Glycosylation and related congenital defects

Pathway network for the Glycosylation and related congenital defects SuperPath

Sources:

WikiPathways
PubChem

Pathways in the Glycosylation and related congenital defects SuperPath

#	Name	Source	Genes
1	Glycosylation and related congenital defects	WikiPathways	ALG1 ALG11 ALG12 ALG13 ALG2 ALG3 ALG6 ALG8 ALG9 B4GALT1 DOLK DPAGT1 DPM1 DPM2 DPM3 GMPPB MAGT1 MGAT2 MOGS MPDU1 MPI PMM2 SRD5A3 TUSC3 (see all 24) (see less)
2	N-glycan biosynthesis	WikiPathways	ALG1 ALG10 ALG10B ALG11 ALG12 ALG13 ALG14 ALG2 ALG3 ALG5 ALG6 ALG8 ALG9 B4GALT1 B4GALT2 B4GALT3 DAD1 DDOST DOLK DOLPP1 DPAGT1 DPM1 DPM2 DPM3 FUT8 GANAB GMPPA GMPPB GPI LOC100130283 MAN1A1 MAN1A2 MAN1B1 MAN1C1 MAN2A1 MAN2A2 MGAT1 MGAT2 MGAT3 MGAT4A MGAT4C MGAT4D MGAT5 MGAT5B MOGS MPDU1 MPI RFT1 RPN1 RPN2 SRD5A3 ST6GAL1 ST6GAL2 STT3A STT3B TUSC3 (see all 56) (see less)
3	dolichyl-diphosphooligosaccharide biosynthesis	PubChem	ALG1 ALG10 ALG11 ALG12 ALG13 ALG2 ALG3 ALG5 ALG6 ALG8 ALG9 DAD1 DDOST DPAGT1 DPM1 DPM2 DPM3 OST4 RPN1 RPN2 STT3A STT3B (see all 22) (see less)

Gene overlap in member pathways for Glycosylation and related congenital defects SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ALG6	ALG6 Alpha-1,3-Glucosyltransferase	Protein Coding	3
2	ALG9	ALG9 Alpha-1,2-Mannosyltransferase	Protein Coding	3
3	ALG12	ALG12 Alpha-1,6-Mannosyltransferase	Protein Coding	3
4	ALG3	ALG3 Alpha-1,3- Mannosyltransferase	Protein Coding	3
5	ALG13	ALG13 UDP-N-Acetylglucosaminyltransferase Subunit	Protein Coding	3
6	ALG1	ALG1 Chitobiosyldiphosphodolichol Beta-Mannosyltransferase	Protein Coding	3
7	ALG11	ALG11 Alpha-1,2-Mannosyltransferase	Protein Coding	3
8	ALG2	ALG2 Alpha-1,3/1,6-Mannosyltransferase	Protein Coding	3
9	ALG8	ALG8 Alpha-1,3-Glucosyltransferase	Protein Coding	3
10	DPAGT1	Dolichyl-Phosphate N-Acetylglucosaminephosphotransferase 1	Protein Coding	3
11	DPM2	Dolichyl-Phosphate Mannosyltransferase Subunit 2, Regulatory	Protein Coding	3
12	DPM3	Dolichyl-Phosphate Mannosyltransferase Subunit 3, Regulatory	Protein Coding	3
13	DPM1	Dolichyl-Phosphate Mannosyltransferase Subunit 1, Catalytic	Protein Coding	3
14	MPDU1	Mannose-P-Dolichol Utilization Defect 1	Protein Coding	2
15	GMPPB	GDP-Mannose Pyrophosphorylase B	Protein Coding	2
16	DOLK	Dolichol Kinase	Protein Coding	2
17	MGAT2	Alpha-1,6-Mannosyl-Glycoprotein 2-Beta-N-Acetylglucosaminyltransferase	Protein Coding	2
18	MPI	Mannose Phosphate Isomerase	Protein Coding	2
19	SRD5A3	Steroid 5 Alpha-Reductase 3	Protein Coding	2
20	B4GALT1	Beta-1,4-Galactosyltransferase 1	Protein Coding	2
21	MOGS	Mannosyl-Oligosaccharide Glucosidase	Protein Coding	2
22	TUSC3	Tumor Suppressor Candidate 3	Protein Coding	2
23	ALG10	ALG10 Alpha-1,2-Glucosyltransferase	Protein Coding	2
24	RPN1	Ribophorin I	Protein Coding	2
25	ALG5	ALG5 Dolichyl-Phosphate Beta-Glucosyltransferase	Protein Coding	2
26	DAD1	Defender Against Cell Death 1	Protein Coding	2
27	RPN2	Ribophorin II	Protein Coding	2
28	STT3A	STT3 Oligosaccharyltransferase Complex Catalytic Subunit A	Protein Coding	2
29	STT3B	STT3 Oligosaccharyltransferase Complex Catalytic Subunit B	Protein Coding	2
30	DDOST	Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Non-Catalytic Subunit	Protein Coding	2
31	PMM2	Phosphomannomutase 2	Protein Coding	1
32	MAGT1	Magnesium Transporter 1	Protein Coding	1
33	B4GALT2	Beta-1,4-Galactosyltransferase 2	Protein Coding	1
34	B4GALT3	Beta-1,4-Galactosyltransferase 3	Protein Coding	1
35	ST6GAL2	ST6 Beta-Galactoside Alpha-2,6-Sialyltransferase 2	Protein Coding	1
36	DOLPP1	Dolichyldiphosphatase 1	Protein Coding	1
37	MAN1C1	Mannosidase Alpha Class 1C Member 1	Protein Coding	1
38	MGAT3	Beta-1,4-Mannosyl-Glycoprotein 4-Beta-N-Acetylglucosaminyltransferase	Protein Coding	1
39	MGAT1	Alpha-1,3-Mannosyl-Glycoprotein 2-Beta-N-Acetylglucosaminyltransferase	Protein Coding	1
40	MAN2A1	Mannosidase Alpha Class 2A Member 1	Protein Coding	1
41	MAN2A2	Mannosidase Alpha Class 2A Member 2	Protein Coding	1
42	MAN1A1	Mannosidase Alpha Class 1A Member 1	Protein Coding	1
43	MGAT4C	MGAT4 Family Member C	Protein Coding	1
44	FUT8	Fucosyltransferase 8	Protein Coding	1
45	MGAT4D	MGAT4 Family Member D	Protein Coding	1
46	MGAT4A	Alpha-1,3-Mannosyl-Glycoprotein 4-Beta-N-Acetylglucosaminyltransferase A	Protein Coding	1
47	MAN1A2	Mannosidase Alpha Class 1A Member 2	Protein Coding	1
48	RFT1	RFT1 Glycolipid Translocator Homolog	Protein Coding	1
49	ST6GAL1	ST6 Beta-Galactoside Alpha-2,6-Sialyltransferase 1	Protein Coding	1
50	MGAT5	Alpha-1,6-Mannosylglycoprotein 6-Beta-N-Acetylglucosaminyltransferase	Protein Coding	1
51	GMPPA	GDP-Mannose Pyrophosphorylase A	Protein Coding	1
52	GPI	Glucose-6-Phosphate Isomerase	Protein Coding	1
53	GANAB	Glucosidase II Alpha Subunit	Protein Coding	1
54	ALG14	ALG14 UDP-N-Acetylglucosaminyltransferase Subunit	Protein Coding	1
55	MGAT5B	Alpha-1,6-Mannosylglycoprotein 6-Beta-N-Acetylglucosaminyltransferase B	Protein Coding	1
56	ALG10B	ALG10 Alpha-1,2-Glucosyltransferase B	Protein Coding	1
57	MAN1B1	Mannosidase Alpha Class 1B Member 1	Protein Coding	1
58	LOC100130283	Uncharacterized LOC100130283	RNA Gene	1
59	OST4	Oligosaccharyltransferase Complex Subunit 4, Non-Catalytic	Protein Coding	1

Disorders associated with Glycosylation and related congenital defects SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Congenital disorder of glycosylation, type in	Enrichment	ALG1, ALG13, ALG3, DPAGT1, MAGT1, PMM2, SRD5A3	10.74
2	Developmental and epileptic encephalopathy 36	Enrichment	ALG1, ALG13, DPM1, PMM2	9.82
3	Congenital myasthenic syndromes with glycosylation defect	Enrichment	ALG14, ALG2, DPAGT1, GMPPB	8.87
4	Autosomal dominant polycystic kidney disease	Enrichment	ALG5, ALG9, GANAB	4.53
5	Polycystic liver disease	Enrichment	ALG8, ALG9, GANAB	4.36
6	Autosomal dominant polycystic liver disease	Enrichment	ALG8, ALG9, GANAB	4.36
7	Muscular dystrophy	Enrichment	GMPPB, PMM2	3.09
8	Muscular dystrophy-dystroglycanopathy , type c, 15	Enrichment	DPM3	2.79
9	Myasthenic syndrome, congenital, 14	Enrichment	ALG2	2.79
10	Congenital disorder of glycosylation, type iw, autosomal recessive	Enrichment	STT3A	2.79
11	Congenital disorder of glycosylation, type ih	Enrichment	ALG8	2.79
12	Congenital disorder of glycosylation, type iu	Enrichment	DPM2	2.79
13	Muscular dystrophy-dystroglycanopathy , type b, 15	Enrichment	DPM3	2.79
14	Polycystic kidney disease 7	Enrichment	ALG5	2.79
15	Gillessen-kaesbach-nishimura syndrome	Enrichment	ALG9	2.79
16	Congenital disorder of glycosylation, type ic	Enrichment	ALG6	2.79
17	Congenital disorder of glycosylation, type ir	Enrichment	DDOST	2.79
18	Polycystic liver disease 3 with or without kidney cysts	Enrichment	ALG8	2.79
19	Congenital disorder of glycosylation iw	Enrichment	STT3A	2.79
20	Congenital disorder of glycosylation, type iia	Enrichment	MGAT2	2.75
21	Congenital disorder of glycosylation, type ib	Enrichment	MPI	2.75
22	Congenital disorder of glycosylation, type iid	Enrichment	B4GALT1	2.75
23	Congenital disorder of glycosylation, type im	Enrichment	DOLK	2.75
24	Intellectual developmental disorder, autosomal recessive 7	Enrichment	TUSC3	2.75
25	Congenital disorder of glycosylation, type ia	Enrichment	PMM2	2.75
26	Congenital disorder of glycosylation, type icc	Enrichment	MAGT1	2.75
27	Kahrizi syndrome	Enrichment	SRD5A3	2.75
28	Combined low ldl and fibrinogen	Enrichment	B4GALT1	2.75
29	Congenital disorder of glycosylation, type ij	Enrichment	DPAGT1	2.49
30	Myasthenic syndrome, congenital, 13	Enrichment	DPAGT1	2.49
31	Congenital disorder of glycosylation, type ix	Enrichment	STT3B	2.49
32	Congenital disorder of glycosylation, type ig	Enrichment	ALG12	2.49
33	Congenital disorder of glycosylation, type iw, autosomal dominant	Enrichment	STT3A	2.49
34	Acute myeloid leukemia with inv(3)(q21q26.2) or t(3;3)(q21;q26.2)	Enrichment	RPN1	2.49
35	Dpagt1-congenital disorder of glycosylation	Enrichment	DPAGT1	2.49
36	Immunodeficiency, x-linked, with magnesium defect, epstein-barr virus infection, and neoplasia	Enrichment	MAGT1	2.45
37	Congenital disorder of glycosylation, type iib	Enrichment	MOGS	2.45
38	Congenital disorder of glycosylation, type if	Enrichment	MPDU1	2.45
39	Muscular dystrophy-dystroglycanopathy , type a, 14	Enrichment	GMPPB	2.45
40	Muscular dystrophy-dystroglycanopathy , type b, 14	Enrichment	GMPPB	2.45
41	Muscular dystrophy-dystroglycanopathy , type c, 14	Enrichment	GMPPB	2.45
42	Congenital disorder of glycosylation, type iq	Enrichment	SRD5A3	2.45
43	Intellectual developmental disorder, autosomal recessive 24	Enrichment	TUSC3	2.45
44	Congenital muscular dystrophy-dystroglycanopathy type a14	Enrichment	GMPPB	2.45
45	Intellectual developmental disorder with epilepsy, behavioral abnormalities, and coarse facies	Enrichment	ALG14	2.38
46	Anemia, congenital, nonspherocytic hemolytic, 4	Enrichment	GPI	2.38
47	Man1b1-congenital disorder of glycosylation	Enrichment	MAN1B1	2.38
48	Wilson disease	Enrichment	ALG11	2.31
49	Congenital disorder of glycosylation, type ip	Enrichment	ALG11	2.31
50	Congenital disorder of glycosylation, type ik	Enrichment	ALG1	2.19
51	Congenital disorder of glycosylation, type id	Enrichment	ALG3	2.09
52	Congenital disorder of glycosylation, type il	Enrichment	ALG9	2.09
53	Alg9-congenital disorder of glycosylation	Enrichment	ALG9	2.09
54	Chromosomal instability with tissue-specific radiosensitivity	Enrichment	GMPPA	2.08
55	Myasthenic syndrome, congenital, 15	Enrichment	ALG14	2.08
56	Rafiq syndrome	Enrichment	MAN1B1	2.08
57	Alacrima, achalasia, and impaired intellectual development syndrome	Enrichment	GMPPA	2.08
58	Congenital disorder of glycosylation with defective fucosylation 1	Enrichment	FUT8	2.08
59	Syndromic x-linked intellectual disability 17	Enrichment	GMPPA	2.08
60	Myopathy, epilepsy, and progressive cerebral atrophy	Enrichment	ALG14	2.08
61	Polycystic kidney disease 3	Enrichment	GANAB	2.08
62	Congenital muscular dystrophy with intellectual disability	Enrichment	GMPPB	2.05
63	Congenital muscular dystrophy with cerebellar involvement	Enrichment	GMPPB	1.98
64	Polycystic kidney disease 1 with or without polycystic liver disease	Enrichment	ALG9	1.95
65	Polycystic kidney disease 1	Enrichment	ALG9	1.95
66	Muscular dystrophy-dystroglycanopathy	Enrichment	GMPPB	1.91
67	Congenital muscular dystrophy due to dystroglycanopathy	Enrichment	GMPPB	1.91
68	Myopathy, tubular aggregate, 1	Enrichment	DPAGT1	1.89
69	Immunodeficiency 47	Enrichment	ALG2	1.89
70	Nephrotic syndrome, type 1	Enrichment	ALG1	1.84
71	Congenital nervous system abnormality	Enrichment	SRD5A3, TUSC3	1.83
72	Nervous system disease	Enrichment	SRD5A3, TUSC3	1.83
73	Achalasia-addisonianism-alacrima syndrome	Enrichment	GMPPA	1.78
74	Long qt syndrome 2	Enrichment	ALG10B	1.78
75	Optic nerve disease	Enrichment	SRD5A3	1.76
76	Muscle eye brain disease	Enrichment	GMPPB	1.76
77	Diabetes mellitus	Enrichment	PMM2	1.71
78	Variegate porphyria	Enrichment	B4GALT3	1.69
79	Polycystic kidney disease 3 with or without polycystic liver disease	Enrichment	GANAB	1.69
80	Autosomal recessive non-syndromic intellectual disability	Enrichment	MAN1B1, TUSC3	1.62
81	Rare genetic intellectual disability	Enrichment	ALG13	1.62
82	Hereditary spherocytosis	Enrichment	GPI	1.61
83	Creatine phosphokinase, elevated serum	Enrichment	GMPPB	1.55
84	Cerebellar hypoplasia/atrophy, epilepsy, and global developmental delay	Enrichment	PMM2	1.55
85	Isolated elevated serum creatine phosphokinase levels	Enrichment	GMPPB	1.55
86	Hemolytic anemia	Enrichment	GPI	1.54
87	Focal segmental glomerulosclerosis	Enrichment	PMM2	1.46
88	Cone dystrophy	Enrichment	SRD5A3	1.38
89	Non-syndromic x-linked intellectual disability	Enrichment	ALG13	1.25
90	Myopathy	Enrichment	DPM3	1.20
91	Cerebral palsy	Enrichment	PMM2	1.18
92	Congenital myopathy	Enrichment	ALG14	1.12
93	Familial isolated dilated cardiomyopathy	Enrichment	DOLK	1.05
94	Primary ovarian insufficiency	Enrichment	PMM2	1.00
95	Autism	Enrichment	SRD5A3	0.92
96	Microcephaly	Enrichment	ALG13	0.74

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Glycosylation and related congenital defects

Pathway Network for Glycosylation and related congenital defects

Pathway network for the Glycosylation and related congenital defects SuperPath

Member Pathways for Glycosylation and related congenital defects

Pathways in the Glycosylation and related congenital defects SuperPath

Gene overlap in member pathways for Glycosylation and related congenital defects SuperPath

Associated Genes for Glycosylation and related congenital defects

Associated Disorders for Glycosylation and related congenital defects

Disorders associated with Glycosylation and related congenital defects SuperPath

STRING Interaction Network for Glycosylation and related congenital defects

Sources for Glycosylation and related congenital defects