrome B	Reactome	NAGLU
13	MPS IV - Morquio syndrome A	Reactome	GALNS
14	MPS IIIC - Sanfilippo syndrome C	Reactome	HGSNAT

Gene overlap in member pathways for Glycosaminoglycan metabolism SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	GUSB	Glucuronidase Beta	Protein Coding	6
2	HYAL1	Hyaluronidase 1	Protein Coding	6
3	HGSNAT	Heparan-Alpha-Glucosaminide N-Acetyltransferase	Protein Coding	5
4	HYAL4	Hyaluronidase 4	Protein Coding	5
5	GALNS	Galactosamine (N-Acetyl)-6-Sulfatase	Protein Coding	5
6	GNS	Glucosamine (N-Acetyl)-6-Sulfatase	Protein Coding	5
7	HEXA	Hexosaminidase Subunit Alpha	Protein Coding	5
8	HEXB	Hexosaminidase Subunit Beta	Protein Coding	5
9	ARSB	Arylsulfatase B	Protein Coding	5
10	NAGLU	N-Acetyl-Alpha-Glucosaminidase	Protein Coding	5
11	SGSH	N-Sulfoglucosamine Sulfohydrolase	Protein Coding	5
12	HYAL2	Hyaluronidase 2	Protein Coding	5
13	LYVE1	Lymphatic Vessel Endothelial Hyaluronan Receptor 1	Protein Coding	4
14	CHP1	Calcineurin Like EF-Hand Protein 1	Protein Coding	4
15	SLC26A2	Solute Carrier Family 26 Member 2	Protein Coding	4
16	SLC17A5	Solute Carrier Family 17 Member 5	Protein Coding	4
17	GLB1	Galactosidase Beta 1	Protein Coding	4
18	HMMR	Hyaluronan Mediated Motility Receptor	Protein Coding	4
19	IDS	Iduronate 2-Sulfatase	Protein Coding	4
20	IDUA	Alpha-L-Iduronidase	Protein Coding	4
21	STAB2	Stabilin 2	Protein Coding	4
22	CEMIP	Cell Migration Inducing Hyaluronidase 1	Protein Coding	4
23	SLC9A1	Solute Carrier Family 9 Member A1	Protein Coding	4
24	SPAM1	Sperm Adhesion Molecule 1	Protein Coding	4
25	HYAL3	Hyaluronidase 3	Protein Coding	4
26	CD44	CD44 Molecule (IN Blood Group)	Protein Coding	4
27	ABCC5	ATP Binding Cassette Subfamily C Member 5	Protein Coding	3
28	HPSE	Heparanase	Protein Coding	3
29	SLC26A1	Solute Carrier Family 26 Member 1	Protein Coding	3
30	SLC26A11	Solute Carrier Family 26 Member 11	Protein Coding	3
31	HAS1	Hyaluronan Synthase 1	Protein Coding	3
32	HAS2	Hyaluronan Synthase 2	Protein Coding	3
33	HAS3	Hyaluronan Synthase 3	Protein Coding	3
34	SLC35B2	Solute Carrier Family 35 Member B2	Protein Coding	3
35	SLC35B3	Solute Carrier Family 35 Member B3	Protein Coding	3
36	HPSE2	Heparanase 2 (Inactive)	Protein Coding	3
37	PAPSS2	3''-Phosphoadenosine 5''-Phosphosulfate Synthase 2	Protein Coding	3
38	PAPSS1	3''-Phosphoadenosine 5''-Phosphosulfate Synthase 1	Protein Coding	3
39	GPC6	Glypican 6	Protein Coding	2
40	UST	Uronyl 2-Sulfotransferase	Protein Coding	2
41	B3GNT3	UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 3	Protein Coding	2
42	ST3GAL6	ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 6	Protein Coding	2
43	CSPG5	Chondroitin Sulfate Proteoglycan 5	Protein Coding	2
44	B3GNT2	UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 2	Protein Coding	2
45	B4GAT1	Beta-1,4-Glucuronyltransferase 1	Protein Coding	2
46	SLC35D2	Solute Carrier Family 35 Member D2	Protein Coding	2
47	KERA	Keratocan	Protein Coding	2
48	B4GALT7	Beta-1,4-Galactosyltransferase 7	Protein Coding	2
49	GLB1L3	Galactosidase Beta 1 Like 3	Protein Coding	2
50	CHST14	Carbohydrate Sulfotransferase 14	Protein Coding	2
51	B3GALT6	Beta-1,3-Galactosyltransferase 6	Protein Coding	2
52	B3GAT2	Beta-1,3-Glucuronyltransferase 2	Protein Coding	2
53	VCAN	Versican	Protein Coding	2
54	NCAN	Neurocan	Protein Coding	2
55	CSPG4	Chondroitin Sulfate Proteoglycan 4	Protein Coding	2
56	CTSL	Cathepsin L	Protein Coding	2
57	DCN	Decorin	Protein Coding	2
58	CHST13	Carbohydrate Sulfotransferase 13	Protein Coding	2
59	ACAN	Aggrecan	Protein Coding	2
60	EXT1	Exostosin Glycosyltransferase 1	Protein Coding	2
61	EXT2	Exostosin Glycosyltransferase 2	Protein Coding	2
62	EXTL2	Exostosin Like Glycosyltransferase 2	Protein Coding	2
63	EXTL3	Exostosin Like Glycosyltransferase 3	Protein Coding	2
64	GPC2	Glypican 2	Protein Coding	2
65	HS3ST5	Heparan Sulfate-Glucosamine 3-Sulfotransferase 5	Protein Coding	2
66	GPC4	Glypican 4	Protein Coding	2
67	GPC5	Glypican 5	Protein Coding	2
68	CHSY1	Chondroitin Sulfate Synthase 1	Protein Coding	2
69	FMOD	Fibromodulin	Protein Coding	2
70	CHST5	Carbohydrate Sulfotransferase 5	Protein Coding	2
71	GLCE	Glucuronic Acid Epimerase	Protein Coding	2
72	B3GAT3	Beta-1,3-Glucuronyltransferase 3	Protein Coding	2
73	HS6ST3	Heparan Sulfate 6-O-Sulfotransferase 3	Protein Coding	2
74	B4GALT1	Beta-1,4-Galactosyltransferase 1	Protein Coding	2
75	B3GAT1	Beta-1,3-Glucuronyltransferase 1	Protein Coding	2
76	GPC3	Glypican 3	Protein Coding	2
77	GPC1	Glypican 1	Protein Coding	2
78	DSE	Dermatan Sulfate Epimerase	Protein Coding	2
79	HSPG2	Heparan Sulfate Proteoglycan 2	Protein Coding	2
80	NDST1	N-Deacetylase And N-Sulfotransferase 1	Protein Coding	2
81	CHSY3	Chondroitin Sulfate Synthase 3	Protein Coding	2
82	AGRN	Agrin	Protein Coding	2
83	LUM	Lumican	Protein Coding	2
84	CHST6	Carbohydrate Sulfotransferase 6	Protein Coding	2
85	OMD	Osteomodulin	Protein Coding	2
86	OGN	Osteoglycin	Protein Coding	2
87	CHST11	Carbohydrate Sulfotransferase 11	Protein Coding	2
88	CHST15	Carbohydrate Sulfotransferase 15	Protein Coding	2
89	CHPF2	Chondroitin Polymerizing Factor 2	Protein Coding	2
90	CSGALNACT2	Chondroitin Sulfate N-Acetylgalactosaminyltransferase 2	Protein Coding	2
91	PRELP	Proline And Arginine Rich End Leucine Rich Repeat Protein	Protein Coding	2
92	CHST12	Carbohydrate Sulfotransferase 12	Protein Coding	2
93	CSGALNACT1	Chondroitin Sulfate N-Acetylgalactosaminyltransferase 1	Protein Coding	2
94	CHST7	Carbohydrate Sulfotransferase 7	Protein Coding	2
95	BGN	Biglycan	Protein Coding	2
96	SDC1	Syndecan 1	Protein Coding	2
97	BCAN	Brevican	Protein Coding	2
98	SDC2	Syndecan 2	Protein Coding	2
99	SDC4	Syndecan 4	Protein Coding	2
100	XYLT1	Xylosyltransferase 1	Protein Coding	2
101	XYLT2	Xylosyltransferase 2	Protein Coding	2
102	NDST4	N-Deacetylase And N-Sulfotransferase 4	Protein Coding	2
103	HS3ST6	Heparan Sulfate-Glucosamine 3-Sulfotransferase 6	Protein Coding	2
104	ST3GAL1	ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 1	Protein Coding	2
105	ST3GAL2	ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 2	Protein Coding	2
106	ST3GAL4	ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 4	Protein Coding	2
107	ST3GAL3	ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 3	Protein Coding	2
108	B3GNT4	UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 4	Protein Coding	2
109	GLB1L	Galactosidase Beta 1 Like	Protein Coding	2
110	CHPF	Chondroitin Polymerizing Factor	Protein Coding	2
111	UXS1	UDP-Glucuronate Decarboxylase 1	Protein Coding	2
112	CHST9	Carbohydrate Sulfotransferase 9	Protein Coding	2
113	NDST2	N-Deacetylase And N-Sulfotransferase 2	Protein Coding	2
114	CHST1	Carbohydrate Sulfotransferase 1	Protein Coding	2
115	B4GALT4	Beta-1,4-Galactosyltransferase 4	Protein Coding	2
116	B4GALT3	Beta-1,4-Galactosyltransferase 3	Protein Coding	2
117	B4GALT2	Beta-1,4-Galactosyltransferase 2	Protein Coding	2
118	GLB1L2	Galactosidase Beta 1 Like 2	Protein Coding	2
119	HS6ST2	Heparan Sulfate 6-O-Sulfotransferase 2	Protein Coding	2
120	DSEL	Dermatan Sulfate Epimerase Like	Protein Coding	2
121	PXYLP1	2-Phosphoxylose Phosphatase 1	Protein Coding	2
122	B3GNT7	UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 7	Protein Coding	2
123	B4GALT6	Beta-1,4-Galactosyltransferase 6	Protein Coding	2
124	B4GALT5	Beta-1,4-Galactosyltransferase 5	Protein Coding	2
125	NDST3	N-Deacetylase And N-Sulfotransferase 3	Protein Coding	2
126	HS6ST1	Heparan Sulfate 6-O-Sulfotransferase 1	Protein Coding	2
127	CHST2	Carbohydrate Sulfotransferase 2	Protein Coding	2
128	CHST3	Carbohydrate Sulfotransferase 3	Protein Coding	2
129	HS2ST1	Heparan Sulfate 2-O-Sulfotransferase 1	Protein Coding	2
130	SDC3	Syndecan 3	Protein Coding	2
131	FAM20B	FAM20B Glycosaminoglycan Xylosylkinase	Protein Coding	2
132	HS3ST4	Heparan Sulfate-Glucosamine 3-Sulfotransferase 4	Protein Coding	2
133	HS3ST3B1	Heparan Sulfate-Glucosamine 3-Sulfotransferase 3B1	Protein Coding	2
134	HS3ST3A1	Heparan Sulfate-Glucosamine 3-Sulfotransferase 3A1	Protein Coding	2
135	HS3ST2	Heparan Sulfate-Glucosamine 3-Sulfotransferase 2	Protein Coding	2
136	HS3ST1	Heparan Sulfate-Glucosamine 3-Sulfotransferase 1	Protein Coding	2
137	GNPDA1	Glucosamine-6-Phosphate Deaminase 1	Protein Coding	1
138	B3GALT5	Beta-1,3-Galactosyltransferase 5	Protein Coding	1
139	AKR1A1	Aldo-Keto Reductase Family 1 Member A1	Protein Coding	1
140	FUT9	Fucosyltransferase 9	Protein Coding	1
141	NUP50	Nucleoporin 50	Protein Coding	1
142	NUP42	Nucleoporin 42	Protein Coding	1
143	B4GALNT2	Beta-1,4-N-Acetyl-Galactosaminyltransferase 2 (SID Blood Group)	Protein Coding	1
144	NUP35	Nucleoporin 35	Protein Coding	1
145	GALM	Galactose Mutarotase	Protein Coding	1
146	GLYCTK	Glycerate Kinase	Protein Coding	1
147	GNPDA2	Glucosamine-6-Phosphate Deaminase 2	Protein Coding	1
148	AGL	Amylo-Alpha-1,6-Glucosidase And 4-Alpha-Glucanotransferase	Protein Coding	1
149	ENO1	Enolase 1	Protein Coding	1
150	ENO2	Enolase 2	Protein Coding	1
151	ENO3	Enolase 3	Protein Coding	1
152	ALDH1A1	Aldehyde Dehydrogenase 1 Family Member A1	Protein Coding	1
153	SLC37A2	Solute Carrier Family 37 Member 2	Protein Coding	1
154	FBP1	Fructose-Bisphosphatase 1	Protein Coding	1
155	PRPS1L1	Phosphoribosyl Pyrophosphate Synthetase 1 Like 1	Protein Coding	1
156	ALDOA	Aldolase, Fructose-Bisphosphate A	Protein Coding	1
157	ALDOB	Aldolase, Fructose-Bisphosphate B	Protein Coding	1
158	RPIA	Ribose 5-Phosphate Isomerase A	Protein Coding	1
159	ALDOC	Aldolase, Fructose-Bisphosphate C	Protein Coding	1
160	AKR1B1	Aldo-Keto Reductase Family 1 Member B	Protein Coding	1
161	NUP205	Nucleoporin 205	Protein Coding	1
162	NUP210	Nucleoporin 210	Protein Coding	1
163	NUP160	Nucleoporin 160	Protein Coding	1
164	MAN2B2	Mannosidase Alpha Class 2B Member 2	Protein Coding	1
165	NUP188	Nucleoporin 188	Protein Coding	1
166	NUP62	Nucleoporin 62	Protein Coding	1
167	SHPK	Sedoheptulokinase	Protein Coding	1
168	FUT1	Fucosyltransferase 1 (H Blood Group)	Protein Coding	1
169	FUT2	Fucosyltransferase 2 (H Blood Group)	Protein Coding	1
170	FUT3	Fucosyltransferase 3 (Lewis Blood Group)	Protein Coding	1
171	FUT4	Fucosyltransferase 4	Protein Coding	1
172	FUT5	Fucosyltransferase 5	Protein Coding	1
173	FUT6	Fucosyltransferase 6	Protein Coding	1
174	FUT7	Fucosyltransferase 7	Protein Coding	1
175	G6PC1	Glucose-6-Phosphatase Catalytic Subunit 1	Protein Coding	1
176	G6PD	Glucose-6-Phosphate Dehydrogenase	Protein Coding	1
177	SLC37A4	Solute Carrier Family 37 Member 4	Protein Coding	1
178	GAA	Alpha Glucosidase	Protein Coding	1
179	PGLS	6-Phosphogluconolactonase	Protein Coding	1
180	GALE	UDP-Galactose-4-Epimerase	Protein Coding	1
181	GALK1	Galactokinase 1	Protein Coding	1
182	GALT	Galactose-1-Phosphate Uridylyltransferase	Protein Coding	1
183	GAPDH	Glyceraldehyde-3-Phosphate Dehydrogenase	Protein Coding	1
184	TKFC	Triokinase And FMN Cyclase	Protein Coding	1
185	GBE1	1,4-Alpha-Glucan Branching Enzyme 1	Protein Coding	1
186	GAPDHS	Glyceraldehyde-3-Phosphate Dehydrogenase, Spermatogenic	Protein Coding	1
187	GCK	Glucokinase	Protein Coding	1
188	GCKR	Glucokinase Regulator	Protein Coding	1
189	ABO	ABO, Alpha 1-3-N-Acetylgalactosaminyltransferase And Alpha 1-3-Galactosyltransferase	Protein Coding	1
190	GPI	Glucose-6-Phosphate Isomerase	Protein Coding	1
191	PGM2L1	Phosphoglucomutase 2 Like 1	Protein Coding	1
192	GYG1	Glycogenin 1	Protein Coding	1
193	GYS1	Glycogen Synthase 1	Protein Coding	1
194	GYS2	Glycogen Synthase 2	Protein Coding	1
195	ST6GALNAC6	ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 6	Protein Coding	1
196	HK1	Hexokinase 1	Protein Coding	1
197	HK2	Hexokinase 2	Protein Coding	1
198	HK3	Hexokinase 3	Protein Coding	1
199	NUP43	Nucleoporin 43	Protein Coding	1
200	NHLRC1	NHL Repeat Containing E3 Ubiquitin Protein Ligase 1	Protein Coding	1
201	KHK	Ketohexokinase	Protein Coding	1
202	ENO4	Enolase 4	Protein Coding	1
203	LALBA	Lactalbumin Alpha	Protein Coding	1
204	MAN2C1	Mannosidase Alpha Class 2C Member 1	Protein Coding	1
205	MAN2B1	Mannosidase Alpha Class 2B Member 1	Protein Coding	1
206	MANBA	Mannosidase Beta	Protein Coding	1
207	NUP88	Nucleoporin 88	Protein Coding	1
208	NUP98	Nucleoporin 98 And 96 Precursor	Protein Coding	1
209	PC	Pyruvate Carboxylase	Protein Coding	1
210	PCK1	Phosphoenolpyruvate Carboxykinase 1	Protein Coding	1
211	PCK2	Phosphoenolpyruvate Carboxykinase 2, Mitochondrial	Protein Coding	1
212	DERA	Deoxyribose-Phosphate Aldolase	Protein Coding	1
213	CRYL1	Crystallin Lambda 1	Protein Coding	1
214	DCXR	Dicarbonyl And L-Xylulose Reductase	Protein Coding	1
215	PFKFB1	6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 1	Protein Coding	1
216	PFKFB2	6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 2	Protein Coding	1
217	PFKFB3	6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3	Protein Coding	1
218	PFKFB4	6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 4	Protein Coding	1
219	PFKL	Phosphofructokinase, Liver Type	Protein Coding	1
220	PFKM	Phosphofructokinase, Muscle	Protein Coding	1
221	PFKP	Phosphofructokinase, Platelet	Protein Coding	1
222	PGAM1	Phosphoglycerate Mutase 1	Protein Coding	1
223	PGAM2	Phosphoglycerate Mutase 2	Protein Coding	1
224	PGD	Phosphogluconate Dehydrogenase	Protein Coding	1
225	PGK1	Phosphoglycerate Kinase 1	Protein Coding	1
226	PGK2	Phosphoglycerate Kinase 2	Protein Coding	1
227	PGM1	Phosphoglucomutase 1	Protein Coding	1
228	PHKA1	Phosphorylase Kinase Regulatory Subunit Alpha 1	Protein Coding	1
229	PHKA2	Phosphorylase Kinase Regulatory Subunit Alpha 2	Protein Coding	1
230	PHKB	Phosphorylase Kinase Regulatory Subunit Beta	Protein Coding	1
231	PHKG1	Phosphorylase Kinase Catalytic Subunit Gamma 1	Protein Coding	1
232	PHKG2	Phosphorylase Kinase Catalytic Subunit Gamma 2	Protein Coding	1
233	PKLR	Pyruvate Kinase L/R	Protein Coding	1
234	PKM	Pyruvate Kinase M1/2	Protein Coding	1
235	NUP54	Nucleoporin 54	Protein Coding	1
236	SLC37A1	Solute Carrier Family 37 Member 1	Protein Coding	1
237	PPP1R3C	Protein Phosphatase 1 Regulatory Subunit 3C	Protein Coding	1
238	PPP2CA	Protein Phosphatase 2 Catalytic Subunit Alpha	Protein Coding	1
239	PPP2CB	Protein Phosphatase 2 Catalytic Subunit Beta	Protein Coding	1
240	PPP2R1A	Protein Phosphatase 2 Scaffold Subunit Aalpha	Protein Coding	1
241	PPP2R1B	Protein Phosphatase 2 Scaffold Subunit Abeta	Protein Coding	1
242	PGM2	Phosphoglucomutase 2	Protein Coding	1
243	PPP2R5D	Protein Phosphatase 2 Regulatory Subunit B''Delta	Protein Coding	1
244	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	1
245	PRKACB	Protein Kinase CAMP-Activated Catalytic Subunit Beta	Protein Coding	1
246	PRKACG	Protein Kinase CAMP-Activated Catalytic Subunit Gamma	Protein Coding	1
247	NDC1	NDC1 Transmembrane Nucleoporin	Protein Coding	1
248	NUP133	Nucleoporin 133	Protein Coding	1
249	PRPS1	Phosphoribosyl Pyrophosphate Synthetase 1	Protein Coding	1
250	PRPS2	Phosphoribosyl Pyrophosphate Synthetase 2	Protein Coding	1
251	NUP107	Nucleoporin 107	Protein Coding	1
252	G6PC2	Glucose-6-Phosphatase Catalytic Subunit 2	Protein Coding	1
253	PYGB	Glycogen Phosphorylase B	Protein Coding	1
254	PYGL	Glycogen Phosphorylase L	Protein Coding	1
255	PYGM	Glycogen Phosphorylase, Muscle Associated	Protein Coding	1
256	RANBP2	RAN Binding Protein 2	Protein Coding	1
257	RHCE	Rh Blood Group CcEe Antigens	Protein Coding	1
258	RHD	Rh Blood Group D Antigen	Protein Coding	1
259	RPE	Ribulose-5-Phosphate-3-Epimerase	Protein Coding	1
260	RPS27A	Ribosomal Protein S27a	Protein Coding	1
261	SEC13	SEC13 Homolog, Nuclear Pore And COPII Component	Protein Coding	1
262	RBKS	Ribokinase	Protein Coding	1
263	SLC2A1	Solute Carrier Family 2 Member 1	Protein Coding	1
264	SORD	Sorbitol Dehydrogenase	Protein Coding	1
265	BPGM	Bisphosphoglycerate Mutase	Protein Coding	1
266	TALDO1	Transaldolase 1	Protein Coding	1
267	TKT	Transketolase	Protein Coding	1
268	TPI1	Triosephosphate Isomerase 1	Protein Coding	1
269	TPR	Translocated Promoter Region, Nuclear Basket Protein	Protein Coding	1
270	RPEL1	Ribulose-5-Phosphate-3-Epimerase Like 1	Protein Coding	1
271	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	1
272	UBB	Ubiquitin B	Protein Coding	1
273	UBC	Ubiquitin C	Protein Coding	1
274	UGP2	UDP-Glucose Pyrophosphorylase 2	Protein Coding	1
275	NUP37	Nucleoporin 37	Protein Coding	1
276	EPM2A	EPM2A Glucan Phosphatase, Laforin	Protein Coding	1
277	NUP85	Nucleoporin 85	Protein Coding	1
278	CALM1	Calmodulin 1	Protein Coding	1
279	HKDC1	Hexokinase Domain Containing 1	Protein Coding	1
280	NUP214	Nucleoporin 214	Protein Coding	1
281	CALM2	Calmodulin 2	Protein Coding	1
282	CALM3	Calmodulin 3	Protein Coding	1
283	AAAS	Aladin WD Repeat Nucleoporin	Protein Coding	1
284	SEH1L	SEH1 Like Nucleoporin	Protein Coding	1
285	ADPGK	ADP Dependent Glucokinase	Protein Coding	1
286	AKR1E2	Aldo-Keto Reductase Family 1 Member E2	Protein Coding	1
287	RAE1	Ribonucleic Acid Export 1	Protein Coding	1
288	B3GALT4	Beta-1,3-Galactosyltransferase 4	Protein Coding	1
289	B3GALT2	Beta-1,3-Galactosyltransferase 2	Protein Coding	1
290	B3GALT1	Beta-1,3-Galactosyltransferase 1	Protein Coding	1
291	FBP2	Fructose-Bisphosphatase 2	Protein Coding	1
292	GYG2	Glycogenin 2	Protein Coding	1
293	G6PC3	Glucose-6-Phosphatase Catalytic Subunit 3	Protein Coding	1
294	NUP155	Nucleoporin 155	Protein Coding	1
295	NUP93	Nucleoporin 93	Protein Coding	1
296	NUP58	Nucleoporin 58	Protein Coding	1
297	POM121	POM121 Transmembrane Nucleoporin	Protein Coding	1
298	XYLB	Xylulokinase	Protein Coding	1
299	NUP153	Nucleoporin 153	Protein Coding	1

Disorders associated with Glycosaminoglycan metabolism SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Mucopolysaccharidosis-plus syndrome	Direct
2	Achondrogenesis, type ib	Direct
3	Diastrophic dysplasia	Direct
4	Atelosteogenesis	Direct
5	Mucopolysaccharidosis iii	Direct
6	Mucopolysaccharidosis, type vi	Direct
7	Mucopolysaccharidosis iv	Direct
8	Glycogen storage disease	Enrichment	AGL, G6PC1, GAA, GBE1, GYG1, GYS1, GYS2, PFKM, PYGM, SLC37A4	10.65
9	Spondyloepiphyseal dysplasia with congenital joint dislocations	Enrichment	ACAN, B3GALT6, B3GAT3, B4GALT7, CHST3, GLB1	10.52
10	Multiple joint dislocations, short stature, and craniofacial dysmorphism with or without congenital heart defects	Enrichment	B3GAT3, B4GALT7, CHST3	6.01
11	Larsen-like syndrome b3gat3 type	Enrichment	B3GAT3, B4GALT7, CHST3	6.01
12	Phosphorylase kinase deficiency	Enrichment	PHKA1, PHKA2, PHKB, PHKG2	5.94
13	Genetic steroid-resistant nephrotic syndrome	Enrichment	NUP107, NUP133, NUP160, NUP205, NUP37, NUP85, NUP93	5.12
14	Mucopolysaccharidosis, type iva	Enrichment	GALNS, IDUA	4.83
15	Mucopolysaccharidosis, type iiia	Enrichment	IDS, SGSH, SLC26A11	4.71
16	Glycogen storage disease ia	Enrichment	G6PC1, GAA, SLC37A4	4.38
17	Exostoses, multiple, type i	Enrichment	EXT1, EXT2	4.00
18	Nephrolithiasis, calcium oxalate, 1	Enrichment	IDUA, SLC26A1	4.00
19	Hurler-scheie syndrome	Enrichment	IDUA, SLC26A1	4.00
20	Scheie syndrome	Enrichment	IDUA, SLC26A1	4.00
21	Ehlers-danlos syndrome, spondylodysplastic type, 2	Enrichment	B3GALT6, B4GALT7	4.00
22	Hypersulfaturia	Enrichment	IDUA, SLC26A1	4.00
23	Calcium oxalate nephrolithiasis	Enrichment	IDUA, SLC26A1	4.00
24	Simpson-golabi-behmel syndrome, type 1	Enrichment	GPC3, GPC4	3.53
25	Hurler syndrome	Enrichment	IDUA, SLC26A1	3.53
26	Musculocontractural ehlers-danlos syndrome	Enrichment	CHST14, DSE	3.53
27	Bombay phenotype	Enrichment	FUT1, FUT2	3.31
28	Glycogen storage disease due to liver phosphorylase kinase deficiency	Enrichment	PHKA2, PHKG2	3.31
29	Atelosteogenesis, type ii	Enrichment	SLC26A2	3.29
30	Brachyolmia type 4 with mild epiphyseal and metaphyseal changes	Enrichment	PAPSS2	3.29
31	Epiphyseal dysplasia, multiple, 4	Enrichment	SLC26A2	3.29
32	Leukodystrophy, hypomyelinating, 26, with chondrodysplasia	Enrichment	SLC35B2	3.29
33	Brachyolmia	Enrichment	PAPSS2	3.29
34	Autosomal recessive brachyolmia	Enrichment	PAPSS2	3.29
35	Primary bone dysplasia with multiple joint dislocations	Enrichment	SLC35B2	3.29
36	Catecholaminergic polymorphic ventricular tachycardia	Enrichment	CALM1, CALM2, CALM3	3.26
37	3mc syndrome 2	Enrichment	SLC26A2	2.99
38	Lichtenstein-knorr syndrome	Enrichment	SLC9A1	2.93
39	Sandhoff disease	Enrichment	HEXB	2.93
40	Mucopolysaccharidosis, type ix	Enrichment	HYAL1	2.93
41	Spastic ataxia 9, autosomal recessive	Enrichment	CHP1	2.93
42	Muggenthaler-chowdhury-chioza syndrome	Enrichment	HYAL2	2.93
43	Cleft lip and palate-craniofacial dysmorphism-congenital heart defect-hearing loss syndrome	Enrichment	HYAL2	2.93
44	Hyal2 deficiency	Enrichment	HYAL2	2.93
45	Mucopolysaccharidosis, type iiid	Enrichment	GNS	2.90
46	Glb1-related disorders	Enrichment	GLB1	2.90
47	Glycogen storage disease iv	Enrichment	GAA, GBE1	2.84
48	Glycogen storage disease ixd	Enrichment	PHKA1, PHKG1	2.84
49	Hemolytic disease of fetus and newborn, rh-induced	Enrichment	RHCE, RHD	2.84
50	Phosphoenolpyruvate carboxykinase deficiency	Enrichment	PCK1, PCK2	2.84
51	Desbuquois dysplasia 1	Enrichment	CSGALNACT1, XYLT1	2.84
52	Pseudoxanthoma elasticum	Enrichment	XYLT1, XYLT2	2.84
53	Mucopolysaccharidosis, type vii	Enrichment	GUSB	2.63
54	Gm2-gangliosidosis, ab variant	Enrichment	HEXA	2.63
55	Auroneurodental syndrome	Enrichment	HYAL3	2.63
56	Mucopolysaccharidosis, type iiic	Enrichment	HGSNAT	2.60
57	Urofacial syndrome 1	Enrichment	HPSE2	2.60
58	Mucopolysaccharidosis, type iiib	Enrichment	NAGLU	2.60
59	Retinitis pigmentosa 73	Enrichment	HGSNAT	2.60
60	Charcot-marie-tooth disease, axonal, type 2v	Enrichment	NAGLU	2.60
61	Myoclonic epilepsy of lafora 1	Enrichment	EPM2A, NHLRC1	2.55
62	Familial infantile bilateral striatal necrosis	Enrichment	NUP54, NUP62	2.55
63	Tay-sachs disease	Enrichment	HEXA	2.45
64	Gm1-gangliosidosis, type i	Enrichment	GLB1	2.43
65	Mucopolysaccharidosis, type ivb	Enrichment	GLB1	2.43
66	Gm1-gangliosidosis, type ii	Enrichment	GLB1	2.43
67	Mucopolysaccharidosis, type ii	Enrichment	IDS	2.43
68	Gm1-gangliosidosis, type iii	Enrichment	GLB1	2.43
69	Gm1 gangliosidosis	Enrichment	GLB1	2.43
70	Mucopolysaccharidosis with skin involvement	Enrichment	IDS	2.43
71	Infantile sialic acid storage disease	Enrichment	SLC17A5	2.33
72	Salla disease	Enrichment	SLC17A5	2.33
73	Osteochondrodysplasia	Enrichment	GALNS, SLC26A2	2.29
74	Free sialic acid storage disorder	Enrichment	SLC17A5	2.23
75	Gitelman syndrome	Enrichment	IDUA	2.20
76	Metachromatic leukodystrophy	Enrichment	ARSB	2.13
77	Diarrhea	Enrichment	SGSH	2.13
78	Hypertrichosis	Enrichment	NAGLU	2.13
79	Progressive familial intrahepatic cholestasis	Enrichment	GLB1	2.06
80	Hemolytic anemia	Enrichment	GPI, PKLR	2.02
81	Short stature and advanced bone age with or without early-onset osteoarthritis and/or osteochondritis dissecans	Enrichment	ACAN	2.00
82	Macular dystrophy, corneal	Enrichment	CHST6	2.00
83	Chondrosarcoma	Enrichment	EXT1	2.00
84	Congenital disorder of glycosylation, type iid	Enrichment	B4GALT1	2.00
85	Al-gazali syndrome	Enrichment	B3GALT6	2.00
86	Intellectual developmental disorder, autosomal recessive 12	Enrichment	ST3GAL3	2.00
87	Ehlers-danlos syndrome, musculocontractural type, 2	Enrichment	DSE	2.00
88	Ehlers-danlos syndrome, spondylodysplastic type, 1	Enrichment	B4GALT7	2.00
89	Muscular dystrophy-dystroglycanopathy , type a, 13	Enrichment	B4GAT1	2.00
90	Cornea plana 2, autosomal recessive	Enrichment	KERA	2.00
91	Neurofacioskeletal syndrome with or without renal agenesis	Enrichment	HS2ST1	2.00
92	Spondyloepimetaphyseal dysplasia with joint laxity, type 1, with or without fractures	Enrichment	B3GALT6	2.00
93	Intellectual developmental disorder, autosomal recessive 46	Enrichment	NDST1	2.00
94	Angioedema, hereditary, 8	Enrichment	HS3ST6	2.00
95	Keipert syndrome	Enrichment	GPC4	2.00
96	Immunoskeletal dysplasia with neurodevelopmental abnormalities	Enrichment	EXTL3	2.00
97	Meester-loeys syndrome	Enrichment	BGN	2.00
98	Paganini-miozzo syndrome	Enrichment	HS6ST2	2.00
99	Spondyloepimetaphyseal dysplasia, aggrecan type	Enrichment	ACAN	2.00
100	Spondyloocular syndrome	Enrichment	XYLT2	2.00
101	Spondyloepiphyseal dysplasia, kimberley type	Enrichment	ACAN	2.00
102	Osteochondrodysplasia, brachydactyly, and overlapping malformed digits	Enrichment	CHST11	2.00
103	Hypogonadotropic hypogonadism 15 with or without anosmia	Enrichment	HS6ST1	2.00
104	Hereditary multiple osteochondromas	Enrichment	EXT1	2.00
105	Skeletal dysplasia, mild, with joint laxity and advanced bone age	Enrichment	CSGALNACT1	2.00
106	Combined low ldl and fibrinogen	Enrichment	B4GALT1	2.00
107	Exostosis	Enrichment	EXT1	2.00
108	Arteriosclerosis	Enrichment	HS3ST1	2.00
109	Spondylodysplastic ehlers-danlos syndrome	Enrichment	B4GALT7	2.00
110	Spondyloepimetaphyseal dysplasia with joint laxity	Enrichment	B3GALT6	2.00
111	Osteochondritis dissecans	Enrichment	ACAN	2.00
112	Hereditary multiple exostoses	Enrichment	EXT1	2.00
113	Xylt1-congenital disorder of glycosylation	Enrichment	XYLT1	2.00
114	Skeletal dysplasia-t-cell immunodeficiency-developmental delay syndrome	Enrichment	EXTL3	2.00
115	St3gal3-cdg	Enrichment	ST3GAL3	2.00
116	Short stature-advanced bone age-early-onset osteoarthritis syndrome	Enrichment	ACAN	2.00
117	Primary bone dysplasia	Enrichment	GALNS	1.90
118	Ellis-van creveld syndrome	Enrichment	PRKACA, PRKACB	1.80
119	Connective tissue disease	Enrichment	SLC26A2	1.79
120	Galloway-mowat syndrome	Enrichment	NUP107, NUP133	1.71
121	Exostoses, multiple, type ii	Enrichment	EXT2	1.70
122	Wagner vitreoretinopathy	Enrichment	VCAN	1.70
123	Spondyloepimetaphyseal dysplasia, x-linked	Enrichment	BGN	1.70
124	Omodysplasia 1	Enrichment	GPC6	1.70
125	Ehlers-danlos syndrome, musculocontractural type, 1	Enrichment	CHST14	1.70
126	Corneal dystrophy, congenital stromal	Enrichment	DCN	1.70
127	Schwartz-jampel syndrome, type 1	Enrichment	HSPG2	1.70
128	Deafness, autosomal dominant 64	Enrichment	B3GNT4	1.70
129	Developmental and epileptic encephalopathy 15	Enrichment	ST3GAL3	1.70
130	Seizures, scoliosis, and macrocephaly/microcephaly syndrome	Enrichment	EXT2	1.70
131	Temtamy preaxial brachydactyly syndrome	Enrichment	CHSY1	1.70
132	Wagner disease	Enrichment	VCAN	1.70
133	Adenosine triphosphate, elevated, of erythrocytes	Enrichment	PKLR	1.66
134	Blood group, rh system	Enrichment	RHD	1.66
135	Erythrocytosis, familial, 8	Enrichment	BPGM	1.66
136	Glycogen storage disease vi	Enrichment	PYGL	1.66
137	Glycoprotein storage disease	Enrichment	GAA	1.66
138	Glycogen storage disease v	Enrichment	PYGM	1.66
139	D-glyceric aciduria	Enrichment	GLYCTK	1.66
140	Anemia, congenital, nonspherocytic hemolytic, 5	Enrichment	HK1	1.66
141	Anemia, congenital, nonspherocytic hemolytic, 2	Enrichment	PKLR	1.66
142	Charcot-marie-tooth disease, x-linked recessive, 5	Enrichment	PRPS1	1.66
143	Phosphoenolpyruvate carboxykinase deficiency, cytosolic	Enrichment	PCK1	1.66
144	Fructose-1,6-bisphosphatase deficiency	Enrichment	FBP1	1.66
145	Phosphoglycerate kinase 1 deficiency	Enrichment	PGK1	1.66
146	Arts syndrome	Enrichment	PRPS1	1.66
147	Polyglucosan body neuropathy, adult form	Enrichment	GBE1	1.66
148	Stomatin-deficient cryohydrocytosis with neurologic defects	Enrichment	SLC2A1	1.66
149	Glycogen storage disease xiii	Enrichment	ENO3	1.66
150	Glycogen storage disease ixc	Enrichment	PHKG2	1.66
151	Maturity-onset diabetes of the young, type 2	Enrichment	GCK	1.66
152	Glycogen storage disease ic	Enrichment	SLC37A4	1.66
153	Glycogen storage disease ib	Enrichment	SLC37A4	1.66
154	Fructosuria, essential	Enrichment	KHK	1.66
155	Galactosemia iii	Enrichment	GALE	1.66
156	Short stature, developmental delay, and congenital heart defects	Enrichment	TKT	1.66
157	Triosephosphate isomerase deficiency	Enrichment	TPI1	1.66
158	Fucosyltransferase 6 deficiency	Enrichment	FUT6	1.66
159	Blood group, sid system	Enrichment	B4GALNT2	1.66
160	Retinitis pigmentosa 79	Enrichment	HK1	1.66
161	Fetal akinesia deformation sequence 4	Enrichment	NUP88	1.66
162	Neurodevelopmental disorder with achalasia, polyneuropathy, and alacrima	Enrichment	NDC1	1.66
163	Atrial fibrillation, familial, 15	Enrichment	NUP155	1.66
164	Sedoheptulokinase deficiency	Enrichment	SHPK	1.66
165	Congenital disorder of glycosylation, type iiw	Enrichment	SLC37A4	1.66
166	Dystonia 37, early-onset, with striatal lesions	Enrichment	NUP54	1.66
167	Nephrotic syndrome, type 19	Enrichment	NUP160	1.66
168	Myoclonic epilepsy of lafora 2	Enrichment	NHLRC1	1.66
169	Neurodevelopmental disorder with hypotonia, dysmorphic facies, and skin abnormalities	Enrichment	PGM2L1	1.66
170	Blood group, lewis system	Enrichment	FUT3	1.66
171	Phosphoribosylpyrophosphate synthetase superactivity	Enrichment	PRPS1	1.66
172	Deafness, x-linked 1	Enrichment	PRPS1	1.66
173	Galloway-mowat syndrome 8	Enrichment	NUP133	1.66
174	Galactosemia iv	Enrichment	GALM	1.66
175	Cardioacrofacial dysplasia 2	Enrichment	PRKACB	1.66
176	Nephrotic syndrome, type 13	Enrichment	NUP205	1.66
177	Leukodystrophy, childhood-onset, remitting	Enrichment	FBP2	1.66
178	Pentosuria	Enrichment	DCXR	1.66
179	Ribose 5-phosphate isomerase deficiency	Enrichment	RPIA	1.66
180	Houge-janssens syndrome 2	Enrichment	PPP2R1A	1.66
181	Hyperinsulinemic hypoglycemia, familial, 3	Enrichment	GCK	1.66
182	Neuropathy, hereditary motor and sensory, russe type	Enrichment	HK1	1.66
183	Microcephaly 24, primary, autosomal recessive	Enrichment	NUP37	1.66
184	Galloway-mowat syndrome 7	Enrichment	NUP107	1.66
185	Neurodevelopmental disorder with visual defects and brain anomalies	Enrichment	HK1	1.66
186	Epilepsy, idiopathic generalized 12	Enrichment	SLC2A1	1.66
187	Long qt syndrome 16	Enrichment	CALM3	1.66
188	Neuronopathy, distal hereditary motor, autosomal recessive 8	Enrichment	SORD	1.66
189	Nephrotic syndrome, type 12	Enrichment	NUP93	1.66
190	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	1.66
191	Anemia, congenital, nonspherocytic hemolytic, 4	Enrichment	GPI	1.66
192	Fasting plasma glucose level quantitative trait locus 5	Enrichment	GCKR	1.66
193	Nephrotic syndrome, type 11	Enrichment	NUP107	1.66
194	Adult polyglucosan body disease	Enrichment	GBE1	1.66
195	Triokinase and fmn cyclase deficiency syndrome	Enrichment	TKFC	1.66
196	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	1.66
197	Encephalopathy, acute, infection-induced 9	Enrichment	NUP214	1.66
198	Sandestig-stefanova syndrome	Enrichment	NUP188	1.66
199	Rh-null, amorph type	Enrichment	RHCE	1.66
200	Ovarian dysgenesis 6	Enrichment	NUP107	1.66
201	Intellectual developmental disorder, autosomal recessive 79	Enrichment	TPR	1.66
202	Nephrotic syndrome, type 18	Enrichment	NUP133	1.66
203	Developmental and epileptic encephalopathy 83	Enrichment	UGP2	1.66
204	Man2b2-cdg	Enrichment	MAN2B2	1.66
205	Long qt syndrome 15	Enrichment	CALM2	1.66
206	Thrombocytopenia 13, syndromic	Enrichment	GALE	1.66
207	Gestational diabetes	Enrichment	GCK	1.66
208	Congenital disorder of glycosylation type 1ee with or without immunodeficiency	Enrichment	MAN2B2	1.66
209	Congenital nonspherocytic hemolytic anemia	Enrichment	G6PD	1.66
210	Pompe disease, late-onset	Enrichment	GAA	1.66
211	Glycogen storage disease due to glucose-6-phosphatase deficiency type ib	Enrichment	SLC37A4	1.66
212	Autosomal recessive secondary polycythemia not associated with vhl gene	Enrichment	BPGM	1.66
213	Inherited metabolic disorder	Enrichment	TKFC	1.66
214	Epilepsy with myoclonic absences	Enrichment	SLC2A1	1.66
215	Familial acute necrotizing encephalopathy	Enrichment	RANBP2	1.66
216	Glycogen storage disease type 1 due to slc37a4 mutation	Enrichment	SLC37A4	1.66
217	X-linked intellectual disability-limb spasticity-retinal dystrophy-diabetes insipidus syndrome	Enrichment	PRPS1	1.66
218	Ppp2r1a-related neurodevelopmental disorder	Enrichment	PPP2R1A	1.66
219	Male infertility due to obstructive azoospermia	Enrichment	PGK1	1.66
220	Hereditary cryohydrocytosis with reduced stomatin	Enrichment	SLC2A1	1.66
221	Leukodystrophy	Enrichment	HEXA	1.63
222	Long qt syndrome 1	Enrichment	CALM1, CALM2, CALM3	1.56
223	Larsen syndrome	Enrichment	CHST3	1.53
224	Dyssegmental dysplasia, silverman-handmaker type	Enrichment	HSPG2	1.53
225	Sudden infant death with dysgenesis of the testes syndrome	Enrichment	DSE	1.53
226	Desbuquois dysplasia 2	Enrichment	XYLT1	1.53
227	Congenital cornea plana	Enrichment	KERA	1.53
228	Hydrops fetalis, nonimmune	Enrichment	GUSB	1.52
229	Non-immune hydrops fetalis	Enrichment	GUSB	1.44
230	Trichorhinophalangeal syndrome, type ii	Enrichment	EXT1	1.40
231	Potocki-shaffer syndrome	Enrichment	EXT2	1.40
232	Coronary artery anomaly	Enrichment	HS3ST1	1.40
233	Hereditary angioedema with normal c1inh not related to f12 or plg variant	Enrichment	HS3ST6	1.40
234	Cakut	Enrichment	HPSE2	1.38
235	Maturity-onset diabetes of the young, type 1	Enrichment	GCK	1.36
236	Glycogen storage disease 0, liver	Enrichment	GYS2	1.36
237	Galactosemia ii	Enrichment	GALK1	1.36
238	Fructose intolerance, hereditary	Enrichment	ALDOB	1.36
239	Phosphoenolpyruvate carboxykinase deficiency, mitochondrial	Enrichment	PCK2	1.36
240	Glycogen storage disease vii	Enrichment	PFKM	1.36
241	Camptodactyly-arthropathy-coxa vara-pericarditis syndrome	Enrichment	TPR	1.36
242	Striatonigral degeneration, infantile	Enrichment	NUP62	1.36
243	Glycogen storage disease ixa1	Enrichment	PHKA2	1.36
244	Galactosemia i	Enrichment	GALT	1.36
245	Dystonia 9	Enrichment	SLC2A1	1.36
246	Glut1 deficiency syndrome 1	Enrichment	SLC2A1	1.36
247	Ventricular tachycardia, catecholaminergic polymorphic, 4	Enrichment	CALM1	1.36
248	Osteogenesis imperfecta, type xv	Enrichment	GBE1	1.36
249	Diabetes mellitus, permanent neonatal, 1	Enrichment	GCK	1.36
250	Bone marrow failure syndrome 2	Enrichment	GCK	1.36
251	Glycogen storage disease xv	Enrichment	GYG1	1.36
252	Neutropenia, severe congenital, 4, autosomal recessive	Enrichment	G6PC3	1.36
253	Vitamin b12 plasma level quantitative trait locus 1	Enrichment	FUT2	1.36
254	Bleeding disorder, platelet-type, 19	Enrichment	PRKACG	1.36
255	Congenital disorder of glycosylation, type it	Enrichment	PGM1	1.36
256	Glycogen storage disease iii	Enrichment	AGL	1.36
257	Polyglucosan body myopathy 2	Enrichment	GYG1	1.36
258	Long qt syndrome 14	Enrichment	CALM1	1.36
259	Houge-janssens syndrome 1	Enrichment	PPP2R5D	1.36
260	Epidermolysis bullosa, junctional 5a, intermediate	Enrichment	GALK1	1.36
261	Congenital disorder of deglycosylation 2	Enrichment	MAN2C1	1.36
262	Microcephaly 21, primary, autosomal recessive	Enrichment	GAPDH	1.36
263	Nephrotic syndrome, type 17	Enrichment	NUP85	1.36
264	Glucose transporter type 1 deficiency syndrome	Enrichment	SLC2A1	1.36
265	Glycogen storage disease 0, muscle	Enrichment	GYS1	1.36
266	Glycogen storage disease xii	Enrichment	ALDOA	1.36
267	Transaldolase deficiency	Enrichment	TALDO1	1.36
268	Fibrolamellar carcinoma	Enrichment	PRKACA	1.36
269	Congenital hemolytic anemia	Enrichment	G6PD	1.36
270	Glucosephosphate dehydrogenase deficiency	Enrichment	G6PD	1.36
271	Glycogen storage disorder due to hepatic glycogen synthase deficiency	Enrichment	GYS2	1.36
272	Houge-janssens syndrome 3	Enrichment	PPP2CA	1.36
273	Severe congenital neutropenia 4	Enrichment	G6PC3	1.36
274	Galactosemia	Enrichment	GALT	1.36
275	Acute myeloid leukemia with t(6;9) (p23;q34.1)	Enrichment	NUP214	1.36
276	Glycogen storage disease due to muscle and heart glycogen synthase deficiency	Enrichment	GYS1	1.36
277	Glycogen storage disease viii	Enrichment	PHKA2	1.36
278	Acute necrotizing encephalopathy of childhood	Enrichment	RANBP2	1.36
279	Submucosal cleft palate	Enrichment	UBB	1.36
280	Cleft hard palate	Enrichment	UBB	1.36
281	Muscular dystrophy-dystroglycanopathy , type a, 1	Enrichment	B4GAT1	1.31
282	Variegate porphyria	Enrichment	B4GALT3	1.31
283	Myasthenic syndrome, congenital, 8	Enrichment	AGRN	1.31
284	Hereditary retinal dystrophy	Enrichment	HGSNAT, SGSH	1.30
285	Fundus dystrophy	Enrichment	HGSNAT, SGSH	1.30
286	Charcot-marie-tooth disease	Enrichment	NAGLU	1.30
287	Congenital disorder of glycosylation, type in	Enrichment	PGM1, SLC37A4	1.28
288	Spastic ataxia	Enrichment	GLB1	1.19
289	Mannosidosis, beta a, lysosomal	Enrichment	MANBA	1.19
290	Nijmegen breakage syndrome	Enrichment	GCK	1.19
291	Sengers syndrome	Enrichment	TKFC	1.19
292	Glycogen storage disease ixb	Enrichment	PHKB	1.19
293	Pompe disease, infantile-onset	Enrichment	GAA	1.19
294	Pyruvate carboxylase deficiency	Enrichment	PC	1.19
295	Uvula, bifid	Enrichment	UBB	1.19
296	Methylmalonic aciduria due to methylmalonyl-coa mutase deficiency	Enrichment	MAN2B1	1.19
297	Glut1 deficiency syndrome 2	Enrichment	SLC2A1	1.19
298	Cleft soft palate	Enrichment	UBB	1.19
299	Ectodermal dysplasia 11b, hypohidrotic/hair/tooth type, autosomal recessive	Enrichment	RANBP2	1.19
300	Retinitis pigmentosa 92	Enrichment	HKDC1	1.19
301	Cutis laxa, autosomal recessive, type ib	Enrichment	GBE1	1.19
302	Chromosome 17q23.1-q23.2 deletion syndrome	Enrichment	SLC2A1	1.19
303	Craniosynostosis	Enrichment	GPC4, MAN2B1	1.15
304	Ovarian cancer	Enrichment	EXT1, EXT2, HMMR	1.09
305	Breast cancer	Enrichment	HMMR	1.07
306	Ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive	Enrichment	RANBP2	1.07
307	Achalasia-addisonianism-alacrima syndrome	Enrichment	AAAS	1.07
308	Aland island eye disease	Enrichment	PHKA2	1.07
309	Maturity-onset diabetes of the young, type 3	Enrichment	GCK	1.07
310	Glycogen storage disease x	Enrichment	PGAM2	1.07
311	Ectodermal dysplasia	Enrichment	RANBP2	1.07
312	Rare x-linked non-syndromic sensorineural deafness type dfn	Enrichment	PRPS1	1.07
313	Stickler syndrome	Enrichment	VCAN	1.02
314	Presynaptic congenital myasthenic syndromes	Enrichment	AGRN	0.98
315	Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant	Enrichment	RANBP2	0.98
316	Epidermolysis bullosa simplex 1c, localized	Enrichment	GALK1	0.98
317	Mannosidosis, alpha b, lysosomal	Enrichment	MAN2B1	0.98
318	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	G6PD	0.98
319	Hypoglycemia	Enrichment	G6PC1	0.98
320	Autosomal recessive hypohidrotic ectodermal dysplasia syndrome	Enrichment	RANBP2	0.98
321	Postsynaptic congenital myasthenic syndromes	Enrichment	AGRN	0.94
322	Chromosome 1p36 deletion syndrome	Enrichment	HSPG2	0.91
323	Hyperinsulinemic hypoglycemia, familial, 1	Enrichment	GCK	0.90
324	Epidermolysis bullosa, junctional 1a, intermediate	Enrichment	GALK1	0.90
325	Epidermolysis bullosa, junctional 5b, with pyloric atresia	Enrichment	GALK1	0.90
326	Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy	Enrichment	CALM1	0.90
327	Inflammatory myofibroblastic tumor	Enrichment	RANBP2	0.90
328	Junctional epidermolysis bullosa non-herlitz type	Enrichment	GALK1	0.90
329	Hereditary spherocytosis	Enrichment	GPI	0.90
330	Nonsyndromic genetic hyperinsulinism	Enrichment	GCK	0.90
331	Walker-warburg syndrome	Enrichment	B4GAT1	0.88
332	Congenital myasthenic syndrome	Enrichment	AGRN	0.88
333	Wilms tumor 1	Enrichment	GPC3	0.85
334	Mitochondrial dna depletion syndrome 4a	Enrichment	RANBP2	0.84
335	Neutropenia	Enrichment	SLC37A4	0.84
336	Epidermolysis bullosa simplex	Enrichment	GALK1	0.84
337	Paroxysmal dystonia	Enrichment	SLC2A1	0.84
338	Long qt syndrome	Enrichment	CALM1, CALM2	0.83
339	Mitochondrial dna depletion syndrome 4b	Enrichment	RANBP2	0.79
340	Alternating hemiplegia of childhood	Enrichment	SLC2A1	0.79
341	Catecholaminergic polymorphic ventricular tachycardia 1	Enrichment	CALM1	0.79
342	Permanent neonatal diabetes mellitus	Enrichment	GCK	0.79
343	Normosmic congenital hypogonadotropic hypogonadism	Enrichment	HS6ST1	0.78
344	Orofacial cleft 1	Enrichment	HKDC1	0.74
345	Coronary heart disease 5	Enrichment	G6PD	0.74
346	Myoclonic-atonic epilepsy	Enrichment	SLC2A1	0.74
347	Junctional epidermolysis bullosa	Enrichment	GALK1	0.74
348	Hepatoblastoma	Enrichment	EXT2	0.72
349	Fetal akinesia deformation sequence 1	Enrichment	GBE1, NUP88	0.71
350	Progressive myoclonus epilepsy	Enrichment	EPM2A	0.70
351	Kallmann syndrome	Enrichment	HS6ST1	0.68
352	Immune deficiency disease	Enrichment	SLC37A4	0.66
353	Diabetes mellitus	Enrichment	GCK	0.66
354	Benign epilepsy with centrotemporal spikes	Enrichment	EPM2A, SLC2A1	0.64
355	46 xx gonadal dysgenesis	Enrichment	NUP107	0.63
356	Retinitis pigmentosa	Enrichment	HGSNAT	0.63
357	Centralopathic epilepsy	Enrichment	EPM2A, SLC2A1	0.61
358	Myoclonic epilepsy of unverricht and lundborg	Enrichment	EPM2A	0.57
359	Seckel syndrome	Enrichment	NUP85	0.57
360	Complex neurodevelopmental disorder	Enrichment	HS2ST1, MAN2C1, PGM2L1, PPP2CA	0.53
361	Creatine phosphokinase, elevated serum	Enrichment	GAA	0.52
362	Isolated elevated serum creatine phosphokinase levels	Enrichment	GAA	0.52
363	Developmental and epileptic encephalopathy	Enrichment	ST3GAL3	0.52
364	Sudden infant death syndrome	Enrichment	CALM2	0.50
365	Neuromuscular disease	Enrichment	SORD	0.48
366	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	BGN	0.45
367	Maturity-onset diabetes of the young	Enrichment	GCK	0.44
368	Focal segmental glomerulosclerosis	Enrichment	NUP93	0.44
369	Autosomal recessive non-syndromic intellectual disability	Enrichment	NDST1, TPR	0.44
370	Tooth agenesis	Enrichment	RANBP2	0.41
371	Body mass index quantitative trait locus 11	Enrichment	SDC3	0.40
372	Malaria	Enrichment	G6PD	0.40
373	Precursor t-cell acute lymphoblastic leukemia	Enrichment	NUP214	0.40
374	Familial atrial fibrillation	Enrichment	NUP155	0.38
375	Developmental and epileptic encephalopathy 1	Enrichment	SLC2A1	0.37
376	Strabismus	Enrichment	SLC2A1	0.34
377	Hirschsprung disease 1	Enrichment	NUP98	0.32
378	Differentiated thyroid carcinoma	Enrichment	TPR	0.32
379	Lung cancer	Enrichment	PPP2R1B	0.29
380	Primary autosomal recessive microcephaly	Enrichment	NUP37	0.29
381	Leukemia, acute myeloid	Enrichment	NUP214	0.23
382	Epilepsy	Enrichment	SLC2A1	0.23
383	Myopathy	Enrichment	GAA	0.23
384	Type 2 diabetes mellitus	Enrichment	GCK	0.22
385	Distal arthrogryposis	Enrichment	GBE1	0.22
386	Nephrotic syndrome	Enrichment	NUP93	0.21
387	West syndrome	Enrichment	SLC2A1	0.20
388	Congenital nervous system abnormality	Enrichment	AAAS, EPM2A	0.17
389	Nervous system disease	Enrichment	AAAS, EPM2A	0.17
390	Primary ovarian insufficiency	Enrichment	GALT	0.14
391	Inherited cancer-predisposing syndrome	Enrichment	EXT2	0.13
392	Microcephaly	Enrichment	NUP188, SLC2A1	0.12
393	Rare genetic deafness	Enrichment	GAA	0.08
394	Autism spectrum disorder	Enrichment	HK1	0.04

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Glycosaminoglycan metabolism

Pathway Network for Glycosaminoglycan metabolism

Pathway network for the Glycosaminoglycan metabolism SuperPath

Member Pathways for Glycosaminoglycan metabolism

Pathways in the Glycosaminoglycan metabolism SuperPath

Gene overlap in member pathways for Glycosaminoglycan metabolism SuperPath

Associated Genes for Glycosaminoglycan metabolism

Associated Disorders for Glycosaminoglycan metabolism

Disorders associated with Glycosaminoglycan metabolism SuperPath

STRING Interaction Network for Glycosaminoglycan metabolism

Sources for Glycosaminoglycan metabolism