GPCR downstream signalling

Pathway network for the GPCR downstream signalling SuperPath

Sources:

Reactome

Pathways in the GPCR downstream signalling SuperPath

#	Name	Source	Genes
1	GPCR downstream signalling	Reactome	ABHD12 ABHD6 ABR ACKR3 ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADCYAP1 ADCYAP1R1 ADM ADM2 ADORA1 ADORA2A ADORA2B ADORA3 ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C ADRB1 ADRB2 ADRB3 AGT AGTR1 AGTR2 AHCYL1 AKAP13 AKT1 AKT2 AKT3 ANXA1 APLN APLNR APP ARHGEF1 ARHGEF10 ARHGEF10L ARHGEF11 ARHGEF12 ARHGEF15 ARHGEF16 ARHGEF17 ARHGEF18 ARHGEF19 ARHGEF2 ARHGEF25 ARHGEF26 ARHGEF3 ARHGEF33 ARHGEF35 ARHGEF37 ARHGEF38 ARHGEF39 ARHGEF4 ARHGEF40 ARHGEF5 ARHGEF6 ARHGEF7 ARHGEF9 ARRB1 ARRB2 AVP AVPR1A AVPR1B AVPR2 BDKRB1 BDKRB2 BRS3 BTK C3 C3AR1 C5 C5AR1 CALCA CALCB CALCR CALCRL CALM1 CALM2 CALM3 CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 CAMKK1 CAMKK2 CASR CCK CCKAR CCKBR CCL1 CCL13 CCL16 CCL19 CCL20 CCL21 CCL23 CCL25 CCL27 CCL28 CCL4 CCL4L1 CCL4L2 CCL5 CCR1 CCR10 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9 CDC42 CDK5 CGA CHRM1 CHRM2 CHRM3 CHRM4 CHRM5 CNR1 CNR2 CORT CREB1 CRH CRHR1 CRHR2 CX3CL1 CX3CR1 CXCL1 CXCL10 CXCL11 CXCL12 CXCL13 CXCL16 CXCL2 CXCL3 CXCL5 CXCL6 CXCL8 CXCL9 CXCR1 CXCR2 CXCR3 CXCR4 CXCR5 CXCR6 CYSLTR1 CYSLTR2 DAGLA DAGLB DGKA DGKB DGKD DGKE DGKG DGKH DGKI DGKK DGKQ DGKZ DRD1 DRD3 DRD4 DRD5 ECT2 EDN1 EDN2 EDN3 EDNRA EDNRB EGFR F2 F2R F2RL1 F2RL2 F2RL3 FFAR1 FFAR2 FFAR3 FFAR4 FGD1 FGD2 FGD3 FGD4 FN1 FPR1 FPR2 FPR3 FSHB FSHR GABBR1 GABBR2 GAL GALR1 GALR2 GALR3 GAST GCG GCGR GHRH GHRHR GHRL GHSR GIP GIPR GLP1R GLP2R GNA11 GNA12 GNA13 GNA14 GNA15 GNAI1 GNAI2 GNAI3 GNAL GNAQ GNAS GNAT1 GNAT2 GNAT3 GNAZ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GNRH1 GNRH2 GNRHR GPBAR1 GPER1 GPHA2 GPHB5 GPR132 GPR143 GPR15 GPR150 GPR17 GPR176 GPR18 GPR183 GPR20 GPR25 GPR27 GPR31 GPR32 GPR37 GPR37L1 GPR39 GPR4 GPR45 GPR55 GPR65 GPR68 GPR83 GPR84 GPRC6A GPSM1 GPSM2 GPSM3 GRB2 GRK2 GRK3 GRK5 GRK6 GRM1 GRM2 GRM3 GRM4 GRM5 GRM6 GRM7 GRM8 GRP GRPR HBEGF HCAR1 HCAR2 HCAR3 HCRT HCRTR1 HCRTR2 HEBP1 HRAS HRH1 HRH2 HRH4 HTR1B HTR1D HTR1E HTR1F HTR2A HTR2B HTR2C HTR4 HTR5A HTR6 HTR7 IAPP INSL3 INSL5 ITGA5 ITGB1 ITPR1 ITPR2 ITPR3 ITSN1 KALRN KISS1 KISS1R KNG1 KPNA2 KRAS LHB LHCGR LPAR1 LPAR2 LPAR3 LPAR4 LPAR5 LPAR6 LTB4R LTB4R2 MAPK1 MAPK3 MAPK7 MC1R MC2R MC3R MC4R MC5R MCF2 MCF2L MCHR1 MCHR2 MGLL MLN MLNR MMP3 MTNR1A MTNR1B NBEA NET1 NGEF NMB NMBR NMS NMU NMUR1 NMUR2 NPB NPBWR1 NPBWR2 NPFF NPFFR1 NPFFR2 NPS NPSR1 NPW NPY NPY1R NPY2R NPY4R NPY4R2 NPY5R NRAS NTS NTSR1 NTSR2 OPN1LW OPN1MW OPN1MW3 OPN1SW OPN3 OPN4 OPN5 OPRD1 OPRK1 OPRL1 OPRM1 OXER1 OXGR1 OXT OXTR P2RY1 P2RY10 P2RY11 P2RY12 P2RY13 P2RY14 P2RY2 P2RY4 P2RY6 PAK1 PCP2 PDE10A PDE11A PDE1A PDE1B PDE1C PDE2A PDE3A PDE3B PDE4A PDE4B PDE4C PDE4D PDE7A PDE7B PDE8A PDE8B PDPK1 PDYN PENK PF4 PIK3CA PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PIK3R6 PLA2G4A PLCB1 PLCB2 PLCB3 PLCB4 PLEKHG2 PLEKHG5 PLXNB1 PMCH PNOC POMC PPBP PPP1CA PPP1R1B PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PPP3CA PPP3CB PPP3CC PPP3R1 PPY PREX1 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKX PROK1 PROK2 PROKR1 PROKR2 PSAP PTAFR PTGDR PTGDR2 PTGER1 PTGER2 PTGER3 PTGER4 PTGFR PTGIR PTH PTH1R PTH2 PTH2R PTHLH PYY QRFP QRFPR RAMP1 RAMP2 RAMP3 RASGRF2 RASGRP1 RASGRP2 RGR RGS1 RGS10 RGS11 RGS12 RGS13 RGS14 RGS16 RGS17 RGS18 RGS19 RGS2 RGS20 RGS21 RGS22 RGS3 RGS4 RGS5 RGS6 RGS7 RGS8 RGS9 RGSL1 RHO RHOA RHOB RHOC RLN2 RLN3 ROCK1 ROCK2 RPS6KA1 RPS6KA2 RPS6KA3 RRH RXFP1 RXFP2 RXFP3 RXFP4 S1PR2 S1PR3 S1PR4 S1PR5 SAA1 SCT SCTR SHC1 SOS1 SOS2 SRC SST SSTR1 SSTR2 SSTR3 SSTR4 SSTR5 SUCNR1 TAAR1 TAAR2 TAAR5 TAAR6 TAAR8 TAAR9 TAC1 TAC3 TACR1 TACR2 TACR3 TAS1R1 TAS1R2 TAS1R3 TAS2R1 TAS2R10 TAS2R13 TAS2R14 TAS2R16 TAS2R19 TAS2R20 TAS2R3 TAS2R30 TAS2R31 TAS2R38 TAS2R39 TAS2R4 TAS2R40 TAS2R41 TAS2R42 TAS2R43 TAS2R46 TAS2R5 TAS2R50 TAS2R60 TAS2R7 TAS2R8 TAS2R9 TBXA2R TIAM1 TIAM2 TRH TRHR TRIO TRPC3 TRPC6 TRPC7 TSHB TSHR UTS2 UTS2B UTS2R VAV1 VAV2 VAV3 VIP VIPR1 VIPR2 XCL1 XCL2 XCR1 (see all 632) (see less)
2	Signaling by GPCR	Reactome	ABHD12 ABHD6 ABR ACKR1 ACKR2 ACKR3 ACKR4 ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADCYAP1 ADCYAP1R1 ADGRE1 ADGRE2 ADGRE3 ADGRE5 ADM ADM2 ADORA1 ADORA2A ADORA2B ADORA3 ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C ADRB1 ADRB2 ADRB3 AGT AGTR1 AGTR2 AHCYL1 AKAP13 AKT1 AKT2 AKT3 ANXA1 APLN APLNR APP ARHGEF1 ARHGEF10 ARHGEF10L ARHGEF11 ARHGEF12 ARHGEF15 ARHGEF16 ARHGEF17 ARHGEF18 ARHGEF19 ARHGEF2 ARHGEF25 ARHGEF26 ARHGEF3 ARHGEF33 ARHGEF35 ARHGEF37 ARHGEF38 ARHGEF39 ARHGEF4 ARHGEF40 ARHGEF5 ARHGEF6 ARHGEF7 ARHGEF9 ARRB1 ARRB2 AVP AVPR1A AVPR1B AVPR2 BDKRB1 BDKRB2 BRS3 BTK C3 C3AR1 C5 C5AR1 C5AR2 CALCA CALCB CALCR CALCRL CALM1 CALM2 CALM3 CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 CAMKK1 CAMKK2 CASR CCK CCKAR CCKBR CCL1 CCL11 CCL13 CCL16 CCL17 CCL19 CCL2 CCL20 CCL21 CCL22 CCL23 CCL25 CCL27 CCL28 CCL3 CCL3L1 CCL3L3 CCL4 CCL4L1 CCL4L2 CCL5 CCL7 CCR1 CCR10 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9 CCRL2 CD55 CDC42 CDK5 CGA CHRM1 CHRM2 CHRM3 CHRM4 CHRM5 CMKLR1 CNR1 CNR2 CORT CREB1 CRH CRHBP CRHR1 CRHR2 CX3CL1 CX3CR1 CXCL1 CXCL10 CXCL11 CXCL12 CXCL13 CXCL16 CXCL2 CXCL3 CXCL5 CXCL6 CXCL8 CXCL9 CXCR1 CXCR2 CXCR3 CXCR4 CXCR5 CXCR6 CYSLTR1 CYSLTR2 DAGLA DAGLB DGKA DGKB DGKD DGKE DGKG DGKH DGKI DGKK DGKQ DGKZ DHH DRD1 DRD2 DRD3 DRD4 DRD5 ECE1 ECE2 ECT2 EDN1 EDN2 EDN3 EDNRA EDNRB EEF1AKMT4-ECE2 EGFR F2 F2R F2RL1 F2RL2 F2RL3 FFAR1 FFAR2 FFAR3 FFAR4 FGD1 FGD2 FGD3 FGD4 FN1 FPR1 FPR2 FPR3 FSHB FSHR FZD1 FZD10 FZD2 FZD3 FZD4 FZD5 FZD6 FZD7 FZD8 FZD9 GABBR1 GABBR2 GAL GALR1 GALR2 GALR3 GAST GCG GCGR GHRH GHRHR GHRL GHSR GIP GIPR GLP1R GLP2R GNA11 GNA12 GNA13 GNA14 GNA15 GNAI1 GNAI2 GNAI3 GNAL GNAQ GNAS GNAT1 GNAT2 GNAT3 GNAZ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GNRH1 GNRH2 GNRHR GPBAR1 GPER1 GPHA2 GPHB5 GPR132 GPR143 GPR15 GPR150 GPR17 GPR176 GPR18 GPR183 GPR20 GPR25 GPR27 GPR31 GPR32 GPR35 GPR37 GPR37L1 GPR39 GPR4 GPR45 GPR55 GPR65 GPR68 GPR83 GPR84 GPRC6A GPSM1 GPSM2 GPSM3 GRB2 GRK2 GRK3 GRK5 GRK6 GRM1 GRM2 GRM3 GRM4 GRM5 GRM6 GRM7 GRM8 GRP GRPR HBEGF HCAR1 HCAR2 HCAR3 HCRT HCRTR1 HCRTR2 HEBP1 HRAS HRH1 HRH2 HRH3 HRH4 HTR1A HTR1B HTR1D HTR1E HTR1F HTR2A HTR2B HTR2C HTR4 HTR5A HTR6 HTR7 IAPP IHH INSL3 INSL5 ITGA5 ITGB1 ITPR1 ITPR2 ITPR3 ITSN1 KALRN KEL KISS1 KISS1R KNG1 KPNA2 KRAS LHB LHCGR LPAR1 LPAR2 LPAR3 LPAR4 LPAR5 LPAR6 LTB4R LTB4R2 MAPK1 MAPK3 MAPK7 MAS1 MC1R MC2R MC3R MC4R MC5R MCF2 MCF2L MCHR1 MCHR2 MGLL MLN MLNR MMP3 MRGPRD MTNR1A MTNR1B NBEA NET1 NGEF NLN NMB NMBR NMS NMU NMUR1 NMUR2 NPB NPBWR1 NPBWR2 NPFF NPFFR1 NPFFR2 NPS NPSR1 NPW NPY NPY1R NPY2R NPY4R NPY4R2 NPY5R NRAS NTS NTSR1 NTSR2 OPN1LW OPN1MW OPN1MW3 OPN1SW OPN3 OPN4 OPN5 OPRD1 OPRK1 OPRL1 OPRM1 OXER1 OXGR1 OXT OXTR P2RY1 P2RY10 P2RY11 P2RY12 P2RY13 P2RY14 P2RY2 P2RY4 P2RY6 PAK1 PCP2 PDE10A PDE11A PDE1A PDE1B PDE1C PDE2A PDE3A PDE3B PDE4A PDE4B PDE4C PDE4D PDE7A PDE7B PDE8A PDE8B PDPK1 PDYN PENK PF4 PIK3CA PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PIK3R6 PLA2G4A PLCB1 PLCB2 PLCB3 PLCB4 PLEKHG2 PLEKHG5 PLPPR1 PLPPR2 PLPPR3 PLPPR4 PLPPR5 PLXNB1 PMCH PNOC POMC PPBP PPP1CA PPP1R1B PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PPP3CA PPP3CB PPP3CC PPP3R1 PPY PREX1 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKX PRLH PRLHR PROK1 PROK2 PROKR1 PROKR2 PSAP PTAFR PTCH1 PTCH2 PTGDR PTGDR2 PTGER1 PTGER2 PTGER3 PTGER4 PTGFR PTGIR PTH PTH1R PTH2 PTH2R PTHLH PYY QRFP QRFPR RAMP1 RAMP2 RAMP3 RASGRF2 RASGRP1 RASGRP2 RGR RGS1 RGS10 RGS11 RGS12 RGS13 RGS14 RGS16 RGS17 RGS18 RGS19 RGS2 RGS20 RGS21 RGS22 RGS3 RGS4 RGS5 RGS6 RGS7 RGS8 RGS9 RGSL1 RHO RHOA RHOB RHOC RLN2 RLN3 ROCK1 ROCK2 RPS6KA1 RPS6KA2 RPS6KA3 RRH RXFP1 RXFP2 RXFP3 RXFP4 S1PR1 S1PR2 S1PR3 S1PR4 S1PR5 SAA1 SCT SCTR SHC1 SHH SMO SOS1 SOS2 SRC SST SSTR1 SSTR2 SSTR3 SSTR4 SSTR5 SUCNR1 TAAR1 TAAR2 TAAR5 TAAR6 TAAR8 TAAR9 TAC1 TAC3 TACR1 TACR2 TACR3 TAS1R1 TAS1R2 TAS1R3 TAS2R1 TAS2R10 TAS2R13 TAS2R14 TAS2R16 TAS2R19 TAS2R20 TAS2R3 TAS2R30 TAS2R31 TAS2R38 TAS2R39 TAS2R4 TAS2R40 TAS2R41 TAS2R42 TAS2R43 TAS2R46 TAS2R5 TAS2R50 TAS2R60 TAS2R7 TAS2R8 TAS2R9 TBXA2R TIAM1 TIAM2 TRH TRHR TRIO TRPC3 TRPC6 TRPC7 TSHB TSHR UCN UCN2 UCN3 UTS2 UTS2B UTS2R VAV1 VAV2 VAV3 VIP VIPR1 VIPR2 WNT1 WNT10A WNT10B WNT11 WNT16 WNT2 WNT2B WNT3 WNT3A WNT4 WNT5A WNT6 WNT7A WNT7B WNT8A WNT8B WNT9A WNT9B XCL1 XCL2 XCR1 XK (see all 709) (see less)
3	G alpha (i) signalling events	Reactome	ACKR3 ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADORA1 ADORA3 ADRA2A ADRA2B ADRA2C AGT AGTR2 AHCYL1 ANXA1 APLN APLNR APP BDKRB1 BDKRB2 C3 C3AR1 C5 C5AR1 CALM1 CALM2 CALM3 CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 CAMKK1 CAMKK2 CASR CCL1 CCL13 CCL16 CCL19 CCL20 CCL21 CCL23 CCL25 CCL27 CCL28 CCL4 CCL4L1 CCL4L2 CCL5 CCR1 CCR10 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9 CDK5 CHRM2 CHRM4 CNR1 CNR2 CORT CREB1 CX3CL1 CX3CR1 CXCL1 CXCL10 CXCL11 CXCL12 CXCL13 CXCL16 CXCL2 CXCL3 CXCL5 CXCL6 CXCL8 CXCL9 CXCR1 CXCR2 CXCR3 CXCR4 CXCR5 CXCR6 DRD3 DRD4 FPR1 FPR2 FPR3 GABBR1 GABBR2 GAL GALR1 GALR2 GALR3 GNA11 GNA14 GNA15 GNAI1 GNAI2 GNAI3 GNAL GNAQ GNAS GNAT1 GNAT2 GNAT3 GNAZ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GPER1 GPR17 GPR18 GPR183 GPR31 GPR37 GPR37L1 GPR55 GPSM1 GPSM2 GPSM3 GRK2 GRM2 GRM3 GRM4 GRM6 GRM7 GRM8 HCAR1 HCAR2 HCAR3 HEBP1 HRH4 HTR1B HTR1D HTR1E HTR1F HTR5A INSL5 ITPR1 ITPR2 ITPR3 KNG1 KPNA2 LPAR1 LPAR2 LPAR3 LPAR5 MAPK1 MCHR1 MCHR2 MTNR1A MTNR1B NBEA NMS NMU NMUR1 NMUR2 NPB NPBWR1 NPBWR2 NPW NPY NPY1R NPY2R NPY4R NPY4R2 NPY5R OPN1LW OPN1MW OPN1MW3 OPN1SW OPN3 OPN5 OPRD1 OPRK1 OPRL1 OPRM1 OXER1 OXGR1 P2RY12 P2RY13 P2RY14 P2RY4 PCP2 PDE1A PDE1B PDE1C PDE4A PDE4B PDE4C PDE4D PDYN PENK PF4 PLA2G4A PLCB1 PLCB2 PLCB3 PLCB4 PMCH PNOC POMC PPBP PPP1CA PPP1R1B PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PPP3CA PPP3CB PPP3CC PPP3R1 PPY PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCD PRKCG PRKX PSAP PTGDR2 PTGER3 PYY RGR RGS1 RGS10 RGS11 RGS12 RGS13 RGS14 RGS16 RGS17 RGS18 RGS19 RGS20 RGS21 RGS22 RGS3 RGS4 RGS5 RGS6 RGS7 RGS8 RGS9 RGSL1 RHO RLN3 RRH RXFP3 RXFP4 S1PR2 S1PR3 S1PR4 S1PR5 SAA1 SRC SST SSTR1 SSTR2 SSTR3 SSTR4 SSTR5 SUCNR1 TAS1R1 TAS1R2 TAS1R3 TAS2R1 TAS2R10 TAS2R13 TAS2R14 TAS2R16 TAS2R19 TAS2R20 TAS2R3 TAS2R30 TAS2R31 TAS2R38 TAS2R39 TAS2R4 TAS2R40 TAS2R41 TAS2R42 TAS2R43 TAS2R46 TAS2R5 TAS2R50 TAS2R60 TAS2R7 TAS2R8 TAS2R9 (see all 319) (see less)
4	G alpha (q) signalling events	Reactome	ABHD12 ABHD6 ADRA1A ADRA1B ADRA1D AGT AGTR1 ANXA1 APP ARHGEF25 AVP AVPR1A AVPR1B BDKRB1 BDKRB2 BRS3 BTK CASR CCK CCKAR CCKBR CCL23 CHRM1 CHRM3 CHRM5 CREB1 CYSLTR1 CYSLTR2 DAGLA DAGLB DGKA DGKB DGKD DGKE DGKG DGKH DGKI DGKK DGKQ DGKZ EDN1 EDN2 EDN3 EDNRA EDNRB EGFR F2 F2R F2RL1 F2RL2 F2RL3 FFAR1 FFAR2 FFAR3 FFAR4 FPR2 GAST GCG GCGR GHRL GHSR GNA11 GNA14 GNA15 GNAQ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GNRH1 GNRH2 GNRHR GPR132 GPR143 GPR17 GPR39 GPR4 GPR65 GPR68 GPRC6A GRB2 GRK2 GRK5 GRM1 GRM5 GRP GRPR HBEGF HCRT HCRTR1 HCRTR2 HRAS HRH1 HTR2A HTR2B HTR2C ITPR1 ITPR2 ITPR3 KALRN KISS1 KISS1R KNG1 KRAS LPAR1 LPAR2 LPAR3 LPAR4 LPAR5 LPAR6 LTB4R LTB4R2 MAPK1 MAPK3 MAPK7 MCHR1 MCHR2 MGLL MLN MLNR MMP3 NMB NMBR NMS NMU NMUR1 NMUR2 NPFF NPFFR1 NPFFR2 NPS NPSR1 NRAS NTS NTSR1 NTSR2 OPN4 OXT OXTR P2RY1 P2RY10 P2RY11 P2RY2 P2RY6 PIK3CA PIK3R1 PIK3R2 PIK3R3 PLCB1 PLCB2 PLCB3 PLCB4 PMCH PRKCA PRKCD PRKCE PRKCH PROK1 PROK2 PROKR1 PROKR2 PTAFR PTGER1 PTGFR QRFP QRFPR RASGRP1 RASGRP2 RGS1 RGS13 RGS16 RGS17 RGS18 RGS19 RGS2 RGS21 RGS3 RGS4 RGS5 RGSL1 RPS6KA1 RPS6KA2 RPS6KA3 SAA1 SOS1 TAC1 TAC3 TACR1 TACR2 TACR3 TBXA2R TRH TRHR TRIO TRPC3 TRPC6 TRPC7 UTS2 UTS2B UTS2R XCL1 XCL2 XCR1 (see all 216) (see less)

Gene overlap in member pathways for GPCR downstream signalling SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	RGS19	Regulator Of G Protein Signaling 19	Protein Coding	4
2	NMUR1	Neuromedin U Receptor 1	Protein Coding	4
3	GNB5	G Protein Subunit Beta 5	Protein Coding	4
4	NMU	Neuromedin U	Protein Coding	4
5	NMS	Neuromedin S	Protein Coding	4
6	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	4
7	GRK2	G Protein-Coupled Receptor Kinase 2	Protein Coding	4
8	AGT	Angiotensinogen	Protein Coding	4
9	LPAR1	Lysophosphatidic Acid Receptor 1	Protein Coding	4
10	PLCB1	Phospholipase C Beta 1	Protein Coding	4
11	LPAR3	Lysophosphatidic Acid Receptor 3	Protein Coding	4
12	FPR2	Formyl Peptide Receptor 2	Protein Coding	4
13	RGS17	Regulator Of G Protein Signaling 17	Protein Coding	4
14	GNA11	G Protein Subunit Alpha 11	Protein Coding	4
15	GNA15	G Protein Subunit Alpha 15	Protein Coding	4
16	GNAQ	G Protein Subunit Alpha Q	Protein Coding	4
17	GNB1	G Protein Subunit Beta 1	Protein Coding	4
18	GNB2	G Protein Subunit Beta 2	Protein Coding	4
19	GNB3	G Protein Subunit Beta 3	Protein Coding	4
20	GNG3	G Protein Subunit Gamma 3	Protein Coding	4
21	GNG4	G Protein Subunit Gamma 4	Protein Coding	4
22	GNG5	G Protein Subunit Gamma 5	Protein Coding	4
23	GNG7	G Protein Subunit Gamma 7	Protein Coding	4
24	GNG10	G Protein Subunit Gamma 10	Protein Coding	4
25	GNG11	G Protein Subunit Gamma 11	Protein Coding	4
26	GNGT1	G Protein Subunit Gamma Transducin 1	Protein Coding	4
27	GNGT2	G Protein Subunit Gamma Transducin 2	Protein Coding	4
28	GPR17	G Protein-Coupled Receptor 17	Protein Coding	4
29	MCHR1	Melanin Concentrating Hormone Receptor 1	Protein Coding	4
30	ANXA1	Annexin A1	Protein Coding	4
31	APP	Amyloid Beta Precursor Protein	Protein Coding	4
32	RGSL1	Regulator Of G Protein Signaling Like 1	Protein Coding	4
33	ITPR1	Inositol 1,4,5-Trisphosphate Receptor Type 1	Protein Coding	4
34	ITPR2	Inositol 1,4,5-Trisphosphate Receptor Type 2	Protein Coding	4
35	ITPR3	Inositol 1,4,5-Trisphosphate Receptor Type 3	Protein Coding	4
36	KNG1	Kininogen 1	Protein Coding	4
37	RGS21	Regulator Of G Protein Signaling 21	Protein Coding	4
38	GNG13	G Protein Subunit Gamma 13	Protein Coding	4
39	PLCB2	Phospholipase C Beta 2	Protein Coding	4
40	PLCB3	Phospholipase C Beta 3	Protein Coding	4
41	PLCB4	Phospholipase C Beta 4	Protein Coding	4
42	PMCH	Pro-Melanin Concentrating Hormone	Protein Coding	4
43	GNG2	G Protein Subunit Gamma 2	Protein Coding	4
44	PRKCA	Protein Kinase C Alpha	Protein Coding	4
45	PRKCD	Protein Kinase C Delta	Protein Coding	4
46	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	4
47	GNG12	G Protein Subunit Gamma 12	Protein Coding	4
48	NMUR2	Neuromedin U Receptor 2	Protein Coding	4
49	LPAR5	Lysophosphatidic Acid Receptor 5	Protein Coding	4
50	GNB4	G Protein Subunit Beta 4	Protein Coding	4
51	RGS1	Regulator Of G Protein Signaling 1	Protein Coding	4
52	RGS3	Regulator Of G Protein Signaling 3	Protein Coding	4
53	RGS4	Regulator Of G Protein Signaling 4	Protein Coding	4
54	RGS13	Regulator Of G Protein Signaling 13	Protein Coding	4
55	RGS16	Regulator Of G Protein Signaling 16	Protein Coding	4
56	BDKRB1	Bradykinin Receptor B1	Protein Coding	4
57	BDKRB2	Bradykinin Receptor B2	Protein Coding	4
58	SAA1	Serum Amyloid A1	Protein Coding	4
59	CCL23	C-C Motif Chemokine Ligand 23	Protein Coding	4
60	RGS18	Regulator Of G Protein Signaling 18	Protein Coding	4
61	MCHR2	Melanin Concentrating Hormone Receptor 2	Protein Coding	4
62	CASR	Calcium Sensing Receptor	Protein Coding	4
63	RGS5	Regulator Of G Protein Signaling 5	Protein Coding	4
64	LPAR2	Lysophosphatidic Acid Receptor 2	Protein Coding	4
65	GNG8	G Protein Subunit Gamma 8	Protein Coding	4
66	GNA14	G Protein Subunit Alpha 14	Protein Coding	4
67	INSL5	Insulin Like 5	Protein Coding	3
68	NPY4R2	Neuropeptide Y Receptor Y4-2	Protein Coding	3
69	OPN1MW3	Opsin 1, Medium Wave Sensitive 3	Protein Coding	3
70	RASGRP1	RAS Guanyl Releasing Protein 1	Protein Coding	3
71	LPAR6	Lysophosphatidic Acid Receptor 6	Protein Coding	3
72	CDK5	Cyclin Dependent Kinase 5	Protein Coding	3
73	RASGRP2	RAS Guanyl Releasing Protein 2	Protein Coding	3
74	CXCL13	C-X-C Motif Chemokine Ligand 13	Protein Coding	3
75	RGS14	Regulator Of G Protein Signaling 14	Protein Coding	3
76	CAMKK2	Calcium/Calmodulin Dependent Protein Kinase Kinase 2	Protein Coding	3
77	CXCR6	C-X-C Motif Chemokine Receptor 6	Protein Coding	3
78	RRH	Retinal Pigment Epithelium-Derived Rhodopsin Homolog	Protein Coding	3
79	ADCY1	Adenylate Cyclase 1	Protein Coding	3
80	AHCYL1	Adenosylhomocysteinase Like 1	Protein Coding	3
81	ADCY2	Adenylate Cyclase 2	Protein Coding	3
82	CYSLTR1	Cysteinyl Leukotriene Receptor 1	Protein Coding	3
83	CCR9	C-C Motif Chemokine Receptor 9	Protein Coding	3
84	CCL27	C-C Motif Chemokine Ligand 27	Protein Coding	3
85	NPFFR2	Neuropeptide FF Receptor 2	Protein Coding	3
86	PROKR1	Prokineticin Receptor 1	Protein Coding	3
87	ADCY3	Adenylate Cyclase 3	Protein Coding	3
88	UTS2	Urotensin 2	Protein Coding	3
89	ADCY5	Adenylate Cyclase 5	Protein Coding	3
90	ADCY6	Adenylate Cyclase 6	Protein Coding	3
91	PTGDR2	Prostaglandin D2 Receptor 2	Protein Coding	3
92	CHRM1	Cholinergic Receptor Muscarinic 1	Protein Coding	3
93	CHRM2	Cholinergic Receptor Muscarinic 2	Protein Coding	3
94	ADCY7	Adenylate Cyclase 7	Protein Coding	3
95	CHRM3	Cholinergic Receptor Muscarinic 3	Protein Coding	3
96	CHRM4	Cholinergic Receptor Muscarinic 4	Protein Coding	3
97	CHRM5	Cholinergic Receptor Muscarinic 5	Protein Coding	3
98	MGLL	Monoglyceride Lipase	Protein Coding	3
99	ADCY8	Adenylate Cyclase 8	Protein Coding	3
100	ADCY9	Adenylate Cyclase 9	Protein Coding	3
101	ARHGEF25	Rho Guanine Nucleotide Exchange Factor 25	Protein Coding	3
102	RLN3	Relaxin 3	Protein Coding	3
103	CCR1	C-C Motif Chemokine Receptor 1	Protein Coding	3
104	CCR3	C-C Motif Chemokine Receptor 3	Protein Coding	3
105	CCR4	C-C Motif Chemokine Receptor 4	Protein Coding	3
106	CCR5	C-C Motif Chemokine Receptor 5	Protein Coding	3
107	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	3
108	CCR7	C-C Motif Chemokine Receptor 7	Protein Coding	3
109	CCR8	C-C Motif Chemokine Receptor 8	Protein Coding	3
110	LTB4R	Leukotriene B4 Receptor	Protein Coding	3
111	PCP2	Purkinje Cell Protein 2	Protein Coding	3
112	CNR1	Cannabinoid Receptor 1	Protein Coding	3
113	CNR2	Cannabinoid Receptor 2	Protein Coding	3
114	PROKR2	Prokineticin Receptor 2	Protein Coding	3
115	CORT	Cortistatin	Protein Coding	3
116	ADORA1	Adenosine A1 Receptor	Protein Coding	3
117	DGKK	Diacylglycerol Kinase Kappa	Protein Coding	3
118	ADORA3	Adenosine A3 Receptor	Protein Coding	3
119	ADRA1D	Adrenoceptor Alpha 1D	Protein Coding	3
120	ADRA1B	Adrenoceptor Alpha 1B	Protein Coding	3
121	ADRA1A	Adrenoceptor Alpha 1A	Protein Coding	3
122	ADRA2A	Adrenoceptor Alpha 2A	Protein Coding	3
123	ADRA2B	Adrenoceptor Alpha 2B	Protein Coding	3
124	ADRA2C	Adrenoceptor Alpha 2C	Protein Coding	3
125	CX3CR1	C-X3-C Motif Chemokine Receptor 1	Protein Coding	3
126	DGKA	Diacylglycerol Kinase Alpha	Protein Coding	3
127	DGKB	Diacylglycerol Kinase Beta	Protein Coding	3
128	DGKG	Diacylglycerol Kinase Gamma	Protein Coding	3
129	DGKH	Diacylglycerol Kinase Eta	Protein Coding	3
130	DGKQ	Diacylglycerol Kinase Theta	Protein Coding	3
131	OXER1	Oxoeicosanoid Receptor 1	Protein Coding	3
132	DRD3	Dopamine Receptor D3	Protein Coding	3
133	DRD4	Dopamine Receptor D4	Protein Coding	3
134	HBEGF	Heparin Binding EGF Like Growth Factor	Protein Coding	3
135	AGTR1	Angiotensin II Receptor Type 1	Protein Coding	3
136	AGTR2	Angiotensin II Receptor Type 2	Protein Coding	3
137	APLNR	Apelin Receptor	Protein Coding	3
138	GPR183	G Protein-Coupled Receptor 183	Protein Coding	3
139	S1PR3	Sphingosine-1-Phosphate Receptor 3	Protein Coding	3
140	EDN1	Endothelin 1	Protein Coding	3
141	EDN2	Endothelin 2	Protein Coding	3
142	EDN3	Endothelin 3	Protein Coding	3
143	EDNRA	Endothelin Receptor Type A	Protein Coding	3
144	EDNRB	Endothelin Receptor Type B	Protein Coding	3
145	EGFR	Epidermal Growth Factor Receptor	Protein Coding	3
146	ADCY4	Adenylate Cyclase 4	Protein Coding	3
147	F2	Coagulation Factor II, Thrombin	Protein Coding	3
148	F2R	Coagulation Factor II Thrombin Receptor	Protein Coding	3
149	F2RL1	F2R Like Trypsin Receptor 1	Protein Coding	3
150	F2RL2	Coagulation Factor II Thrombin Receptor Like 2	Protein Coding	3
151	OPN5	Opsin 5	Protein Coding	3
152	DAGLB	Diacylglycerol Lipase Beta	Protein Coding	3
153	GPRC6A	G Protein-Coupled Receptor Class C Group 6 Member A	Protein Coding	3
154	FPR1	Formyl Peptide Receptor 1	Protein Coding	3
155	FPR3	Formyl Peptide Receptor 3	Protein Coding	3
156	OPN3	Opsin 3	Protein Coding	3
157	NTSR2	Neurotensin Receptor 2	Protein Coding	3
158	GAST	Gastrin	Protein Coding	3
159	GABBR1	Gamma-Aminobutyric Acid Type B Receptor Subunit 1	Protein Coding	3
160	NPB	Neuropeptide B	Protein Coding	3
161	UTS2B	Urotensin 2B	Protein Coding	3
162	GALR1	Galanin Receptor 1	Protein Coding	3
163	TAS2R39	Taste 2 Receptor Member 39	Protein Coding	3
164	TAS2R40	Taste 2 Receptor Member 40	Protein Coding	3
165	TAS2R41	Taste 2 Receptor Member 41	Protein Coding	3
166	TAS2R43	Taste 2 Receptor Member 43	Protein Coding	3
167	TAS2R31	Taste 2 Receptor Member 31	Protein Coding	3
168	TAS2R46	Taste 2 Receptor Member 46	Protein Coding	3
169	TAS2R30	Taste 2 Receptor Member 30	Protein Coding	3
170	TAS2R19	Taste 2 Receptor Member 19	Protein Coding	3
171	TAS2R20	Taste 2 Receptor Member 20	Protein Coding	3
172	TAS2R50	Taste 2 Receptor Member 50	Protein Coding	3
173	GPSM1	G Protein Signaling Modulator 1	Protein Coding	3
174	ABHD12	Abhydrolase Domain Containing 12, Lysophospholipase	Protein Coding	3
175	RGS22	Regulator Of G Protein Signaling 22	Protein Coding	3
176	GCG	Glucagon	Protein Coding	3
177	GCGR	Glucagon Receptor	Protein Coding	3
178	OPN1MW	Opsin 1, Medium Wave Sensitive	Protein Coding	3
179	GHSR	Growth Hormone Secretagogue Receptor	Protein Coding	3
180	NBEA	Neurobeachin	Protein Coding	3
181	HCAR1	Hydroxycarboxylic Acid Receptor 1	Protein Coding	3
182	OXGR1	Oxoglutarate Receptor 1	Protein Coding	3
183	P2RY10	P2Y Receptor Family Member 10	Protein Coding	3
184	GNAI1	G Protein Subunit Alpha I1	Protein Coding	3
185	GNAI2	G Protein Subunit Alpha I2	Protein Coding	3
186	GNAI3	G Protein Subunit Alpha I3	Protein Coding	3
187	GNAL	G Protein Subunit Alpha L	Protein Coding	3
188	GNAS	GNAS Complex Locus	Protein Coding	3
189	GNAT1	G Protein Subunit Alpha Transducin 1	Protein Coding	3
190	GNAT2	G Protein Subunit Alpha Transducin 2	Protein Coding	3
191	GNAZ	G Protein Subunit Alpha Z	Protein Coding	3
192	GNRH1	Gonadotropin Releasing Hormone 1	Protein Coding	3
193	GNRH2	Gonadotropin Releasing Hormone 2	Protein Coding	3
194	GNRHR	Gonadotropin Releasing Hormone Receptor	Protein Coding	3
195	CCR10	C-C Motif Chemokine Receptor 10	Protein Coding	3
196	GPR4	G Protein-Coupled Receptor 4	Protein Coding	3
197	XCR1	X-C Motif Chemokine Receptor 1	Protein Coding	3
198	NPBWR1	Neuropeptides B And W Receptor 1	Protein Coding	3
199	NPBWR2	Neuropeptides B And W Receptor 2	Protein Coding	3
200	CXCR3	C-X-C Motif Chemokine Receptor 3	Protein Coding	3
201	UTS2R	Urotensin 2 Receptor	Protein Coding	3
202	NPW	Neuropeptide W	Protein Coding	3
203	GPR18	G Protein-Coupled Receptor 18	Protein Coding	3
204	LPAR4	Lysophosphatidic Acid Receptor 4	Protein Coding	3
205	GPER1	G Protein-Coupled Estrogen Receptor 1	Protein Coding	3
206	GPR31	G Protein-Coupled Receptor 31	Protein Coding	3
207	GPR37	G Protein-Coupled Receptor 37	Protein Coding	3
208	MLNR	Motilin Receptor	Protein Coding	3
209	GPR39	G Protein-Coupled Receptor 39	Protein Coding	3
210	FFAR1	Free Fatty Acid Receptor 1	Protein Coding	3
211	FFAR3	Free Fatty Acid Receptor 3	Protein Coding	3
212	FFAR2	Free Fatty Acid Receptor 2	Protein Coding	3
213	GRK5	G Protein-Coupled Receptor Kinase 5	Protein Coding	3
214	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	3
215	GRM1	Glutamate Metabotropic Receptor 1	Protein Coding	3
216	GRM2	Glutamate Metabotropic Receptor 2	Protein Coding	3
217	GRM3	Glutamate Metabotropic Receptor 3	Protein Coding	3
218	GRM4	Glutamate Metabotropic Receptor 4	Protein Coding	3
219	GRM5	Glutamate Metabotropic Receptor 5	Protein Coding	3
220	GRM6	Glutamate Metabotropic Receptor 6	Protein Coding	3
221	GRM7	Glutamate Metabotropic Receptor 7	Protein Coding	3
222	GRM8	Glutamate Metabotropic Receptor 8	Protein Coding	3
223	CXCL1	C-X-C Motif Chemokine Ligand 1	Protein Coding	3
224	CXCL2	C-X-C Motif Chemokine Ligand 2	Protein Coding	3
225	CXCL3	C-X-C Motif Chemokine Ligand 3	Protein Coding	3
226	GRP	Gastrin Releasing Peptide	Protein Coding	3
227	GRPR	Gastrin Releasing Peptide Receptor	Protein Coding	3
228	GPSM2	G Protein Signaling Modulator 2	Protein Coding	3
229	GPR132	G Protein-Coupled Receptor 132	Protein Coding	3
230	HCRT	Hypocretin Neuropeptide Precursor	Protein Coding	3
231	HCRTR1	Hypocretin Receptor 1	Protein Coding	3
232	HCRTR2	Hypocretin Receptor 2	Protein Coding	3
233	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	3
234	HRH1	Histamine Receptor H1	Protein Coding	3
235	HTR1B	5-Hydroxytryptamine Receptor 1B	Protein Coding	3
236	HTR1D	5-Hydroxytryptamine Receptor 1D	Protein Coding	3
237	HTR1E	5-Hydroxytryptamine Receptor 1E	Protein Coding	3
238	HTR1F	5-Hydroxytryptamine Receptor 1F	Protein Coding	3
239	HTR2A	5-Hydroxytryptamine Receptor 2A	Protein Coding	3
240	HTR2B	5-Hydroxytryptamine Receptor 2B	Protein Coding	3
241	HTR2C	5-Hydroxytryptamine Receptor 2C	Protein Coding	3
242	HTR5A	5-Hydroxytryptamine Receptor 5A	Protein Coding	3
243	TAS2R60	Taste 2 Receptor Member 60	Protein Coding	3
244	HCAR2	Hydroxycarboxylic Acid Receptor 2	Protein Coding	3
245	FFAR4	Free Fatty Acid Receptor 4	Protein Coding	3
246	RXFP4	Relaxin Family Peptide/INSL5 Receptor 4	Protein Coding	3
247	GNAT3	G Protein Subunit Alpha Transducin 3	Protein Coding	3
248	QRFP	Pyroglutamylated RFamide Peptide	Protein Coding	3
249	TAS2R42	Taste 2 Receptor Member 42	Protein Coding	3
250	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	3
251	CXCR1	C-X-C Motif Chemokine Receptor 1	Protein Coding	3
252	CXCR2	C-X-C Motif Chemokine Receptor 2	Protein Coding	3
253	CXCL10	C-X-C Motif Chemokine Ligand 10	Protein Coding	3
254	KISS1	KiSS-1 Metastasis Suppressor	Protein Coding	3
255	KPNA2	Karyopherin Subunit Alpha 2	Protein Coding	3
256	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	3
257	NPSR1	Neuropeptide S Receptor 1	Protein Coding	3
258	CCL4L1	C-C Motif Chemokine Ligand 4 Like 1	Protein Coding	3
259	CXCL9	C-X-C Motif Chemokine Ligand 9	Protein Coding	3
260	MLN	Motilin	Protein Coding	3
261	MMP3	Matrix Metallopeptidase 3	Protein Coding	3
262	MTNR1A	Melatonin Receptor 1A	Protein Coding	3
263	MTNR1B	Melatonin Receptor 1B	Protein Coding	3
264	NMB	Neuromedin B	Protein Coding	3
265	NMBR	Neuromedin B Receptor	Protein Coding	3
266	NPY	Neuropeptide Y	Protein Coding	3
267	NPY1R	Neuropeptide Y Receptor Y1	Protein Coding	3
268	NPY2R	Neuropeptide Y Receptor Y2	Protein Coding	3
269	NPY5R	Neuropeptide Y Receptor Y5	Protein Coding	3
270	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	3
271	NTS	Neurotensin	Protein Coding	3
272	NTSR1	Neurotensin Receptor 1	Protein Coding	3
273	GPR143	G Protein-Coupled Receptor 143	Protein Coding	3
274	OPRD1	Opioid Receptor Delta 1	Protein Coding	3
275	OPRK1	Opioid Receptor Kappa 1	Protein Coding	3
276	OPRL1	Opioid Related Nociceptin Receptor 1	Protein Coding	3
277	OPRM1	Opioid Receptor Mu 1	Protein Coding	3
278	OXT	Oxytocin/Neurophysin I Prepropeptide	Protein Coding	3
279	OXTR	Oxytocin Receptor	Protein Coding	3
280	P2RY1	Purinergic Receptor P2Y1	Protein Coding	3
281	P2RY2	Purinergic Receptor P2Y2	Protein Coding	3
282	P2RY4	Pyrimidinergic Receptor P2Y4	Protein Coding	3
283	P2RY6	Pyrimidinergic Receptor P2Y6	Protein Coding	3
284	P2RY11	Purinergic Receptor P2Y11	Protein Coding	3
285	TAS2R3	Taste 2 Receptor Member 3	Protein Coding	3
286	TAS2R4	Taste 2 Receptor Member 4	Protein Coding	3
287	TAS2R16	Taste 2 Receptor Member 16	Protein Coding	3
288	TAS2R1	Taste 2 Receptor Member 1	Protein Coding	3
289	TAS2R9	Taste 2 Receptor Member 9	Protein Coding	3
290	TAS2R8	Taste 2 Receptor Member 8	Protein Coding	3
291	TAS2R7	Taste 2 Receptor Member 7	Protein Coding	3
292	TAS2R13	Taste 2 Receptor Member 13	Protein Coding	3
293	TAS2R10	Taste 2 Receptor Member 10	Protein Coding	3
294	TAS2R14	Taste 2 Receptor Member 14	Protein Coding	3
295	HEBP1	Heme Binding Protein 1	Protein Coding	3
296	GAL	Galanin And GMAP Prepropeptide	Protein Coding	3
297	RXFP3	Relaxin Family Peptide Receptor 3	Protein Coding	3
298	PDE1A	Phosphodiesterase 1A	Protein Coding	3
299	PDE1C	Phosphodiesterase 1C	Protein Coding	3
300	PDE4A	Phosphodiesterase 4A	Protein Coding	3
301	PDE4B	Phosphodiesterase 4B	Protein Coding	3
302	PDE4C	Phosphodiesterase 4C	Protein Coding	3
303	PDE4D	Phosphodiesterase 4D	Protein Coding	3
304	PDE1B	Phosphodiesterase 1B	Protein Coding	3
305	PDYN	Prodynorphin	Protein Coding	3
306	GHRL	Ghrelin And Obestatin Prepropeptide	Protein Coding	3
307	PENK	Proenkephalin	Protein Coding	3
308	PF4	Platelet Factor 4	Protein Coding	3
309	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	3
310	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	3
311	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	3
312	PLA2G4A	Phospholipase A2 Group IVA	Protein Coding	3
313	S1PR5	Sphingosine-1-Phosphate Receptor 5	Protein Coding	3
314	PNOC	Prepronociceptin	Protein Coding	3
315	P2RY13	Purinergic Receptor P2Y13	Protein Coding	3
316	TAS2R5	Taste 2 Receptor Member 5	Protein Coding	3
317	POMC	Proopiomelanocortin	Protein Coding	3
318	PPBP	Pro-Platelet Basic Protein	Protein Coding	3
319	PPP1CA	Protein Phosphatase 1 Catalytic Subunit Alpha	Protein Coding	3
320	AVP	Arginine Vasopressin	Protein Coding	3
321	PPP2CA	Protein Phosphatase 2 Catalytic Subunit Alpha	Protein Coding	3
322	PPP2CB	Protein Phosphatase 2 Catalytic Subunit Beta	Protein Coding	3
323	PPP2R1A	Protein Phosphatase 2 Scaffold Subunit Aalpha	Protein Coding	3
324	PPP2R1B	Protein Phosphatase 2 Scaffold Subunit Abeta	Protein Coding	3
325	AVPR1A	Arginine Vasopressin Receptor 1A	Protein Coding	3
326	PPP2R5D	Protein Phosphatase 2 Regulatory Subunit B''Delta	Protein Coding	3
327	AVPR1B	Arginine Vasopressin Receptor 1B	Protein Coding	3
328	PPP3CA	Protein Phosphatase 3 Catalytic Subunit Alpha	Protein Coding	3
329	PPP3CB	Protein Phosphatase 3 Catalytic Subunit Beta	Protein Coding	3
330	PPP3CC	Protein Phosphatase 3 Catalytic Subunit Gamma	Protein Coding	3
331	PPP3R1	Protein Phosphatase 3 Regulatory Subunit B, Alpha	Protein Coding	3
332	PPY	Pancreatic Polypeptide	Protein Coding	3
333	NPY4R	Neuropeptide Y Receptor Y4	Protein Coding	3
334	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	3
335	PRKACB	Protein Kinase CAMP-Activated Catalytic Subunit Beta	Protein Coding	3
336	PRKACG	Protein Kinase CAMP-Activated Catalytic Subunit Gamma	Protein Coding	3
337	PRKAR1A	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Alpha	Protein Coding	3
338	PRKAR1B	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Beta	Protein Coding	3
339	PRKAR2A	Protein Kinase CAMP-Dependent Type II Regulatory Subunit Alpha	Protein Coding	3
340	PRKAR2B	Protein Kinase CAMP-Dependent Type II Regulatory Subunit Beta	Protein Coding	3
341	PRKCE	Protein Kinase C Epsilon	Protein Coding	3
342	PRKCG	Protein Kinase C Gamma	Protein Coding	3
343	PRKCH	Protein Kinase C Eta	Protein Coding	3
344	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	3
345	MAPK7	Mitogen-Activated Protein Kinase 7	Protein Coding	3
346	PRKX	Protein Kinase CAMP-Dependent X-Linked Catalytic Subunit	Protein Coding	3
347	LTB4R2	Leukotriene B4 Receptor 2	Protein Coding	3
348	CCL28	C-C Motif Chemokine Ligand 28	Protein Coding	3
349	PSAP	Prosaposin	Protein Coding	3
350	SUCNR1	Succinate Receptor 1	Protein Coding	3
351	PYY	Peptide YY	Protein Coding	3
352	ACKR3	Atypical Chemokine Receptor 3	Protein Coding	3
353	CYSLTR2	Cysteinyl Leukotriene Receptor 2	Protein Coding	3
354	TRPC7	Transient Receptor Potential Cation Channel Subfamily C Member 7	Protein Coding	3
355	PTAFR	Platelet Activating Factor Receptor	Protein Coding	3
356	TAS2R38	Taste 2 Receptor Member 38	Protein Coding	3
357	PTGER1	Prostaglandin E Receptor 1	Protein Coding	3
358	PTGER3	Prostaglandin E Receptor 3	Protein Coding	3
359	PTGFR	Prostaglandin F Receptor	Protein Coding	3
360	ABHD6	Abhydrolase Domain Containing 6, Acylglycerol Lipase	Protein Coding	3
361	CXCL16	C-X-C Motif Chemokine Ligand 16	Protein Coding	3
362	HRH4	Histamine Receptor H4	Protein Coding	3
363	NPS	Neuropeptide S	Protein Coding	3
364	OPN1LW	Opsin 1, Long Wave Sensitive	Protein Coding	3
365	RGR	Retinal G Protein Coupled Receptor	Protein Coding	3
366	RGS2	Regulator Of G Protein Signaling 2	Protein Coding	3
367	RGS7	Regulator Of G Protein Signaling 7	Protein Coding	3
368	RGS10	Regulator Of G Protein Signaling 10	Protein Coding	3
369	RGS12	Regulator Of G Protein Signaling 12	Protein Coding	3
370	RHO	Rhodopsin	Protein Coding	3
371	PROK2	Prokineticin 2	Protein Coding	3
372	OPN1SW	Opsin 1, Short Wave Sensitive	Protein Coding	3
373	RPS6KA1	Ribosomal Protein S6 Kinase A1	Protein Coding	3
374	RPS6KA2	Ribosomal Protein S6 Kinase A2	Protein Coding	3
375	RPS6KA3	Ribosomal Protein S6 Kinase A3	Protein Coding	3
376	CCL1	C-C Motif Chemokine Ligand 1	Protein Coding	3
377	CCL4	C-C Motif Chemokine Ligand 4	Protein Coding	3
378	CCL5	C-C Motif Chemokine Ligand 5	Protein Coding	3
379	CCL13	C-C Motif Chemokine Ligand 13	Protein Coding	3
380	CCL16	C-C Motif Chemokine Ligand 16	Protein Coding	3
381	CCL19	C-C Motif Chemokine Ligand 19	Protein Coding	3
382	CCL20	C-C Motif Chemokine Ligand 20	Protein Coding	3
383	CCL21	C-C Motif Chemokine Ligand 21	Protein Coding	3
384	CCL25	C-C Motif Chemokine Ligand 25	Protein Coding	3
385	CXCL6	C-X-C Motif Chemokine Ligand 6	Protein Coding	3
386	CXCL11	C-X-C Motif Chemokine Ligand 11	Protein Coding	3
387	CXCL5	C-X-C Motif Chemokine Ligand 5	Protein Coding	3
388	XCL1	X-C Motif Chemokine Ligand 1	Protein Coding	3
389	CX3CL1	C-X3-C Motif Chemokine Ligand 1	Protein Coding	3
390	CXCL12	C-X-C Motif Chemokine Ligand 12	Protein Coding	3
391	GPSM3	G Protein Signaling Modulator 3	Protein Coding	3
392	NPFFR1	Neuropeptide FF Receptor 1	Protein Coding	3
393	CXCR5	C-X-C Motif Chemokine Receptor 5	Protein Coding	3
394	P2RY12	Purinergic Receptor P2Y12	Protein Coding	3
395	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	3
396	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	3
397	SST	Somatostatin	Protein Coding	3
398	SSTR1	Somatostatin Receptor 1	Protein Coding	3
399	SSTR2	Somatostatin Receptor 2	Protein Coding	3
400	SSTR3	Somatostatin Receptor 3	Protein Coding	3
401	SSTR4	Somatostatin Receptor 4	Protein Coding	3
402	SSTR5	Somatostatin Receptor 5	Protein Coding	3
403	BRS3	Bombesin Receptor Subtype 3	Protein Coding	3
404	XCL2	X-C Motif Chemokine Ligand 2	Protein Coding	3
405	TAC1	Tachykinin Precursor 1	Protein Coding	3
406	TACR2	Tachykinin Receptor 2	Protein Coding	3
407	TAC3	Tachykinin Precursor 3	Protein Coding	3
408	TACR1	Tachykinin Receptor 1	Protein Coding	3
409	TACR3	Tachykinin Receptor 3	Protein Coding	3
410	TBXA2R	Thromboxane A2 Receptor	Protein Coding	3
411	BTK	Bruton Tyrosine Kinase	Protein Coding	3
412	C3	Complement C3	Protein Coding	3
413	C3AR1	Complement C3a Receptor 1	Protein Coding	3
414	TRH	Thyrotropin Releasing Hormone	Protein Coding	3
415	TRHR	Thyrotropin Releasing Hormone Receptor	Protein Coding	3
416	TRIO	Trio Rho Guanine Nucleotide Exchange Factor	Protein Coding	3
417	TRPC3	Transient Receptor Potential Cation Channel Subfamily C Member 3	Protein Coding	3
418	TRPC6	Transient Receptor Potential Cation Channel Subfamily C Member 6	Protein Coding	3
419	C5	Complement C5	Protein Coding	3
420	C5AR1	Complement C5a Receptor 1	Protein Coding	3
421	CCR2	C-C Motif Chemokine Receptor 2	Protein Coding	3
422	DAGLA	Diacylglycerol Lipase Alpha	Protein Coding	3
423	CXCR4	C-X-C Motif Chemokine Receptor 4	Protein Coding	3
424	CALM1	Calmodulin 1	Protein Coding	3
425	CALM2	Calmodulin 2	Protein Coding	3
426	CALM3	Calmodulin 3	Protein Coding	3
427	TAS1R2	Taste 1 Receptor Member 2	Protein Coding	3
428	TAS1R1	Taste 1 Receptor Member 1	Protein Coding	3
429	GPR68	G Protein-Coupled Receptor 68	Protein Coding	3
430	CAMK4	Calcium/Calmodulin Dependent Protein Kinase IV	Protein Coding	3
431	CAMK2A	Calcium/Calmodulin Dependent Protein Kinase II Alpha	Protein Coding	3
432	CAMK2B	Calcium/Calmodulin Dependent Protein Kinase II Beta	Protein Coding	3
433	CAMK2D	Calcium/Calmodulin Dependent Protein Kinase II Delta	Protein Coding	3
434	CAMK2G	Calcium/Calmodulin Dependent Protein Kinase II Gamma	Protein Coding	3
435	TAS1R3	Taste 1 Receptor Member 3	Protein Coding	3
436	QRFPR	Pyroglutamylated RFamide Peptide Receptor	Protein Coding	3
437	PPP1R1B	Protein Phosphatase 1 Regulatory Inhibitor Subunit 1B	Protein Coding	3
438	CAMKK1	Calcium/Calmodulin Dependent Protein Kinase Kinase 1	Protein Coding	3
439	PROK1	Prokineticin 1	Protein Coding	3
440	KISS1R	KISS1 Receptor	Protein Coding	3
441	GPR65	G Protein-Coupled Receptor 65	Protein Coding	3
442	GALR3	Galanin Receptor 3	Protein Coding	3
443	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	3
444	DGKZ	Diacylglycerol Kinase Zeta	Protein Coding	3
445	DGKE	Diacylglycerol Kinase Epsilon	Protein Coding	3
446	DGKD	Diacylglycerol Kinase Delta	Protein Coding	3
447	RGS8	Regulator Of G Protein Signaling 8	Protein Coding	3
448	RGS20	Regulator Of G Protein Signaling 20	Protein Coding	3
449	NPFF	Neuropeptide FF-Amide Peptide Precursor	Protein Coding	3
450	S1PR4	Sphingosine-1-Phosphate Receptor 4	Protein Coding	3
451	RGS11	Regulator Of G Protein Signaling 11	Protein Coding	3
452	RGS9	Regulator Of G Protein Signaling 9	Protein Coding	3
453	GALR2	Galanin Receptor 2	Protein Coding	3
454	HCAR3	Hydroxycarboxylic Acid Receptor 3	Protein Coding	3
455	CCK	Cholecystokinin	Protein Coding	3
456	CCKAR	Cholecystokinin A Receptor	Protein Coding	3
457	APLN	Apelin	Protein Coding	3
458	CCKBR	Cholecystokinin B Receptor	Protein Coding	3
459	KALRN	Kalirin RhoGEF Kinase	Protein Coding	3
460	F2RL3	F2R Like Thrombin Or Trypsin Receptor 3	Protein Coding	3
461	DGKI	Diacylglycerol Kinase Iota	Protein Coding	3
462	GPR37L1	G Protein-Coupled Receptor 37 Like 1	Protein Coding	3
463	GPR55	G Protein-Coupled Receptor 55	Protein Coding	3
464	S1PR2	Sphingosine-1-Phosphate Receptor 2	Protein Coding	3
465	OPN4	Opsin 4	Protein Coding	3
466	CCL4L2	C-C Motif Chemokine Ligand 4 Like 2	Protein Coding	3
467	GABBR2	Gamma-Aminobutyric Acid Type B Receptor Subunit 2	Protein Coding	3
468	RGS6	Regulator Of G Protein Signaling 6	Protein Coding	3
469	P2RY14	Purinergic Receptor P2Y14	Protein Coding	3
470	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	2
471	ARHGEF33	Rho Guanine Nucleotide Exchange Factor 33	Protein Coding	2
472	CALCRL	Calcitonin Receptor Like Receptor	Protein Coding	2
473	RAMP2	Receptor Activity Modifying Protein 2	Protein Coding	2
474	RAMP1	Receptor Activity Modifying Protein 1	Protein Coding	2
475	RAMP3	Receptor Activity Modifying Protein 3	Protein Coding	2
476	NET1	Neuroepithelial Cell Transforming 1	Protein Coding	2
477	VAV3	Vav Guanine Nucleotide Exchange Factor 3	Protein Coding	2
478	GNA13	G Protein Subunit Alpha 13	Protein Coding	2
479	CGA	Glycoprotein Hormones, Alpha Polypeptide	Protein Coding	2
480	PDE10A	Phosphodiesterase 10A	Protein Coding	2
481	GPR83	G Protein-Coupled Receptor 83	Protein Coding	2
482	AKAP13	A-Kinase Anchoring Protein 13	Protein Coding	2
483	GPR176	G Protein-Coupled Receptor 176	Protein Coding	2
484	GPR45	G Protein-Coupled Receptor 45	Protein Coding	2
485	PTH2	Parathyroid Hormone 2	Protein Coding	2
486	ADCYAP1	Adenylate Cyclase Activating Polypeptide 1	Protein Coding	2
487	ADCYAP1R1	ADCYAP Receptor Type I	Protein Coding	2
488	FGD4	FYVE, RhoGEF And PH Domain Containing 4	Protein Coding	2
489	RXFP2	Relaxin Family Peptide Receptor 2	Protein Coding	2
490	GPHB5	Glycoprotein Hormone Subunit Beta 5	Protein Coding	2
491	ARHGEF19	Rho Guanine Nucleotide Exchange Factor 19	Protein Coding	2
492	ADM	Adrenomedullin	Protein Coding	2
493	TAAR9	Trace Amine Associated Receptor 9	Protein Coding	2
494	TAAR1	Trace Amine Associated Receptor 1	Protein Coding	2
495	ADORA2A	Adenosine A2a Receptor	Protein Coding	2
496	ADORA2B	Adenosine A2b Receptor	Protein Coding	2
497	CRH	Corticotropin Releasing Hormone	Protein Coding	2
498	CRHR1	Corticotropin Releasing Hormone Receptor 1	Protein Coding	2
499	CRHR2	Corticotropin Releasing Hormone Receptor 2	Protein Coding	2
500	PIK3R6	Phosphoinositide-3-Kinase Regulatory Subunit 6	Protein Coding	2
501	GPBAR1	G Protein-Coupled Bile Acid Receptor 1	Protein Coding	2
502	ADRB1	Adrenoceptor Beta 1	Protein Coding	2
503	ADRB2	Adrenoceptor Beta 2	Protein Coding	2
504	ADRB3	Adrenoceptor Beta 3	Protein Coding	2
505	GRK3	G Protein-Coupled Receptor Kinase 3	Protein Coding	2
506	GPHA2	Glycoprotein Hormone Subunit Alpha 2	Protein Coding	2
507	DRD1	Dopamine Receptor D1	Protein Coding	2
508	DRD5	Dopamine Receptor D5	Protein Coding	2
509	ECT2	Epithelial Cell Transforming 2	Protein Coding	2
510	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	2
511	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	2
512	FGD2	FYVE, RhoGEF And PH Domain Containing 2	Protein Coding	2
513	FGD1	FYVE, RhoGEF And PH Domain Containing 1	Protein Coding	2
514	ARHGEF15	Rho Guanine Nucleotide Exchange Factor 15	Protein Coding	2
515	ARHGEF9	Cdc42 Guanine Nucleotide Exchange Factor 9	Protein Coding	2
516	MCF2L	MCF.2 Cell Line Derived Transforming Sequence Like	Protein Coding	2
517	FN1	Fibronectin 1	Protein Coding	2
518	ARHGEF12	Rho Guanine Nucleotide Exchange Factor 12	Protein Coding	2
519	ARHGEF18	Rho/Rac Guanine Nucleotide Exchange Factor 18	Protein Coding	2
520	PIK3R5	Phosphoinositide-3-Kinase Regulatory Subunit 5	Protein Coding	2
521	FSHB	Follicle Stimulating Hormone Subunit Beta	Protein Coding	2
522	FSHR	Follicle Stimulating Hormone Receptor	Protein Coding	2
523	NGEF	Neuronal Guanine Nucleotide Exchange Factor	Protein Coding	2
524	ARHGEF26	Rho Guanine Nucleotide Exchange Factor 26	Protein Coding	2
525	TIAM2	TIAM Rac1 Associated GEF 2	Protein Coding	2
526	GHRH	Growth Hormone Releasing Hormone	Protein Coding	2
527	GHRHR	Growth Hormone Releasing Hormone Receptor	Protein Coding	2
528	GIP	Gastric Inhibitory Polypeptide	Protein Coding	2
529	GIPR	Gastric Inhibitory Polypeptide Receptor	Protein Coding	2
530	PDE7B	Phosphodiesterase 7B	Protein Coding	2
531	ARHGEF16	Rho Guanine Nucleotide Exchange Factor 16	Protein Coding	2
532	GLP1R	Glucagon Like Peptide 1 Receptor	Protein Coding	2
533	GNA12	G Protein Subunit Alpha 12	Protein Coding	2
534	GPR15	G Protein-Coupled Receptor 15	Protein Coding	2
535	GPR20	G Protein-Coupled Receptor 20	Protein Coding	2
536	GPR25	G Protein-Coupled Receptor 25	Protein Coding	2
537	GPR27	G Protein-Coupled Receptor 27	Protein Coding	2
538	GPR32	G Protein-Coupled Receptor 32	Protein Coding	2
539	GPR150	G Protein-Coupled Receptor 150	Protein Coding	2
540	GRK6	G Protein-Coupled Receptor Kinase 6	Protein Coding	2
541	ABR	ABR Activator Of RhoGEF And GTPase	Protein Coding	2
542	TAAR6	Trace Amine Associated Receptor 6	Protein Coding	2
543	HRH2	Histamine Receptor H2	Protein Coding	2
544	HTR4	5-Hydroxytryptamine Receptor 4	Protein Coding	2
545	HTR6	5-Hydroxytryptamine Receptor 6	Protein Coding	2
546	HTR7	5-Hydroxytryptamine Receptor 7	Protein Coding	2
547	IAPP	Islet Amyloid Polypeptide	Protein Coding	2
548	INSL3	Insulin Like 3	Protein Coding	2
549	ITGA5	Integrin Subunit Alpha 5	Protein Coding	2
550	ITGB1	Integrin Subunit Beta 1	Protein Coding	2
551	RHOA	Ras Homolog Family Member A	Protein Coding	2
552	RHOB	Ras Homolog Family Member B	Protein Coding	2
553	RHOC	Ras Homolog Family Member C	Protein Coding	2
554	ARHGEF37	Rho Guanine Nucleotide Exchange Factor 37	Protein Coding	2
555	LHB	Luteinizing Hormone Subunit Beta	Protein Coding	2
556	LHCGR	Luteinizing Hormone/Choriogonadotropin Receptor	Protein Coding	2
557	ARRB1	Arrestin Beta 1	Protein Coding	2
558	ARRB2	Arrestin Beta 2	Protein Coding	2
559	MC1R	Melanocortin 1 Receptor	Protein Coding	2
560	MC2R	Melanocortin 2 Receptor	Protein Coding	2
561	MC3R	Melanocortin 3 Receptor	Protein Coding	2
562	MC4R	Melanocortin 4 Receptor	Protein Coding	2
563	MC5R	Melanocortin 5 Receptor	Protein Coding	2
564	MCF2	MCF.2 Cell Line Derived Transforming Sequence	Protein Coding	2
565	ARHGEF35	Rho Guanine Nucleotide Exchange Factor 35	Protein Coding	2
566	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	2
567	ARHGEF4	Rho Guanine Nucleotide Exchange Factor 4	Protein Coding	2
568	ARHGEF3	Rho Guanine Nucleotide Exchange Factor 3	Protein Coding	2
569	PDE11A	Phosphodiesterase 11A	Protein Coding	2
570	PDE2A	Phosphodiesterase 2A	Protein Coding	2
571	PDE3A	Phosphodiesterase 3A	Protein Coding	2
572	PDE3B	Phosphodiesterase 3B	Protein Coding	2
573	PDE7A	Phosphodiesterase 7A	Protein Coding	2
574	PDE8A	Phosphodiesterase 8A	Protein Coding	2
575	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	2
576	PIK3CG	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma	Protein Coding	2
577	PLXNB1	Plexin B1	Protein Coding	2
578	GPR84	G Protein-Coupled Receptor 84	Protein Coding	2
579	ARHGEF38	Rho Guanine Nucleotide Exchange Factor 38	Protein Coding	2
580	ARHGEF10L	Rho Guanine Nucleotide Exchange Factor 10 Like	Protein Coding	2
581	AVPR2	Arginine Vasopressin Receptor 2	Protein Coding	2
582	ARHGEF40	Rho Guanine Nucleotide Exchange Factor 40	Protein Coding	2
583	PRKCB	Protein Kinase C Beta	Protein Coding	2
584	PTGDR	Prostaglandin D2 Receptor	Protein Coding	2
585	PTGER2	Prostaglandin E Receptor 2	Protein Coding	2
586	PTGER4	Prostaglandin E Receptor 4	Protein Coding	2
587	PTGIR	Prostaglandin I2 Receptor	Protein Coding	2
588	PTH	Parathyroid Hormone	Protein Coding	2
589	PTHLH	Parathyroid Hormone Like Hormone	Protein Coding	2
590	PLEKHG5	Pleckstrin Homology And RhoGEF Domain Containing G5	Protein Coding	2
591	PTH1R	Parathyroid Hormone 1 Receptor	Protein Coding	2
592	PTH2R	Parathyroid Hormone 2 Receptor	Protein Coding	2
593	PREX1	Phosphatidylinositol-3,4,5-Trisphosphate Dependent Rac Exchange Factor 1	Protein Coding	2
594	RASGRF2	Ras Protein Specific Guanine Nucleotide Releasing Factor 2	Protein Coding	2
595	RXFP1	Relaxin Family Peptide Receptor 1	Protein Coding	2
596	RLN2	Relaxin 2	Protein Coding	2
597	ROCK1	Rho Associated Coiled-Coil Containing Protein Kinase 1	Protein Coding	2
598	SCT	Secretin	Protein Coding	2
599	SCTR	Secretin Receptor	Protein Coding	2
600	ITSN1	Intersectin 1	Protein Coding	2
601	SHC1	SHC Adaptor Protein 1	Protein Coding	2
602	PLEKHG2	Pleckstrin Homology And RhoGEF Domain Containing G2	Protein Coding	2
603	SOS2	SOS Ras/Rho Guanine Nucleotide Exchange Factor 2	Protein Coding	2
604	TIAM1	TIAM Rac1 Associated GEF 1	Protein Coding	2
605	TSHB	Thyroid Stimulating Hormone Subunit Beta	Protein Coding	2
606	TSHR	Thyroid Stimulating Hormone Receptor	Protein Coding	2
607	VAV1	Vav Guanine Nucleotide Exchange Factor 1	Protein Coding	2
608	VAV2	Vav Guanine Nucleotide Exchange Factor 2	Protein Coding	2
609	VIP	Vasoactive Intestinal Peptide	Protein Coding	2
610	VIPR1	Vasoactive Intestinal Peptide Receptor 1	Protein Coding	2
611	VIPR2	Vasoactive Intestinal Peptide Receptor 2	Protein Coding	2
612	CALCA	Calcitonin Related Polypeptide Alpha	Protein Coding	2
613	CALCB	Calcitonin Related Polypeptide Beta	Protein Coding	2
614	ARHGEF5	Rho Guanine Nucleotide Exchange Factor 5	Protein Coding	2
615	CALCR	Calcitonin Receptor	Protein Coding	2
616	ADM2	Adrenomedullin 2	Protein Coding	2
617	TAAR8	Trace Amine Associated Receptor 8	Protein Coding	2
618	ARHGEF39	Rho Guanine Nucleotide Exchange Factor 39	Protein Coding	2
619	PDE8B	Phosphodiesterase 8B	Protein Coding	2
620	ARHGEF7	Rho Guanine Nucleotide Exchange Factor 7	Protein Coding	2
621	FGD3	FYVE, RhoGEF And PH Domain Containing 3	Protein Coding	2
622	TAAR5	Trace Amine Associated Receptor 5	Protein Coding	2
623	ARHGEF1	Rho Guanine Nucleotide Exchange Factor 1	Protein Coding	2
624	ARHGEF2	Rho/Rac Guanine Nucleotide Exchange Factor 2	Protein Coding	2
625	TAAR2	Trace Amine Associated Receptor 2	Protein Coding	2
626	GLP2R	Glucagon Like Peptide 2 Receptor	Protein Coding	2
627	ARHGEF6	Rac/Cdc42 Guanine Nucleotide Exchange Factor 6	Protein Coding	2
628	ROCK2	Rho Associated Coiled-Coil Containing Protein Kinase 2	Protein Coding	2
629	ARHGEF10	Rho Guanine Nucleotide Exchange Factor 10	Protein Coding	2
630	ARHGEF11	Rho Guanine Nucleotide Exchange Factor 11	Protein Coding	2
631	ARHGEF17	Rho Guanine Nucleotide Exchange Factor 17	Protein Coding	2
632	CDC42	Cell Division Cycle 42	Protein Coding	2
633	EEF1AKMT4-ECE2	EEF1AKMT4-ECE2 Readthrough	Protein Coding	1
634	FZD10	Frizzled Class Receptor 10	Protein Coding	1
635	HRH3	Histamine Receptor H3	Protein Coding	1
636	UCN3	Urocortin 3	Protein Coding	1
637	MRGPRD	MAS Related GPR Family Member D	Protein Coding	1
638	ACKR2	Atypical Chemokine Receptor 2	Protein Coding	1
639	CMKLR1	Chemerin Chemokine-Like Receptor 1	Protein Coding	1
640	CRHBP	Corticotropin Releasing Hormone Binding Protein	Protein Coding	1
641	CD55	CD55 Molecule (Cromer Blood Group)	Protein Coding	1
642	PLPPR5	Phospholipid Phosphatase Related 5	Protein Coding	1
643	DRD2	Dopamine Receptor D2	Protein Coding	1
644	ECE1	Endothelin Converting Enzyme 1	Protein Coding	1
645	S1PR1	Sphingosine-1-Phosphate Receptor 1	Protein Coding	1
646	ADGRE1	Adhesion G Protein-Coupled Receptor E1	Protein Coding	1
647	ACKR1	Atypical Chemokine Receptor 1 (Duffy Blood Group)	Protein Coding	1
648	FZD2	Frizzled Class Receptor 2	Protein Coding	1
649	C5AR2	Complement C5a Receptor 2	Protein Coding	1
650	PRLHR	Prolactin Releasing Hormone Receptor	Protein Coding	1
651	GPR35	G Protein-Coupled Receptor 35	Protein Coding	1
652	ADGRE2	Adhesion G Protein-Coupled Receptor E2	Protein Coding	1
653	HTR1A	5-Hydroxytryptamine Receptor 1A	Protein Coding	1
654	IHH	Indian Hedgehog Signaling Molecule	Protein Coding	1
655	KEL	Kell Metallo-Endopeptidase (Kell Blood Group)	Protein Coding	1
656	CCL3L3	C-C Motif Chemokine Ligand 3 Like 3	Protein Coding	1
657	MAS1	MAS1 Proto-Oncogene, G Protein-Coupled Receptor	Protein Coding	1
658	DHH	Desert Hedgehog Signaling Molecule	Protein Coding	1
659	PRLH	Prolactin Releasing Hormone	Protein Coding	1
660	WNT16	Wnt Family Member 16	Protein Coding	1
661	ACKR4	Atypical Chemokine Receptor 4	Protein Coding	1
662	WNT4	Wnt Family Member 4	Protein Coding	1
663	PLPPR1	Phospholipid Phosphatase Related 1	Protein Coding	1
664	PTCH1	Patched 1	Protein Coding	1
665	NLN	Neurolysin	Protein Coding	1
666	CCL2	C-C Motif Chemokine Ligand 2	Protein Coding	1
667	CCL3	C-C Motif Chemokine Ligand 3	Protein Coding	1
668	CCL3L1	C-C Motif Chemokine Ligand 3 Like 1	Protein Coding	1
669	CCL7	C-C Motif Chemokine Ligand 7	Protein Coding	1
670	CCL11	C-C Motif Chemokine Ligand 11	Protein Coding	1
671	CCL17	C-C Motif Chemokine Ligand 17	Protein Coding	1
672	CCL22	C-C Motif Chemokine Ligand 22	Protein Coding	1
673	SHH	Sonic Hedgehog Signaling Molecule	Protein Coding	1
674	PLPPR2	Phospholipid Phosphatase Related 2	Protein Coding	1
675	SMO	Smoothened, Frizzled Class Receptor	Protein Coding	1
676	UCN	Urocortin	Protein Coding	1
677	WNT1	Wnt Family Member 1	Protein Coding	1
678	WNT2	Wnt Family Member 2	Protein Coding	1
679	WNT3	Wnt Family Member 3	Protein Coding	1
680	WNT5A	Wnt Family Member 5A	Protein Coding	1
681	WNT6	Wnt Family Member 6	Protein Coding	1
682	WNT7A	Wnt Family Member 7A	Protein Coding	1
683	WNT7B	Wnt Family Member 7B	Protein Coding	1
684	WNT8A	Wnt Family Member 8A	Protein Coding	1
685	WNT8B	Wnt Family Member 8B	Protein Coding	1
686	WNT10B	Wnt Family Member 10B	Protein Coding	1
687	WNT11	Wnt Family Member 11	Protein Coding	1
688	WNT2B	Wnt Family Member 2B	Protein Coding	1
689	WNT9A	Wnt Family Member 9A	Protein Coding	1
690	WNT9B	Wnt Family Member 9B	Protein Coding	1
691	XK	X-Linked Kx Blood Group Antigen, Kell And VPS13A Binding Protein	Protein Coding	1
692	FZD5	Frizzled Class Receptor 5	Protein Coding	1
693	FZD3	Frizzled Class Receptor 3	Protein Coding	1
694	PLPPR3	Phospholipid Phosphatase Related 3	Protein Coding	1
695	WNT10A	Wnt Family Member 10A	Protein Coding	1
696	FZD1	Frizzled Class Receptor 1	Protein Coding	1
697	FZD4	Frizzled Class Receptor 4	Protein Coding	1
698	FZD6	Frizzled Class Receptor 6	Protein Coding	1
699	FZD7	Frizzled Class Receptor 7	Protein Coding	1
700	FZD8	Frizzled Class Receptor 8	Protein Coding	1
701	FZD9	Frizzled Class Receptor 9	Protein Coding	1
702	ADGRE3	Adhesion G Protein-Coupled Receptor E3	Protein Coding	1
703	PTCH2	Patched 2	Protein Coding	1
704	WNT3A	Wnt Family Member 3A	Protein Coding	1
705	UCN2	Urocortin 2	Protein Coding	1
706	CCRL2	C-C Motif Chemokine Receptor Like 2	Protein Coding	1
707	ECE2	Endothelin Converting Enzyme 2	Protein Coding	1
708	ADGRE5	Adhesion G Protein-Coupled Receptor E5	Protein Coding	1
709	PLPPR4	Phospholipid Phosphatase Related 4	Protein Coding	1

Disorders associated with GPCR downstream signalling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Normosmic congenital hypogonadotropic hypogonadism	Enrichment	GNRH1, GNRHR, KISS1, KISS1R, PROK2, PROKR2, TAC3, TACR3	9.84
2	Human immunodeficiency virus type 1	Enrichment	CCL11, CCL2, CCL3, CCL3L1, CCL5, CCR2, CCR5, CX3CR1, CXCL12, CXCR1	8.37
3	Lung non-small cell carcinoma	Enrichment	EGFR, HRAS, KRAS, NRAS, PIK3CA	6.38
4	Melanoma, uveal	Enrichment	CYSLTR2, GNA11, GNAQ, PLCB4	6.04
5	Hypogonadotropic hypogonadism 7 with or without anosmia	Enrichment	GNRHR, KISS1R, PROKR2, TAC3, TACR3	5.76
6	Nevus, epidermal	Enrichment	HRAS, KRAS, NRAS, PIK3CA	5.68
7	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	GNA11, PIK3CA, PIK3R1	5.40
8	Anastomosing haemangioma	Enrichment	GNA11, GNA14, GNAQ	5.40
9	Hypogonadotropic hypogonadism	Enrichment	GNRHR, KISS1R, PROKR2, TACR3	5.13
10	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	4.80
11	Capillary malformations, congenital	Enrichment	GNA11, GNAQ, PIK3CA	4.41
12	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, KRAS, NRAS, SOS1	4.13
13	Lung squamous cell carcinoma	Enrichment	EGFR, KRAS, PIK3CA	4.11
14	Hypertension, essential	Enrichment	AGT, AGTR1, GNB3, RGS5	3.90
15	Noonan syndrome 3	Enrichment	HRAS, KRAS, SOS1	3.88
16	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	3.60
17	Autosomal dominant hypocalcemia	Enrichment	CASR, GNA11	3.60
18	Phakomatosis cesioflammea	Enrichment	GNA11, GNAQ	3.60
19	Auriculocondylar syndrome 1	Enrichment	EDN1, GNAI3, PLCB4	3.41
20	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3, PIK3CA, PIK3R2	3.41
21	Noonan syndrome 1	Enrichment	HRAS, KRAS, NRAS, SOS1	3.36
22	Blue cone monochromacy	Enrichment	OPN1LW, OPN1MW	3.26
23	Pigmented nodular adrenocortical disease, primary, 1	Enrichment	GNAS, PRKAR1A	3.26
24	Acrodysostosis	Enrichment	PDE4D, PRKAR1A	3.26
25	X-linked cone dysfunction syndrome with myopia	Enrichment	OPN1LW, OPN1MW	3.26
26	Catecholaminergic polymorphic ventricular tachycardia	Enrichment	CALM1, CALM2, CALM3	3.18
27	Rasopathy	Enrichment	HRAS, KRAS, NRAS, SOS1	3.15
28	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	3.13
29	Lip and oral cavity carcinoma	Enrichment	EGFR, HRAS, PIK3CA	3.10
30	Autosomal dominant non-syndromic intellectual disability	Enrichment	CAMK2A, CAMK2B, GABBR1, GNB1, NBEA, PPP3CA	2.97
31	Bladder cancer	Enrichment	EGFR, HRAS, KRAS, PIK3CA	2.96
32	Differentiated thyroid carcinoma	Enrichment	HRAS, KRAS, LPAR4, NRAS	2.96
33	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	2.83
34	Genetic central precocious puberty in male	Enrichment	KISS1, KISS1R	2.83
35	Breast adenocarcinoma	Enrichment	AKT1, KRAS, PIK3CA	2.74
36	Congenital stationary night blindness	Enrichment	GNAT1, GNB3, GRM6, RHO	2.73
37	Pseudohypoparathyroidism	Enrichment	GNAS, PTH1R	2.66
38	Isolated primary pigmented nodular adrenocortical disease	Enrichment	PDE11A, PRKAR1A	2.66
39	Isolated micronodular adrenocortical disease	Enrichment	PDE11A, PDE8B	2.66
40	Achromatopsia 4	Enrichment	GNAI3, GNAT2	2.49
41	Hirschsprung disease 1	Enrichment	ECE1, EDN3, EDNRB, IHH, PROKR1, SMO	2.47
42	Klippel-trenaunay-weber syndrome	Enrichment	GNAQ, PIK3CA	2.44
43	Cowden syndrome 1	Enrichment	EGFR, PIK3CA	2.44
44	Waardenburg syndrome, type 4a	Enrichment	EDN3, EDNRB	2.44
45	Renal tubular dysgenesis	Enrichment	AGT, AGTR1	2.44
46	Infertility	Enrichment	GNRHR, TAC3	2.44
47	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS, NRAS	2.30
48	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, PIK3CA	2.30
49	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	2.30
50	Gallbladder cancer	Enrichment	KRAS, PIK3CA	2.30
51	Follicular thyroid carcinoma	Enrichment	HRAS, NRAS	2.30
52	Long qt syndrome 1	Enrichment	CALM1, CALM2, CALM3, ITPR3	2.29
53	Night blindness, congenital stationary, type 1c	Enrichment	GNAT1, GRM6	2.28
54	Kallmann syndrome	Enrichment	PROK2, PROKR2, TACR3	2.25
55	Brachydactyly, type e1	Enrichment	PTH1R, PTHLH	2.20
56	Familial isolated hypoparathyroidism	Enrichment	CASR, PTH	2.20
57	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, NRAS	2.18
58	Narcolepsy 1	Enrichment	HCRT, P2RY11	2.18
59	Osteoporosis, juvenile	Enrichment	WNT1, WNT3A	2.10
60	Body mass index quantitative trait locus 11	Enrichment	ADCY3, ADRB3, GHRL, GNAS, MC3R, MC4R, POMC	2.09
61	Arteriovenous malformation	Enrichment	HRAS, PIK3CA	2.07
62	Stroke, ischemic	Enrichment	F2, PRKCH	1.98
63	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, PIK3CA	1.98
64	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3, PIK3R2	1.91
65	Carney complex variant	Enrichment	PDE11A, PRKAR1A	1.91
66	Primary hyperparathyroidism	Enrichment	CASR, PTH	1.91
67	Specific learning disability	Enrichment	MAPK1, RPS6KA3	1.90
68	Lung cancer	Enrichment	EGFR, KRAS, PIK3CA	1.85
69	Juvenile myelomonocytic leukemia	Enrichment	KRAS, NRAS	1.82
70	Polydactyly, preaxial ii	Enrichment	PTCH1, SHH	1.82
71	Robinow syndrome, autosomal dominant 1	Enrichment	FZD2, WNT5A	1.82
72	Autosomal dominant robinow syndrome	Enrichment	FZD2, WNT5A	1.82
73	Precocious puberty, central, 1	Enrichment	KISS1R	1.80
74	Anhidrosis, isolated, with normal sweat glands	Enrichment	ITPR2	1.80
75	Macrodactyly	Enrichment	PIK3CA	1.80
76	Diabetes insipidus, neurohypophyseal	Enrichment	AVP	1.80
77	Hypocalciuric hypercalcemia, familial, type ii	Enrichment	GNA11	1.80
78	High molecular weight kininogen deficiency	Enrichment	KNG1	1.80
79	Hypogonadotropic hypogonadism 3 with or without anosmia	Enrichment	PROKR2	1.80
80	Nystagmus 6, congenital, x-linked	Enrichment	GPR143	1.80
81	Coffin-lowry syndrome	Enrichment	RPS6KA3	1.80
82	Thyrotropin-releasing hormone deficiency	Enrichment	TRH	1.80
83	Oculoectodermal syndrome	Enrichment	KRAS	1.80
84	Hypocalcemia, autosomal dominant 1	Enrichment	CASR	1.80
85	Noonan syndrome 4	Enrichment	SOS1	1.80
86	Hypocalciuric hypercalcemia, familial, type i	Enrichment	CASR	1.80
87	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	1.80
88	Prothrombin deficiency, congenital	Enrichment	F2	1.80
89	Cowden syndrome 5	Enrichment	PIK3CA	1.80
90	Focal segmental glomerulosclerosis 2	Enrichment	TRPC6	1.80
91	Mandibulofacial dysostosis with alopecia	Enrichment	EDNRA	1.80
92	Melanosis, neurocutaneous	Enrichment	NRAS	1.80
93	Hypogonadotropic hypogonadism 8 with or without anosmia	Enrichment	KISS1R	1.80
94	Bleeding disorder, platelet-type, 18	Enrichment	RASGRP2	1.80
95	Noonan syndrome 6	Enrichment	NRAS	1.80
96	Hirschsprung disease 4	Enrichment	EDN3	1.80
97	Waardenburg syndrome, type 4b	Enrichment	EDN3	1.80
98	Spinocerebellar ataxia 41	Enrichment	TRPC3	1.80
99	Neuroocular syndrome 2, paroxysmal type	Enrichment	DAGLA	1.80
100	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	1.80
101	Sturge-weber syndrome	Enrichment	GNAQ	1.80
102	Spinocerebellar ataxia, autosomal recessive 13	Enrichment	GRM1	1.80
103	Immunodeficiency 64 with lymphoproliferation	Enrichment	RASGRP1	1.80
104	Cerebral cavernous malformations 4	Enrichment	PIK3CA	1.80
105	Neurodevelopmental disorder with hypotonia and dysmorphic facies	Enrichment	GNB2	1.80
106	Auriculocondylar syndrome 3	Enrichment	EDN1	1.80
107	Noonan syndrome 13	Enrichment	MAPK1	1.80
108	Spondylometaphyseal dysplasia with corneal dystrophy	Enrichment	PLCB3	1.80
109	Charcot-marie-tooth disease, demyelinating, type 1j	Enrichment	ITPR3	1.80
110	Short syndrome	Enrichment	PIK3R1	1.80
111	Bleeding disorder, platelet-type, 13	Enrichment	TBXA2R	1.80
112	Auriculocondylar syndrome 2a	Enrichment	PLCB4	1.80
113	Isolated growth hormone deficiency type iii	Enrichment	BTK	1.80
114	Intellectual developmental disorder, x-linked 19	Enrichment	RPS6KA3	1.80
115	Hypogonadotropic hypogonadism 4 with or without anosmia	Enrichment	PROK2	1.80
116	Angioedema, hereditary, 6	Enrichment	KNG1	1.80
117	Central diabetes insipidus	Enrichment	AVP	1.80
118	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	1.80
119	Lodder-merla syndrome, type 2, with developmental delay and with or without cardiac arrhythmia	Enrichment	GNB5	1.80
120	Hemifacial myohyperplasia	Enrichment	PIK3CA	1.80
121	Question mark ears, isolated	Enrichment	EDN1	1.80
122	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	1.80
123	Cerebral amyloid angiopathy, app-related	Enrichment	APP	1.80
124	Body mass index quantitative trait locus 10	Enrichment	FFAR4	1.80
125	Coronary heart disease 6	Enrichment	MMP3	1.80
126	Epilepsy, idiopathic generalized 8	Enrichment	CASR	1.80
127	Hypogonadotropic hypogonadism 10 with or without anosmia	Enrichment	TAC3	1.80
128	Hypogonadotropic hypogonadism 13 with or without anosmia	Enrichment	KISS1	1.80
129	Hypothyroidism, congenital, nongoitrous, 7	Enrichment	TRHR	1.80
130	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	1.80
131	Hypogonadotropic hypogonadism 12 with or without anosmia	Enrichment	GNRH1	1.80
132	Hypocalcemia, autosomal dominant 2	Enrichment	GNA11	1.80
133	Charcot-marie-tooth disease, dominant intermediate f	Enrichment	GNB4	1.80
134	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	1.80
135	Pregnancy loss, recurrent 2	Enrichment	F2	1.80
136	Mahvash disease	Enrichment	GCGR	1.80
137	Intellectual developmental disorder, autosomal dominant 42	Enrichment	GNB1	1.80
138	Spinocerebellar ataxia 44	Enrichment	GRM1	1.80
139	Sick sinus syndrome 4	Enrichment	GNB2	1.80
140	Amelogenesis imperfecta, hypomaturation type, iia6	Enrichment	GPR68	1.80
141	Intellectual developmental disorder, autosomal dominant 63, with macrocephaly	Enrichment	TRIO	1.80
142	Serum amyloid a amyloidosis	Enrichment	SAA1	1.80
143	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	1.80
144	Auriculocondylar syndrome 2b	Enrichment	PLCB4	1.80
145	Narcolepsy	Enrichment	HCRT	1.80
146	Isolated gonadotropin-releasing hormone deficiency	Enrichment	GNRHR	1.80
147	Short stature due to growth hormone secretagogue receptor deficiency	Enrichment	GHSR	1.80
148	Symptomatic form of coffin-lowry syndrome in female carriers	Enrichment	RPS6KA3	1.80
149	Hypospadias	Enrichment	PIK3CA	1.80
150	Immunodeficiency 133 with ectodermal dysplasia with or without peripheral neuropathy	Enrichment	ITPR3	1.80
151	Hypercalcemia	Enrichment	CASR	1.80
152	Prothrombin deficiency	Enrichment	F2	1.80
153	Familial hypocalciuric hypercalcemia	Enrichment	CASR	1.80
154	Congenital pulmonary airway malformation	Enrichment	KRAS	1.80
155	Rare venous malformation	Enrichment	PIK3CA	1.80
156	Immunodeficiency 64	Enrichment	RASGRP1	1.80
157	Diaphragmatic eventration	Enrichment	PIK3CA	1.80
158	Ebv-induced lymphoproliferative disease due to rasgrp1 deficiency	Enrichment	RASGRP1	1.80
159	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	1.80
160	Short sleep, familial natural, 3	Enrichment	NPSR1	1.80
161	Rare combined vascular malformation	Enrichment	PIK3CA	1.80
162	Bleeding diathesis due to thromboxane synthesis deficiency	Enrichment	TBXA2R	1.80
163	Cavernous lymphangioma	Enrichment	PIK3CA	1.80
164	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	1.80
165	Phakomatosis pigmentokeratotica	Enrichment	HRAS	1.80
166	Phakomatosis cesiomarmorata	Enrichment	GNA11	1.80
167	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	1.80
168	Kaposiform hemangioendothelioma	Enrichment	GNA14	1.80
169	Chondromyxoid fibroma	Enrichment	GRM1	1.80
170	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	1.80
171	Macrodactyly of toe	Enrichment	PIK3CA	1.80
172	Neurocutaneous melanocytosis	Enrichment	NRAS	1.80
173	Hereditary arginine vasopressin deficiency	Enrichment	AVP	1.80
174	Ellis-van creveld syndrome	Enrichment	PRKACA, PRKACB	1.75
175	Hemolytic uremic syndrome, atypical 1	Enrichment	C3AR1, DGKE	1.70
176	Hemimegalencephaly	Enrichment	AKT3, PIK3CA	1.70
177	Lung cancer susceptibility 3	Enrichment	EGFR, KRAS	1.69
178	Pituitary stalk interruption syndrome	Enrichment	KISS1R, PROKR2	1.69
179	Achromatopsia	Enrichment	GNAT2, OPN1MW	1.66
180	Meningioma	Enrichment	AKT1, PIK3CA, SMO	1.66
181	Lynch syndrome	Enrichment	KRAS, PIK3CA	1.64
182	Male infertility with spermatogenesis disorder	Enrichment	PROK2, PROKR2	1.64
183	Thiourea tasting	Enrichment	TAS2R38	1.63
184	Acrodysostosis 1 with or without hormone resistance	Enrichment	PRKAR1A	1.63
185	Metachromatic leukodystrophy due to saposin b deficiency	Enrichment	PSAP	1.63
186	Complement component 5 deficiency	Enrichment	C5	1.63
187	Colorblindness, partial, deutan series	Enrichment	OPN1MW	1.63
188	Night blindness, congenital stationary, autosomal dominant 1	Enrichment	RHO	1.63
189	Pseudohypoparathyroidism, type ic	Enrichment	GNAS	1.63
190	Carney complex, type 1	Enrichment	PRKAR1A	1.63
191	Osseous heteroplasia, progressive	Enrichment	GNAS	1.63
192	Hemolytic uremic syndrome, atypical 5	Enrichment	C3	1.63
193	Polycystic lung disease	Enrichment	CCR2	1.63
194	Tremor, hereditary essential, 1	Enrichment	DRD3	1.63
195	Dyskinesia with orofacial involvement, autosomal dominant	Enrichment	ADCY5	1.63
196	Epilepsy, familial temporal lobe, 8	Enrichment	GAL	1.63
197	Deafness, autosomal recessive 44	Enrichment	ADCY1	1.63
198	Eculizumab, poor response to	Enrichment	C5	1.63
199	Whim syndrome 1	Enrichment	CXCR4	1.63
200	Lissencephaly 7 with cerebellar hypoplasia	Enrichment	CDK5	1.63
201	Ventricular tachycardia, familial	Enrichment	GNAI2	1.63
202	Tritanopia	Enrichment	OPN1SW	1.63
203	Acth-independent macronodular adrenal hyperplasia 1	Enrichment	GNAS	1.63
204	Neurodevelopmental disorder with hyperkinetic movements and dyskinesia	Enrichment	ADCY5	1.63
205	Pituitary adenoma 3, multiple types	Enrichment	GNAS	1.63
206	Intellectual developmental disorder, autosomal recessive 63	Enrichment	CAMK2A	1.63
207	Developmental and epileptic encephalopathy 91	Enrichment	PPP3CA	1.63
208	Intellectual developmental disorder, autosomal dominant 54	Enrichment	CAMK2B	1.63
209	Arthrogryposis, cleft palate, craniosynostosis, and impaired intellectual development	Enrichment	PPP3CA	1.63
210	Neurodevelopmental disorder with poor language and loss of hand skills	Enrichment	GABBR2	1.63
211	Developmental and epileptic encephalopathy 59	Enrichment	GABBR2	1.63
212	Colorblindness, partial, protan series	Enrichment	OPN1LW	1.63
213	Deafness, autosomal recessive 68	Enrichment	S1PR2	1.63
214	Cardioacrofacial dysplasia 2	Enrichment	PRKACB	1.63
215	Parkinson disease 24, autosomal dominant	Enrichment	PSAP	1.63
216	Neurodevelopmental disorder with hypotonia, impaired speech, and behavioral abnormalities	Enrichment	GNAI1	1.63
217	Myxoma, intracardiac	Enrichment	PRKAR1A	1.63
218	Neurodevelopmental disorder with or without early-onset generalized epilepsy	Enrichment	NBEA	1.63
219	Prolonged electroretinal response suppression 1	Enrichment	RGS9	1.63
220	Houge-janssens syndrome 2	Enrichment	PPP2R1A	1.63
221	Dyskinesia with orofacial involvement, autosomal recessive	Enrichment	ADCY5	1.63
222	Spinocerebellar ataxia 14	Enrichment	PRKCG	1.63
223	Gaucher disease, atypical, due to saposin c deficiency	Enrichment	PSAP	1.63
224	Night blindness, congenital stationary, autosomal dominant 3	Enrichment	GNAT1	1.63
225	Retinitis pigmentosa 44	Enrichment	RGR	1.63
226	Cytosolic phospholipase-a2 alpha deficiency associated bleeding disorder	Enrichment	PLA2G4A	1.63
227	Dystonia 25	Enrichment	GNAL	1.63
228	Night blindness, congenital stationary, type 1g	Enrichment	GNAT1	1.63
229	Long qt syndrome 16	Enrichment	CALM3	1.63
230	Acrodysostosis 2 with or without hormone resistance	Enrichment	PDE4D	1.63
231	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	1.63
232	Oculomotor-abducens synkinesis	Enrichment	ACKR3	1.63
233	Retinitis pigmentosa 4	Enrichment	RHO	1.63
234	Macular degeneration, age-related, 9	Enrichment	C3	1.63
235	Type 1 diabetes mellitus 22	Enrichment	CCR5	1.63
236	Krabbe disease, atypical, due to saposin a deficiency	Enrichment	PSAP	1.63
237	Disorders of gnas inactivation	Enrichment	GNAS	1.63
238	Complement component 3 deficiency, autosomal recessive	Enrichment	C3	1.63
239	Macular degeneration, age-related, 12	Enrichment	CX3CR1	1.63
240	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	1.63
241	Thrombocytopenia 6	Enrichment	SRC	1.63
242	Gastrointestinal ulceration, recurrent, with dysfunctional platelets	Enrichment	PLA2G4A	1.63
243	Deafness, autosomal dominant 74	Enrichment	PDE1C	1.63
244	Neurodevelopmental disorder with seizures, hypotonia, and brain imaging abnormalities	Enrichment	GRM7	1.63
245	Intellectual developmental disorder, autosomal dominant 53	Enrichment	CAMK2A	1.63
246	Beta-glucopyranoside tasting	Enrichment	TAS2R16	1.63
247	Red-green color blindness	Enrichment	OPN1MW	1.63
248	Nephrolithiasis, calcium oxalate, 2, with or without nephrocalcinosis	Enrichment	OXGR1	1.63
249	Neurodevelopmental disorder with language delay and variable cognitive abnormalities	Enrichment	GABBR1	1.63
250	Whim syndrome 2	Enrichment	CXCR2	1.63
251	Intellectual developmental disorder, autosomal dominant 59	Enrichment	CAMK2G	1.63
252	Complement component 3 deficiency	Enrichment	C3	1.63
253	Long qt syndrome 15	Enrichment	CALM2	1.63
254	Lipodystrophy, familial partial, type 8	Enrichment	ADRA2A	1.63
255	Autonomic nervous system disease	Enrichment	DRD4	1.63
256	Prkar1b-related neurodegenerative dementia with intermediate filaments	Enrichment	PRKAR1B	1.63
257	Membranoproliferative glomerulonephritis	Enrichment	C3	1.63
258	Primary membranoproliferative glomerulonephritis	Enrichment	C3	1.63
259	Autosomal recessive severe congenital neutropenia due to cxcr2 deficiency	Enrichment	CXCR2	1.63
260	Cryptogenic multifocal ulcerous stenosing enteritis	Enrichment	PLA2G4A	1.63
261	Monostotic fibrous dysplasia	Enrichment	GNAS	1.63
262	Ppp2r1a-related neurodevelopmental disorder	Enrichment	PPP2R1A	1.63
263	Mazabraud syndrome	Enrichment	GNAS	1.63
264	Robinow syndrome, autosomal recessive 1	Enrichment	FZD2, WNT5A	1.61
265	Hemihyperplasia, isolated	Enrichment	PIK3CA, RHOA	1.54
266	Spinocerebellar ataxia 29	Enrichment	ITPR1	1.50
267	Cerebral amyloid angiopathy, cst3-related	Enrichment	APP	1.50
268	Fibromatosis, gingival, 1	Enrichment	SOS1	1.50
269	Scoliosis, isolated 1	Enrichment	MAPK7	1.50
270	Aganglionosis, total intestinal	Enrichment	EDNRB	1.50
271	Costello syndrome	Enrichment	HRAS	1.50
272	Cutis marmorata telangiectatica congenita	Enrichment	GNA11	1.50
273	Hyperparathyroidism, neonatal severe	Enrichment	CASR	1.50
274	Abcd syndrome	Enrichment	EDNRB	1.50
275	Pulmonic stenosis	Enrichment	SOS1	1.50
276	Isolated growth hormone deficiency, type iii, with agammaglobulinemia	Enrichment	BTK	1.50
277	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	1.50
278	Obsessive-compulsive disorder	Enrichment	HTR2A	1.50
279	Deafness, autosomal recessive 28	Enrichment	TRIO	1.50
280	Keratosis, seborrheic	Enrichment	PIK3CA	1.50
281	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	1.50
282	Hypogonadotropic hypogonadism 11 with or without anosmia	Enrichment	TACR3	1.50
283	Growth hormone deficiency, isolated partial	Enrichment	GHSR	1.50
284	Angioma, tufted	Enrichment	GNA14	1.50
285	Night blindness, congenital stationary, type 1h	Enrichment	GNB3	1.50
286	Noonan syndrome 8	Enrichment	PIK3CA	1.50
287	Retinal dystrophy, iris coloboma, and comedogenic acne syndrome	Enrichment	FFAR4	1.50
288	Agammaglobulinemia, x-linked	Enrichment	BTK	1.50
289	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	1.50
290	Central precocious puberty	Enrichment	KISS1R	1.50
291	Polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract	Enrichment	ABHD12	1.50
292	Ocular melanoma	Enrichment	PLCB4	1.50
293	Nephrotic syndrome, type 7	Enrichment	DGKE	1.50
294	Lodder-merla syndrome, type 1, with impaired intellectual development and cardiac arrhythmia	Enrichment	GNB5	1.50
295	Progressive retinal dystrophy due to retinol transport defect	Enrichment	FFAR4	1.50
296	Qualitative or quantitative defects of caveolin-3	Enrichment	OXTR	1.50
297	Hemolytic-uremic syndrome	Enrichment	DGKE	1.50
298	Cerebral visual impairment	Enrichment	GNB1	1.50
299	Wooly hair nevus	Enrichment	HRAS	1.50
300	Osteoporosis	Enrichment	CALCR, SRC, WNT1	1.47
301	Basal cell nevus syndrome 1	Enrichment	PTCH1, PTCH2	1.45
302	Basal cell carcinoma 1	Enrichment	PTCH1, PTCH2	1.45
303	Autosomal recessive robinow syndrome	Enrichment	FZD2, WNT5A	1.45
304	Arteriovenous malformations of the brain	Enrichment	EGFR, KRAS	1.44
305	Pseudohypoparathyroidism, type ia	Enrichment	GNAS	1.33
306	Amelogenesis imperfecta, type ig	Enrichment	PRKAR1A	1.33
307	Pituitary adenoma 4, acth-secreting	Enrichment	GNAI2	1.33
308	N-acetylglutamate synthase deficiency	Enrichment	PYY	1.33
309	West nile virus	Enrichment	CCR5	1.33
310	Pseudopseudohypoparathyroidism	Enrichment	GNAS	1.33
311	Bleeding disorder, platelet-type, 8	Enrichment	P2RY12	1.33
312	Ventricular tachycardia, catecholaminergic polymorphic, 4	Enrichment	CALM1	1.33
313	Lethal congenital contracture syndrome 8	Enrichment	ADCY6	1.33
314	Chudley-mccullough syndrome	Enrichment	GPSM2	1.33
315	Bleeding disorder, platelet-type, 19	Enrichment	PRKACG	1.33
316	Chromosome 5q12 deletion syndrome	Enrichment	PDE4D	1.33
317	Lathosterolosis	Enrichment	C5	1.33
318	Spinocerebellar ataxia 23	Enrichment	PDYN	1.33
319	Long qt syndrome 14	Enrichment	CALM1	1.33
320	Houge-janssens syndrome 1	Enrichment	PPP2R5D	1.33
321	Marbach-schaaf neurodevelopmental syndrome	Enrichment	PRKAR1B	1.33
322	Neuropathy, congenital hypomyelinating, 2	Enrichment	RHO	1.33
323	Neutropenia, severe congenital, 10, autosomal recessive	Enrichment	GALR2	1.33
324	Cerebellar, ocular, craniofacial, and genital syndrome	Enrichment	NBEA	1.33
325	Usher syndrome, type iv	Enrichment	PRKAR1A	1.33
326	Combined saposin deficiency	Enrichment	PSAP	1.33
327	Optic disk drusen	Enrichment	RHO	1.33
328	Body mass index quantitative trait locus 19	Enrichment	ADCY3	1.33
329	Fibrolamellar carcinoma	Enrichment	PRKACA	1.33
330	Ciliary dyskinesia, primary, 18	Enrichment	PRKAR1B	1.33
331	Hypopituitarism	Enrichment	GNAI2	1.33
332	Bradyopsia	Enrichment	RGS9	1.33
333	Combined psap deficiency	Enrichment	PSAP	1.33
334	Houge-janssens syndrome 3	Enrichment	PPP2CA	1.33
335	Acth-independent macronodular adrenal hyperplasia	Enrichment	GNAS	1.33
336	Proteus syndrome	Enrichment	AKT1	1.33
337	Hypertension and brachydactyly syndrome	Enrichment	PDE3A	1.33
338	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	1.33
339	Developmental and epileptic encephalopathy 8	Enrichment	ARHGEF9	1.33
340	Body mass index quantitative trait locus 9	Enrichment	MC3R	1.33
341	Nephrogenic syndrome of inappropriate antidiuresis	Enrichment	AVPR2	1.33
342	Diabetes insipidus, nephrogenic, 1, x-linked	Enrichment	AVPR2	1.33
343	Asthma-related traits 1	Enrichment	PTGDR	1.33
344	Striatal degeneration, autosomal dominant 1	Enrichment	PDE8B	1.33
345	Resting heart rate, variation in	Enrichment	ADRB1	1.33
346	Blepharospasm, benign essential	Enrichment	DRD5	1.33
347	Noonan syndrome 9	Enrichment	SOS2	1.33
348	Increased analgesia from kappa-opioid receptor agonist, female-specific	Enrichment	MC1R	1.33
349	Dyskinesia, limb and orofacial, infantile-onset	Enrichment	PDE10A	1.33
350	Charcot-marie-tooth disease, demyelinating, type 4h	Enrichment	FGD4	1.33
351	Ataxia-oculomotor apraxia 3	Enrichment	PIK3R5	1.33
352	Hypogonadotropic hypogonadism 23 with or without anosmia	Enrichment	LHB	1.33
353	Ovarian dysgenesis 1	Enrichment	FSHR	1.33
354	Spinal muscular atrophy, facioscapulohumeral type	Enrichment	PLEKHG5	1.33
355	Immunodeficiency 62	Enrichment	ARHGEF1	1.33
356	Neurodevelopmental disorder with midbrain and hindbrain malformations	Enrichment	ARHGEF2	1.33
357	Twinning, dizygotic	Enrichment	FSHR	1.33
358	Retinitis pigmentosa 78	Enrichment	ARHGEF18	1.33
359	Skin/hair/eye pigmentation, variation in, 2	Enrichment	MC1R	1.33
360	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	1.33
361	Hypothyroidism, congenital, nongoitrous, 4	Enrichment	TSHB	1.33
362	Body mass index quantitative trait locus 20	Enrichment	MC4R	1.33
363	Intellectual developmental disorder, x-linked 46	Enrichment	ARHGEF6	1.33
364	Intellectual developmental disorder with paroxysmal dyskinesia or seizures	Enrichment	PDE2A	1.33
365	X-linked nephrogenic diabetes insipidus	Enrichment	AVPR2	1.33
366	Charcot-marie-tooth disease type 4h	Enrichment	FGD4	1.33
367	Slowed nerve conduction velocity, autosomal dominant	Enrichment	ARHGEF10	1.33
368	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	1.33
369	Ovarian hyperstimulation syndrome	Enrichment	FSHR	1.33
370	Cowden syndrome 6	Enrichment	AKT1	1.33
371	Amenorrhea	Enrichment	FSHR	1.33
372	Melanoma, cutaneous malignant 5	Enrichment	MC1R	1.33
373	Brachydactyly, type e2	Enrichment	PTHLH	1.33
374	Immunodeficiency 97 with autoinflammation	Enrichment	PIK3CG	1.33
375	Brain small vessel disease 5 with osteoporosis	Enrichment	ARHGEF15	1.33
376	Schizophrenia 16	Enrichment	VIPR2	1.33
377	Pigmented nodular adrenocortical disease, primary, 3	Enrichment	PDE8B	1.33
378	Striatal degeneration, autosomal dominant 2	Enrichment	PDE10A	1.33
379	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	1.33
380	Takenouchi-kosaki syndrome	Enrichment	CDC42	1.33
381	Isolated growth hormone deficiency, type iv	Enrichment	GHRHR	1.33
382	Neurodevelopmental disorder with language delay and seizures	Enrichment	TIAM1	1.33
383	Short sleep, familial natural, 2	Enrichment	ADRB1	1.33
384	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	1.33
385	Obesity due to melanocortin 4 receptor deficiency	Enrichment	MC4R	1.33
386	Capillary hemangioma	Enrichment	AKT3	1.33
387	Striatal degeneration, autosomal dominant	Enrichment	PDE8B	1.33
388	Acute encephalopathy with biphasic seizures and late reduced diffusion	Enrichment	ADORA2A	1.33
389	Nocarh syndrome	Enrichment	CDC42	1.33
390	Childhood-onset benign chorea with striatal involvement	Enrichment	PDE10A	1.33
391	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	1.33
392	Blepharospasm	Enrichment	DRD5	1.33
393	Prune belly syndrome	Enrichment	CHRM3	1.33
394	Hypogonadotropic hypogonadism 2 with or without anosmia	Enrichment	PROKR2	1.33
395	Gillespie syndrome	Enrichment	ITPR1	1.33
396	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.33
397	Hirschsprung disease 2	Enrichment	EDNRB	1.33
398	Agammaglobulinemia 1, autosomal recessive	Enrichment	BTK	1.33
399	Nuchal bleb, familial	Enrichment	SOS1	1.33
400	Langerhans cell histiocytosis	Enrichment	NRAS	1.33
401	Rippling muscle disease 2	Enrichment	OXTR	1.33
402	Long qt syndrome 9	Enrichment	OXTR	1.33
403	Myopathy, distal, tateyama type	Enrichment	OXTR	1.33
404	Woolly hair, autosomal recessive 3	Enrichment	LPAR6	1.33
405	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	1.33
406	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	1.33
407	Hypotrichosis 8	Enrichment	LPAR6	1.33
408	Agammaglobulinemia 1	Enrichment	BTK	1.33
409	Intellectual developmental disorder, autosomal dominant 44, with microcephaly	Enrichment	TRIO	1.33
410	Precocious puberty, central, 2	Enrichment	KISS1R	1.33
411	Immunodeficiency 14	Enrichment	PIK3R1	1.33
412	Parathyroid adenoma	Enrichment	CASR	1.33
413	Spermatocytoma	Enrichment	HRAS	1.33
414	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	1.33
415	Melanoma of soft tissue	Enrichment	CREB1	1.33
416	Keratoacanthoma	Enrichment	PIK3CA	1.33
417	Cerebral sinovenous thrombosis	Enrichment	F2	1.33
418	Coats disease	Enrichment	FZD4, RHO	1.32
419	Overgrowth syndrome	Enrichment	PIK3R1, PTCH1	1.32
420	Dystonia	Enrichment	CAMK2B, GNAL, GNB1	1.31
421	Holoprosencephaly 3	Enrichment	SHH	1.28
422	Vibratory urticaria	Enrichment	ADGRE2	1.28
423	Nail disorder, nonsyndromic congenital, 1	Enrichment	FZD6	1.28
424	Mullerian aplasia and hyperandrogenism	Enrichment	WNT4	1.28
425	46,xy sex reversal 7	Enrichment	DHH	1.28
426	Mcleod syndrome	Enrichment	XK	1.28
427	Curry-jones syndrome	Enrichment	SMO	1.28
428	46,xx sex reversal with dysgenesis of kidneys, adrenals, and lungs	Enrichment	WNT4	1.28
429	Schilbach-rott syndrome	Enrichment	PTCH1	1.28
430	Omodysplasia 2	Enrichment	FZD2	1.28
431	White blood cell count quantitative trait locus 1	Enrichment	ACKR1	1.28
432	Blood group--kell system	Enrichment	KEL	1.28
433	Microphthalmia/coloboma 5	Enrichment	SHH	1.28
434	Split-hand/foot malformation 6	Enrichment	WNT10B	1.28
435	Complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy	Enrichment	CD55	1.28
436	Blood group, cromer system	Enrichment	CD55	1.28
437	Tooth agenesis, selective, 8	Enrichment	WNT10B	1.28
438	Diarrhea 9	Enrichment	WNT2B	1.28
439	Bone mineral density quantitative trait locus 16	Enrichment	WNT1	1.28
440	Acrocapitofemoral dysplasia	Enrichment	IHH	1.28
441	Santos syndrome	Enrichment	WNT7A	1.28
442	Hirschsprung disease, cardiac defects, and autonomic dysfunction	Enrichment	ECE1	1.28
443	Periodic fever, menstrual cycle-dependent	Enrichment	HTR1A	1.28
444	Microphthalmia/coloboma 11	Enrichment	FZD5	1.28
445	Turner syndrome	Enrichment	PTCH1	1.28
446	Protein-losing enteropathy	Enrichment	CD55	1.28
447	Monosomy 9q22.3	Enrichment	PTCH1	1.28
448	Autosomal dominant preaxial polydactyly-upperback hypertrichosis syndrome	Enrichment	SHH	1.28
449	Cardiofaciocutaneous syndrome 1	Enrichment	KRAS	1.21
450	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	1.21
451	Spastic paraplegia 17, autosomal dominant	Enrichment	GNG3	1.21
452	Lipodystrophy, congenital generalized, type 2	Enrichment	GNG3	1.21
453	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.21
454	Spinocerebellar ataxia 15	Enrichment	ITPR1	1.21
455	Developmental and epileptic encephalopathy 12	Enrichment	PLCB1	1.21
456	Cardiofaciocutaneous syndrome	Enrichment	KRAS	1.21
457	Lung sarcomatoid carcinoma	Enrichment	KRAS	1.21
458	Cerebrovascular disease	Enrichment	PIK3CA	1.21
459	Pilocytic astrocytoma	Enrichment	KRAS	1.21
460	Epidermolytic nevus	Enrichment	HRAS	1.21
461	Diabetes insipidus	Enrichment	AVP	1.21
462	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.21
463	Gingival fibromatosis	Enrichment	SOS1	1.21
464	Hereditary angioedema with normal c1inh not related to f12 or plg variant	Enrichment	KNG1	1.21
465	Familial sick sinus syndrome	Enrichment	GNB2	1.21
466	Cryptorchidism, unilateral or bilateral	Enrichment	INSL3, RXFP2	1.20
467	Cowden syndrome	Enrichment	AKT1, PIK3CA	1.20
468	Mccune-albright syndrome	Enrichment	GNAS	1.16
469	Night blindness, congenital stationary, type 1b	Enrichment	GRM6	1.16
470	Obesity, early-onset, with adrenal insufficiency and red hair	Enrichment	POMC	1.16
471	Hepatitis c virus	Enrichment	CCR5	1.16
472	Nizon-isidor syndrome	Enrichment	P2RY12	1.16
473	Microcephaly 17, primary, autosomal recessive	Enrichment	RHO	1.16
474	Cushing syndrome due to bilateral macronodular adrenocortical disease	Enrichment	GNAS	1.16
475	Aggressive periodontitis	Enrichment	FPR1	1.16
476	Genetic atypical hemolytic-uremic syndrome	Enrichment	C3	1.16
477	Hypomyelination neuropathy-arthrogryposis syndrome	Enrichment	ADCY6	1.16
478	Obesity due to pro-opiomelanocortin deficiency	Enrichment	POMC	1.16
479	Non-immune hydrops fetalis	Enrichment	CALCRL, FZD6, HRAS, KRAS	1.12
480	Hypogonadotropic hypogonadism 1 with or without anosmia	Enrichment	PROKR2	1.11
481	Major depressive disorder	Enrichment	HTR2A	1.11
482	Narcolepsy 2	Enrichment	HCRT	1.11
483	Familial woolly hair syndrome	Enrichment	LPAR6	1.11
484	Attention deficit-hyperactivity disorder	Enrichment	DRD4, DRD5, GNB5	1.10
485	Macs syndrome	Enrichment	PTCH1, SHH, WNT7B	1.08
486	Chorea, benign hereditary	Enrichment	ADCY5	1.04
487	Krabbe disease	Enrichment	PSAP	1.04
488	Pseudohypoparathyroidism, type ib	Enrichment	GNAS	1.04
489	Arrhythmogenic right ventricular dysplasia, familial, 10	Enrichment	PRKAR1A	1.04
490	Tobacco addiction	Enrichment	GABBR2	1.04
491	Hereditary ataxia	Enrichment	PRKCG	1.04
492	Failure of tooth eruption, primary	Enrichment	PTH1R	1.04
493	Hypoparathyroidism, familial isolated, 1	Enrichment	PTH	1.04
494	Precocious puberty, male-limited	Enrichment	LHCGR	1.04
495	Glucocorticoid deficiency 1	Enrichment	MC2R	1.04
496	Metaphyseal chondrodysplasia, jansen type	Enrichment	PTH1R	1.04
497	Spondyloepimetaphyseal dysplasia, strudwick type	Enrichment	FN1	1.04
498	Spondylometaphyseal dysplasia, corner fracture type	Enrichment	FN1	1.04
499	Leydig cell hypoplasia, type i	Enrichment	LHCGR	1.04
500	Chondrodysplasia, blomstrand type	Enrichment	PTH1R	1.04
501	Hypogonadotropic hypogonadism 24 with or without anosmia	Enrichment	FSHB	1.04
502	Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2	Enrichment	PIK3R5	1.04
503	Hyperthyroidism, familial gestational	Enrichment	TSHR	1.04
504	Eiken syndrome	Enrichment	PTH1R	1.04
505	Vitamin d hydroxylation-deficient rickets, type 1b	Enrichment	PDE3B	1.04
506	Pigmented nodular adrenocortical disease, primary, 2	Enrichment	PDE11A	1.04
507	Neuronopathy, distal hereditary motor, autosomal recessive 4	Enrichment	PLEKHG5	1.04
508	Charcot-marie-tooth disease, recessive intermediate c	Enrichment	PLEKHG5	1.04
509	Senior-loken syndrome 7	Enrichment	AKT3	1.04
510	Lymphatic malformation 8	Enrichment	CALCRL	1.04
511	Immune system disease	Enrichment	CDC42	1.04
512	Bardet-biedl syndrome 16	Enrichment	AKT3	1.04
513	Aarskog syndrome	Enrichment	FGD1	1.04
514	Leydig cell hypoplasia type ii	Enrichment	LHCGR	1.04
515	Albinism, ocular, type i	Enrichment	GPR143	1.04
516	Spinocerebellar ataxia, autosomal recessive 16	Enrichment	ITPR1	1.04
517	Waardenburg syndrome	Enrichment	EDNRB	1.04
518	Albinism	Enrichment	GPR143	1.04
519	Tooth agenesis, selective, 4	Enrichment	WNT10A	0.99
520	Pallister-hall-like syndrome	Enrichment	SMO	0.99
521	Schopf-schulz-passarge syndrome	Enrichment	WNT10A	0.99
522	Ulna and fibula, absence of, with severe limb deficiency	Enrichment	WNT7A	0.99
523	Bladder exstrophy and epispadias complex	Enrichment	WNT3	0.99
524	Odontoonychodermal dysplasia	Enrichment	WNT10A	0.99
525	46,xy gonadal dysgenesis with minifascicular neuropathy	Enrichment	DHH	0.99
526	Tetraamelia syndrome 1	Enrichment	WNT3	0.99
527	Osteogenesis imperfecta, type xv	Enrichment	WNT1	0.99
528	Solitary median maxillary central incisor	Enrichment	SHH	0.99
529	Robinow syndrome, autosomal dominant 3	Enrichment	FZD2	0.99
530	Fibular aplasia or hypoplasia, femoral bowing, and poly-, syn-, and oligodactyly	Enrichment	WNT7A	0.99
531	Bladder exstrophy-epispadias-cloacal exstrophy complex	Enrichment	WNT3	0.99
532	Isolated radial hemimelia	Enrichment	SHH	0.99
533	Commissural facial cleft	Enrichment	PTCH2	0.99
534	Thrombophilia due to thrombin defect	Enrichment	F2	0.97
535	Squamous cell carcinoma, head and neck	Enrichment	EGFR	0.97
536	Waardenburg syndrome, type 2e	Enrichment	EDNRB	0.97
537	Alzheimer's disease 1	Enrichment	APP	0.97
538	Pilomyxoid astrocytoma	Enrichment	KRAS	0.97
539	Amelogenesis imperfecta type 2	Enrichment	GPR68	0.97
540	Early-onset autosomal dominant alzheimer disease	Enrichment	APP	0.97
541	Moyamoya angiopathy	Enrichment	ARHGEF25	0.97
542	Retinal detachment	Enrichment	RHO	0.95
543	Breast-ovarian cancer, familial 2	Enrichment	GPSM2	0.95
544	Night blindness	Enrichment	RHO	0.95
545	Diffuse cutaneous systemic sclerosis	Enrichment	CCR6	0.95
546	Breast cancer	Enrichment	GNG3, KRAS, PIK3CA	0.93
547	Gastroesophageal reflux	Enrichment	RPS6KA3	0.92
548	Myopathy, tubular aggregate, 1	Enrichment	OXTR	0.92
549	Orthostatic intolerance	Enrichment	RPS6KA3	0.92
550	Hypothyroidism	Enrichment	GNB1	0.92
551	Septooptic dysplasia	Enrichment	PROKR2, SHH	0.90
552	Cerebral palsy	Enrichment	F2, GNB1	0.89
553	Leukemia, acute myeloid	Enrichment	KRAS, NRAS	0.88
554	Alcohol dependence	Enrichment	TAS2R16	0.88
555	Metachromatic leukodystrophy	Enrichment	PSAP	0.88
556	Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy	Enrichment	CALM1	0.88
557	Familial adult myoclonic epilepsy	Enrichment	ADRA2B	0.88
558	Adrenocortical carcinoma	Enrichment	PRKAR1A	0.88
559	Limited scleroderma	Enrichment	CCR6	0.88
560	Atypical hemolytic uremic syndrome with complement gene abnormality	Enrichment	C3	0.88
561	Asthma, nasal polyps, and aspirin intolerance	Enrichment	PTGER2	0.87
562	Aarskog-scott syndrome	Enrichment	FGD1	0.87
563	Vitamin d hydroxylation-deficient rickets, type 1a	Enrichment	PDE3B	0.87
564	Intellectual developmental disorder, x-linked, syndromic, claes-jensen type	Enrichment	FGD1	0.87
565	Glomerulopathy with fibronectin deposits 2	Enrichment	FN1	0.87
566	Hyperthyroidism, nonautoimmune	Enrichment	TSHR	0.87
567	Hypothyroidism, congenital, nongoitrous, 1	Enrichment	TSHR	0.87
568	Isolated growth hormone deficiency, type ib	Enrichment	GHRHR	0.87
569	Leukodystrophy and acquired microcephaly with or without dystonia	Enrichment	PLEKHG2	0.87
570	Gonadal dysgenesis	Enrichment	FSHR	0.87
571	Nephrogenic diabetes insipidus	Enrichment	AVPR2	0.87
572	Syndromic x-linked intellectual disability claes-jensen type	Enrichment	FGD1	0.87
573	Familial hyperthyroidism due to mutations in tsh receptor	Enrichment	TSHR	0.87
574	Coronary heart disease 5	Enrichment	KALRN	0.87
575	Developmental and epileptic encephalopathy 14	Enrichment	PLCB1	0.87
576	Adult hepatocellular carcinoma	Enrichment	PIK3CA	0.87
577	Congenital central hypoventilation syndrome	Enrichment	EDN3	0.87
578	Ventricular septal defect	Enrichment	RPS6KA3	0.87
579	Autosomal dominant cerebellar ataxia	Enrichment	DAGLA	0.87
580	Hypotrichosis simplex	Enrichment	LPAR6	0.87
581	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	0.83
582	Brachydactyly, type a1	Enrichment	IHH	0.83
583	Syndactyly, type iv	Enrichment	SHH	0.83
584	Mullerian duct aplasia, unilateral renal agenesis, and cervicothoracic somite anomalies	Enrichment	WNT4	0.83
585	Microphthalmia, syndromic 9	Enrichment	WNT7B	0.83
586	Tooth agenesis, selective, 2	Enrichment	WNT10A	0.83
587	Holoprosencephaly 7	Enrichment	PTCH1	0.83
588	Nail disease	Enrichment	FZD6	0.83
589	Hypoplastic or aplastic tibia with polydactyly	Enrichment	SHH	0.83
590	Tetraamelia syndrome	Enrichment	WNT3	0.83
591	Mpv17-related mitochondrial dna maintenance defect	Enrichment	UCN	0.83
592	Gastric cancer	Enrichment	KRAS, PIK3CA	0.83
593	Nephrotic syndrome	Enrichment	DGKE, TRPC6	0.83
594	Atypical hemolytic-uremic syndrome	Enrichment	C3, DGKE	0.82
595	Fundus albipunctatus	Enrichment	RHO	0.81
596	Myelofibrosis	Enrichment	SRC	0.81
597	Rett syndrome	Enrichment	GABBR2	0.81
598	Brachydactyly	Enrichment	GNAS	0.81
599	Immunodeficiency due to a late component of complement deficiency	Enrichment	C5	0.81
600	Hereditary breast carcinoma	Enrichment	KRAS, PIK3CA	0.81
601	Colorectal cancer	Enrichment	NRAS, PIK3CA, PIK3R1	0.79
602	Leukemia, acute lymphoblastic	Enrichment	GNB1	0.79
603	Myelodysplastic syndrome	Enrichment	GNB1	0.79
604	Medulloblastoma	Enrichment	PTCH1, PTCH2	0.78
605	Long qt syndrome	Enrichment	CALM1, CALM2	0.78
606	Spastic paraplegia 4, autosomal dominant	Enrichment	GNAS	0.76
607	Rett syndrome, congenital variant	Enrichment	GABBR2	0.76
608	Catecholaminergic polymorphic ventricular tachycardia 1	Enrichment	CALM1	0.76
609	Essential tremor	Enrichment	DRD3	0.76
610	Intellectual developmental disorder, autosomal dominant 1	Enrichment	ITSN1	0.76
611	Smith-lemli-opitz syndrome	Enrichment	TSHR	0.76
612	Bone mineral density quantitative trait locus 15	Enrichment	CALCR	0.76
613	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42	0.76
614	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	SOS2	0.76
615	Congenital long qt syndrome	Enrichment	ITPR3	0.76
616	Septopreoptic holoprosencephaly	Enrichment	PTCH1, SHH	0.74
617	Midline interhemispheric variant of holoprosencephaly	Enrichment	PTCH1, SHH	0.74
618	Syndromic intellectual disability	Enrichment	PTH2R, TRIO	0.73
619	Aortic valve disease 1	Enrichment	SOS1	0.72
620	Alzheimer's disease	Enrichment	APP	0.72
621	Amelogenesis imperfecta	Enrichment	GPR68	0.72
622	Protein-deficiency anemia	Enrichment	NRAS	0.72
623	Neurofibromatosis, type i	Enrichment	GABBR1	0.71
624	Primary hyperaldosteronism	Enrichment	GNAS	0.71
625	Ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive	Enrichment	WNT10A	0.71
626	Mitochondrial dna depletion syndrome 6	Enrichment	UCN	0.71
627	Schizencephaly	Enrichment	SHH	0.71
628	Charcot-marie-tooth disease, axonal, type 2ee	Enrichment	UCN	0.71
629	Ectodermal dysplasia	Enrichment	WNT10A	0.71
630	Retinopathy of prematurity	Enrichment	FZD4	0.71
631	Eyelid coloboma	Enrichment	FZD5	0.71
632	Lens coloboma	Enrichment	FZD5	0.71
633	Hypertelorism	Enrichment	PIK3CA, RPS6KA3	0.70
634	Multiple sclerosis	Enrichment	ITPR1	0.70
635	46,xy partial gonadal dysgenesis	Enrichment	SOS1	0.70
636	Creatine phosphokinase, elevated serum	Enrichment	OXTR, XK	0.69
637	Isolated elevated serum creatine phosphokinase levels	Enrichment	OXTR, XK	0.69
638	Rhabdomyosarcoma	Enrichment	HRAS, PTCH1	0.69
639	Microform holoprosencephaly	Enrichment	PTCH1, SHH	0.69
640	Lobar holoprosencephaly	Enrichment	PTCH1, SHH	0.69
641	Enchondromatosis, multiple, ollier type	Enrichment	PTH1R	0.67
642	Albinism, oculocutaneous, type ii	Enrichment	MC1R	0.67
643	Convulsions, familial infantile, with paroxysmal choreoathetosis	Enrichment	PDE2A	0.67
644	Pseudohermaphroditism	Enrichment	LHCGR	0.67
645	Familial glucocorticoid deficiency	Enrichment	MC2R	0.67
646	Anterior segment dysgenesis	Enrichment	ITPR1	0.67
647	Cone-rod dystrophy 2	Enrichment	OPN1LW, OPN1MW, RHO	0.67
648	Ovarian cancer	Enrichment	EGFR, KRAS, PIK3CA	0.66
649	Alobar holoprosencephaly	Enrichment	PTCH1, SHH	0.65
650	Myeloma, multiple	Enrichment	KRAS, PIK3R2	0.65
651	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PROK2, PROKR2	0.65
652	Gliosarcoma	Enrichment	EGFR	0.64
653	Non-syndromic x-linked intellectual disability	Enrichment	AGTR2, ARHGEF6, RPS6KA3	0.63
654	Exudative vitreoretinopathy 1	Enrichment	FZD4	0.63
655	Congenital disorder of glycosylation, type id	Enrichment	EEF1AKMT4-ECE2	0.63
656	Norrie disease	Enrichment	FZD4	0.63
657	Cholangitis, primary sclerosing	Enrichment	GPR35	0.63
658	Robinow syndrome, autosomal dominant 2	Enrichment	FZD2	0.63
659	Persistent hyperplastic primary vitreous	Enrichment	FZD4	0.63
660	Autosomal recessive hypohidrotic ectodermal dysplasia syndrome	Enrichment	WNT10A	0.63
661	Coloboma of choroid and retina	Enrichment	FZD5	0.63
662	Alzheimer disease, familial, 1	Enrichment	APP	0.62
663	Pancreatitis, hereditary	Enrichment	CASR	0.62
664	Cleft palate, isolated	Enrichment	GNB1	0.62
665	Giant cell glioblastoma	Enrichment	EGFR	0.62
666	Semilobar holoprosencephaly	Enrichment	PTCH1, SHH	0.62
667	Heart, malformation of	Enrichment	MAPK1	0.60
668	Diffuse large b-cell lymphoma	Enrichment	BTK	0.58
669	Acute promyelocytic leukemia	Enrichment	PRKAR1A	0.57
670	Focal segmental glomerulosclerosis	Enrichment	TRPC6	0.56
671	Coloboma of optic nerve	Enrichment	FZD5	0.56
672	Dystonia 11, myoclonic	Enrichment	DRD2	0.56
673	Renal dysplasia, cystic	Enrichment	WNT9B	0.56
674	Renal hypoplasia	Enrichment	WNT9B	0.56
675	Diarrhea	Enrichment	WNT2B	0.56
676	Multicystic kidney dysplasia	Enrichment	FZD3	0.56
677	Multicystic dysplastic kidney	Enrichment	FZD3	0.56
678	Cone-rod dystrophy 6	Enrichment	GNAT2	0.55
679	Cataract	Enrichment	RHO	0.55
680	Hypothyroidism, congenital, nongoitrous, 2	Enrichment	TSHR	0.55
681	Megacolon	Enrichment	AKT3	0.55
682	Autosomal dominant sleep-related hypermotor epilepsy	Enrichment	CRH	0.55
683	Paroxysmal dystonia	Enrichment	PDE2A	0.55
684	Endometrial cancer	Enrichment	PIK3CA	0.54
685	Hepatocellular carcinoma	Enrichment	PIK3CA	0.53
686	Cone dystrophy	Enrichment	ABHD12, GNAT2	0.51
687	Microcephaly	Enrichment	GNB1, MAPK1, TRIO	0.51
688	Thrombocytopenia	Enrichment	P2RY12, SRC	0.51
689	Congenital hydrocephalus	Enrichment	PTCH1	0.50
690	Spondylocostal dysostosis 1, autosomal recessive	Enrichment	PLEKHG2	0.50
691	Cryptorchidism	Enrichment	INSL3	0.50
692	Choreatic disease	Enrichment	PDE2A	0.50
693	Cardiomyopathy, familial hypertrophic, 1	Enrichment	OXTR	0.49
694	Microphthalmia	Enrichment	PTCH1, WNT7B	0.49
695	Tooth agenesis	Enrichment	WNT10A, WNT10B	0.49
696	Pancreatic cancer	Enrichment	KRAS	0.48
697	Jeune thoracic dystrophy	Enrichment	GRK2	0.48
698	Sudden infant death syndrome	Enrichment	CALM2	0.48
699	Hydrops fetalis, nonimmune	Enrichment	HRAS	0.47
700	Early infantile developmental and epileptic encephalopathy	Enrichment	GRM7	0.46
701	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	ADCY1, GPSM2, S1PR2	0.46
702	Juvenile amyotrophic lateral sclerosis	Enrichment	PLEKHG5	0.46
703	Renal hypodysplasia/aplasia 1	Enrichment	WNT9B	0.46
704	Exudative vitreoretinopathy	Enrichment	FZD4	0.46
705	Isolated split hand-split foot malformation	Enrichment	WNT10B	0.46
706	Strabismus	Enrichment	GNB1	0.45
707	Asphyxiating thoracic dystrophy	Enrichment	GRK2	0.44
708	Behcet syndrome	Enrichment	CCR1	0.44
709	Parkinson's disease	Enrichment	PSAP	0.44
710	Prostate cancer	Enrichment	PIK3CA	0.43
711	Severe covid-19	Enrichment	DGKE	0.43
712	Polymicrogyria	Enrichment	AKT3	0.42
713	Melanoma	Enrichment	MC1R	0.42
714	Undetermined early-onset epileptic encephalopathy	Enrichment	GABBR2, PPP3CA	0.42
715	Renal agenesis, bilateral	Enrichment	WNT9B	0.42
716	Cystic fibrosis	Enrichment	EDNRA	0.40
717	Short-rib thoracic dysplasia 1 with or without polydactyly	Enrichment	GRK2	0.39
718	Familial hypertrophic cardiomyopathy	Enrichment	OXTR	0.39
719	Cat eye syndrome	Enrichment	FZD5	0.38
720	Genetic steroid-resistant nephrotic syndrome	Enrichment	TRPC6	0.38
721	Parkinson disease, late-onset	Enrichment	PSAP	0.36
722	Congenital hypothyroidism	Enrichment	TSHR	0.36
723	46 xx gonadal dysgenesis	Enrichment	FSHR	0.36
724	Asthma	Enrichment	CCL11	0.35
725	46,xy complete gonadal dysgenesis	Enrichment	DHH	0.35
726	Neural tube defects	Enrichment	ITGB1	0.34
727	Pulmonary disease, chronic obstructive	Enrichment	PDE3B	0.34
728	Benign epilepsy with centrotemporal spikes	Enrichment	PLCB1	0.32
729	Cleft lip/palate	Enrichment	ARHGEF38	0.31
730	Centralopathic epilepsy	Enrichment	PLCB1	0.30
731	Hypertrophic cardiomyopathy	Enrichment	CASR	0.30
732	Microphthalmia/coloboma 12	Enrichment	FZD5	0.30
733	Osteogenesis imperfecta, type iv	Enrichment	WNT1	0.30
734	Chronic kidney disease	Enrichment	WNT9B	0.30
735	West syndrome	Enrichment	PLCB1	0.29
736	Autism	Enrichment	CAMK2G, NBEA	0.29
737	Autism spectrum disorder	Enrichment	GNB1, TACR3	0.28
738	Schizophrenia	Enrichment	DRD3, HTR2A, PDE11A	0.28
739	Perrault syndrome 1	Enrichment	FSHR	0.27
740	Sensorineural hearing loss	Enrichment	EDN3	0.27
741	Coloboma of macula	Enrichment	FZD5	0.26
742	Polydactyly, postaxial, type a1	Enrichment	PTCH1	0.26
743	Osteogenesis imperfecta, type iii	Enrichment	WNT1	0.26
744	Hydrocephalus	Enrichment	FZD3	0.26
745	Melanoma, cutaneous malignant 1	Enrichment	MC1R	0.26
746	Epilepsy	Enrichment	NBEA, TSHR	0.25
747	Eye disease	Enrichment	GNAT2	0.25
748	Spastic ataxia	Enrichment	ITPR1	0.24
749	Charcot-marie-tooth disease type 4	Enrichment	FGD4	0.24
750	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS	0.23
751	Type 2 diabetes mellitus	Enrichment	AKT2, MTNR1B	0.23
752	Esophageal atresia/tracheoesophageal fistula	Enrichment	ITSN1	0.22
753	Deafness, autosomal recessive	Enrichment	EDNRB	0.20
754	Autosomal recessive nonsyndromic deafness	Enrichment	EDNRB	0.19
755	Leber plus disease	Enrichment	GRM6, RGS9	0.18
756	Hereditary retinal dystrophy	Enrichment	GNAT1, GNAT2, GRM6, RGR, RGS9, RHO	0.17
757	Fundus dystrophy	Enrichment	GNAT1, GNAT2, GRM6, RGR, RGS9, RHO	0.17
758	Brittle bone disorder	Enrichment	WNT1	0.15
759	Malaria	Enrichment	ACKR1	0.15
760	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	PDE1C	0.15
761	Congenital nervous system abnormality	Enrichment	CAMK2B, GNB5	0.15
762	Nervous system disease	Enrichment	CAMK2B, GNB5	0.15
763	Rare genetic deafness	Enrichment	EDNRB	0.14
764	Autosomal recessive non-syndromic intellectual disability	Enrichment	GRM7	0.13
765	Complex neurodevelopmental disorder	Enrichment	GNB2, PPP2CA	0.10
766	Developmental and epileptic encephalopathy	Enrichment	ARHGEF15	0.09
767	Primary ciliary dyskinesia	Enrichment	PRKAR1B	0.08
768	Charcot-marie-tooth disease	Enrichment	ARHGEF10	0.07
769	Hereditary spastic paraplegia	Enrichment	PLEKHG5	0.06
770	Retinitis pigmentosa	Enrichment	GNAT1, RGR, RHO	0.06
771	Inherited cancer-predisposing syndrome	Enrichment	EGFR	0.05
772	Distal arthrogryposis	Enrichment	FZD3	0.05

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

GPCR downstream signalling

Pathway Network for GPCR downstream signalling

Pathway network for the GPCR downstream signalling SuperPath

Member Pathways for GPCR downstream signalling

Pathways in the GPCR downstream signalling SuperPath

Gene overlap in member pathways for GPCR downstream signalling SuperPath

Associated Genes for GPCR downstream signalling

Associated Disorders for GPCR downstream signalling

Disorders associated with GPCR downstream signalling SuperPath

STRING Interaction Network for GPCR downstream signalling

Sources for GPCR downstream signalling