Glyoxylate metabolism and glycine degradation

Pathway network for the Glyoxylate metabolism and glycine degradation SuperPath

Sources:

Reactome
WikiPathways
PubChem

Pathways in the Glyoxylate metabolism and glycine degradation SuperPath

#	Name	Source	Genes
1	Glyoxylate metabolism and glycine degradation	Reactome	AGXT AGXT2 ALDH4A1 AMT DAO DDO DLD DLST GCSH GLDC GNMT GOT2 GRHPR HAO1 HOGA1 KGD4 OGDH PRODH2 PXMP2 (see all 19) (see less)
2	Glyoxylate metabolism	WikiPathways	AGXT ALDH4A1 DAO GOT2 GRHPR HAO1 HOGA1 LDHA PRODH2 PXMP2 SLC26A1 (see all 11) (see less)
3	Glycine degradation	Reactome	AMT DLD DLST GCSH GLDC KGD4 OGDH (see all 7) (see less)
4	OGDH complex synthesizes succinyl-CoA from 2-OG	Reactome	DLD DLST KGD4 OGDH
5	2-oxoglutarate decarboxylation to succinyl-CoA	PubChem	DLD DLST OGDH
6	glycine biosynthesis	PubChem	AGXT AGXT2

Gene overlap in member pathways for Glyoxylate metabolism and glycine degradation SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	DLD	Dihydrolipoamide Dehydrogenase	Protein Coding	4
2	DLST	Dihydrolipoamide S-Succinyltransferase	Protein Coding	4
3	OGDH	Oxoglutarate Dehydrogenase	Protein Coding	4
4	AGXT	Alanine--Glyoxylate Aminotransferase	Protein Coding	3
5	KGD4	Alpha-Ketoglutarate Dehydrogenase Subunit 4	Protein Coding	3
6	HOGA1	4-Hydroxy-2-Oxoglutarate Aldolase 1	Protein Coding	2
7	DAO	D-Amino Acid Oxidase	Protein Coding	2
8	GCSH	Glycine Cleavage System Protein H	Protein Coding	2
9	GLDC	Glycine Decarboxylase	Protein Coding	2
10	AMT	Aminomethyltransferase	Protein Coding	2
11	GOT2	Glutamic-Oxaloacetic Transaminase 2	Protein Coding	2
12	HAO1	Hydroxyacid Oxidase 1	Protein Coding	2
13	PXMP2	Peroxisomal Membrane Protein 2	Protein Coding	2
14	PRODH2	Proline Dehydrogenase 2	Protein Coding	2
15	AGXT2	Alanine--Glyoxylate Aminotransferase 2	Protein Coding	2
16	ALDH4A1	Aldehyde Dehydrogenase 4 Family Member A1	Protein Coding	2
17	GRHPR	Glyoxylate And Hydroxypyruvate Reductase	Protein Coding	2
18	GNMT	Glycine N-Methyltransferase	Protein Coding	1
19	DDO	D-Aspartate Oxidase	Protein Coding	1
20	SLC26A1	Solute Carrier Family 26 Member 1	Protein Coding	1
21	LDHA	Lactate Dehydrogenase A	Protein Coding	1

Disorders associated with Glyoxylate metabolism and glycine degradation SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Atypical glycine encephalopathy	Enrichment	AMT, GCSH, GLDC	9.43
2	Glycine encephalopathy	Enrichment	AMT, GCSH, GLDC	8.77
3	Glycine encephalopathy 1	Enrichment	AMT, GCSH, GLDC	8.32
4	Primary hyperoxaluria	Enrichment	AGXT, GRHPR	6.22
5	Nephrocalcinosis	Enrichment	AGXT, GRHPR	4.57
6	Nephrolithiasis	Enrichment	AGXT, GRHPR	4.57
7	Beta-aminoisobutyric aciduria	Enrichment	AGXT2	3.83
8	Hyperoxaluria, primary, type i	Enrichment	AGXT	3.83
9	Oxoglutarate dehydrogenase deficiency	Enrichment	OGDH	3.66
10	Pheochromocytoma/paraganglioma syndrome 7	Enrichment	DLST	3.66
11	Dihydrolipoamide dehydrogenase deficiency	Enrichment	DLD	3.35
12	Methemoglobinemia due to deficiency of methemoglobin reductase	Enrichment	DLD	3.35
13	Hyperoxaluria, primary, type ii	Enrichment	GRHPR	3.09
14	Hyperoxaluria, primary, type iii	Enrichment	HOGA1	3.09
15	Multiple mitochondrial dysfunctions syndrome 7	Enrichment	GCSH	2.99
16	Glycine encephalopathy 2	Enrichment	AMT	2.99
17	Nephrolithiasis, calcium oxalate, 1	Enrichment	SLC26A1	2.79
18	Fanconi-bickel syndrome	Enrichment	LDHA	2.79
19	Hyperprolinemia, type ii	Enrichment	ALDH4A1	2.79
20	Hurler-scheie syndrome	Enrichment	SLC26A1	2.79
21	Scheie syndrome	Enrichment	SLC26A1	2.79
22	Developmental and epileptic encephalopathy 82	Enrichment	GOT2	2.79
23	Hypersulfaturia	Enrichment	SLC26A1	2.79
24	Calcium oxalate nephrolithiasis	Enrichment	SLC26A1	2.79
25	Generalized epilepsy	Enrichment	GLDC	2.69
26	Hurler syndrome	Enrichment	SLC26A1	2.61
27	Mucopolysaccharidosis-plus syndrome	Enrichment	SLC26A1	2.61
28	Lactic acidosis	Enrichment	DLD	2.58
29	Glycine n-methyltransferase deficiency	Enrichment	GNMT	2.55
30	Peroxisome biogenesis disorder 4b	Enrichment	GNMT	2.55
31	Brown-vialetto-van laere syndrome 2	Enrichment	GNMT	2.38
32	Hereditary paraganglioma-pheochromocytoma syndromes	Enrichment	DLST	2.33
33	Nephrotic syndrome	Enrichment	AGXT	2.20
34	Body mass index quantitative trait locus 11	Enrichment	GLDC	1.59
35	Developmental and epileptic encephalopathy	Enrichment	GOT2	1.54
36	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	DAO	1.34
37	Retinitis pigmentosa	Enrichment	GLDC	0.98

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Glyoxylate metabolism and glycine degradation

Pathway Network for Glyoxylate metabolism and glycine degradation

Pathway network for the Glyoxylate metabolism and glycine degradation SuperPath

Member Pathways for Glyoxylate metabolism and glycine degradation

Pathways in the Glyoxylate metabolism and glycine degradation SuperPath

Gene overlap in member pathways for Glyoxylate metabolism and glycine degradation SuperPath

Associated Genes for Glyoxylate metabolism and glycine degradation

Associated Disorders for Glyoxylate metabolism and glycine degradation

Disorders associated with Glyoxylate metabolism and glycine degradation SuperPath

STRING Interaction Network for Glyoxylate metabolism and glycine degradation

Sources for Glyoxylate metabolism and glycine degradation