Glypican 3 network

No Pathway Network information available for Glypican 3 network

Pathways in the Glypican 3 network SuperPath

#	Name	Source	Genes
1	Glypican 3 network	PubChem	BMP4 DKK1 FGF7 FURIN GPC3 MAPK8 PTCH1 SHH (see all 8) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	GPC3	Glypican 3	Protein Coding	1
2	DKK1	Dickkopf Wnt Signaling Pathway Inhibitor 1	Protein Coding	1
3	FGF7	Fibroblast Growth Factor 7	Protein Coding	1
4	SHH	Sonic Hedgehog Signaling Molecule	Protein Coding	1
5	BMP4	Bone Morphogenetic Protein 4	Protein Coding	1
6	PTCH1	Patched 1	Protein Coding	1
7	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
8	FURIN	Furin, Paired Basic Amino Acid Cleaving Enzyme	Protein Coding	1

Disorders associated with Glypican 3 network SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Polydactyly, preaxial ii	Enrichment	PTCH1, SHH	5.74
2	Septopreoptic holoprosencephaly	Enrichment	PTCH1, SHH	4.50
3	Midline interhemispheric variant of holoprosencephaly	Enrichment	PTCH1, SHH	4.50
4	Microform holoprosencephaly	Enrichment	PTCH1, SHH	4.44
5	Lobar holoprosencephaly	Enrichment	PTCH1, SHH	4.44
6	Alobar holoprosencephaly	Enrichment	PTCH1, SHH	4.39
7	Semilobar holoprosencephaly	Enrichment	PTCH1, SHH	4.33
8	Macs syndrome	Enrichment	PTCH1, SHH	4.24
9	Holoprosencephaly 3	Enrichment	SHH	3.23
10	Chiari malformation type i	Enrichment	DKK1	3.23
11	Schilbach-rott syndrome	Enrichment	PTCH1	3.23
12	Microphthalmia/coloboma 5	Enrichment	SHH	3.23
13	Microphthalmia, syndromic 6	Enrichment	BMP4	3.23
14	Orofacial cleft 11	Enrichment	BMP4	3.23
15	Turner syndrome	Enrichment	PTCH1	3.23
16	Monosomy 9q22.3	Enrichment	PTCH1	3.23
17	Autosomal dominant preaxial polydactyly-upperback hypertrichosis syndrome	Enrichment	SHH	3.23
18	Solitary median maxillary central incisor	Enrichment	SHH	2.93
19	Isolated radial hemimelia	Enrichment	SHH	2.93
20	Syndactyly, type iv	Enrichment	SHH	2.75
21	Simpson-golabi-behmel syndrome, type 1	Enrichment	GPC3	2.75
22	Osteoporosis, juvenile	Enrichment	DKK1	2.75
23	Holoprosencephaly 7	Enrichment	PTCH1	2.75
24	Hypoplastic or aplastic tibia with polydactyly	Enrichment	SHH	2.75
25	Schizencephaly	Enrichment	SHH	2.63
26	Basal cell nevus syndrome 1	Enrichment	PTCH1	2.45
27	Anterior segment dysgenesis 5	Enrichment	BMP4	2.45
28	Basal cell carcinoma 1	Enrichment	PTCH1	2.45
29	Congenital hydrocephalus	Enrichment	PTCH1	2.38
30	Overgrowth syndrome	Enrichment	PTCH1	2.38
31	Peters-plus syndrome	Enrichment	BMP4	2.23
32	Stickler syndrome	Enrichment	BMP4	2.23
33	Septooptic dysplasia	Enrichment	SHH	2.15
34	Renal hypodysplasia/aplasia 3	Enrichment	BMP4	2.15
35	Medulloblastoma	Enrichment	PTCH1	2.08
36	Cleft lip/palate	Enrichment	BMP4	2.08
37	Polydactyly, postaxial, type a1	Enrichment	PTCH1	2.05
38	Wilms tumor 1	Enrichment	GPC3	2.05
39	Rhabdomyosarcoma	Enrichment	PTCH1	2.03
40	Microphthalmia	Enrichment	PTCH1	1.89
41	Hereditary breast ovarian cancer syndrome	Enrichment	PTCH1	1.50
42	Autism	Enrichment	SHH	1.38
43	Ovarian cancer	Enrichment	PTCH1	1.24
44	Inherited cancer-predisposing syndrome	Enrichment	PTCH1	1.12

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Glypican 3 network

Pathway Network for Glypican 3 network

Member Pathways for Glypican 3 network

Pathways in the Glypican 3 network SuperPath

Associated Genes for Glypican 3 network

Associated Disorders for Glypican 3 network

Disorders associated with Glypican 3 network SuperPath

STRING Interaction Network for Glypican 3 network

Sources for Glypican 3 network