GPCR Pathway

Pathway network for the GPCR Pathway SuperPath

Sources:

QIAGEN

Pathways in the GPCR Pathway SuperPath

#	Name	Source	Genes
1	GPCR Pathway	QIAGEN	ADCY1 ADCY2 ADCY3 AKT1 ALK ANGPTL6 AREG ARHGEF1 ARHGEF10 ARHGEF11 ARHGEF12 ARHGEF15 ARHGEF16 ARHGEF2 ARHGEF3 ARHGEF4 ARHGEF5 ARHGEF6 ARHGEF7 ARHGEF9 ATF4 AXL BCL10 BDNF BMP1 BMP10 BMP2 BMP3 BMP4 BMP5 BMP6 BMP7 BMP8A BRAF BTC CALM1 CALM2 CALM3 CARD10 CCN2 CDC42 CHUK CLEC11A CREB1 CREB3 CREB3L4 CRIPTO CRK CSF1R CXCL12 DDR1 DDR2 DIRAS3 DRC4 EGF EGFR ELK1 EPHA1 EPHA2 EPHA3 EPHA4 EPHA5 EPHA7 EPHA8 EPHB1 EPHB2 EPHB3 EPHB4 EPHB6 EPOR ERBB2 ERBB3 ERBB4 FGF1 FGF10 FGF11 FGF12 FGF13 FGF14 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF21 FGF22 FGF23 FGF4 FGF5 FGF6 FGF7 FGF8 FGFR1 FGFR2 FGFR3 FGFR4 FLT1 FLT3 FLT4 FOS GAS1 GAS2 GAS6 GDF10 GDF15 GDF2 GDF5 GDF6 GDF9 GFER GH1 GH2 GHRH GMFG GNA11 GNA12 GNA13 GNA14 GNA15 GNAI1 GNAI2 GNAI3 GNAS GNB1 GNB2 GNB3 GNB4 GNB5 GNG2 GNG3 GNG4 GNRH1 GNRH2 GPC6 GPR119 GRB2 HDGF HGF HRAS IGF1 IGF1R IGF2 IGF2-AS IKBKB IKBKE IKBKG IL2 IL3 IL6 IL9 INSR INSRR ITPR1 ITPR2 ITPR3 JUN KDR KIT KITLG KLF10 KRAS LEFTY1 LEFTY2 LHB LIFR LMTK2 LMTK3 LTBP1 LTBP2 LTBP3 LTBP4 MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7 MAP3K2 MAP3K3 MAP3K4 MAP3K5 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK6 MAPK7 MAPK8 MAPK9 MCF2L MDK MERTK MET MRAS MST1R MUSK NET1 NFAT5 NFATC1 NFATC2 NFATC3 NFATC4 NFKB1 NFKBIA NFKBIB NFKBIE NGF NRAS NRG1 NRG2 NRG3 NTF3 NTF4 NTRK1 NTRK2 NTRK3 NUDT6 OGN P2RY13 PAK1 PAK2 PAK3 PAK4 PAK5 PAK6 PDGFA PDGFB PDGFC PDGFD PDGFRA PDGFRB PENK PGF PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PLCB1 PLCB2 PLCB3 PLCB4 PLPP3 PPBP PPP3CA PPP3CB PPP3CC PPP3R1 PPP3R2 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCI PRKCQ PRKCZ PRKD1 PRKD3 PROK1 PSIP1 PTK2 PTK2B PTK7 PTN PXN RAC1 RAC2 RAC3 RAF1 RAP1A RAP1B RAPGEF4 RHOA RHOB RHOC RHOD RHOG RHOH RND2 RND3 ROCK1 ROCK2 ROR1 ROR2 ROS1 RRAS RRAS2 RYK SEMA3A SEMA4B SEMA4G SEMA5A SOS1 SOS2 SPON1 SRC SRF STAT1 STAT2 STAT3 STAT4 STAT5A STAT5B STAT6 TBRG1 TEK TGFA TGFB1 TGFB2 TGFB3 THPO TIE1 TIMP1 TIMP2 TIMP3 TIMP4 TYMP TYRO3 UTS2 VEGFB VEGFC VEGFD (see all 336) (see less)
2	Breast Cancer Regulation by Stathmin1	QIAGEN	ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ALK ANGPTL6 ARAF AREG ARHGEF1 ARHGEF10 ARHGEF11 ARHGEF12 ARHGEF15 ARHGEF16 ARHGEF2 ARHGEF3 ARHGEF4 ARHGEF5 ARHGEF6 ARHGEF7 ARHGEF9 AXL BDNF BMP1 BMP10 BMP2 BMP3 BMP4 BMP5 BMP6 BMP7 BMP8A BRAF BTC CALM1 CALM2 CALM3 CAMK1 CAMK1G CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 CCN2 CCNA1 CCNA2 CCNB1 CCNB2 CCNB3 CCNC CCND1 CCND2 CCND3 CCNE1 CCNE2 CCNG1 CCNH CCNT1 CCNT2 CDC42 CDK1 CDK2 CDKN1A CDKN1B CLEC11A CLEC14A CRIPTO CSF1R CXCL12 DDR1 DDR2 DRC4 E2F1 E2F2 E2F3 E2F4 E2F5 EGF EGFR EPHA1 EPHA2 EPHA3 EPHA4 EPHA5 EPHA7 EPHA8 EPHB1 EPHB2 EPHB3 EPHB4 EPHB6 EPOR ERBB2 ERBB3 ERBB4 FGF1 FGF10 FGF11 FGF12 FGF13 FGF14 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF21 FGF22 FGF23 FGF4 FGF5 FGF6 FGF7 FGF8 FGFR1 FGFR2 FGFR3 FGFR4 FLT1 FLT3 FLT4 GAS1 GAS2 GAS6 GDF10 GDF15 GDF2 GDF5 GDF6 GDF9 GFER GH1 GH2 GHRH GLG1 GMFG GNA11 GNA12 GNA13 GNA14 GNA15 GNAI1 GNAI2 GNAI3 GNAL GNAO1 GNAS GNAT1 GNAT2 GNAZ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GNRH1 GNRH2 GPC6 GRB10 GRB14 GRB2 GRB7 HBEGF HDGF HGF HRAS IGF1 IGF1R IGF2 IGF2-AS IGF2R IL2 IL2RA IL3 IL6 IL9 INSR INSRR ITPR1 ITPR2 ITPR3 KDR KIT KITLG KLF10 KRAS LEFTY1 LEFTY2 LHB LIFR LIMK1 LIMK2 LMTK2 LMTK3 LTBP1 LTBP2 LTBP3 LTBP4 MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK4 MAPK6 MAPK7 MAPK8 MAPK9 MCF2L MDK MERTK MET MRAS MST1R MUSK NET1 NGF NGFR NRAS NRG1 NRG2 NRG3 NRP1 NRP2 NTF3 NTF4 NTRK1 NTRK2 NTRK3 NUDT6 OGFR OGN PAK1 PDGFA PDGFB PDGFC PDGFD PDGFRA PDGFRB PENK PGF PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PLCB1 PLCB2 PLCB3 PLCB4 PLCD1 PLCD3 PLCD4 PLCE1 PLCG1 PLCG2 PLCZ1 PLPP3 PPBP PPP1R10 PPP1R11 PPP1R12A PPP1R12B PPP1R12C PPP1R13B PPP1R14A PPP1R14B PPP1R15A PPP1R16A PPP1R1A PPP1R1B PPP1R2 PPP1R3A PPP1R3B PPP1R3C PPP1R3D PPP1R3F PPP1R7 PPP1R8 PPP1R9A PPP1R9B PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R2A PPP2R2B PPP2R2C PPP2R3A PPP2R3B PPP2R5A PPP2R5B PPP2R5C PPP2R5E PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCQ PRKD1 PRKD3 PRKX PROK1 PSIP1 PTK7 PTN PTPA RAC1 RAC2 RAC3 RAF1 RB1CC1 RHOA ROCK1 ROCK2 ROR1 ROR2 ROS1 RRAS RRAS2 RYK SEMA3A SEMA4B SEMA4G SEMA5A SOS1 SOS2 SPON1 STMN1 TBRG1 TEK TGFA TGFB1 TGFB2 TGFB3 TGFBR1 TGFBR3 THPO TIE1 TIMP1 TIMP2 TIMP3 TIMP4 TP53 TP53BP2 TRPC5 TSG101 TUBA3C TUBA4A TUBA8 TUBB1 TUBB2A TUBB2B TUBB3 TUBB6 TUBB7P TYMP TYRO3 UHMK1 UTS2 VEGFB VEGFC VEGFD (see all 399) (see less)
3	Estrogen Pathway	QIAGEN	AKT1 AKT2 AKT3 ALK ANGPTL6 ARAF AREG ATF4 AXL BCL2 BDNF BMP1 BMP10 BMP2 BMP3 BMP4 BMP5 BMP6 BMP7 BMP8A BRAF BRCA1 BTC CCN2 CCND1 CHUK CLEC11A CREB1 CREB3 CREB3L4 CREBBP CRIPTO CSF1R CXCL12 DDR1 DDR2 DDX17 DRC4 EGF EGFR ELK1 EP300 EPHA1 EPHA2 EPHA3 EPHA4 EPHA5 EPHA7 EPHA8 EPHB1 EPHB2 EPHB3 EPHB4 EPHB6 EPOR ERBB2 ERBB3 ERBB4 ESR1 ESR2 FGF1 FGF10 FGF11 FGF12 FGF13 FGF14 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF21 FGF22 FGF23 FGF4 FGF5 FGF6 FGF7 FGF8 FGFR1 FGFR2 FGFR3 FGFR4 FLT1 FLT3 FLT4 FOS GAS1 GAS2 GAS6 GDF10 GDF15 GDF2 GDF5 GDF6 GDF9 GFER GH1 GH2 GHRH GMFG GNA11 GNA12 GNA13 GNA14 GNA15 GNAI1 GNAI2 GNAI3 GNAL GNAO1 GNAS GNAT1 GNAT2 GNAZ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GNRH1 GNRH2 GPC6 GRB2 GTF2A1 GTF2A2 GTF2B GTF2E1 GTF2E2 GTF2F1 GTF2F2 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 HDAC1 HDAC10 HDAC11 HDAC2 HDAC3 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDGF HGF HRAS IGF1 IGF1R IGF2 IGF2-AS IKBKB IKBKE IKBKG IL2 IL3 IL6 IL9 INSR INSRR JUN KDR KIT KITLG KLF10 KRAS LEFTY1 LEFTY2 LHB LIFR LMTK2 LMTK3 LTBP1 LTBP2 LTBP3 LTBP4 MAP3K2 MAP3K3 MAP3K4 MAP3K5 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK8 MAPK9 MDK MED1 MERTK MET MRAS MRGPRF MST1R MUSK NCOA1 NCOA2 NCOA3 NCOR1 NCOR2 NFKB1 NGF NOS3 NR0B1 NRAS NRG1 NRG2 NRG3 NRIP1 NTF3 NTF4 NTRK1 NTRK2 NTRK3 NUDT6 OGN PDGFA PDGFB PDGFC PDGFD PDGFRA PDGFRB PELP1 PENK PGF PHB2 PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PLPP3 POLR1A POLR2A POLR2B POLR2C PPARGC1A PPBP PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PROK1 PSIP1 PTK7 PTN RAF1 ROR1 ROR2 ROS1 RRAS RRAS2 RYK SEMA3A SEMA4B SEMA4G SEMA5A SIN3A SIN3B SOS1 SOS2 SP1 SPON1 SRA1 SRC TAF1 TAF10 TAF11 TAF12 TAF13 TAF15 TAF1A TAF1B TAF1C TAF1L TAF2 TAF4 TAF5 TAF5L TAF6 TAF6L TAF7 TAF7L TAF9 TAF9B TBP TBRG1 TEK TGFA TGFB1 TGFB2 TGFB3 THPO TIE1 TIMP1 TIMP2 TIMP3 TIMP4 TYMP TYRO3 UBE3A UTS2 VEGFB VEGFC VEGFD (see all 325) (see less)
4	NFAT in Immune Response	QIAGEN	AKAP5 AKT1 AKT2 AKT3 ALK ANGPTL6 AREG ATF2 AXL BDNF BLNK BMP1 BMP10 BMP2 BMP3 BMP4 BMP5 BMP6 BMP7 BMP8A BTC BTK CABIN1 CALM1 CALM2 CALM3 CCN2 CD247 CD28 CD3D CD3E CD3G CD4 CD79A CD79B CD80 CD86 CHUK CLEC11A CRIPTO CSF1R CSNK1A1 CSNK1D CSNK1E CSNK1G1 CSNK1G2 CSNK1G3 CXCL12 DDR1 DDR2 DRC4 EGF EGFR EPHA1 EPHA2 EPHA3 EPHA4 EPHA5 EPHA7 EPHA8 EPHB1 EPHB2 EPHB3 EPHB4 EPHB6 EPOR ERBB2 ERBB3 ERBB4 FCER1A FCER1G FCER2 FCGR1A FCGR2A FCGR3B FGF1 FGF10 FGF11 FGF12 FGF13 FGF14 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF21 FGF22 FGF23 FGF4 FGF5 FGF6 FGF7 FGF8 FGFR1 FGFR2 FGFR3 FGFR4 FLT1 FLT3 FLT4 FOS FYN GAS1 GAS2 GAS6 GATA4 GDF10 GDF15 GDF2 GDF5 GDF6 GDF9 GFER GH1 GH2 GHRH GMFG GNA11 GNA12 GNA13 GNA14 GNA15 GNAL GNAS GNB1 GNB2 GNB3 GNB4 GNB5 GNG2 GNG3 GNG4 GNRH1 GNRH2 GPC6 GPR119 GRB2 GSK3A GSK3B HDGF HGF HLA-DMA HLA-DMB HLA-DOA HLA-DOB HLA-DPA1 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DRA HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 IGF1 IGF1R IGF2 IGF2-AS IKBKB IKBKE IKBKG IL2 IL3 IL6 IL9 INSR INSRR IPO5 ITK ITPR1 ITPR2 ITPR3 JUN KDR KIT KITLG KLF10 KPNA1 KPNA2 KPNA3 KPNA4 KPNB1 LAT LCK LCP2 LEFTY1 LEFTY2 LHB LIFR LMTK2 LMTK3 LTBP1 LTBP2 LTBP3 LTBP4 LYN MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK4 MAPK6 MAPK7 MAPK8 MAPK9 MDK MERTK MET MST1R MUSK NFAT5 NFATC1 NFATC2 NFATC3 NFATC4 NFKB1 NGF NRG1 NRG2 NRG3 NTF3 NTF4 NTRK1 NTRK2 NTRK3 NUDT6 OGN P2RY13 PDGFA PDGFB PDGFC PDGFD PDGFRA PDGFRB PENK PGF PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PLCB1 PLCB2 PLCB3 PLCB4 PLCG1 PLCG2 PLPP3 PPBP PPP3CA PPP3CB PPP3CC PPP3R1 PPP3R2 PRKCQ PROK1 PSIP1 PTK7 PTN RCAN1 RCAN2 RCAN3 ROR1 ROR2 ROS1 RYK SEMA3A SEMA4B SEMA4G SEMA5A SOS1 SOS2 SPON1 SYK TBRG1 TEK TGFA TGFB1 TGFB2 TGFB3 THPO TIE1 TIMP1 TIMP2 TIMP3 TIMP4 TNPO1 TYMP TYRO3 UTS2 VEGFB VEGFC VEGFD XPO1 ZAP70 (see all 300) (see less)
5	Pancreatic Adenocarcinoma	QIAGEN	AKT1 AKT2 AKT3 ALK ANGPTL6 ARAF AREG ARHGEF1 ARHGEF10 ARHGEF11 ARHGEF12 ARHGEF15 ARHGEF16 ARHGEF2 ARHGEF3 ARHGEF4 ARHGEF5 ARHGEF6 ARHGEF7 ARHGEF9 AXL BCL2 BCL2L1 BDNF BIRC5 BMP1 BMP10 BMP2 BMP3 BMP4 BMP5 BMP6 BMP7 BMP8A BRAF BRCA2 BTC CCN2 CCNA1 CCNA2 CCNB1 CCNB2 CCNB3 CCNC CCND1 CCND2 CCND3 CCNE1 CCNE2 CCNF CCNG1 CCNH CCNT1 CCNT2 CDC42 CDK2 CDK4 CDKN1A CDKN1B CDKN2A CDKN2B CDKN2C CDKN2D CLEC11A CRIPTO CSF1R CXCL12 CYP2E1 DDR1 DDR2 DIRAS3 DRC4 E2F1 E2F2 E2F3 E2F4 E2F5 EGF EGFR ELK1 EPHA1 EPHA2 EPHA3 EPHA4 EPHA5 EPHA7 EPHA8 EPHB1 EPHB2 EPHB3 EPHB4 EPHB6 EPOR ERBB2 ERBB3 ERBB4 FGF1 FGF10 FGF11 FGF12 FGF13 FGF14 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF21 FGF22 FGF23 FGF4 FGF5 FGF6 FGF7 FGF8 FGFR1 FGFR2 FGFR3 FGFR4 FLT1 FLT3 FLT4 GAS1 GAS2 GAS6 GDF10 GDF15 GDF2 GDF5 GDF6 GDF9 GFER GH1 GH2 GHRH GMFG GNRH1 GNRH2 GPC6 GRB2 HBEGF HDGF HGF HSP90AA1 IGF1 IGF1R IGF2 IGF2-AS IL2 IL3 IL6 IL9 INSR INSRR JAK1 JAK2 JAK3 KDR KIT KITLG KLF10 KRAS LEFTY1 LEFTY2 LHB LIFR LMTK2 LMTK3 LTBP1 LTBP2 LTBP3 LTBP4 MAP2K1 MAP2K2 MAPK1 MAPK3 MAPK6 MCF2L MDK MDM2 MERTK MET MMP1 MMP10 MMP11 MMP12 MMP13 MMP19 MMP2 MMP20 MMP21 MMP23B MMP26 MMP27 MMP28 MMP3 MMP7 MMP8 MMP9 MST1R MUSK NET1 NFKB1 NGF NOTCH1 NRG1 NRG2 NRG3 NTF3 NTF4 NTRK1 NTRK2 NTRK3 NUDT6 OGN PDGFA PDGFB PDGFC PDGFD PDGFRA PDGFRB PENK PGF PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PLPP3 PPBP PROK1 PSIP1 PTGS2 PTK7 PTN RAC1 RAC2 RAC3 RAF1 RB1 RHOA RHOB RHOC RHOD RHOG RHOH RND2 RND3 ROR1 ROR2 ROS1 RYK SEMA3A SEMA4B SEMA4G SEMA5A SMAD2 SMAD3 SMAD4 SOS1 SOS2 SPON1 SRC STAT1 STAT2 STAT3 STAT4 STAT5A STAT5B STAT6 TBRG1 TEK TGFA TGFB1 TGFB2 TGFB3 TGFBR1 TGFBR2 THPO TIE1 TIMP1 TIMP2 TIMP3 TIMP4 TP53 TYMP TYRO3 UTS2 VEGFA VEGFB VEGFC VEGFD (see all 293) (see less)
6	Ras Pathway	QIAGEN	ACTA1 ACTA2 ACTB ACTG1 ACTG2 ALK ANGPTL6 ARAF AREG ARHGAP5 ARHGEF1 ARHGEF10 ARHGEF11 ARHGEF12 ARHGEF15 ARHGEF16 ARHGEF2 ARHGEF3 ARHGEF4 ARHGEF5 ARHGEF6 ARHGEF7 ARHGEF9 ATF2 AXL BDNF BMP1 BMP10 BMP2 BMP3 BMP4 BMP5 BMP6 BMP7 BMP8A BRAF BTC CCN2 CD247 CD3E CDC42 CLEC11A CRIPTO CSF1R CXCL12 DDR1 DDR2 DIRAS3 DRC4 EGF EGFR ELK1 EPHA1 EPHA2 EPHA3 EPHA4 EPHA5 EPHA7 EPHA8 EPHB1 EPHB2 EPHB3 EPHB4 EPHB6 EPOR ERBB2 ERBB3 ERBB4 FGF1 FGF10 FGF11 FGF12 FGF13 FGF14 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF21 FGF22 FGF23 FGF4 FGF5 FGF6 FGF7 FGF8 FGFR1 FGFR2 FGFR3 FGFR4 FLT1 FLT3 FLT4 FOS GAS1 GAS2 GAS6 GDF10 GDF15 GDF2 GDF5 GDF6 GDF9 GFER GH1 GH2 GHRH GMFG GNRH1 GNRH2 GPC6 GPLD1 GRB2 HDGF HGF HRAS IGF1 IGF1R IGF2 IGF2-AS IL2 IL3 IL6 IL9 INSR INSRR ITGA1 ITGA10 ITGA11 ITGA2 ITGA2B ITGA3 ITGA4 ITGA5 ITGA6 ITGA7 ITGA8 ITGA9 ITGAD ITGAE ITGAL ITGAM ITGAV ITGAX ITGB1 ITGB2 ITGB3 ITGB4 ITGB5 ITGB6 ITGB7 ITGB8 JUN KDR KIT KITLG KLF10 KRAS LCK LEFTY1 LEFTY2 LHB LIFR LMTK2 LMTK3 LTBP1 LTBP2 LTBP3 LTBP4 MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7 MAPK1 MAPK10 MAPK12 MAPK3 MAPK6 MAPK7 MAPK8 MAPK9 MCF2L MDK MERTK MET MRAS MST1R MUSK NET1 NGF NRAS NRG1 NRG2 NRG3 NTF3 NTF4 NTRK1 NTRK2 NTRK3 NUDT6 OGN PAK1 PAK2 PAK3 PAK4 PAK5 PAK6 PDGFA PDGFB PDGFC PDGFD PDGFRA PDGFRB PENK PGF PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PLCE1 PLD1 PLD2 PLD3 PLPP3 PPBP PROK1 PSIP1 PTK7 PTN RAC1 RAC2 RAC3 RAF1 RALA RALB RALBP1 RALGDS RAP1A RASA1 RHOA RHOB RHOC RHOD RHOG RHOH RND2 RND3 ROR1 ROR2 ROS1 RRAS RRAS2 RYK SEMA3A SEMA4B SEMA4G SEMA5A SOS1 SOS2 SPON1 TBRG1 TEK TGFA TGFB1 TGFB2 TGFB3 THPO TIE1 TIMP1 TIMP2 TIMP3 TIMP4 TYMP TYRO3 UTS2 VEGFB VEGFC VEGFD (see all 284) (see less)
7	Paxillin Interactions	QIAGEN	ACTA1 ACTA2 ACTB ACTG1 ACTG2 ALK ANGPTL6 AREG ARF1 ARF3 ARF4 ARF5 ARF6 ARFGAP1 ARFGAP3 ARFIP2 ARHGEF6 ARHGEF7 AXL BCAR1 BDNF BMP1 BMP10 BMP2 BMP3 BMP4 BMP5 BMP6 BMP7 BMP8A BTC CCN2 CDC42 CLEC11A CRIPTO CRK CSF1R CSK CXCL12 DDR1 DDR2 DOCK1 DRC4 EGF EGFR EPHA1 EPHA2 EPHA3 EPHA4 EPHA5 EPHA7 EPHA8 EPHB1 EPHB2 EPHB3 EPHB4 EPHB6 EPOR ERBB2 ERBB3 ERBB4 FGF1 FGF10 FGF11 FGF12 FGF13 FGF14 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF21 FGF22 FGF23 FGF4 FGF5 FGF6 FGF7 FGF8 FGFR1 FGFR2 FGFR3 FGFR4 FLT1 FLT3 FLT4 GAS1 GAS2 GAS6 GDF10 GDF15 GDF2 GDF5 GDF6 GDF9 GFER GH1 GH2 GHRH GMFG GNRH1 GNRH2 GPC6 GPR119 GRB2 HDGF HGF HRAS IGF1 IGF1R IGF2 IGF2-AS IL2 IL3 IL6 IL9 INSR INSRR ITGA1 ITGA10 ITGA11 ITGA2 ITGA2B ITGA3 ITGA4 ITGA5 ITGA6 ITGA7 ITGA8 ITGA9 ITGAD ITGAE ITGAL ITGAM ITGAV ITGAX ITGB1 ITGB2 ITGB3 ITGB4 ITGB5 ITGB6 ITGB7 ITGB8 KDR KIT KITLG KLF10 KRAS LEFTY1 LEFTY2 LHB LIFR LMTK2 LMTK3 LTBP1 LTBP2 LTBP3 LTBP4 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK8 MAPK9 MDK MERTK MET MRAS MST1R MUSK NCK1 NCK2 NGF NRAS NRG1 NRG2 NRG3 NTF3 NTF4 NTRK1 NTRK2 NTRK3 NUDT6 OGN P2RY13 PAK1 PAK2 PAK3 PAK4 PAK5 PAK6 PARVA PDGFA PDGFB PDGFC PDGFD PDGFRA PDGFRB PENK PGF PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PLPP3 PPBP PROK1 PSIP1 PTK2 PTK2B PTK7 PTN PTPN12 PXN RAC1 RAPGEF1 ROR1 ROR2 ROS1 RRAS RRAS2 RYK SEMA3A SEMA4B SEMA4G SEMA5A SOS1 SOS2 SPON1 SRC TBRG1 TEK TGFA TGFB1 TGFB2 TGFB3 THPO TIE1 TIMP1 TIMP2 TIMP3 TIMP4 TLN1 TLN2 TYMP TYRO3 UTS2 VCL VEGFB VEGFC VEGFD (see all 256) (see less)
8	P2Y Receptor Signaling	QIAGEN	ADCY1 ADCY2 ADCY3 AKT1 ALK ARAF ATF4 AXL BRAF CREB1 CREB3 CREB3L4 CSF1R DDR1 DDR2 EGF EGFR EPHA1 EPHA2 EPHA3 EPHA4 EPHA5 EPHA7 EPHA8 EPHB1 EPHB2 EPHB3 EPHB4 EPHB6 EPOR ERBB2 ERBB3 ERBB4 FGF1 FGF10 FGF11 FGF12 FGF13 FGF14 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF21 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FLT1 FLT3 FLT4 FOS GNAI1 GNAI2 GNAI3 GNAS GNB1 GNB2 GNB3 GNB4 GNB5 GNG2 GNG3 GNG4 HRAS IGF1R INSR INSRR JUN KDR KIT KRAS LIFR LMTK2 LMTK3 MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAPK1 MAPK3 MERTK MET MRAS MST1R MUSK MYC NFKB1 NRAS NTRK1 NTRK2 NTRK3 P2RY1 P2RY11 P2RY12 P2RY2 P2RY4 P2RY6 PDGFRA PDGFRB PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PLCB1 PLCB2 PLCB3 PLCB4 PLCD1 PLCD3 PLCD4 PLCE1 PLCG1 PLCG2 PLCZ1 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PTK7 RAF1 ROR1 ROR2 ROS1 RRAS RRAS2 RYK TEK TIE1 TYRO3 VEGFA VEGFB VEGFC VEGFD (see all 151) (see less)

Gene overlap in member pathways for GPCR Pathway SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ALK	ALK Receptor Tyrosine Kinase	Protein Coding	8
2	AXL	AXL Receptor Tyrosine Kinase	Protein Coding	8
3	CSF1R	Colony Stimulating Factor 1 Receptor	Protein Coding	8
4	DDR1	Discoidin Domain Receptor Tyrosine Kinase 1	Protein Coding	8
5	DDR2	Discoidin Domain Receptor Tyrosine Kinase 2	Protein Coding	8
6	EGF	Epidermal Growth Factor	Protein Coding	8
7	EGFR	Epidermal Growth Factor Receptor	Protein Coding	8
8	EPHA1	EPH Receptor A1	Protein Coding	8
9	EPHA2	EPH Receptor A2	Protein Coding	8
10	EPHA3	EPH Receptor A3	Protein Coding	8
11	EPHA4	EPH Receptor A4	Protein Coding	8
12	EPHA5	EPH Receptor A5	Protein Coding	8
13	EPHA7	EPH Receptor A7	Protein Coding	8
14	EPHA8	EPH Receptor A8	Protein Coding	8
15	EPHB1	EPH Receptor B1	Protein Coding	8
16	EPHB2	EPH Receptor B2	Protein Coding	8
17	EPHB3	EPH Receptor B3	Protein Coding	8
18	EPHB4	EPH Receptor B4	Protein Coding	8
19	EPHB6	EPH Receptor B6	Protein Coding	8
20	EPOR	Erythropoietin Receptor	Protein Coding	8
21	ERBB2	Erb-B2 Receptor Tyrosine Kinase 2	Protein Coding	8
22	ERBB3	Erb-B2 Receptor Tyrosine Kinase 3	Protein Coding	8
23	ERBB4	Erb-B2 Receptor Tyrosine Kinase 4	Protein Coding	8
24	FGF1	Fibroblast Growth Factor 1	Protein Coding	8
25	FGF10	Fibroblast Growth Factor 10	Protein Coding	8
26	FGF11	Fibroblast Growth Factor 11	Protein Coding	8
27	FGF12	Fibroblast Growth Factor 12	Protein Coding	8
28	FGF13	Fibroblast Growth Factor 13	Protein Coding	8
29	FGF14	Fibroblast Growth Factor 14	Protein Coding	8
30	FGF16	Fibroblast Growth Factor 16	Protein Coding	8
31	FGF17	Fibroblast Growth Factor 17	Protein Coding	8
32	FGF18	Fibroblast Growth Factor 18	Protein Coding	8
33	FGF19	Fibroblast Growth Factor 19	Protein Coding	8
34	FGF2	Fibroblast Growth Factor 2	Protein Coding	8
35	FGF20	Fibroblast Growth Factor 20	Protein Coding	8
36	FGF21	Fibroblast Growth Factor 21	Protein Coding	8
37	FGF22	Fibroblast Growth Factor 22	Protein Coding	8
38	FGF23	Fibroblast Growth Factor 23	Protein Coding	8
39	FGF4	Fibroblast Growth Factor 4	Protein Coding	8
40	FGF5	Fibroblast Growth Factor 5	Protein Coding	8
41	FGF6	Fibroblast Growth Factor 6	Protein Coding	8
42	FGF7	Fibroblast Growth Factor 7	Protein Coding	8
43	FGF8	Fibroblast Growth Factor 8	Protein Coding	8
44	FGFR1	Fibroblast Growth Factor Receptor 1	Protein Coding	8
45	FGFR2	Fibroblast Growth Factor Receptor 2	Protein Coding	8
46	FGFR3	Fibroblast Growth Factor Receptor 3	Protein Coding	8
47	FGFR4	Fibroblast Growth Factor Receptor 4	Protein Coding	8
48	VEGFD	Vascular Endothelial Growth Factor D	Protein Coding	8
49	FLT1	Fms Related Receptor Tyrosine Kinase 1	Protein Coding	8
50	FLT3	Fms Related Receptor Tyrosine Kinase 3	Protein Coding	8
51	FLT4	Fms Related Receptor Tyrosine Kinase 4	Protein Coding	8
52	IGF1R	Insulin Like Growth Factor 1 Receptor	Protein Coding	8
53	INSR	Insulin Receptor	Protein Coding	8
54	INSRR	Insulin Receptor Related Receptor	Protein Coding	8
55	KDR	Kinase Insert Domain Receptor	Protein Coding	8
56	KIT	KIT Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	8
57	LIFR	LIF Receptor Subunit Alpha	Protein Coding	8
58	LMTK2	Lemur Tyrosine Kinase 2	Protein Coding	8
59	LMTK3	Lemur Tyrosine Kinase 3	Protein Coding	8
60	MERTK	MER Proto-Oncogene, Tyrosine Kinase	Protein Coding	8
61	MET	MET Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	8
62	MST1R	Macrophage Stimulating 1 Receptor	Protein Coding	8
63	MUSK	Muscle Associated Receptor Tyrosine Kinase	Protein Coding	8
64	NTRK1	Neurotrophic Receptor Tyrosine Kinase 1	Protein Coding	8
65	NTRK2	Neurotrophic Receptor Tyrosine Kinase 2	Protein Coding	8
66	NTRK3	Neurotrophic Receptor Tyrosine Kinase 3	Protein Coding	8
67	PIK3R5	Phosphoinositide-3-Kinase Regulatory Subunit 5	Protein Coding	8
68	PDGFRA	Platelet Derived Growth Factor Receptor Alpha	Protein Coding	8
69	PDGFRB	Platelet Derived Growth Factor Receptor Beta	Protein Coding	8
70	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	8
71	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	8
72	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	8
73	PIK3R4	Phosphoinositide-3-Kinase Regulatory Subunit 4	Protein Coding	8
74	PTK7	Protein Tyrosine Kinase 7 (Inactive)	Protein Coding	8
75	ROR1	Receptor Tyrosine Kinase Like Orphan Receptor 1	Protein Coding	8
76	ROR2	Receptor Tyrosine Kinase Like Orphan Receptor 2	Protein Coding	8
77	ROS1	ROS Proto-Oncogene 1, Receptor Tyrosine Kinase	Protein Coding	8
78	RYK	Receptor Like Tyrosine Kinase	Protein Coding	8
79	TEK	TEK Receptor Tyrosine Kinase	Protein Coding	8
80	TIE1	Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains 1	Protein Coding	8
81	TYRO3	TYRO3 Protein Tyrosine Kinase	Protein Coding	8
82	VEGFB	Vascular Endothelial Growth Factor B	Protein Coding	8
83	VEGFC	Vascular Endothelial Growth Factor C	Protein Coding	8
84	ANGPTL6	Angiopoietin Like 6	Protein Coding	7
85	AREG	Amphiregulin	Protein Coding	7
86	BDNF	Brain Derived Neurotrophic Factor	Protein Coding	7
87	BMP1	Bone Morphogenetic Protein 1	Protein Coding	7
88	BMP10	Bone Morphogenetic Protein 10	Protein Coding	7
89	BMP2	Bone Morphogenetic Protein 2	Protein Coding	7
90	BMP3	Bone Morphogenetic Protein 3	Protein Coding	7
91	BMP4	Bone Morphogenetic Protein 4	Protein Coding	7
92	BMP5	Bone Morphogenetic Protein 5	Protein Coding	7
93	BMP6	Bone Morphogenetic Protein 6	Protein Coding	7
94	BMP7	Bone Morphogenetic Protein 7	Protein Coding	7
95	BMP8A	Bone Morphogenetic Protein 8a	Protein Coding	7
96	BTC	Betacellulin	Protein Coding	7
97	CCN2	Cellular Communication Network Factor 2	Protein Coding	7
98	CXCL12	C-X-C Motif Chemokine Ligand 12	Protein Coding	7
99	LEFTY2	Left-Right Determination Factor 2	Protein Coding	7
100	TYMP	Thymidine Phosphorylase	Protein Coding	7
101	GAS1	Growth Arrest Specific 1	Protein Coding	7
102	GAS2	Growth Arrest Specific 2	Protein Coding	7
103	GAS6	Growth Arrest Specific 6	Protein Coding	7
104	DRC4	Dynein Regulatory Complex Subunit 4	Protein Coding	7
105	GDF10	Growth Differentiation Factor 10	Protein Coding	7
106	GDF2	Growth Differentiation Factor 2	Protein Coding	7
107	GDF5	Growth Differentiation Factor 5	Protein Coding	7
108	GDF6	Growth Differentiation Factor 6	Protein Coding	7
109	GDF9	Growth Differentiation Factor 9	Protein Coding	7
110	GFER	Growth Factor, Augmenter Of Liver Regeneration	Protein Coding	7
111	GH1	Growth Hormone 1	Protein Coding	7
112	GH2	Growth Hormone 2	Protein Coding	7
113	GHRH	Growth Hormone Releasing Hormone	Protein Coding	7
114	GMFG	Glia Maturation Factor Gamma	Protein Coding	7
115	GNRH1	Gonadotropin Releasing Hormone 1	Protein Coding	7
116	GNRH2	Gonadotropin Releasing Hormone 2	Protein Coding	7
117	GPC6	Glypican 6	Protein Coding	7
118	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	7
119	HDGF	Heparin Binding Growth Factor	Protein Coding	7
120	HGF	Hepatocyte Growth Factor	Protein Coding	7
121	IGF1	Insulin Like Growth Factor 1	Protein Coding	7
122	IGF2	Insulin Like Growth Factor 2	Protein Coding	7
123	IGF2-AS	IGF2 Antisense RNA	RNA Gene	7
124	IL2	Interleukin 2	Protein Coding	7
125	IL3	Interleukin 3	Protein Coding	7
126	IL6	Interleukin 6	Protein Coding	7
127	IL9	Interleukin 9	Protein Coding	7
128	KITLG	KIT Ligand	Protein Coding	7
129	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	7
130	LEFTY1	Left-Right Determination Factor 1	Protein Coding	7
131	LHB	Luteinizing Hormone Subunit Beta	Protein Coding	7
132	LTBP1	Latent Transforming Growth Factor Beta Binding Protein 1	Protein Coding	7
133	LTBP2	Latent Transforming Growth Factor Beta Binding Protein 2	Protein Coding	7
134	LTBP3	Latent Transforming Growth Factor Beta Binding Protein 3	Protein Coding	7
135	LTBP4	Latent Transforming Growth Factor Beta Binding Protein 4	Protein Coding	7
136	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	7
137	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	7
138	MDK	Midkine	Protein Coding	7
139	NGF	Nerve Growth Factor	Protein Coding	7
140	NRG1	Neuregulin 1	Protein Coding	7
141	NRG2	Neuregulin 2	Protein Coding	7
142	NRG3	Neuregulin 3	Protein Coding	7
143	NTF3	Neurotrophin 3	Protein Coding	7
144	NTF4	Neurotrophin 4	Protein Coding	7
145	NUDT6	Nudix Hydrolase 6	Protein Coding	7
146	OGN	Osteoglycin	Protein Coding	7
147	PDGFA	Platelet Derived Growth Factor Subunit A	Protein Coding	7
148	PDGFB	Platelet Derived Growth Factor Subunit B	Protein Coding	7
149	PDGFC	Platelet Derived Growth Factor C	Protein Coding	7
150	PENK	Proenkephalin	Protein Coding	7
151	PGF	Placental Growth Factor	Protein Coding	7
152	GDF15	Growth Differentiation Factor 15	Protein Coding	7
153	PLPP3	Phospholipid Phosphatase 3	Protein Coding	7
154	PPBP	Pro-Platelet Basic Protein	Protein Coding	7
155	PROK1	Prokineticin 1	Protein Coding	7
156	PSIP1	PC4 And SRSF1 Interacting Protein 1	Protein Coding	7
157	PTN	Pleiotrophin	Protein Coding	7
158	PDGFD	Platelet Derived Growth Factor D	Protein Coding	7
159	CLEC11A	C-Type Lectin Domain Containing 11A	Protein Coding	7
160	SEMA3A	Semaphorin 3A	Protein Coding	7
161	SEMA4B	Semaphorin 4B	Protein Coding	7
162	SEMA4G	Semaphorin 4G	Protein Coding	7
163	SEMA5A	Semaphorin 5A	Protein Coding	7
164	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	7
165	SOS2	SOS Ras/Rho Guanine Nucleotide Exchange Factor 2	Protein Coding	7
166	SPON1	Spondin 1	Protein Coding	7
167	TBRG1	Transforming Growth Factor Beta Regulator 1	Protein Coding	7
168	CRIPTO	Cripto, EGF-CFC Family Member	Protein Coding	7
169	TGFA	Transforming Growth Factor Alpha	Protein Coding	7
170	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	7
171	TGFB2	Transforming Growth Factor Beta 2	Protein Coding	7
172	TGFB3	Transforming Growth Factor Beta 3	Protein Coding	7
173	THPO	Thrombopoietin	Protein Coding	7
174	KLF10	KLF Transcription Factor 10	Protein Coding	7
175	TIMP1	TIMP Metallopeptidase Inhibitor 1	Protein Coding	7
176	TIMP2	TIMP Metallopeptidase Inhibitor 2	Protein Coding	7
177	TIMP3	TIMP Metallopeptidase Inhibitor 3	Protein Coding	7
178	TIMP4	TIMP Metallopeptidase Inhibitor 4	Protein Coding	7
179	UTS2	Urotensin 2	Protein Coding	7
180	BRAF	B-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	6
181	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	6
182	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	6
183	MAPK12	Mitogen-Activated Protein Kinase 12	Protein Coding	6
184	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	6
185	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	6
186	MRAS	Muscle RAS Oncogene Homolog	Protein Coding	6
187	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	6
188	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	6
189	RRAS	RAS Related	Protein Coding	6
190	RRAS2	RAS Related 2	Protein Coding	6
191	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	5
192	ARHGEF6	Rac/Cdc42 Guanine Nucleotide Exchange Factor 6	Protein Coding	5
193	ARHGEF7	Rho Guanine Nucleotide Exchange Factor 7	Protein Coding	5
194	CDC42	Cell Division Cycle 42	Protein Coding	5
195	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	5
196	GNAS	GNAS Complex Locus	Protein Coding	5
197	GNB1	G Protein Subunit Beta 1	Protein Coding	5
198	GNB2	G Protein Subunit Beta 2	Protein Coding	5
199	GNB3	G Protein Subunit Beta 3	Protein Coding	5
200	GNB4	G Protein Subunit Beta 4	Protein Coding	5
201	GNB5	G Protein Subunit Beta 5	Protein Coding	5
202	GNG2	G Protein Subunit Gamma 2	Protein Coding	5
203	GNG3	G Protein Subunit Gamma 3	Protein Coding	5
204	GNG4	G Protein Subunit Gamma 4	Protein Coding	5
205	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	5
206	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	5
207	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	5
208	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	5
209	MAPK13	Mitogen-Activated Protein Kinase 13	Protein Coding	5
210	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	5
211	MAPK6	Mitogen-Activated Protein Kinase 6	Protein Coding	5
212	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	5
213	RAC1	Rac Family Small GTPase 1	Protein Coding	5
214	ARAF	A-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	5
215	RHOA	Ras Homolog Family Member A	Protein Coding	4
216	ARHGEF1	Rho Guanine Nucleotide Exchange Factor 1	Protein Coding	4
217	ARHGEF10	Rho Guanine Nucleotide Exchange Factor 10	Protein Coding	4
218	ARHGEF11	Rho Guanine Nucleotide Exchange Factor 11	Protein Coding	4
219	ARHGEF12	Rho Guanine Nucleotide Exchange Factor 12	Protein Coding	4
220	ARHGEF15	Rho Guanine Nucleotide Exchange Factor 15	Protein Coding	4
221	ARHGEF16	Rho Guanine Nucleotide Exchange Factor 16	Protein Coding	4
222	ARHGEF2	Rho/Rac Guanine Nucleotide Exchange Factor 2	Protein Coding	4
223	ARHGEF3	Rho Guanine Nucleotide Exchange Factor 3	Protein Coding	4
224	ARHGEF4	Rho Guanine Nucleotide Exchange Factor 4	Protein Coding	4
225	ARHGEF5	Rho Guanine Nucleotide Exchange Factor 5	Protein Coding	4
226	ARHGEF9	Cdc42 Guanine Nucleotide Exchange Factor 9	Protein Coding	4
227	ELK1	ETS Transcription Factor ELK1	Protein Coding	4
228	GNA11	G Protein Subunit Alpha 11	Protein Coding	4
229	GNA12	G Protein Subunit Alpha 12	Protein Coding	4
230	GNA13	G Protein Subunit Alpha 13	Protein Coding	4
231	GNA14	G Protein Subunit Alpha 14	Protein Coding	4
232	GNA15	G Protein Subunit Alpha 15	Protein Coding	4
233	GNAI1	G Protein Subunit Alpha I1	Protein Coding	4
234	GNAI2	G Protein Subunit Alpha I2	Protein Coding	4
235	GNAI3	G Protein Subunit Alpha I3	Protein Coding	4
236	MAP2K3	Mitogen-Activated Protein Kinase Kinase 3	Protein Coding	4
237	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	4
238	MAP2K5	Mitogen-Activated Protein Kinase Kinase 5	Protein Coding	4
239	MAP2K6	Mitogen-Activated Protein Kinase Kinase 6	Protein Coding	4
240	MAPK7	Mitogen-Activated Protein Kinase 7	Protein Coding	4
241	MCF2L	MCF.2 Cell Line Derived Transforming Sequence Like	Protein Coding	4
242	NET1	Neuroepithelial Cell Transforming 1	Protein Coding	4
243	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	4
244	PLCB1	Phospholipase C Beta 1	Protein Coding	4
245	PLCB2	Phospholipase C Beta 2	Protein Coding	4
246	PLCB3	Phospholipase C Beta 3	Protein Coding	4
247	PLCB4	Phospholipase C Beta 4	Protein Coding	4
248	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	4
249	PRKACB	Protein Kinase CAMP-Activated Catalytic Subunit Beta	Protein Coding	4
250	PRKACG	Protein Kinase CAMP-Activated Catalytic Subunit Gamma	Protein Coding	4
251	PRKAR1A	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Alpha	Protein Coding	4
252	PRKAR1B	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Beta	Protein Coding	4
253	PRKAR2A	Protein Kinase CAMP-Dependent Type II Regulatory Subunit Alpha	Protein Coding	4
254	PRKAR2B	Protein Kinase CAMP-Dependent Type II Regulatory Subunit Beta	Protein Coding	4
255	RAC2	Rac Family Small GTPase 2	Protein Coding	4
256	RAC3	Rac Family Small GTPase 3	Protein Coding	4
257	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	4
258	ADCY1	Adenylate Cyclase 1	Protein Coding	3
259	ADCY2	Adenylate Cyclase 2	Protein Coding	3
260	ADCY3	Adenylate Cyclase 3	Protein Coding	3
261	RHOB	Ras Homolog Family Member B	Protein Coding	3
262	RHOC	Ras Homolog Family Member C	Protein Coding	3
263	RHOD	Ras Homolog Family Member D	Protein Coding	3
264	RND3	Rho Family GTPase 3	Protein Coding	3
265	RHOG	Ras Homolog Family Member G	Protein Coding	3
266	RHOH	Ras Homolog Family Member H	Protein Coding	3
267	DIRAS3	DIRAS Family GTPase 3	Protein Coding	3
268	RND2	Rho Family GTPase 2	Protein Coding	3
269	ATF4	Activating Transcription Factor 4	Protein Coding	3
270	CALM1	Calmodulin 1	Protein Coding	3
271	CALM2	Calmodulin 2	Protein Coding	3
272	CALM3	Calmodulin 3	Protein Coding	3
273	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	3
274	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	3
275	CREB3	CAMP Responsive Element Binding Protein 3	Protein Coding	3
276	CREB3L4	CAMP Responsive Element Binding Protein 3 Like 4	Protein Coding	3
277	GPR119	G Protein-Coupled Receptor 119	Protein Coding	3
278	P2RY13	Purinergic Receptor P2Y13	Protein Coding	3
279	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	3
280	IKBKE	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Epsilon	Protein Coding	3
281	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	3
282	ITPR1	Inositol 1,4,5-Trisphosphate Receptor Type 1	Protein Coding	3
283	ITPR2	Inositol 1,4,5-Trisphosphate Receptor Type 2	Protein Coding	3
284	ITPR3	Inositol 1,4,5-Trisphosphate Receptor Type 3	Protein Coding	3
285	PAK2	P21 (RAC1) Activated Kinase 2	Protein Coding	3
286	PAK3	P21 (RAC1) Activated Kinase 3	Protein Coding	3
287	PAK4	P21 (RAC1) Activated Kinase 4	Protein Coding	3
288	PAK6	P21 (RAC1) Activated Kinase 6	Protein Coding	3
289	PAK5	P21 (RAC1) Activated Kinase 5	Protein Coding	3
290	PRKCQ	Protein Kinase C Theta	Protein Coding	3
291	CCND1	Cyclin D1	Protein Coding	3
292	GNAL	G Protein Subunit Alpha L	Protein Coding	3
293	PLCE1	Phospholipase C Epsilon 1	Protein Coding	3
294	PLCG1	Phospholipase C Gamma 1	Protein Coding	3
295	PLCG2	Phospholipase C Gamma 2	Protein Coding	3
296	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	3
297	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	3
298	CRK	CRK Proto-Oncogene, Adaptor Protein	Protein Coding	2
299	MAP2K7	Mitogen-Activated Protein Kinase Kinase 7	Protein Coding	2
300	MAP3K2	Mitogen-Activated Protein Kinase Kinase Kinase 2	Protein Coding	2
301	MAP3K3	Mitogen-Activated Protein Kinase Kinase Kinase 3	Protein Coding	2
302	MAP3K4	Mitogen-Activated Protein Kinase Kinase Kinase 4	Protein Coding	2
303	MAP3K5	Mitogen-Activated Protein Kinase Kinase Kinase 5	Protein Coding	2
304	NFAT5	Nuclear Factor Of Activated T Cells 5	Protein Coding	2
305	NFATC1	Nuclear Factor Of Activated T Cells 1	Protein Coding	2
306	NFATC2	Nuclear Factor Of Activated T Cells 2	Protein Coding	2
307	NFATC3	Nuclear Factor Of Activated T Cells 3	Protein Coding	2
308	NFATC4	Nuclear Factor Of Activated T Cells 4	Protein Coding	2
309	PPP3CA	Protein Phosphatase 3 Catalytic Subunit Alpha	Protein Coding	2
310	PPP3CB	Protein Phosphatase 3 Catalytic Subunit Beta	Protein Coding	2
311	PPP3CC	Protein Phosphatase 3 Catalytic Subunit Gamma	Protein Coding	2
312	PPP3R1	Protein Phosphatase 3 Regulatory Subunit B, Alpha	Protein Coding	2
313	PPP3R2	Protein Phosphatase 3 Regulatory Subunit B, Beta	Protein Coding	2
314	PRKCA	Protein Kinase C Alpha	Protein Coding	2
315	PRKCB	Protein Kinase C Beta	Protein Coding	2
316	PRKCD	Protein Kinase C Delta	Protein Coding	2
317	PRKCE	Protein Kinase C Epsilon	Protein Coding	2
318	PRKCG	Protein Kinase C Gamma	Protein Coding	2
319	PRKCH	Protein Kinase C Eta	Protein Coding	2
320	PRKD1	Protein Kinase D1	Protein Coding	2
321	PRKD3	Protein Kinase D3	Protein Coding	2
322	PTK2	Protein Tyrosine Kinase 2	Protein Coding	2
323	PTK2B	Protein Tyrosine Kinase 2 Beta	Protein Coding	2
324	PXN	Paxillin	Protein Coding	2
325	RAP1A	RAP1A, Member Of RAS Oncogene Family	Protein Coding	2
326	ROCK1	Rho Associated Coiled-Coil Containing Protein Kinase 1	Protein Coding	2
327	ROCK2	Rho Associated Coiled-Coil Containing Protein Kinase 2	Protein Coding	2
328	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	2
329	STAT2	Signal Transducer And Activator Of Transcription 2	Protein Coding	2
330	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	2
331	STAT4	Signal Transducer And Activator Of Transcription 4	Protein Coding	2
332	STAT5A	Signal Transducer And Activator Of Transcription 5A	Protein Coding	2
333	STAT5B	Signal Transducer And Activator Of Transcription 5B	Protein Coding	2
334	STAT6	Signal Transducer And Activator Of Transcription 6	Protein Coding	2
335	CCNA1	Cyclin A1	Protein Coding	2
336	CCNA2	Cyclin A2	Protein Coding	2
337	CCNB1	Cyclin B1	Protein Coding	2
338	CCNB2	Cyclin B2	Protein Coding	2
339	CCNB3	Cyclin B3	Protein Coding	2
340	CCNC	Cyclin C	Protein Coding	2
341	CCND2	Cyclin D2	Protein Coding	2
342	CCND3	Cyclin D3	Protein Coding	2
343	CCNE1	Cyclin E1	Protein Coding	2
344	CCNE2	Cyclin E2	Protein Coding	2
345	CCNG1	Cyclin G1	Protein Coding	2
346	CCNH	Cyclin H	Protein Coding	2
347	CCNT1	Cyclin T1	Protein Coding	2
348	CCNT2	Cyclin T2	Protein Coding	2
349	CDK2	Cyclin Dependent Kinase 2	Protein Coding	2
350	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	2
351	CDKN1B	Cyclin Dependent Kinase Inhibitor 1B	Protein Coding	2
352	HBEGF	Heparin Binding EGF Like Growth Factor	Protein Coding	2
353	E2F1	E2F Transcription Factor 1	Protein Coding	2
354	E2F2	E2F Transcription Factor 2	Protein Coding	2
355	E2F3	E2F Transcription Factor 3	Protein Coding	2
356	E2F4	E2F Transcription Factor 4	Protein Coding	2
357	E2F5	E2F Transcription Factor 5	Protein Coding	2
358	GNAO1	G Protein Subunit Alpha O1	Protein Coding	2
359	GNAT1	G Protein Subunit Alpha Transducin 1	Protein Coding	2
360	GNAT2	G Protein Subunit Alpha Transducin 2	Protein Coding	2
361	GNAZ	G Protein Subunit Alpha Z	Protein Coding	2
362	GNG10	G Protein Subunit Gamma 10	Protein Coding	2
363	GNG11	G Protein Subunit Gamma 11	Protein Coding	2
364	GNG12	G Protein Subunit Gamma 12	Protein Coding	2
365	GNG13	G Protein Subunit Gamma 13	Protein Coding	2
366	GNG5	G Protein Subunit Gamma 5	Protein Coding	2
367	GNG7	G Protein Subunit Gamma 7	Protein Coding	2
368	GNG8	G Protein Subunit Gamma 8	Protein Coding	2
369	GNGT1	G Protein Subunit Gamma Transducin 1	Protein Coding	2
370	GNGT2	G Protein Subunit Gamma Transducin 2	Protein Coding	2
371	MAPK4	Mitogen-Activated Protein Kinase 4	Protein Coding	2
372	PLCD1	Phospholipase C Delta 1	Protein Coding	2
373	PLCD3	Phospholipase C Delta 3	Protein Coding	2
374	PLCD4	Phospholipase C Delta 4	Protein Coding	2
375	PLCZ1	Phospholipase C Zeta 1	Protein Coding	2
376	TGFBR1	Transforming Growth Factor Beta Receptor 1	Protein Coding	2
377	TP53	Tumor Protein P53	Protein Coding	2
378	BCL2	BCL2 Apoptosis Regulator	Protein Coding	2
379	ATF2	Activating Transcription Factor 2	Protein Coding	2
380	CD3E	CD3 Epsilon Subunit Of T-Cell Receptor Complex	Protein Coding	2
381	CD247	CD247 Molecule	Protein Coding	2
382	LCK	LCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	2
383	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	2
384	ACTA1	Actin Alpha 1, Skeletal Muscle	Protein Coding	2
385	ACTA2	Actin Alpha 2, Smooth Muscle	Protein Coding	2
386	ACTB	Actin Beta	Protein Coding	2
387	ACTG1	Actin Gamma 1	Protein Coding	2
388	ACTG2	Actin Gamma 2, Smooth Muscle	Protein Coding	2
389	ITGA1	Integrin Subunit Alpha 1	Protein Coding	2
390	ITGA10	Integrin Subunit Alpha 10	Protein Coding	2
391	ITGA11	Integrin Subunit Alpha 11	Protein Coding	2
392	ITGA2	Integrin Subunit Alpha 2	Protein Coding	2
393	ITGA2B	Integrin Subunit Alpha 2b	Protein Coding	2
394	ITGA3	Integrin Subunit Alpha 3	Protein Coding	2
395	ITGA4	Integrin Subunit Alpha 4	Protein Coding	2
396	ITGA5	Integrin Subunit Alpha 5	Protein Coding	2
397	ITGA6	Integrin Subunit Alpha 6	Protein Coding	2
398	ITGA7	Integrin Subunit Alpha 7	Protein Coding	2
399	ITGA8	Integrin Subunit Alpha 8	Protein Coding	2
400	ITGA9	Integrin Subunit Alpha 9	Protein Coding	2
401	ITGAD	Integrin Subunit Alpha D	Protein Coding	2
402	ITGAE	Integrin Subunit Alpha E	Protein Coding	2
403	ITGAL	Integrin Subunit Alpha L	Protein Coding	2
404	ITGAM	Integrin Subunit Alpha M	Protein Coding	2
405	ITGAV	Integrin Subunit Alpha V	Protein Coding	2
406	ITGAX	Integrin Subunit Alpha X	Protein Coding	2
407	ITGB1	Integrin Subunit Beta 1	Protein Coding	2
408	ITGB2	Integrin Subunit Beta 2	Protein Coding	2
409	ITGB3	Integrin Subunit Beta 3	Protein Coding	2
410	ITGB4	Integrin Subunit Beta 4	Protein Coding	2
411	ITGB5	Integrin Subunit Beta 5	Protein Coding	2
412	ITGB6	Integrin Subunit Beta 6	Protein Coding	2
413	ITGB7	Integrin Subunit Beta 7	Protein Coding	2
414	ITGB8	Integrin Subunit Beta 8	Protein Coding	2
415	BCL10	BCL10 Immune Signaling Adaptor	Protein Coding	1
416	CARD10	Caspase Recruitment Domain Family Member 10	Protein Coding	1
417	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	1
418	NFKBIB	NFKB Inhibitor Beta	Protein Coding	1
419	NFKBIE	NFKB Inhibitor Epsilon	Protein Coding	1
420	PRKCI	Protein Kinase C Iota	Protein Coding	1
421	PRKCZ	Protein Kinase C Zeta	Protein Coding	1
422	RAP1B	RAP1B, Member Of RAS Oncogene Family	Protein Coding	1
423	RAPGEF4	Rap Guanine Nucleotide Exchange Factor 4	Protein Coding	1
424	SRF	Serum Response Factor	Protein Coding	1
425	ADCY4	Adenylate Cyclase 4	Protein Coding	1
426	ADCY5	Adenylate Cyclase 5	Protein Coding	1
427	ADCY6	Adenylate Cyclase 6	Protein Coding	1
428	ADCY7	Adenylate Cyclase 7	Protein Coding	1
429	ADCY8	Adenylate Cyclase 8	Protein Coding	1
430	ADCY9	Adenylate Cyclase 9	Protein Coding	1
431	CLEC14A	C-Type Lectin Domain Containing 14A	Protein Coding	1
432	CAMK1	Calcium/Calmodulin Dependent Protein Kinase I	Protein Coding	1
433	CAMK1G	Calcium/Calmodulin Dependent Protein Kinase IG	Protein Coding	1
434	CAMK2A	Calcium/Calmodulin Dependent Protein Kinase II Alpha	Protein Coding	1
435	CAMK2B	Calcium/Calmodulin Dependent Protein Kinase II Beta	Protein Coding	1
436	CAMK2D	Calcium/Calmodulin Dependent Protein Kinase II Delta	Protein Coding	1
437	CAMK2G	Calcium/Calmodulin Dependent Protein Kinase II Gamma	Protein Coding	1
438	CAMK4	Calcium/Calmodulin Dependent Protein Kinase IV	Protein Coding	1
439	CDK1	Cyclin Dependent Kinase 1	Protein Coding	1
440	GLG1	Golgi Glycoprotein 1	Protein Coding	1
441	GRB10	Growth Factor Receptor Bound Protein 10	Protein Coding	1
442	GRB14	Growth Factor Receptor Bound Protein 14	Protein Coding	1
443	GRB7	Growth Factor Receptor Bound Protein 7	Protein Coding	1
444	IGF2R	Insulin Like Growth Factor 2 Receptor	Protein Coding	1
445	IL2RA	Interleukin 2 Receptor Subunit Alpha	Protein Coding	1
446	UHMK1	U2AF Homology Motif Kinase 1	Protein Coding	1
447	LIMK1	LIM Domain Kinase 1	Protein Coding	1
448	LIMK2	LIM Domain Kinase 2	Protein Coding	1
449	TUBB6	Tubulin Beta 6 Class V	Protein Coding	1
450	TUBB2B	Tubulin Beta 2B Class IIb	Protein Coding	1
451	NGFR	Nerve Growth Factor Receptor	Protein Coding	1
452	NRP1	Neuropilin 1	Protein Coding	1
453	NRP2	Neuropilin 2	Protein Coding	1
454	OGFR	Opioid Growth Factor Receptor	Protein Coding	1
455	PPP1R10	Protein Phosphatase 1 Regulatory Subunit 10	Protein Coding	1
456	PPP1R11	Protein Phosphatase 1 Regulatory Inhibitor Subunit 11	Protein Coding	1
457	PPP1R12A	Protein Phosphatase 1 Regulatory Subunit 12A	Protein Coding	1
458	PPP1R12B	Protein Phosphatase 1 Regulatory Subunit 12B	Protein Coding	1
459	PPP1R12C	Protein Phosphatase 1 Regulatory Subunit 12C	Protein Coding	1
460	PPP1R13B	Protein Phosphatase 1 Regulatory Subunit 13B	Protein Coding	1
461	PPP1R14A	Protein Phosphatase 1 Regulatory Inhibitor Subunit 14A	Protein Coding	1
462	PPP1R14B	Protein Phosphatase 1 Regulatory Inhibitor Subunit 14B	Protein Coding	1
463	PPP1R15A	Protein Phosphatase 1 Regulatory Subunit 15A	Protein Coding	1
464	PPP1R16A	Protein Phosphatase 1 Regulatory Subunit 16A	Protein Coding	1
465	PPP1R1A	Protein Phosphatase 1 Regulatory Inhibitor Subunit 1A	Protein Coding	1
466	PPP1R1B	Protein Phosphatase 1 Regulatory Inhibitor Subunit 1B	Protein Coding	1
467	PPP1R2	Protein Phosphatase 1 Regulatory Inhibitor Subunit 2	Protein Coding	1
468	PPP1R3A	Protein Phosphatase 1 Regulatory Subunit 3A	Protein Coding	1
469	PPP1R3B	Protein Phosphatase 1 Regulatory Subunit 3B	Protein Coding	1
470	PPP1R3C	Protein Phosphatase 1 Regulatory Subunit 3C	Protein Coding	1
471	PPP1R3D	Protein Phosphatase 1 Regulatory Subunit 3D	Protein Coding	1
472	PPP1R3F	Protein Phosphatase 1 Regulatory Subunit 3F	Protein Coding	1
473	PPP1R7	Protein Phosphatase 1 Regulatory Subunit 7	Protein Coding	1
474	PPP1R8	Protein Phosphatase 1 Regulatory Subunit 8	Protein Coding	1
475	PPP1R9A	Protein Phosphatase 1 Regulatory Subunit 9A	Protein Coding	1
476	PPP1R9B	Protein Phosphatase 1 Regulatory Subunit 9B	Protein Coding	1
477	PPP2CA	Protein Phosphatase 2 Catalytic Subunit Alpha	Protein Coding	1
478	PPP2CB	Protein Phosphatase 2 Catalytic Subunit Beta	Protein Coding	1
479	PPP2R1A	Protein Phosphatase 2 Scaffold Subunit Aalpha	Protein Coding	1
480	PPP2R1B	Protein Phosphatase 2 Scaffold Subunit Abeta	Protein Coding	1
481	PPP2R2A	Protein Phosphatase 2 Regulatory Subunit Balpha	Protein Coding	1
482	PPP2R2B	Protein Phosphatase 2 Regulatory Subunit Bbeta	Protein Coding	1
483	PPP2R2C	Protein Phosphatase 2 Regulatory Subunit Bgamma	Protein Coding	1
484	PPP2R3A	Protein Phosphatase 2 Regulatory Subunit B''''Alpha	Protein Coding	1
485	PTPA	Protein Phosphatase 2 Phosphatase Activator	Protein Coding	1
486	PPP2R5A	Protein Phosphatase 2 Regulatory Subunit B''Alpha	Protein Coding	1
487	PPP2R5B	Protein Phosphatase 2 Regulatory Subunit B''Beta	Protein Coding	1
488	PPP2R5C	Protein Phosphatase 2 Regulatory Subunit B''Gamma	Protein Coding	1
489	PPP2R5E	Protein Phosphatase 2 Regulatory Subunit B''Epsilon	Protein Coding	1
490	PPP2R3B	Protein Phosphatase 2 Regulatory Subunit B''''Beta~Name Same As:- HGNC:9310	Protein Coding	1
491	PRKX	Protein Kinase CAMP-Dependent X-Linked Catalytic Subunit	Protein Coding	1
492	RB1CC1	RB1 Inducible Coiled-Coil 1	Protein Coding	1
493	STMN1	Stathmin 1	Protein Coding	1
494	TGFBR3	Transforming Growth Factor Beta Receptor 3	Protein Coding	1
495	TP53BP2	Tumor Protein P53 Binding Protein 2	Protein Coding	1
496	TRPC5	Transient Receptor Potential Cation Channel Subfamily C Member 5	Protein Coding	1
497	TSG101	Tumor Susceptibility 101	Protein Coding	1
498	TUBA4A	Tubulin Alpha 4a	Protein Coding	1
499	TUBA3C	Tubulin Alpha 3c	Protein Coding	1
500	TUBA8	Tubulin Alpha 8	Protein Coding	1
501	TUBB1	Tubulin Beta 1 Class VI	Protein Coding	1
502	TUBB2A	Tubulin Beta 2A Class IIa	Protein Coding	1
503	TUBB3	Tubulin Beta 3 Class III	Protein Coding	1
504	TUBB7P	Tubulin Beta 7 Pseudogene	Pseudogene	1
505	BRCA1	BRCA1 DNA Repair Associated	Protein Coding	1
506	CREBBP	CREB Binding Lysine Acetyltransferase	Protein Coding	1
507	DDX17	DEAD-Box Helicase 17	Protein Coding	1
508	EP300	EP300 Lysine Acetyltransferase	Protein Coding	1
509	ESR1	Estrogen Receptor 1	Protein Coding	1
510	ESR2	Estrogen Receptor 2	Protein Coding	1
511	GTF2A1	General Transcription Factor IIA Subunit 1	Protein Coding	1
512	GTF2A2	General Transcription Factor IIA Subunit 2	Protein Coding	1
513	GTF2B	General Transcription Factor IIB	Protein Coding	1
514	GTF2E1	General Transcription Factor IIE Subunit 1	Protein Coding	1
515	GTF2E2	General Transcription Factor IIE Subunit 2	Protein Coding	1
516	GTF2F1	General Transcription Factor IIF Subunit 1	Protein Coding	1
517	GTF2F2	General Transcription Factor IIF Subunit 2	Protein Coding	1
518	GTF2H1	General Transcription Factor IIH Subunit 1	Protein Coding	1
519	GTF2H2	General Transcription Factor IIH Subunit 2	Protein Coding	1
520	GTF2H3	General Transcription Factor IIH Subunit 3	Protein Coding	1
521	GTF2H4	General Transcription Factor IIH Subunit 4	Protein Coding	1
522	GTF2H5	General Transcription Factor IIH Subunit 5	Protein Coding	1
523	HDAC1	Histone Deacetylase 1	Protein Coding	1
524	HDAC10	Histone Deacetylase 10	Protein Coding	1
525	HDAC11	Histone Deacetylase 11	Protein Coding	1
526	HDAC2	Histone Deacetylase 2	Protein Coding	1
527	HDAC3	Histone Deacetylase 3	Protein Coding	1
528	HDAC5	Histone Deacetylase 5	Protein Coding	1
529	HDAC6	Histone Deacetylase 6	Protein Coding	1
530	HDAC7	Histone Deacetylase 7	Protein Coding	1
531	HDAC8	Histone Deacetylase 8	Protein Coding	1
532	HDAC9	Histone Deacetylase 9	Protein Coding	1
533	MRGPRF	MAS Related GPR Family Member F	Protein Coding	1
534	NCOA1	Nuclear Receptor Coactivator 1	Protein Coding	1
535	NCOA2	Nuclear Receptor Coactivator 2	Protein Coding	1
536	NCOA3	Nuclear Receptor Coactivator 3	Protein Coding	1
537	NCOR1	Nuclear Receptor Corepressor 1	Protein Coding	1
538	NCOR2	Nuclear Receptor Corepressor 2	Protein Coding	1
539	NOS3	Nitric Oxide Synthase 3	Protein Coding	1
540	NR0B1	Nuclear Receptor Subfamily 0 Group B Member 1	Protein Coding	1
541	NRIP1	Nuclear Receptor Interacting Protein 1	Protein Coding	1
542	PELP1	Proline, Glutamate And Leucine Rich Protein 1	Protein Coding	1
543	POLR1A	RNA Polymerase I Subunit A	Protein Coding	1
544	POLR2A	RNA Polymerase II Subunit A	Protein Coding	1
545	POLR2B	RNA Polymerase II Subunit B	Protein Coding	1
546	POLR2C	RNA Polymerase II Subunit C	Protein Coding	1
547	MED1	Mediator Complex Subunit 1	Protein Coding	1
548	PPARGC1A	PPARG Coactivator 1 Alpha	Protein Coding	1
549	PHB2	Prohibitin 2	Protein Coding	1
550	SIN3A	SIN3 Transcription Regulator Family Member A	Protein Coding	1
551	SIN3B	SIN3 Transcription Regulator Family Member B	Protein Coding	1
552	SP1	Sp1 Transcription Factor	Protein Coding	1
553	SRA1	Steroid Receptor RNA Activator 1	Protein Coding	1
554	TAF1	TATA-Box Binding Protein Associated Factor 1	Protein Coding	1
555	TAF10	TATA-Box Binding Protein Associated Factor 10	Protein Coding	1
556	TAF11	TATA-Box Binding Protein Associated Factor 11	Protein Coding	1
557	TAF12	TATA-Box Binding Protein Associated Factor 12	Protein Coding	1
558	TAF13	TATA-Box Binding Protein Associated Factor 13	Protein Coding	1
559	TAF15	TATA-Box Binding Protein Associated Factor 15	Protein Coding	1
560	TAF1A	TATA-Box Binding Protein Associated Factor, RNA Polymerase I Subunit A	Protein Coding	1
561	TAF1B	TATA-Box Binding Protein Associated Factor, RNA Polymerase I Subunit B	Protein Coding	1
562	TAF1C	TATA-Box Binding Protein Associated Factor, RNA Polymerase I Subunit C	Protein Coding	1
563	TAF1L	TATA-Box Binding Protein Associated Factor 1 Like	Protein Coding	1
564	TAF2	TATA-Box Binding Protein Associated Factor 2	Protein Coding	1
565	TAF4	TATA-Box Binding Protein Associated Factor 4	Protein Coding	1
566	TAF5	TATA-Box Binding Protein Associated Factor 5	Protein Coding	1
567	TAF5L	TATA-Box Binding Protein Associated Factor 5 Like	Protein Coding	1
568	TAF6	TATA-Box Binding Protein Associated Factor 6	Protein Coding	1
569	TAF6L	TATA-Box Binding Protein Associated Factor 6 Like	Protein Coding	1
570	TAF7	TATA-Box Binding Protein Associated Factor 7	Protein Coding	1
571	TAF7L	TATA-Box Binding Protein Associated Factor 7 Like	Protein Coding	1
572	TAF9	TATA-Box Binding Protein Associated Factor 9	Protein Coding	1
573	TAF9B	TATA-Box Binding Protein Associated Factor 9b	Protein Coding	1
574	TBP	TATA-Box Binding Protein	Protein Coding	1
575	UBE3A	Ubiquitin Protein Ligase E3A	Protein Coding	1
576	AKAP5	A-Kinase Anchoring Protein 5	Protein Coding	1
577	BLNK	B Cell Linker	Protein Coding	1
578	BTK	Bruton Tyrosine Kinase	Protein Coding	1
579	CABIN1	Calcineurin Binding Protein 1	Protein Coding	1
580	CD28	CD28 Molecule	Protein Coding	1
581	CD3D	CD3 Delta Subunit Of T-Cell Receptor Complex	Protein Coding	1
582	CD3G	CD3 Gamma Subunit Of T-Cell Receptor Complex	Protein Coding	1
583	CD4	CD4 Molecule	Protein Coding	1
584	CD79A	CD79a Molecule	Protein Coding	1
585	CD79B	CD79b Molecule	Protein Coding	1
586	CD80	CD80 Molecule	Protein Coding	1
587	CD86	CD86 Molecule	Protein Coding	1
588	CSNK1A1	Casein Kinase 1 Alpha 1	Protein Coding	1
589	CSNK1D	Casein Kinase 1 Delta	Protein Coding	1
590	CSNK1E	Casein Kinase 1 Epsilon	Protein Coding	1
591	CSNK1G1	Casein Kinase 1 Gamma 1	Protein Coding	1
592	CSNK1G2	Casein Kinase 1 Gamma 2	Protein Coding	1
593	CSNK1G3	Casein Kinase 1 Gamma 3	Protein Coding	1
594	RCAN1	Regulator Of Calcineurin 1	Protein Coding	1
595	RCAN2	Regulator Of Calcineurin 2	Protein Coding	1
596	RCAN3	RCAN Family Member 3	Protein Coding	1
597	FCER1A	Fc Epsilon Receptor Ia	Protein Coding	1
598	FCER1G	Fc Epsilon Receptor Ig	Protein Coding	1
599	FCER2	Fc Epsilon Receptor II	Protein Coding	1
600	FCGR1A	Fc Gamma Receptor Ia	Protein Coding	1
601	FCGR2A	Fc Gamma Receptor IIa	Protein Coding	1
602	FCGR3B	Fc Gamma Receptor IIIb	Protein Coding	1
603	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
604	GATA4	GATA Binding Protein 4	Protein Coding	1
605	GSK3A	Glycogen Synthase Kinase 3 Alpha	Protein Coding	1
606	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
607	HLA-DMA	Major Histocompatibility Complex, Class II, DM Alpha	Protein Coding	1
608	HLA-DMB	Major Histocompatibility Complex, Class II, DM Beta	Protein Coding	1
609	HLA-DOA	Major Histocompatibility Complex, Class II, DO Alpha	Protein Coding	1
610	HLA-DOB	Major Histocompatibility Complex, Class II, DO Beta	Protein Coding	1
611	HLA-DPA1	Major Histocompatibility Complex, Class II, DP Alpha 1	Protein Coding	1
612	HLA-DQA1	Major Histocompatibility Complex, Class II, DQ Alpha 1	Protein Coding	1
613	HLA-DQA2	Major Histocompatibility Complex, Class II, DQ Alpha 2	Protein Coding	1
614	HLA-DQB1	Major Histocompatibility Complex, Class II, DQ Beta 1	Protein Coding	1
615	HLA-DRA	Major Histocompatibility Complex, Class II, DR Alpha	Protein Coding	1
616	HLA-DRB1	Major Histocompatibility Complex, Class II, DR Beta 1	Protein Coding	1
617	HLA-DRB3	Major Histocompatibility Complex, Class II, DR Beta 3	Protein Coding	1
618	HLA-DRB4	Major Histocompatibility Complex, Class II, DR Beta 4	Protein Coding	1
619	HLA-DRB5	Major Histocompatibility Complex, Class II, DR Beta 5	Protein Coding	1
620	ITK	IL2 Inducible T Cell Kinase	Protein Coding	1
621	KPNA1	Karyopherin Subunit Alpha 1	Protein Coding	1
622	KPNA2	Karyopherin Subunit Alpha 2	Protein Coding	1
623	KPNA3	Karyopherin Subunit Alpha 3	Protein Coding	1
624	KPNA4	Karyopherin Subunit Alpha 4	Protein Coding	1
625	KPNB1	Karyopherin Subunit Beta 1	Protein Coding	1
626	IPO5	Importin 5	Protein Coding	1
627	LAT	Linker For Activation Of T Cells	Protein Coding	1
628	LCP2	Lymphocyte Cytosolic Protein 2	Protein Coding	1
629	LYN	LYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
630	SYK	Spleen Associated Tyrosine Kinase	Protein Coding	1
631	TNPO1	Transportin 1	Protein Coding	1
632	XPO1	Exportin 1	Protein Coding	1
633	ZAP70	Zeta Chain Of T Cell Receptor Associated Protein Kinase 70	Protein Coding	1
634	BCL2L1	BCL2 Like 1	Protein Coding	1
635	BIRC5	Baculoviral IAP Repeat Containing 5	Protein Coding	1
636	BRCA2	BRCA2 DNA Repair Associated	Protein Coding	1
637	CCNF	Cyclin F	Protein Coding	1
638	CDK4	Cyclin Dependent Kinase 4	Protein Coding	1
639	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	1
640	CDKN2B	Cyclin Dependent Kinase Inhibitor 2B	Protein Coding	1
641	CDKN2C	Cyclin Dependent Kinase Inhibitor 2C	Protein Coding	1
642	CDKN2D	Cyclin Dependent Kinase Inhibitor 2D	Protein Coding	1
643	CYP2E1	Cytochrome P450 Family 2 Subfamily E Member 1	Protein Coding	1
644	HSP90AA1	Heat Shock Protein 90 Alpha Family Class A Member 1	Protein Coding	1
645	JAK1	Janus Kinase 1	Protein Coding	1
646	JAK2	Janus Kinase 2	Protein Coding	1
647	JAK3	Janus Kinase 3	Protein Coding	1
648	SMAD2	SMAD Family Member 2	Protein Coding	1
649	SMAD3	SMAD Family Member 3	Protein Coding	1
650	SMAD4	SMAD Family Member 4	Protein Coding	1
651	MDM2	MDM2 Proto-Oncogene	Protein Coding	1
652	MMP1	Matrix Metallopeptidase 1	Protein Coding	1
653	MMP10	Matrix Metallopeptidase 10	Protein Coding	1
654	MMP11	Matrix Metallopeptidase 11	Protein Coding	1
655	MMP12	Matrix Metallopeptidase 12	Protein Coding	1
656	MMP13	Matrix Metallopeptidase 13	Protein Coding	1
657	MMP19	Matrix Metallopeptidase 19	Protein Coding	1
658	MMP2	Matrix Metallopeptidase 2	Protein Coding	1
659	MMP20	Matrix Metallopeptidase 20	Protein Coding	1
660	MMP21	Matrix Metallopeptidase 21	Protein Coding	1
661	MMP23B	Matrix Metallopeptidase 23B	Protein Coding	1
662	MMP26	Matrix Metallopeptidase 26	Protein Coding	1
663	MMP27	Matrix Metallopeptidase 27	Protein Coding	1
664	MMP28	Matrix Metallopeptidase 28	Protein Coding	1
665	MMP3	Matrix Metallopeptidase 3	Protein Coding	1
666	MMP7	Matrix Metallopeptidase 7	Protein Coding	1
667	MMP8	Matrix Metallopeptidase 8	Protein Coding	1
668	MMP9	Matrix Metallopeptidase 9	Protein Coding	1
669	NOTCH1	Notch Receptor 1	Protein Coding	1
670	PTGS2	Prostaglandin-Endoperoxide Synthase 2	Protein Coding	1
671	RB1	RB Transcriptional Corepressor 1	Protein Coding	1
672	TGFBR2	Transforming Growth Factor Beta Receptor 2	Protein Coding	1
673	ARHGAP5	Rho GTPase Activating Protein 5	Protein Coding	1
674	GPLD1	Glycosylphosphatidylinositol Specific Phospholipase D1	Protein Coding	1
675	PLD1	Phospholipase D1	Protein Coding	1
676	PLD2	Phospholipase D2	Protein Coding	1
677	PLD3	Phospholipase D Family Member 3	Protein Coding	1
678	RALA	RAS Like Proto-Oncogene A	Protein Coding	1
679	RALB	RAS Like Proto-Oncogene B	Protein Coding	1
680	RALBP1	RalA Binding Protein 1	Protein Coding	1
681	RALGDS	Ral Guanine Nucleotide Dissociation Stimulator	Protein Coding	1
682	RASA1	RAS P21 Protein Activator 1	Protein Coding	1
683	ARF1	ARF GTPase 1	Protein Coding	1
684	ARF3	ARF GTPase 3	Protein Coding	1
685	ARF4	ARF GTPase 4	Protein Coding	1
686	ARF5	ARF GTPase 5	Protein Coding	1
687	ARF6	ARF GTPase 6	Protein Coding	1
688	ARFGAP1	ARF GTPase Activating Protein 1	Protein Coding	1
689	ARFGAP3	ARF GTPase Activating Protein 3	Protein Coding	1
690	ARFIP2	ARF Interacting Protein 2	Protein Coding	1
691	BCAR1	BCAR1 Scaffold Protein, Cas Family Member	Protein Coding	1
692	CSK	C-Terminal Src Kinase	Protein Coding	1
693	DOCK1	Dedicator Of Cytokinesis 1	Protein Coding	1
694	NCK1	NCK Adaptor Protein 1	Protein Coding	1
695	NCK2	NCK Adaptor Protein 2	Protein Coding	1
696	PARVA	Parvin Alpha	Protein Coding	1
697	PTPN12	Protein Tyrosine Phosphatase Non-Receptor Type 12	Protein Coding	1
698	RAPGEF1	Rap Guanine Nucleotide Exchange Factor 1	Protein Coding	1
699	TLN1	Talin 1	Protein Coding	1
700	TLN2	Talin 2	Protein Coding	1
701	VCL	Vinculin	Protein Coding	1
702	FGF3	Fibroblast Growth Factor 3	Protein Coding	1
703	FGF9	Fibroblast Growth Factor 9	Protein Coding	1
704	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	1
705	P2RY1	Purinergic Receptor P2Y1	Protein Coding	1
706	P2RY11	Purinergic Receptor P2Y11	Protein Coding	1
707	P2RY12	Purinergic Receptor P2Y12	Protein Coding	1
708	P2RY2	Purinergic Receptor P2Y2	Protein Coding	1
709	P2RY4	Pyrimidinergic Receptor P2Y4	Protein Coding	1
710	P2RY6	Pyrimidinergic Receptor P2Y6	Protein Coding	1

Disorders associated with GPCR Pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Rasopathy	Enrichment	BRAF, HRAS, KRAS, MAP2K1, MAP2K2, MRAS, NRAS, RAF1, RRAS2, SOS1, SOS2	16.00
2	Lung non-small cell carcinoma	Enrichment	BRAF, EGFR, ERBB2, HRAS, KRAS, MAP2K1, NRAS	10.94
3	Noonan syndrome 1	Enrichment	BRAF, HRAS, KRAS, MAP2K1, MAP2K2, MRAS, NRAS, RAF1, RRAS, RRAS2, SOS1, SOS2	10.74
4	Lung cancer susceptibility 3	Enrichment	BRAF, EGFR, ERBB2, FGF10, KRAS, RB1, ROS1, TP53	9.96
5	Noonan syndrome and noonan-related syndrome	Enrichment	BRAF, HRAS, KRAS, MAP2K1, MAP2K2, NRAS, RAF1	9.90
6	Bladder cancer	Enrichment	BRCA2, CDKN1A, CDKN2A, EGFR, ERBB2, ERBB3, FGFR3, KRAS, RB1, TP53	9.59
7	Pilomyxoid astrocytoma	Enrichment	BRAF, FGFR1, KRAS, NTRK2, RAF1	8.48
8	Loeys-dietz syndrome	Enrichment	SMAD2, SMAD3, TGFB2, TGFB3, TGFBR1, TGFBR2	8.11
9	Melanocytic nevus syndrome, congenital	Enrichment	ALK, BRAF, HRAS, NRAS, RAF1	8.06
10	Cardiofaciocutaneous syndrome 1	Enrichment	BRAF, KRAS, MAP2K1, MAP2K2	7.83
11	Cardiofaciocutaneous syndrome	Enrichment	BRAF, KRAS, MAP2K1, MAP2K2	7.83
12	Differentiated thyroid carcinoma	Enrichment	ALK, BRAF, HRAS, KRAS, NRAS, NTRK1, NTRK3	7.63
13	Lung squamous cell carcinoma	Enrichment	ALK, CDKN2A, EGFR, FGFR3, KRAS	7.57
14	Ovarian cancer	Enrichment	AKT1, ALK, BRCA2, CDKN1B, CDKN2A, EGFR, ERBB2, KIT, KRAS, MET, NTRK1, PDGFRA, RB1, TP53	7.47
15	Colorectal cancer	Enrichment	AKT1, BRAF, BRCA2, CCND1, ERBB2, FGFR2, FGFR3, IGF2, MET, PIK3R1, SMAD4, SRC, TP53	7.38
16	Lip and oral cavity carcinoma	Enrichment	BRAF, CDKN2A, EGFR, KIT, RB1, TP53	7.10
17	Myeloma, multiple	Enrichment	BRAF, BRCA2, CCND1, CDKN2C, FGFR3, FLT3, KRAS, MST1R, PIK3R2, TP53	6.55
18	Arteriovenous malformation	Enrichment	EPHB4, HRAS, MAP2K1, RASA1, TEK	6.34
19	Nevus, epidermal	Enrichment	FGFR3, HRAS, KRAS, NRAS	6.30
20	Myopathy, x-linked, with excessive autophagy	Enrichment	EPHB4, HRAS, MAP2K1, RASA1, TEK	6.05
21	Lung cancer	Enrichment	ALK, BRAF, EGFR, ERBB2, KRAS, MET	5.91
22	Lacrimoauriculodentodigital syndrome 1	Enrichment	FGF10, FGFR2, FGFR3	5.87
23	Langerhans cell histiocytosis	Enrichment	BRAF, MAP2K1, NRAS	5.87
24	Gastric cancer	Enrichment	BRCA2, CDK4, CDKN2A, ERBB2, FGFR2, KRAS, SMAD4, TP53	5.49
25	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	NOTCH1, SMAD2, SMAD3, SMAD4, TGFB2, TGFB3, TGFBR1, TGFBR2	5.41
26	Testicular germ cell tumor	Enrichment	BCL10, FGFR3, KIT, KITLG	5.27
27	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	5.27
28	Capillary malformation-arteriovenous malformation 1	Enrichment	EPHB4, KRAS, MAP2K1, RASA1	5.20
29	Noonan syndrome 3	Enrichment	HRAS, KRAS, RAF1, SOS1	5.20
30	Severe combined immunodeficiency	Enrichment	CD247, CD3D, CD3E, CD3G, IKBKB, LCK, ZAP70	5.20
31	Multiple endocrine neoplasia, type i	Enrichment	CDKN1A, CDKN1B, CDKN2B, CDKN2C	5.15
32	Gallbladder cancer	Enrichment	BRAF, KRAS, SMAD4, TP53	5.15
33	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK1, JAK2, STAT3	5.00
34	Loeys-dietz syndrome 1	Enrichment	SMAD2, TGFBR1, TGFBR2	5.00
35	T-b+ severe combined immunodeficiency due to cd3delta/cd3epsilon/cd3zeta	Enrichment	CD247, CD3D, CD3E	4.97
36	Primary hypereosinophilic syndrome	Enrichment	FGFR1, PDGFRA, PDGFRB	4.88
37	Giant cell glioblastoma	Enrichment	EGFR, FGFR1, FGFR3, ROS1, TP53	4.64
38	Inherited cancer-predisposing syndrome	Enrichment	ALK, BRCA2, CDK4, CDKN1B, CDKN2A, EGFR, KIT, MET, PDGFRA, RB1, SMAD4, TP53	4.54
39	Arteriovenous malformations of the brain	Enrichment	BRAF, EGFR, IL6, KRAS, TIMP3	4.45
40	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3, CCND2, PIK3R2	4.41
41	Marfan syndrome	Enrichment	LTBP2, TGFB2, TGFBR1, TGFBR2	4.39
42	Autosomal non-syndromic agammaglobulinemia	Enrichment	BLNK, CD79A, CD79B, PIK3R1	4.35
43	Thyroid cancer, nonmedullary, 2	Enrichment	BRAF, HRAS, NRAS	4.34
44	Follicular thyroid carcinoma	Enrichment	BRAF, HRAS, NRAS	4.34
45	Ventricular septal defect 1	Enrichment	BMP2, BMP7, GATA4	3.98
46	Lymphatic malformation 1	Enrichment	EPHB4, FLT4	3.91
47	Intracranial hypertension, idiopathic	Enrichment	EPHB4, FLT4	3.91
48	Pigmented nodular adrenocortical disease, primary, 1	Enrichment	GNAS, PRKAR1A	3.91
49	Pfeiffer syndrome	Enrichment	FGFR1, FGFR2	3.91
50	Jackson-weiss syndrome	Enrichment	FGFR1, FGFR2	3.91
51	Encephalocraniocutaneous lipomatosis	Enrichment	FGFR1, KRAS	3.91
52	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	3.91
53	Hereditary lymphedema i	Enrichment	EPHB4, FLT4	3.91
54	Fetomaternal alloimmune thrombocytopenia 1	Enrichment	ITGA2, ITGA2B, ITGB3	3.89
55	Nk-cell enteropathy	Enrichment	AXL, ERBB4, IGF1R, JAK3	3.88
56	Pancreatic cancer	Enrichment	BRCA2, CDKN2A, KRAS, SMAD4, TP53	3.77
57	Hemangioma, capillary infantile	Enrichment	FLT4, KDR, RASA1	3.76
58	Microform holoprosencephaly	Enrichment	CRIPTO, FGF8, FGFR1, GAS1	3.72
59	Lobar holoprosencephaly	Enrichment	CRIPTO, FGF8, FGFR1, GAS1	3.72
60	Li-fraumeni syndrome	Enrichment	CDKN2A, MDM2, TP53	3.72
61	Breast adenocarcinoma	Enrichment	AKT1, KRAS, TP53	3.72
62	Non-immune hydrops fetalis	Enrichment	ACTA1, EPHB4, FLT4, HRAS, KRAS	3.58
63	Juvenile myelomonocytic leukemia	Enrichment	KRAS, NRAS, RRAS	3.56
64	Semilobar holoprosencephaly	Enrichment	CRIPTO, FGF8, FGFR1, GAS1	3.51
65	Normosmic congenital hypogonadotropic hypogonadism	Enrichment	FGF17, FGF8, FGFR1, GNRH1	3.51
66	Gliosarcoma	Enrichment	EGFR, FGFR1, FGFR3, TP53	3.50
67	Essential thrombocythemia	Enrichment	JAK2, THPO, TP53	3.48
68	Hereditary hemorrhagic telangiectasia	Enrichment	CCNH, GDF2, SMAD4	3.48
69	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	CDKN2A, FLT3, TP53	3.48
70	Loeys-dietz syndrome 4	Enrichment	TGFB2, TGFB3	3.45
71	Baraitser-winter cerebrofrontofacial syndrome	Enrichment	ACTB, ACTG1	3.45
72	Crouzon syndrome	Enrichment	FGFR2, FGFR3	3.44
73	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	3.44
74	Testicular germ cell cancer	Enrichment	FGFR3, KIT	3.44
75	Spermatocytoma	Enrichment	FGFR3, HRAS	3.44
76	Melanoma, cutaneous malignant 1	Enrichment	BRAF, CDK4, CDKN2A, CDKN2B	3.39
77	Pulmonic stenosis	Enrichment	BRAF, SOS1	3.36
78	Cervical cancer	Enrichment	FGFR3, TP53	3.33
79	Loeys-dietz syndrome 2	Enrichment	TGFBR1, TGFBR2	3.33
80	Cervix carcinoma	Enrichment	FGFR3, TP53	3.33
81	Metaphyseal anadysplasia	Enrichment	MMP13, MMP9	3.33
82	Celiac disease 1	Enrichment	HLA-DQA1, HLA-DQB1	3.31
83	Angioma, tufted	Enrichment	GNA14, KDR	3.31
84	Bullous pemphigoid	Enrichment	HLA-DQB1, HLA-DRB1	3.31
85	Pediatric multiple sclerosis	Enrichment	HLA-DQB1, HLA-DRB1	3.31
86	Catecholaminergic polymorphic ventricular tachycardia	Enrichment	CALM1, CALM2, CALM3	3.26
87	Witteveen-kolk syndrome	Enrichment	SIN3A, SIN3B	3.24
88	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG, NFKBIA	3.21
89	Diffuse large b-cell lymphoma	Enrichment	BRAF, BRCA2, STAT3, TP53	3.19
90	Auriculocondylar syndrome 1	Enrichment	GNAI3, PLCB4	3.14
91	Saethre-chotzen syndrome	Enrichment	FGFR2, FGFR3	3.14
92	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	3.14
93	Noonan syndrome with multiple lentigines	Enrichment	BRAF, RAF1	3.14
94	Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)	Enrichment	FLT3, KIT	3.14
95	Glioma	Enrichment	FGFR2, NTRK3	3.14
96	Kallmann syndrome	Enrichment	FGF17, FGF8, FGFR1, SEMA3A	3.08
97	Leukemia, acute myeloid	Enrichment	FLT3, KIT, KRAS, NRAS	3.01
98	Bleeding disorder, platelet-type, 16	Enrichment	ITGA2B, ITGB3	2.98
99	Hemifacial hyperplasia	Enrichment	FGFR2, FGFR3	2.92
100	Acute myeloid leukemia with maturation	Enrichment	FLT3, KIT	2.92
101	Holoprosencephaly	Enrichment	FGF8, FGFR1	2.92
102	Acute myeloid leukemia with t(8;21)(q22;q22) translocation	Enrichment	FLT3, KIT	2.92
103	Hydrops fetalis, nonimmune	Enrichment	ACTA1, EPHB4, FLT4, HRAS	2.87
104	Osteogenic sarcoma	Enrichment	RB1, TP53	2.86
105	Dedifferentiated liposarcoma	Enrichment	CDK4, MDM2	2.86
106	Squamous cell carcinoma	Enrichment	RB1, TP53	2.86
107	Bone osteosarcoma	Enrichment	RB1, TP53	2.86
108	Well-differentiated liposarcoma	Enrichment	CDK4, MDM2	2.86
109	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	GNA11, PIK3R1	2.84
110	Anastomosing haemangioma	Enrichment	GNA11, GNA14	2.84
111	Thyroid carcinoma, familial medullary	Enrichment	ESR2, NTRK1	2.77
112	Tethered spinal cord syndrome	Enrichment	BRAF, CREBBP	2.77
113	Holoprosencephaly 1	Enrichment	FGF8, FGFR1	2.75
114	46,xy disorder of sex development	Enrichment	FGFR3, INSR	2.75
115	Testicular cancer	Enrichment	BCL10, FGFR3	2.74
116	Primary hyperaldosteronism	Enrichment	BRAF, GNAS, TP53	2.73
117	Brachydactyly, type a2	Enrichment	BMP2, GDF5	2.68
118	Glaucoma 3, primary infantile, b	Enrichment	LTBP2, TEK	2.68
119	Multiple synostoses syndrome	Enrichment	GDF5, GDF6	2.68
120	Breast cancer	Enrichment	AKT1, BRCA1, ESR1, GNG3, IL2, JUN, KRAS	2.68
121	Tetralogy of fallot	Enrichment	EPHB4, FLT4, KDR, NOTCH1	2.66
122	Gastrointestinal stromal tumor	Enrichment	KIT, PDGFRA	2.60
123	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	2.60
124	Tubulinopathy-associated dysgyria	Enrichment	TUBB2B, TUBB3	2.60
125	Septopreoptic holoprosencephaly	Enrichment	CRIPTO, FGF8, GAS1	2.59
126	Midline interhemispheric variant of holoprosencephaly	Enrichment	CRIPTO, FGF8, GAS1	2.59
127	Erythrocytosis, familial, 1	Enrichment	EPOR, JAK2	2.57
128	Small cell cancer of the lung	Enrichment	RB1, TP53	2.57
129	Thyroid cancer, nonmedullary, 1	Enrichment	BRAF, TP53	2.57
130	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3, PIK3R2	2.57
131	Cholangiocarcinoma	Enrichment	BRCA2, ROS1	2.57
132	Lung sarcomatoid carcinoma	Enrichment	KRAS, TP53	2.57
133	Aortic aneurysm	Enrichment	SMAD3, TGFBR1	2.57
134	Idiopathic achalasia	Enrichment	HLA-DQA1, HLA-DQB1	2.55
135	Systemic-onset juvenile idiopathic arthritis	Enrichment	HLA-DRB1, IL6	2.55
136	Multiple sclerosis	Enrichment	HLA-DQB1, HLA-DRB1, ITPR1	2.49
137	Achromatopsia 4	Enrichment	GNAI3, GNAT2	2.48
138	Insulin-like growth factor i	Enrichment	IGF1, IGF1R	2.47
139	Acute promyelocytic leukemia	Enrichment	PRKAR1A, STAT3, STAT5B	2.45
140	Alobar holoprosencephaly	Enrichment	CRIPTO, FGF8, GAS1	2.43
141	Wilms tumor 1	Enrichment	BRAF, BRCA2, IGF2	2.43
142	Long qt syndrome 1	Enrichment	CALM1, CALM2, CALM3, ITPR3	2.39
143	Ellis-van creveld syndrome	Enrichment	PRKACA, PRKACB	2.38
144	Ventricular septal defect	Enrichment	BRAF, TEK	2.38
145	Rhabdomyosarcoma	Enrichment	ALK, BRCA2, TP53	2.34
146	Narcolepsy 2	Enrichment	HLA-DQB1, HLA-DRB1	2.33
147	Congenital heart defects, multiple types, 4	Enrichment	BMP7, GATA4	2.33
148	Diffuse cutaneous systemic sclerosis	Enrichment	CCN2, HLA-DRB1	2.33
149	Connective tissue disease	Enrichment	FGFR3, NOTCH1, SMAD3, TGFBR2	2.32
150	Tubulinopathy	Enrichment	TUBB2A, TUBB2B	2.30
151	Rare genetic intellectual disability	Enrichment	CREBBP, EP300, GNAO1	2.30
152	Atrial septal defect 1	Enrichment	BMP2, TGFB2	2.30
153	Epidermolysis bullosa, junctional 5b, with pyloric atresia	Enrichment	ITGA6, ITGB4	2.30
154	Pre-eclampsia	Enrichment	FLT1, NOS3	2.26
155	Hemihyperplasia, isolated	Enrichment	IGF2, RHOA	2.21
156	Leukemia, acute lymphoblastic	Enrichment	FLT3, GNB1	2.20
157	Adrenocortical carcinoma	Enrichment	CDKN2A, TP53	2.18
158	Melanoma, uveal	Enrichment	GNA11, PLCB4	2.16
159	Limited scleroderma	Enrichment	CCN2, HLA-DRB1	2.16
160	Glaucoma 3, primary congenital, a	Enrichment	LTBP2, TEK	2.16
161	Glanzmann thrombasthenia 1	Enrichment	ITGA2B, ITGB3	2.16
162	Neuropathy, hereditary sensory and autonomic, type v	Enrichment	NGF, NTRK1	2.16
163	Ehlers-danlos syndrome	Enrichment	SMAD3, TGFB2, TGFBR2	2.13
164	Rubinstein-taybi syndrome 1	Enrichment	CREBBP, EP300	2.09
165	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	CREBBP, EP300	2.09
166	Capillary malformations, congenital	Enrichment	CCNH, GNA11	2.09
167	Familial cerebral saccular aneurysm	Enrichment	ANGPTL6, TGFBR3	2.09
168	Glaucoma, primary open angle	Enrichment	CARD10, LTBP2	2.07
169	Esophageal cancer	Enrichment	TGFBR2, TP53	2.04
170	Myelofibrosis	Enrichment	JAK2, SRC	2.04
171	Squamous cell carcinoma, head and neck	Enrichment	EGFR, TP53	2.04
172	Basal ganglia calcification, idiopathic, 1	Enrichment	PDGFB, PDGFRB	2.04
173	Hemochromatosis, type 1	Enrichment	BMP2, BMP6	2.04
174	Hepatoblastoma	Enrichment	BRCA2, FGFR3, TP53	2.00
175	Lymphatic malformation 5	Enrichment	EPHB4	1.95
176	Brachydactyly, type b1	Enrichment	ROR2	1.95
177	Erythroleukemia, familial	Enrichment	ERBB3	1.95
178	Hypochondroplasia	Enrichment	FGFR3	1.95
179	Proteus syndrome	Enrichment	AKT1	1.95
180	Beare-stevenson cutis gyrata syndrome	Enrichment	FGFR2	1.95
181	Paget disease, extramammary	Enrichment	ERBB2	1.95
182	Osteoglophonic dysplasia	Enrichment	FGFR1	1.95
183	Acrodysostosis 1 with or without hormone resistance	Enrichment	PRKAR1A	1.95
184	Thanatophoric dysplasia, type i	Enrichment	FGFR3	1.95
185	Trigonocephaly 1	Enrichment	FGFR1	1.95
186	Donohue syndrome	Enrichment	INSR	1.95
187	Spinocerebellar ataxia 27a	Enrichment	FGF14	1.95
188	Oculoectodermal syndrome	Enrichment	KRAS	1.95
189	Muenke syndrome	Enrichment	FGFR3	1.95
190	Pallister-killian syndrome	Enrichment	ARAF	1.95
191	Premature aging syndrome, penttinen type	Enrichment	PDGFRB	1.95
192	Hyperinsulinemic hypoglycemia, familial, 5	Enrichment	INSR	1.95
193	Noonan syndrome 5	Enrichment	RAF1	1.95
194	Pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities	Enrichment	INSR	1.95
195	Hypomagnesemia 4, renal	Enrichment	EGF	1.95
196	Diabetes mellitus, insulin-resistant, with acanthosis nigricans	Enrichment	INSR	1.95
197	Pseudohypoparathyroidism, type ic	Enrichment	GNAS	1.95
198	Hypereosinophilic syndrome, idiopathic	Enrichment	PDGFRA	1.95
199	Mastocytosis, cutaneous	Enrichment	KIT	1.95
200	Carney complex, type 1	Enrichment	PRKAR1A	1.95
201	Scaphocephaly, maxillary retrusion, and impaired intellectual development	Enrichment	FGFR2	1.95
202	Melorheostosis, isolated	Enrichment	MAP2K1	1.95
203	Osseous heteroplasia, progressive	Enrichment	GNAS	1.95
204	Noonan syndrome 7	Enrichment	BRAF	1.95
205	Leopard syndrome 3	Enrichment	BRAF	1.95
206	Apert syndrome	Enrichment	FGFR2	1.95
207	Neuroblastoma 3	Enrichment	ALK	1.95
208	Nail disorder, nonsyndromic congenital, 3	Enrichment	PLCD1	1.95
209	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	1.95
210	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	1.95
211	Myofibromatosis, infantile, 1	Enrichment	PDGFRB	1.95
212	Melanosis, neurocutaneous	Enrichment	NRAS	1.95
213	Thanatophoric dysplasia, type ii	Enrichment	FGFR3	1.95
214	Lethal congenital contracture syndrome 2	Enrichment	ERBB3	1.95
215	Noonan syndrome 6	Enrichment	NRAS	1.95
216	Hypogonadotropic hypogonadism 20 with or without anosmia	Enrichment	FGF17	1.95
217	Deafness, autosomal recessive 44	Enrichment	ADCY1	1.95
218	Gist-plus syndrome	Enrichment	PDGFRA	1.95
219	Camptodactyly, tall stature, and hearing loss syndrome	Enrichment	FGFR3	1.95
220	Ataxia-oculomotor apraxia 3	Enrichment	PIK3R5	1.95
221	Aplasia of lacrimal and salivary glands	Enrichment	FGF10	1.95
222	Bent bone dysplasia syndrome 1	Enrichment	FGFR2	1.95
223	Ventricular tachycardia, familial	Enrichment	GNAI2	1.95
224	Acth-independent macronodular adrenal hyperplasia 1	Enrichment	GNAS	1.95
225	Noonan syndrome 11	Enrichment	MRAS	1.95
226	Visceral neuropathy, familial, 2, autosomal recessive	Enrichment	ERBB2	1.95
227	Neurodevelopmental disorder with hypotonia and dysmorphic facies	Enrichment	GNB2	1.95
228	Noonan syndrome 13	Enrichment	MAPK1	1.95
229	Spondylometaphyseal dysplasia with corneal dystrophy	Enrichment	PLCB3	1.95
230	Deafness, autosomal recessive 108	Enrichment	ROR1	1.95
231	Myasthenic syndrome, congenital, 9, associated with acetylcholine receptor deficiency	Enrichment	MUSK	1.95
232	Developmental and epileptic encephalopathy 58	Enrichment	NTRK2	1.95
233	Intellectual developmental disorder, x-linked 110	Enrichment	FGF13	1.95
234	Pituitary adenoma 3, multiple types	Enrichment	GNAS	1.95
235	Spinocerebellar ataxia 27b, late-onset	Enrichment	FGF14	1.95
236	Venous malformations, multiple cutaneous and mucosal	Enrichment	TEK	1.95
237	Short syndrome	Enrichment	PIK3R1	1.95
238	Hereditary lymphedema id	Enrichment	VEGFC	1.95
239	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	1.95
240	Osteofibrous dysplasia	Enrichment	MET	1.95
241	Auriculocondylar syndrome 2a	Enrichment	PLCB4	1.95
242	Spondylometaepiphyseal dysplasia, short limb-hand type	Enrichment	DDR2	1.95
243	Myeloid and lymphoid neoplasms associated with pdgfra rearrangement	Enrichment	PDGFRA	1.95
244	Developmental and epileptic encephalopathy 90	Enrichment	FGF13	1.95
245	Cardioacrofacial dysplasia 2	Enrichment	PRKACB	1.95
246	Metacarpal 4-5 fusion	Enrichment	FGF16	1.95
247	Lymphatic malformation 4	Enrichment	VEGFC	1.95
248	Neurodevelopmental disorder with hypotonia, impaired speech, and behavioral abnormalities	Enrichment	GNAI1	1.95
249	Myxoma, intracardiac	Enrichment	PRKAR1A	1.95
250	Lacrimoauriculodentodigital syndrome 3	Enrichment	FGF10	1.95
251	Familial isolated trichomegaly	Enrichment	FGF5	1.95
252	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	1.95
253	Deafness, autosomal recessive 97	Enrichment	MET	1.95
254	Prostate cancer/brain cancer susceptibility	Enrichment	EPHB2	1.95
255	Microvascular complications of diabetes 1	Enrichment	VEGFA	1.95
256	Lymphangioma	Enrichment	BRAF	1.95
257	Lodder-merla syndrome, type 2, with developmental delay and with or without cardiac arrhythmia	Enrichment	GNB5	1.95
258	Crouzon syndrome with acanthosis nigricans	Enrichment	FGFR3	1.95
259	Phace association	Enrichment	BRAF	1.95
260	Melorheostosis	Enrichment	MAP2K1	1.95
261	Autism 9	Enrichment	MET	1.95
262	Leopard syndrome 2	Enrichment	RAF1	1.95
263	Multiple synostoses syndrome 3	Enrichment	FGF9	1.95
264	Basal ganglia calcification, idiopathic, 4	Enrichment	PDGFRB	1.95
265	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	1.95
266	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	1.95
267	Autoinflammation, antibody deficiency, and immune dysregulation	Enrichment	PLCG2	1.95
268	Cowden syndrome 6	Enrichment	AKT1	1.95
269	Amyotrophic lateral sclerosis 19	Enrichment	ERBB4	1.95
270	Nasopharyngeal carcinoma 3	Enrichment	MST1R	1.95
271	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	1.95
272	Myeloid and lymphoid neoplasms associated with pdgfrb rearrangement	Enrichment	PDGFRB	1.95
273	Charcot-marie-tooth disease, dominant intermediate f	Enrichment	GNB4	1.95
274	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	1.95
275	Acute myeloid leukemia with minimal differentiation	Enrichment	FLT3	1.95
276	Hypogonadotropic hypogonadism 6 with or without anosmia	Enrichment	FGF8	1.95
277	Obesity, hyperphagia, and developmental delay	Enrichment	NTRK2	1.95
278	Disorders of gnas inactivation	Enrichment	GNAS	1.95
279	Achondroplasia, severe, with developmental delay and acanthosis nigricans	Enrichment	FGFR3	1.95
280	Kosaki overgrowth syndrome	Enrichment	PDGFRB	1.95
281	Familial cold autoinflammatory syndrome 3	Enrichment	PLCG2	1.95
282	Tumoral calcinosis, hyperphosphatemic, familial, 2	Enrichment	FGF23	1.95
283	Hartsfield syndrome	Enrichment	FGFR1	1.95
284	Congenital heart defects, multiple types, 7	Enrichment	FLT4	1.95
285	Renal hypodysplasia/aplasia 2	Enrichment	FGF20	1.95
286	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	1.95
287	Bleeding disorder, platelet-type, 22	Enrichment	EPHB2	1.95
288	Intellectual developmental disorder, autosomal dominant 42	Enrichment	GNB1	1.95
289	Glaucoma 3, primary congenital, e	Enrichment	TEK	1.95
290	Sick sinus syndrome 4	Enrichment	GNB2	1.95
291	Brain abnormalities, neurodegeneration, and dysosteosclerosis	Enrichment	CSF1R	1.95
292	Developmental and epileptic encephalopathy 47	Enrichment	FGF12	1.95
293	Ocular pterygium-digital keloid dysplasia syndrome	Enrichment	PDGFRB	1.95
294	Chronic mast cell leukemia	Enrichment	KIT	1.95
295	Trigonitis	Enrichment	RAF1	1.95
296	Warburg-cinotti syndrome	Enrichment	DDR2	1.95
297	Auriculocondylar syndrome 2b	Enrichment	PLCB4	1.95
298	Tufted angioma of skin	Enrichment	KDR	1.95
299	Arthrogryposis, distal, type 11	Enrichment	MET	1.95
300	Lacrimoauriculodentodigital syndrome 2	Enrichment	FGFR3	1.95
301	Csf1r-related disorder	Enrichment	CSF1R	1.95
302	Short-rib thoracic dysplasia 22 without polydactyly	Enrichment	FGF4	1.95
303	Bockenheimer syndrome	Enrichment	TEK	1.95
304	Prkar1b-related neurodegenerative dementia with intermediate filaments	Enrichment	PRKAR1B	1.95
305	Isolated bone marrow mastocytosis	Enrichment	KIT	1.95
306	Congenital pulmonary airway malformation	Enrichment	KRAS	1.95
307	Smoldering systemic mastocytosis	Enrichment	KIT	1.95
308	Alk-positive anaplastic large cell lymphoma	Enrichment	ALK	1.95
309	Spinocerebellar ataxia type 27b	Enrichment	FGF14	1.95
310	Fgfr3-related chondrodysplasia	Enrichment	FGFR3	1.95
311	Mastocytosis	Enrichment	KIT	1.95
312	Congenital primary lymphedema of gordon	Enrichment	VEGFC	1.95
313	Syringocystadenoma papilliferum	Enrichment	BRAF	1.95
314	Camptodactyly-tall stature-scoliosis-hearing loss syndrome	Enrichment	FGFR3	1.95
315	Early-onset calcifying leukoencephalopathy-skeletal dysplasia	Enrichment	CSF1R	1.95
316	Ganglioglioma	Enrichment	BRAF	1.95
317	Cutaneous mastocytoma	Enrichment	KIT	1.95
318	Nongerminomatous germ cell tumor	Enrichment	BRAF	1.95
319	Monostotic fibrous dysplasia	Enrichment	GNAS	1.95
320	Phace syndrome	Enrichment	BRAF	1.95
321	Typical urticaria pigmentosa	Enrichment	KIT	1.95
322	Phakomatosis pigmentokeratotica	Enrichment	HRAS	1.95
323	Classic hairy cell leukemia	Enrichment	BRAF	1.95
324	Nodular urticaria pigmentosa	Enrichment	KIT	1.95
325	Hartsfield-bixler-demyer syndrome	Enrichment	FGFR1	1.95
326	Alk-positive large b-cell lymphoma	Enrichment	ALK	1.95
327	Pseudoxanthomatous diffuse cutaneous mastocytosis	Enrichment	KIT	1.95
328	Telangiectasia macularis eruptiva perstans	Enrichment	KIT	1.95
329	Acute mast cell leukemia	Enrichment	KIT	1.95
330	Mazabraud syndrome	Enrichment	GNAS	1.95
331	Egf-related primary hypomagnesemia with intellectual disability	Enrichment	EGF	1.95
332	Non-syndromic unicoronal craniosynostosis	Enrichment	FGFR2	1.95
333	Plaque-form urticaria pigmentosa	Enrichment	KIT	1.95
334	Interstitial lung disease specific to childhood	Enrichment	FGF10	1.95
335	Serous carcinoma of the corpus uteri	Enrichment	ERBB2	1.95
336	Ephb4-related lymphatic-related hydrops fetalis	Enrichment	EPHB4	1.95
337	Neurocutaneous melanocytosis	Enrichment	NRAS	1.95
338	Bullous diffuse cutaneous mastocytosis	Enrichment	KIT	1.95
339	Vein of galen aneurysmal malformation	Enrichment	EPHB4	1.95
340	Testis seminoma	Enrichment	KIT	1.95
341	Junctional epidermolysis bullosa	Enrichment	ITGA6, ITGB4	1.93
342	Renal agenesis, bilateral	Enrichment	FGF20, ITGA8	1.93
343	Hydrocephalus	Enrichment	FGFR2, PDGFRB	1.93
344	Glioma susceptibility 1	Enrichment	ERBB2, TP53	1.92
345	Isolated growth hormone deficiency, type ia	Enrichment	BRCA2, GH1	1.92
346	Lymphoma, non-hodgkin, familial	Enrichment	BRAF, TP53	1.92
347	Congenital fibrosis of the extraocular muscles	Enrichment	TUBB2B, TUBB3	1.92
348	Narcolepsy 1	Enrichment	HLA-DQB1, HLA-DRB1	1.90
349	Thrombocytopenia	Enrichment	ITGA2B, ITGB3, SRC, THPO	1.90
350	Autosomal dominant macrothrombocytopenia	Enrichment	ITGA2B, ITGB3	1.84
351	Hereditary breast carcinoma	Enrichment	AKT1, BRCA2, KRAS, TP53	1.83
352	Dandy-walker syndrome	Enrichment	BRAF, PDGFRB	1.82
353	Adult hepatocellular carcinoma	Enrichment	EGF, TP53	1.82
354	Inflammatory bowel disease 1	Enrichment	IL6, PRKCQ	1.80
355	Hirschsprung disease 1	Enrichment	ERBB2, ERBB3, NRG3	1.77
356	Cornelia de lange syndrome 1	Enrichment	HDAC8, TAF6	1.73
357	Cornelia de lange syndrome	Enrichment	HDAC8, TAF6	1.73
358	Trichothiodystrophy	Enrichment	GTF2E2, GTF2H5	1.73
359	Leukemia, chronic lymphocytic	Enrichment	CCND1, TP53	1.73
360	Melanoma	Enrichment	BRAF, CDKN2A	1.73
361	Microspherophakia and/or megalocornea, with ectopia lentis and with or without secondary glaucoma	Enrichment	LTBP2	1.72
362	Baraitser-winter syndrome 1	Enrichment	ACTB	1.72
363	Intellectual developmental disorder, x-linked 30	Enrichment	PAK3	1.72
364	Systemic lupus erythematosus 6	Enrichment	ITGAM	1.72
365	Glaucoma 3, primary congenital, d	Enrichment	LTBP2	1.72
366	Microphthalmia, isolated 4	Enrichment	GDF6	1.72
367	Angel-shaped phalangoepiphyseal dysplasia	Enrichment	GDF5	1.72
368	Noonan syndrome 4	Enrichment	SOS1	1.72
369	Deafness, autosomal recessive 39	Enrichment	HGF	1.72
370	Congenital myopathy 2a, typical, autosomal dominant	Enrichment	ACTA1	1.72
371	Basal ganglia calcification, idiopathic, 5	Enrichment	PDGFB	1.72
372	Hyperpigmentation with or without hypopigmentation, familial progressive	Enrichment	KITLG	1.72
373	Noonan syndrome 9	Enrichment	SOS2	1.72
374	Myopathy, scapulohumeroperoneal	Enrichment	ACTA1	1.72
375	Ciliary dyskinesia, primary, 33	Enrichment	DRC4	1.72
376	Hypogonadotropic hypogonadism 23 with or without anosmia	Enrichment	LHB	1.72
377	Weill-marchesani syndrome 3	Enrichment	LTBP2	1.72
378	Megacystis-microcolon-intestinal hypoperistalsis syndrome 5	Enrichment	ACTG2	1.72
379	Multiple synostoses syndrome 4	Enrichment	GDF6	1.72
380	Knobloch syndrome 2	Enrichment	PAK2	1.72
381	Hyperemesis gravidarum	Enrichment	GDF15	1.72
382	Amegakaryocytic thrombocytopenia, congenital, 2	Enrichment	THPO	1.72
383	Deafness, autosomal recessive 125	Enrichment	GAS2	1.72
384	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	1.72
385	Fetomaternal alloimmune thrombocytopenia 2	Enrichment	ITGA2B	1.72
386	Congenital smooth muscle hamartoma, with or without hemihypertrophy	Enrichment	ACTB	1.72
387	Microphthalmia, syndromic 6	Enrichment	BMP4	1.72
388	Intellectual developmental disorder, x-linked 46	Enrichment	ARHGEF6	1.72
389	Orofacial cleft 11	Enrichment	BMP4	1.72
390	Cardiomyopathy, dilated, 1w	Enrichment	VCL	1.72
391	Skin/hair/eye pigmentation, variation in, 7	Enrichment	KITLG	1.72
392	Camurati-engelmann disease 2	Enrichment	TGFB2	1.72
393	Geleophysic dysplasia 3	Enrichment	LTBP3	1.72
394	Becker nevus syndrome	Enrichment	ACTB	1.72
395	Dystonia-deafness syndrome 1	Enrichment	ACTB	1.72
396	Visceral neuropathy, familial, 3, autosomal dominant	Enrichment	ACTG2	1.72
397	Glaucoma 1, open angle, o	Enrichment	NTF4	1.72
398	Iron overload	Enrichment	BMP6	1.72
399	Cardiomyopathy, familial hypertrophic, 15	Enrichment	VCL	1.72
400	Congenital myopathy 2b, severe infantile, autosomal recessive	Enrichment	ACTA1	1.72
401	Hypogonadotropic hypogonadism 12 with or without anosmia	Enrichment	GNRH1	1.72
402	Hypogonadotropic hypogonadism 16 with or without anosmia	Enrichment	SEMA3A	1.72
403	Leber congenital amaurosis 17	Enrichment	GDF6	1.72
404	Telangiectasia, hereditary hemorrhagic, type 5	Enrichment	GDF2	1.72
405	Hereditary thrombocytosis with transverse limb defect	Enrichment	THPO	1.72
406	Autosomal dominant familial visceral neuropathy	Enrichment	ACTG2	1.72
407	Loeys-dietz syndrome 5	Enrichment	TGFB3	1.72
408	20p12.3 microdeletion syndrome	Enrichment	BMP2	1.72
409	Thrombocytopenia 6	Enrichment	SRC	1.72
410	Cutis laxa, autosomal recessive, type iie	Enrichment	LTBP1	1.72
411	Takenouchi-kosaki syndrome	Enrichment	CDC42	1.72
412	Congenital myopathy 2c, severe infantile, autosomal dominant	Enrichment	ACTA1	1.72
413	Short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies 1	Enrichment	BMP2	1.72
414	Thrombocytopenia 8, with dysmorphic features and developmental delay	Enrichment	ACTB	1.72
415	Premature ovarian failure 14	Enrichment	GDF9	1.72
416	Deafness, autosomal dominant 69	Enrichment	KITLG	1.72
417	Thrombocytopenia 9	Enrichment	THPO	1.72
418	Amelogenesis imperfecta, type ih	Enrichment	ITGB6	1.72
419	Baraitser-winter syndrome	Enrichment	ACTB	1.72
420	Glaucoma secondary to spherophakia/ectopia lentis and megalocornea	Enrichment	LTBP2	1.72
421	Fetomaternal alloimmune thrombocytopenia 3	Enrichment	ITGA2	1.72
422	Immune dysregulation, neurodevelopmental defects, and colitis	Enrichment	ITGAV	1.72
423	Zebra body myopathy	Enrichment	ACTA1	1.72
424	Congenital smooth muscle hamartoma	Enrichment	ACTB	1.72
425	Capillary leak syndrome	Enrichment	TLN1	1.72
426	Nocarh syndrome	Enrichment	CDC42	1.72
427	Developmental malformations-deafness-dystonia syndrome	Enrichment	ACTB	1.72
428	Familial progressive hyperpigmentation	Enrichment	KITLG	1.72
429	Actin-accumulation myopathy	Enrichment	ACTA1	1.72
430	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	1.72
431	Myopathic intestinal pseudoobstruction	Enrichment	ACTG2	1.72
432	Familial progressive hyper- and hypopigmentation	Enrichment	KITLG	1.72
433	Temporomandibular joint anomaly	Enrichment	DOCK1	1.72
434	Actg2 visceral myopathy	Enrichment	ACTG2	1.72
435	Craniosynostosis	Enrichment	FGFR2, FGFR3	1.69
436	Renal hypodysplasia/aplasia 3	Enrichment	BMP4, FGFR3	1.68
437	Cystic angiomatosis of bone, diffuse	Enrichment	RASA1	1.68
438	Developmental and epileptic encephalopathy 8	Enrichment	ARHGEF9	1.68
439	Immunodeficiency 73a with defective neutrophil chemotaxis and leukocytosis	Enrichment	RAC2	1.68
440	Cardiac valvular dysplasia 1	Enrichment	PLD1	1.68
441	Immunodeficiency 62	Enrichment	ARHGEF1	1.68
442	Hiatt-neu-cooper neurodevelopmental syndrome	Enrichment	RALA	1.68
443	Neurodevelopmental disorder with midbrain and hindbrain malformations	Enrichment	ARHGEF2	1.68
444	Neurodevelopmental disorder with structural brain anomalies and dysmorphic facies	Enrichment	RAC3	1.68
445	Immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia	Enrichment	RAC2	1.68
446	Immunodeficiency 18	Enrichment	CD3E	1.68
447	Slowed nerve conduction velocity, autosomal dominant	Enrichment	ARHGEF10	1.68
448	Immunodeficiency 25	Enrichment	CD247	1.68
449	Brain small vessel disease 5 with osteoporosis	Enrichment	ARHGEF15	1.68
450	Immunodeficiency 22	Enrichment	LCK	1.68
451	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	1.68
452	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	1.68
453	Immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia	Enrichment	RAC2	1.68
454	Immunodeficiency 129	Enrichment	RHOH	1.68
455	T-cell immunodeficiency with epidermodysplasia verruciformis	Enrichment	RHOH	1.68
456	Gorham's disease	Enrichment	RASA1	1.68
457	Infantile lad-like disease due to rac2 deficiency	Enrichment	RAC2	1.68
458	Reticular dysgenesis-like severe combined immunodeficiency	Enrichment	RAC2	1.68
459	Rac2-related combined immunodeficiency-bronchiectasis-cancer-predisposing syndrome	Enrichment	RAC2	1.68
460	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	1.67
461	Melanoma, cutaneous malignant 3	Enrichment	CDK4	1.67
462	Cavitary optic disc anomalies	Enrichment	MMP19	1.67
463	Glioma susceptibility 3	Enrichment	BRCA2	1.67
464	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3	Enrichment	CCND2	1.67
465	Multiple self-healing squamous epithelioma	Enrichment	TGFBR1	1.67
466	Accelerated tumor formation	Enrichment	MDM2	1.67
467	Pseudo-torch syndrome 3	Enrichment	STAT2	1.67
468	Growth hormone insensitivity syndrome with immune dysregulation 2, autosomal dominant	Enrichment	STAT5B	1.67
469	Hyper-ige syndrome 6, autosomal dominant, with recurrent infections	Enrichment	STAT6	1.67
470	Lessel-kubisch syndrome	Enrichment	MDM2	1.67
471	Disabling pansclerotic morphea of childhood	Enrichment	STAT4	1.67
472	Bone marrow failure syndrome 5	Enrichment	TP53	1.67
473	Frontotemporal dementia and/or amyotrophic lateral sclerosis 5	Enrichment	CCNF	1.67
474	Papilloma of choroid plexus	Enrichment	TP53	1.67
475	Basal cell carcinoma 7	Enrichment	TP53	1.67
476	Anaplastic thyroid carcinoma	Enrichment	TP53	1.67
477	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	1.67
478	Systemic lupus erythematosus 11	Enrichment	STAT4	1.67
479	Pancreatic cancer 2	Enrichment	BRCA2	1.67
480	Heterotaxy, visceral, 7, autosomal	Enrichment	MMP21	1.67
481	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	1.67
482	Neuroendocrine tumor	Enrichment	CDKN1B	1.67
483	Colorectal cancer, hereditary nonpolyposis, type 6	Enrichment	TGFBR2	1.67
484	Coronary heart disease 6	Enrichment	MMP3	1.67
485	Immunodeficiency 31a	Enrichment	STAT1	1.67
486	Loeys-dietz syndrome 6	Enrichment	SMAD2	1.67
487	Immunodeficiency 31b	Enrichment	STAT1	1.67
488	Ductal carcinoma in situ	Enrichment	TP53	1.67
489	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	1.67
490	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	1.67
491	Trilateral retinoblastoma	Enrichment	RB1	1.67
492	Congenital heart defects, multiple types, 8, with or without heterotaxy	Enrichment	SMAD2	1.67
493	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	1.67
494	T-b+ severe combined immunodeficiency due to jak3 deficiency	Enrichment	JAK3	1.67
495	Cdkn2a cancer predisposition	Enrichment	CDKN2A	1.67
496	Heritable thoracic aortic disease	Enrichment	SMAD4	1.67
497	Capillary hemangioma	Enrichment	AKT3	1.67
498	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	1.67
499	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	1.67
500	Choroid plexus cancer	Enrichment	TP53	1.67
501	Pleomorphic xanthoastrocytoma	Enrichment	TP53	1.67
502	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	1.67
503	Mendelian susceptibility to mycobacterial diseases due to partial jak1 deficiency	Enrichment	JAK1	1.67
504	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	1.67
505	Lung oat cell carcinoma	Enrichment	RB1	1.67
506	Anhidrosis, isolated, with normal sweat glands	Enrichment	ITPR2	1.66
507	Hypocalciuric hypercalcemia, familial, type ii	Enrichment	GNA11	1.66
508	Incontinentia pigmenti	Enrichment	IKBKG	1.66
509	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	1.66
510	Advanced sleep phase syndrome, familial, 2	Enrichment	CSNK1D	1.66
511	Fetal encasement syndrome	Enrichment	CHUK	1.66
512	Agammaglobulinemia 3, autosomal recessive	Enrichment	CD79A	1.66
513	Atrioventricular septal defect 4	Enrichment	GATA4	1.66
514	Immunodeficiency 15b	Enrichment	IKBKB	1.66
515	Immunodeficiency 81	Enrichment	LCP2	1.66
516	Immunodeficiency 82 with systemic inflammation	Enrichment	SYK	1.66
517	Immunodeficiency 15a	Enrichment	IKBKB	1.66
518	Charcot-marie-tooth disease, demyelinating, type 1j	Enrichment	ITPR3	1.66
519	Developmental and epileptic encephalopathy 91	Enrichment	PPP3CA	1.66
520	Arthrogryposis, cleft palate, craniosynostosis, and impaired intellectual development	Enrichment	PPP3CA	1.66
521	Immunodeficiency 48	Enrichment	ZAP70	1.66
522	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	1.66
523	Okt4 epitope deficiency	Enrichment	CD4	1.66
524	Isolated growth hormone deficiency type iii	Enrichment	BTK	1.66
525	Pulmonary alveolar proteinosis, acquired	Enrichment	HLA-DRB1	1.66
526	Lymphoproliferative syndrome 1	Enrichment	ITK	1.66
527	Atrial septal defect 2	Enrichment	GATA4	1.66
528	Dystonia 25	Enrichment	GNAL	1.66
529	Long qt syndrome 16	Enrichment	CALM3	1.66
530	Hypocalcemia, autosomal dominant 2	Enrichment	GNA11	1.66
531	Graham little-piccardi-lassueur syndrome	Enrichment	HLA-DRA	1.66
532	Testicular anomalies with or without congenital heart disease	Enrichment	GATA4	1.66
533	Immunodeficiency 123 with hpv-related verrucosis	Enrichment	CD28	1.66
534	Autoimmune disease, multisystem, infantile-onset, 2	Enrichment	ZAP70	1.66
535	8p23.1 microdeletion syndrome	Enrichment	GATA4	1.66
536	Bartsocas-papas syndrome 2	Enrichment	CHUK	1.66
537	Autoinflammatory disease, systemic, with vasculitis	Enrichment	LYN	1.66
538	Immunodeficiency 79	Enrichment	CD4	1.66
539	Immunodeficiency 19, severe combined	Enrichment	CD3D	1.66
540	Spastic paraplegia 88, autosomal dominant	Enrichment	KPNA3	1.66
541	Long qt syndrome 15	Enrichment	CALM2	1.66
542	Immunodeficiency 133 with ectodermal dysplasia with or without peripheral neuropathy	Enrichment	ITPR3	1.66
543	Colitis	Enrichment	SYK	1.66
544	Neonatal alloimmune neutropenia	Enrichment	FCGR3B	1.66
545	Agammaglobulinemia 3	Enrichment	CD79A	1.66
546	Partial atrioventricular septal defect with ventricular hypoplasia	Enrichment	GATA4	1.66
547	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	1.66
548	Immunodeficiency 19	Enrichment	CD3D	1.66
549	Phakomatosis cesiomarmorata	Enrichment	GNA11	1.66
550	Kaposiform hemangioendothelioma	Enrichment	GNA14	1.66
551	Inflammatory bowel disease-recurrent sinopulmonary infections syndrome	Enrichment	NFAT5	1.66
552	Zap70-related severe combined immunodeficiency	Enrichment	ZAP70	1.66
553	Burkitt lymphoma	Enrichment	MYC	1.65
554	Blue rubber bleb nevus	Enrichment	TEK	1.65
555	Myeloproliferative disorder, chronic, with eosinophilia	Enrichment	PDGFRB	1.65
556	Pseudohypoparathyroidism, type ia	Enrichment	GNAS	1.65
557	Otodental dysplasia	Enrichment	FGF3	1.65
558	Costello syndrome	Enrichment	HRAS	1.65
559	Insensitivity to pain, congenital, with anhidrosis	Enrichment	NTRK1	1.65
560	Amelogenesis imperfecta, type ig	Enrichment	PRKAR1A	1.65
561	Trichomegaly	Enrichment	FGF5	1.65
562	Pituitary adenoma 4, acth-secreting	Enrichment	GNAI2	1.65
563	Visceral neuropathy, familial, 1, autosomal recessive	Enrichment	ERBB3	1.65
564	Pulmonary hypoplasia, primary	Enrichment	FGF10	1.65
565	Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2	Enrichment	PIK3R5	1.65
566	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	1.65
567	Pseudopseudohypoparathyroidism	Enrichment	GNAS	1.65
568	Piebald trait	Enrichment	KIT	1.65
569	Bleeding disorder, platelet-type, 8	Enrichment	P2RY12	1.65
570	Hyperinsulinemic hypoglycemia, familial, 4	Enrichment	INSR	1.65
571	Aural atresia, congenital	Enrichment	FGFR2	1.65
572	Keratosis, seborrheic	Enrichment	FGFR3	1.65
573	Deafness, congenital, with inner ear agenesis, microtia, and microdontia	Enrichment	FGF3	1.65
574	Bleeding disorder, platelet-type, 19	Enrichment	PRKACG	1.65
575	Night blindness, congenital stationary, type 1h	Enrichment	GNB3	1.65
576	Spermatogenic failure 17	Enrichment	PLCZ1	1.65
577	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	1.65
578	Pain sensitivity quantitative trait locus 1	Enrichment	NTRK1	1.65
579	Antley-bixler syndrome without genital anomalies or disordered steroidogenesis	Enrichment	FGFR2	1.65
580	Marbach-schaaf neurodevelopmental syndrome	Enrichment	PRKAR1B	1.65
581	Lymphatic malformation 11	Enrichment	TIE1	1.65
582	Noonan syndrome 12	Enrichment	RRAS2	1.65
583	Usher syndrome, type iv	Enrichment	PRKAR1A	1.65
584	Infantile myofibromatosis	Enrichment	PDGFRB	1.65
585	Childhood hepatocellular carcinoma	Enrichment	MET	1.65
586	Split hand-foot malformation	Enrichment	FGFR2	1.65
587	Rosette-forming glioneuronal tumor	Enrichment	FGFR1	1.65
588	Acrodysostosis	Enrichment	PRKAR1A	1.65
589	Pseudohypoparathyroidism	Enrichment	GNAS	1.65
590	Papillary renal cell carcinoma	Enrichment	MET	1.65
591	Congenital mesoblastic nephroma	Enrichment	NTRK3	1.65
592	Body mass index quantitative trait locus 19	Enrichment	ADCY3	1.65
593	Fibrolamellar carcinoma	Enrichment	PRKACA	1.65
594	Ocular melanoma	Enrichment	PLCB4	1.65
595	Fibrosarcoma	Enrichment	NTRK3	1.65
596	Ciliary dyskinesia, primary, 18	Enrichment	PRKAR1B	1.65
597	Hypopituitarism	Enrichment	GNAI2	1.65
598	Retinitis pigmentosa 38	Enrichment	MERTK	1.65
599	Lodder-merla syndrome, type 1, with impaired intellectual development and cardiac arrhythmia	Enrichment	GNB5	1.65
600	Acute myeloid leukemia without maturation	Enrichment	FLT3	1.65
601	Interfrontal craniofaciosynostosis	Enrichment	FGFR1	1.65
602	Isolated primary pigmented nodular adrenocortical disease	Enrichment	PRKAR1A	1.65
603	Autosomal dominant nonsyndromic deafness	Enrichment	FGFR2	1.65
604	Chronic eosinophilic leukemia	Enrichment	PDGFRA	1.65
605	Acth-independent macronodular adrenal hyperplasia	Enrichment	GNAS	1.65
606	B-lymphoblastic leukemia/lymphoma with recurrent genetic abnormality	Enrichment	PDGFRA	1.65
607	Mixed phenotype acute leukemia with t(9;22)(q34.1;q11.2)	Enrichment	FLT3	1.65
608	B-lymphoblastic leukemia/lymphoma with t	Enrichment	KIT	1.65
609	Common variable immunodeficiency 12	Enrichment	NFKB1	1.65
610	Tafro syndrome	Enrichment	MAP2K2	1.65
611	Oculootodental syndrome	Enrichment	FGF3	1.65
612	Cerebral visual impairment	Enrichment	GNB1	1.65
613	Wooly hair nevus	Enrichment	HRAS	1.65
614	Palmoplantar keratoderma, punctate type ii	Enrichment	BRCA1	1.62
615	Chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia	Enrichment	HDAC6	1.62
616	Intellectual developmental disorder, x-linked, syndromic 33	Enrichment	TAF1	1.62
617	Dystonia 3, torsion, x-linked	Enrichment	TAF1	1.62
618	Neurodevelopmental disorder with feeding difficulties, thin corpus callosum, and foot deformity	Enrichment	TAF2	1.62
619	Neurodevelopmental disorder with involuntary movements	Enrichment	GNAO1	1.62
620	Leukodystrophy, hypomyelinating, 27	Enrichment	POLR1A	1.62
621	46,xy sex reversal 2	Enrichment	NR0B1	1.62
622	Adrenal hypoplasia, congenital	Enrichment	NR0B1	1.62
623	Auriculocondylar syndrome 4	Enrichment	HDAC9	1.62
624	Cornelia de lange syndrome 5	Enrichment	HDAC8	1.62
625	Infant-type hemispheric glioma	Enrichment	BRCA1	1.62
626	Trichothiodystrophy 6, nonphotosensitive	Enrichment	GTF2E2	1.62
627	Developmental and epileptic encephalopathy 17	Enrichment	GNAO1	1.62
628	Ovarian dysgenesis 8	Enrichment	ESR2	1.62
629	Night blindness, congenital stationary, autosomal dominant 3	Enrichment	GNAT1	1.62
630	Night blindness, congenital stationary, type 1g	Enrichment	GNAT1	1.62
631	Trichothiodystrophy 3, photosensitive	Enrichment	GTF2H5	1.62
632	Alazami-yuan syndrome	Enrichment	TAF6	1.62
633	Congenital anomalies of kidney and urinary tract 3	Enrichment	NRIP1	1.62
634	Intellectual developmental disorder, autosomal recessive 60	Enrichment	TAF13	1.62
635	Menke-hennekam syndrome 1	Enrichment	CREBBP	1.62
636	Rubinstein-taybi syndrome due to 16p13.3 microdeletion	Enrichment	CREBBP	1.62
637	Chromosome 15q24 deletion syndrome	Enrichment	SIN3A	1.62
638	X-linked intellectual disability-global development delay-facial dysmorphism-sacral caudal remnant syndrome	Enrichment	TAF1	1.62
639	Cerebral cavernous malformations 5	Enrichment	MAP3K3	1.62
640	Menke-hennekam syndrome	Enrichment	CREBBP	1.62
641	15q11q13 microduplication syndrome	Enrichment	UBE3A	1.62
642	Gnao1-related disorder	Enrichment	GNAO1	1.62
643	Verrucous hemangioma	Enrichment	MAP3K3	1.62
644	Primary peritoneal carcinoma	Enrichment	BRCA1	1.62
645	Prostate cancer	Enrichment	BRCA2, EPHB2, TP53	1.62
646	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	1.61
647	Immunodeficiency 89 and autoimmunity	Enrichment	CARD10	1.61
648	Spinocerebellar ataxia 14	Enrichment	PRKCG	1.61
649	Thrombocytopenia 11 with multiple congenital anomalies and dysmorphic facies	Enrichment	RAP1B	1.61
650	Congenital heart defects and ectodermal dysplasia	Enrichment	PRKD1	1.61
651	Sezary's disease	Enrichment	BCL10	1.61
652	Malignant epithelial tumor of salivary glands	Enrichment	PRKD1	1.61
653	Mucosa-associated lymphoma	Enrichment	BCL10	1.61
654	Hepatocellular carcinoma	Enrichment	IGF2R, MET, TP53	1.59
655	Cakut	Enrichment	ACTG1, GDF6, LIFR	1.59
656	Meningioma	Enrichment	AKT1, PDGFB	1.58
657	Precursor t-cell acute lymphoblastic leukemia	Enrichment	FLT3, MYC	1.57
658	Cleft lip/palate	Enrichment	BMP4, PDGFRA	1.56
659	Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement	Enrichment	TUBB3	1.53
660	Type 1 diabetes mellitus 10	Enrichment	IL2RA	1.53
661	Spinocerebellar ataxia 12	Enrichment	PPP2R2B	1.53
662	Dyskinesia with orofacial involvement, autosomal dominant	Enrichment	ADCY5	1.53
663	Macrothrombocytopenia, isolated, 1, autosomal dominant	Enrichment	TUBB1	1.53
664	Parkinson disease 25, autosomal recessive early-onset, with impaired intellectual development	Enrichment	PTPA	1.53
665	Neurodevelopmental disorder with hyperkinetic movements and dyskinesia	Enrichment	ADCY5	1.53
666	Intellectual developmental disorder, autosomal recessive 63	Enrichment	CAMK2A	1.53
667	Intellectual developmental disorder, autosomal dominant 54	Enrichment	CAMK2B	1.53
668	Houge-janssens syndrome 4	Enrichment	PPP2R5C	1.53
669	Houge-janssens syndrome 2	Enrichment	PPP2R1A	1.53
670	Dyskinesia with orofacial involvement, autosomal recessive	Enrichment	ADCY5	1.53
671	Cortical dysplasia, complex, with other brain malformations 7	Enrichment	TUBB2B	1.53
672	Oocyte/zygote/embryo maturation arrest 23	Enrichment	TUBA4A	1.53
673	Frontotemporal dementia and/or amyotrophic lateral sclerosis 9	Enrichment	TUBA4A	1.53
674	Facial palsy, congenital, with ptosis and velopharyngeal dysfunction	Enrichment	TUBB6	1.53
675	Intellectual developmental disorder, autosomal dominant 53	Enrichment	CAMK2A	1.53
676	Intellectual developmental disorder, autosomal dominant 59	Enrichment	CAMK2G	1.53
677	Macrothrombocytopenia, isolated, 2, autosomal dominant	Enrichment	TUBA8	1.53
678	Congenital myopathy 26	Enrichment	TUBA4A	1.53
679	Spastic ataxia 11, autosomal dominant	Enrichment	TUBA4A	1.53
680	Amyotrophic lateral sclerosis type 22	Enrichment	TUBA4A	1.53
681	Polymicrogyria with optic nerve hypoplasia	Enrichment	TUBA8	1.53
682	Ppp2r1a-related neurodevelopmental disorder	Enrichment	PPP2R1A	1.53
683	Silver-russell syndrome due to maternal uniparental disomy of chromosome 7	Enrichment	GRB10	1.53
684	Aortic valve disease 1	Enrichment	NOTCH1, SOS1	1.51
685	Congenital myopathy 4a, autosomal dominant	Enrichment	ACTA1, ITGA7	1.50
686	Fetal akinesia deformation sequence 1	Enrichment	ACTA1, MUSK, ROR2	1.49
687	Achondroplasia	Enrichment	FGFR3	1.48
688	Mccune-albright syndrome	Enrichment	GNAS	1.48
689	Hypogonadotropic hypogonadism 2 with or without anosmia	Enrichment	FGFR1	1.48
690	Larsen syndrome	Enrichment	FGFR3	1.48
691	Ataxia-telangiectasia	Enrichment	BRAF	1.48
692	Tumoral calcinosis, hyperphosphatemic, familial, 1	Enrichment	FGF23	1.48
693	Hypophosphatemic rickets, autosomal dominant	Enrichment	FGF23	1.48
694	Leukoencephalopathy, hereditary diffuse, with spheroids 1	Enrichment	CSF1R	1.48
695	Stuve-wiedemann syndrome 1	Enrichment	LIFR	1.48
696	Nephrotic syndrome, type 3	Enrichment	PLCE1	1.48
697	Chromosome 8p11 myeloproliferative syndrome	Enrichment	FGFR1	1.48
698	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	1.48
699	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	1.48
700	Nizon-isidor syndrome	Enrichment	P2RY12	1.48
701	Primary polycythemia	Enrichment	EPOR	1.48
702	Bronchopulmonary dysplasia	Enrichment	MUSK	1.48
703	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	MYC	1.48
704	Hamartoma	Enrichment	FGFR3	1.48
705	Lymphatic malformation 7	Enrichment	EPHB4	1.48
706	Immunodeficiency 14	Enrichment	PIK3R1	1.48
707	Capillary malformation-arteriovenous malformation 2	Enrichment	EPHB4	1.48
708	Cushing syndrome due to bilateral macronodular adrenocortical disease	Enrichment	GNAS	1.48
709	Growth delay due to insulin-like growth factor i resistance	Enrichment	IGF1R	1.48
710	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	1.48
711	Melanoma of soft tissue	Enrichment	CREB1	1.48
712	Mixed phenotype acute leukemia with t	Enrichment	FLT3	1.48
713	Renal cell carcinoma	Enrichment	MET	1.48
714	Stüve-wiedemann syndrome	Enrichment	LIFR	1.48
715	Aortic aneurysm, familial thoracic 1	Enrichment	NOTCH1, SMAD3	1.45
716	46,xy partial gonadal dysgenesis	Enrichment	GATA4, SOS1	1.43
717	Acromicric dysplasia	Enrichment	LTBP3	1.43
718	Cri-du-chat syndrome	Enrichment	SEMA5A	1.43
719	Leukocyte adhesion deficiency, type i	Enrichment	ITGB2	1.43
720	Sorsby fundus dystrophy	Enrichment	TIMP3	1.43
721	Fibromatosis, gingival, 1	Enrichment	SOS1	1.43
722	Camurati-engelmann disease 1	Enrichment	TGFB1	1.43
723	Kyphomelic dysplasia	Enrichment	CCN2	1.43
724	Omodysplasia 1	Enrichment	GPC6	1.43
725	Dermatofibrosarcoma protuberans	Enrichment	PDGFB	1.43
726	Parkinson disease 8, autosomal dominant	Enrichment	GDF6	1.43
727	Aortic aneurysm, familial thoracic 2	Enrichment	ACTA2	1.43
728	Deafness, autosomal dominant 20	Enrichment	ACTG1	1.43
729	Multiple synostoses syndrome 2	Enrichment	GDF5	1.43
730	Smooth muscle dysfunction syndrome	Enrichment	ACTA2	1.43
731	Leukocyte adhesion deficiency, type iii	Enrichment	ITGB2	1.43
732	Myopathy, mitochondrial progressive, with congenital cataract and developmental delay	Enrichment	GFER	1.43
733	Cutis laxa, autosomal recessive, type ic	Enrichment	LTBP4	1.43
734	Aortic aneurysm, familial thoracic 6	Enrichment	ACTA2	1.43
735	Baraitser-winter syndrome 2	Enrichment	ACTG1	1.43
736	Silver-russell syndrome 3	Enrichment	IGF2	1.43
737	Osteogenesis imperfecta, type xiii	Enrichment	BMP1	1.43
738	Moyamoya disease 5	Enrichment	ACTA2	1.43
739	Brachydactyly, type a1, c	Enrichment	GDF5	1.43
740	Symphalangism, proximal, 1b	Enrichment	GDF5	1.43
741	Spondyloepimetaphyseal dysplasia, li-shao-li type	Enrichment	CCN2	1.43
742	Waardenburg syndrome, type 2f	Enrichment	KITLG	1.43
743	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	1.43
744	Periventricular nodular heterotopia 8	Enrichment	ARF1	1.43
745	Epidermolysis bullosa, junctional 5a, intermediate	Enrichment	ITGB4	1.43
746	Inflammatory bowel disease, immunodeficiency, and encephalopathy	Enrichment	TGFB1	1.43
747	Kowarski syndrome	Enrichment	GH1	1.43
748	Epidermolysis bullosa, junctional 7, with interstitial lung disease and nephrotic syndrome	Enrichment	ITGA3	1.43
749	Camurati-engelmann disease	Enrichment	TGFB1	1.43
750	Microphthalmia/coloboma 6	Enrichment	GDF6	1.43
751	Immune system disease	Enrichment	CDC42	1.43
752	Proximal symphalangism	Enrichment	GDF5	1.43
753	Craniosynostosis 7	Enrichment	BMP2	1.43
754	Congenital amegakaryocytic thrombocytopenia	Enrichment	THPO	1.43
755	Short stature due to growth hormone qualitative anomaly	Enrichment	GH1	1.43
756	Localized junctional epidermolysis bullosa, non-herlitz type	Enrichment	ITGB4	1.43
757	Growth delay due to insulin-like growth factor type 1 deficiency	Enrichment	IGF1	1.43
758	Silver-russell syndrome due to an imprinting defect of 11p15	Enrichment	IGF2	1.43
759	Intestinal obstruction	Enrichment	ACTG2	1.43
760	Silver-russell syndrome due to 11p15 microduplication	Enrichment	IGF2	1.43
761	Primary ovarian insufficiency	Enrichment	BMP6, JAK2, KDR, NTRK1	1.42
762	Myelodysplastic syndrome	Enrichment	GNB1, TP53	1.40
763	Lynch syndrome	Enrichment	KRAS, TGFBR2	1.39
764	Scoliosis, isolated 1	Enrichment	MAPK7	1.38
765	Charcot-marie-tooth disease, demyelinating, type 4f	Enrichment	PLD3	1.38
766	Spinocerebellar ataxia 46	Enrichment	PLD3	1.38
767	Charcot-marie-tooth disease type 4f	Enrichment	PLD3	1.38
768	Melanoma-astrocytoma syndrome	Enrichment	CDKN2A	1.37
769	Myhre syndrome	Enrichment	SMAD4	1.37
770	Adrenocortical carcinoma, hereditary	Enrichment	TP53	1.37
771	Hemangiopericytoma, malignant	Enrichment	STAT6	1.37
772	Metaphyseal dysplasia, spahr type	Enrichment	MMP13	1.37
773	Growth hormone insensitivity syndrome with immune dysregulation 1, autosomal recessive	Enrichment	STAT5B	1.37
774	Spondyloepimetaphyseal dysplasia, missouri type	Enrichment	MMP13	1.37
775	Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome	Enrichment	SMAD4	1.37
776	Amelogenesis imperfecta, hypomaturation type, iia2	Enrichment	MMP20	1.37
777	Microvascular complications of diabetes 5	Enrichment	TGFBR2	1.37
778	Melanoma, cutaneous malignant 2	Enrichment	CDKN2A	1.37
779	Adams-oliver syndrome 5	Enrichment	NOTCH1	1.37
780	Chromosome 13q14 deletion syndrome	Enrichment	RB1	1.37
781	Lymphoma, hodgkin, classic	Enrichment	TP53	1.37
782	Thrombocythemia 3	Enrichment	JAK2	1.37
783	Multiple endocrine neoplasia, type iv	Enrichment	CDKN1B	1.37
784	Loeys-dietz syndrome 3	Enrichment	SMAD3	1.37
785	Immunodeficiency 31c	Enrichment	STAT1	1.37
786	Intravascular large b-cell lymphoma	Enrichment	BCL2	1.37
787	Diffuse midline glioma, h3 k27m-mutant	Enrichment	BRCA2	1.37
788	Recessive dystrophic epidermolysis bullosa	Enrichment	MMP1	1.37
789	Senior-loken syndrome 7	Enrichment	AKT3	1.37
790	Melanoma-pancreatic cancer syndrome	Enrichment	CDKN2A	1.37
791	Preterm premature rupture of the membranes	Enrichment	MMP8	1.37
792	Congenital fibrosarcoma	Enrichment	TP53	1.37
793	Metaphyseal anadysplasia 2	Enrichment	MMP9	1.37
794	Li-fraumeni syndrome 1	Enrichment	TP53	1.37
795	Sarcoma	Enrichment	TP53	1.37
796	Fanconi anemia, complementation group d1	Enrichment	BRCA2	1.37
797	Autoinflammation, immune dysregulation, and eosinophilia	Enrichment	JAK1	1.37
798	Hodgkin's lymphoma	Enrichment	TP53	1.37
799	Bardet-biedl syndrome 16	Enrichment	AKT3	1.37
800	Inflammatory breast carcinoma	Enrichment	BRCA2	1.37
801	Polycythemia	Enrichment	JAK2	1.37
802	Bilateral breast cancer	Enrichment	BRCA2	1.37
803	Hypereosinophilic syndrome	Enrichment	JAK2	1.37
804	Familial retinoblastoma	Enrichment	RB1	1.37
805	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	1.37
806	Laron syndrome with immunodeficiency	Enrichment	STAT5B	1.37
807	Neuroendocrine tumor of pancreas	Enrichment	BRCA2	1.37
808	Spinocerebellar ataxia 29	Enrichment	ITPR1	1.36
809	Cutis marmorata telangiectatica congenita	Enrichment	GNA11	1.36
810	Immunodeficiency 33	Enrichment	IKBKG	1.36
811	Isolated growth hormone deficiency, type iii, with agammaglobulinemia	Enrichment	BTK	1.36
812	Agammaglobulinemia 4, autosomal recessive	Enrichment	BLNK	1.36
813	Agammaglobulinemia 6, autosomal recessive	Enrichment	CD79B	1.36
814	Ventricular tachycardia, catecholaminergic polymorphic, 4	Enrichment	CALM1	1.36
815	Creutzfeldt-jakob disease	Enrichment	HLA-DQB1	1.36
816	Sarcoidosis 1	Enrichment	HLA-DRB1	1.36
817	Long qt syndrome 14	Enrichment	CALM1	1.36
818	Agammaglobulinemia, x-linked	Enrichment	BTK	1.36
819	Lymphoproliferative syndrome	Enrichment	ITK	1.36
820	Agammaglobulinemia 4	Enrichment	BLNK	1.36
821	Agammaglobulinemia 6	Enrichment	CD79B	1.36
822	Autosomal dominant hypocalcemia	Enrichment	GNA11	1.36
823	Spastic paraplegia 37, autosomal dominant	Enrichment	KPNA3	1.36
824	46,xy sex reversal 3	Enrichment	GATA4	1.36
825	Immunodeficiency 17	Enrichment	CD3G	1.36
826	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	1.36
827	Immunodeficiency 52	Enrichment	LAT	1.36
828	Joint contractures, osteochondromas, and b-cell lymphoma	Enrichment	NFATC2	1.36
829	Arthritis	Enrichment	SYK	1.36
830	Primary mediastinal large b-cell lymphoma	Enrichment	XPO1	1.36
831	Phakomatosis cesioflammea	Enrichment	GNA11	1.36
832	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	1.36
833	Spastic paraplegia 17, autosomal dominant	Enrichment	GNG3	1.36
834	Pseudohypoparathyroidism, type ib	Enrichment	GNAS	1.36
835	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	1.36
836	Lipodystrophy, congenital generalized, type 2	Enrichment	GNG3	1.36
837	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.36
838	Carney complex variant	Enrichment	PRKAR1A	1.36
839	Arrhythmogenic right ventricular dysplasia, familial, 10	Enrichment	PRKAR1A	1.36
840	Barrett esophagus	Enrichment	ERBB2	1.36
841	Developmental and epileptic encephalopathy 12	Enrichment	PLCB1	1.36
842	Congenital generalized lipodystrophy	Enrichment	FOS	1.36
843	Chronic myelomonocytic leukemia	Enrichment	FLT3	1.36
844	Craniopharyngioma	Enrichment	BRAF	1.36
845	Pilocytic astrocytoma	Enrichment	KRAS	1.36
846	Newborn respiratory distress syndrome	Enrichment	BRAF	1.36
847	Epidermolytic nevus	Enrichment	HRAS	1.36
848	Non-syndromic bicoronal craniosynostosis	Enrichment	FGFR3	1.36
849	Systemic mastocytosis with associated hematologic neoplasm	Enrichment	KIT	1.36
850	Familial sick sinus syndrome	Enrichment	GNB2	1.36
851	Thumb deformity	Enrichment	CREBBP	1.32
852	Spinocerebellar ataxia 17	Enrichment	TBP	1.32
853	Syndactyly, type iii	Enrichment	HDAC8	1.32
854	Intellectual developmental disorder, autosomal dominant 73	Enrichment	TAF4	1.32
855	Fanconi anemia, complementation group s	Enrichment	BRCA1	1.32
856	Menke-hennekam syndrome 2	Enrichment	EP300	1.32
857	Pancreatic cancer 4	Enrichment	BRCA1	1.32
858	Wilson-turner syndrome	Enrichment	HDAC8	1.32
859	Acute myeloid leukemia with kat6a-crebbp fusion	Enrichment	CREBBP	1.32
860	Acrofacial dysostosis, cincinnati type	Enrichment	POLR1A	1.32
861	Peritoneum cancer	Enrichment	BRCA1	1.32
862	Angelman syndrome due to maternal 15q11q13 deletion	Enrichment	UBE3A	1.32
863	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	1.31
864	Immunodeficiency 37	Enrichment	BCL10	1.31
865	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	CSF1R, ERBB4, PPARGC1A, TAF15	1.30
866	Cataract 6, multiple types	Enrichment	EPHA2	1.26
867	Robinow syndrome, autosomal recessive 1	Enrichment	ROR2	1.26
868	Histiocytoid hemangioma	Enrichment	FOS	1.26
869	Aniridia	Enrichment	EPHA2	1.26
870	Systemic lupus erythematosus	Enrichment	FCGR2A, FCGR3B, HLA-DRB1	1.26
871	Brachydactyly, type a1	Enrichment	GDF5	1.26
872	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	ITGB3	1.26
873	Brachydactyly, type c	Enrichment	GDF5	1.26
874	Klippel-feil syndrome 1, autosomal dominant	Enrichment	GDF6	1.26
875	Exfoliation syndrome	Enrichment	LTBP2	1.26
876	Acromesomelic dysplasia 2a	Enrichment	GDF5	1.26
877	Thrombocythemia 1	Enrichment	THPO	1.26
878	Acromesomelic dysplasia 2c	Enrichment	GDF5	1.26
879	Acromesomelic dysplasia 2b	Enrichment	GDF5	1.26
880	Uvula, bifid	Enrichment	ARF3	1.26
881	Nuchal bleb, familial	Enrichment	SOS1	1.26
882	Muscular dystrophy, duchenne type	Enrichment	LTBP4	1.26
883	Transposition of the great arteries, dextro-looped	Enrichment	BMP2	1.26
884	Muscular dystrophy, congenital, due to integrin alpha-7 deficiency	Enrichment	ITGA7	1.26
885	Dyskeratosis congenita, autosomal dominant 6	Enrichment	THPO	1.26
886	Epidermolysis bullosa, junctional 6, with pyloric atresia	Enrichment	ITGA6	1.26
887	Weill-marchesani syndrome 1	Enrichment	LTBP2	1.26
888	Autosomal recessive cutis laxa type i	Enrichment	LTBP1	1.26
889	Isolated growth hormone deficiency, type ib	Enrichment	GH1	1.26
890	Kyphosis	Enrichment	ARF3	1.26
891	High bone mass osteogenesis imperfecta	Enrichment	BMP1	1.26
892	Bleeding disorder, platelet-type, 24	Enrichment	ITGB3	1.26
893	Geleophysic dysplasia	Enrichment	LTBP3	1.26
894	Alopecia - intellectual disability syndrome	Enrichment	ITGB6	1.26
895	Isolated klippel-feil syndrome	Enrichment	GDF6	1.26
896	Beckwith-wiedemann syndrome due to imprinting defect of 11p15	Enrichment	IGF2	1.26
897	Immunodeficiency 41 with lymphoproliferation and autoimmunity	Enrichment	IL2RA	1.24
898	Lethal congenital contracture syndrome 8	Enrichment	ADCY6	1.24
899	Genitourinary and/or brain malformation syndrome	Enrichment	PPP1R12A	1.24
900	Cortical dysplasia, complex, with other brain malformations 1	Enrichment	TUBB3	1.24
901	Houge-janssens syndrome 3	Enrichment	PPP2CA	1.24
902	Autosomal dominant non-syndromic intellectual disability	Enrichment	CAMK2A, CAMK2B, ERBB4, GNB1	1.23
903	Heart, malformation of	Enrichment	GATA4, MAPK1	1.23
904	Alzheimer disease, familial, 1	Enrichment	CSF1R, NOS3	1.21
905	Hypertension, essential	Enrichment	GNB3, NOS3	1.21
906	Succinic semialdehyde dehydrogenase deficiency	Enrichment	GPLD1	1.21
907	Wieacker-wolff syndrome	Enrichment	RASA1	1.21
908	Type 2 diabetes mellitus	Enrichment	AKT2, IL6, INSR	1.21
909	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-negative, nk cell-negative, due to adenosine deaminase deficiency	Enrichment	JAK3	1.20
910	Retinoblastoma	Enrichment	RB1	1.20
911	Juvenile polyposis syndrome	Enrichment	SMAD4	1.20
912	Polycythemia vera	Enrichment	JAK2	1.20
913	Multicentric osteolysis, nodulosis, and arthropathy	Enrichment	MMP2	1.20
914	Nasopharyngeal carcinoma	Enrichment	TP53	1.20
915	Woolly hair, autosomal recessive 3	Enrichment	RB1	1.20
916	Tumor predisposition syndrome 1	Enrichment	BRCA2	1.20
917	Hypotrichosis 8	Enrichment	RB1	1.20
918	Hyper ige syndrome	Enrichment	STAT3	1.20
919	Atypical teratoid rhabdoid tumor	Enrichment	TP53	1.20
920	Anaplastic astrocytoma	Enrichment	TP53	1.20
921	Adenocarcinoma	Enrichment	TP53	1.20
922	Immunodeficiency 44	Enrichment	STAT2	1.20
923	Bap1 tumor predisposition syndrome	Enrichment	BRCA2	1.20
924	Keratoacanthoma	Enrichment	NOTCH1	1.20
925	Tooth agenesis	Enrichment	FGFR1, TGFA	1.19
926	Gillespie syndrome	Enrichment	ITPR1	1.19
927	Mycosis fungoides	Enrichment	CD28	1.19
928	Agammaglobulinemia 1, autosomal recessive	Enrichment	BTK	1.19
929	Agammaglobulinemia 1	Enrichment	BTK	1.19
930	Adult-onset myasthenia gravis	Enrichment	HLA-DQA1	1.19
931	Advanced sleep phase syndrome	Enrichment	CSNK1D	1.19
932	Vogt-koyanagi-harada disease	Enrichment	HLA-DRB1	1.19
933	Saczary syndrome	Enrichment	CD28	1.19
934	Cowden syndrome 1	Enrichment	EGFR	1.19
935	Split-hand/foot malformation 1	Enrichment	FGFR2	1.19
936	Wilms tumor 5	Enrichment	BRAF	1.19
937	Inflammatory myofibroblastic tumor	Enrichment	ALK	1.19
938	Autosomal recessive robinow syndrome	Enrichment	ROR2	1.19
939	Cerebral palsy	Enrichment	GNB1, PDGFRB	1.16
940	Burn-mckeown syndrome	Enrichment	POLR1A	1.15
941	Estrogen resistance	Enrichment	ESR1	1.15
942	Intraocular pressure quantitative trait locus	Enrichment	CREBBP	1.15
943	Migraine without aura	Enrichment	ESR1	1.15
944	Angelman syndrome due to imprinting defect in 15q11-q13	Enrichment	UBE3A	1.15
945	Mesothelioma, malignant	Enrichment	BCL10	1.14
946	T-cell acute lymphoblastic leukemia	Enrichment	BCL10	1.14
947	West syndrome	Enrichment	CSNK1E, NTRK2, PLCB1	1.14
948	Kaposi sarcoma	Enrichment	IL6	1.13
949	Amelogenesis imperfecta, type iiia	Enrichment	ITGB6	1.13
950	Isolated growth hormone deficiency, type ii	Enrichment	GH1	1.13
951	Nemaline myopathy 2	Enrichment	ACTA1	1.13
952	Megacystis-microcolon-intestinal hypoperistalsis syndrome 1	Enrichment	ACTG2	1.13
953	Autoimmune lymphoproliferative syndrome	Enrichment	ACTA2	1.13
954	Microtia-anotia	Enrichment	BMP5	1.13
955	Epidermolysis bullosa simplex 5c, with pyloric atresia	Enrichment	ITGB4	1.13
956	Retinitis pigmentosa 26	Enrichment	ITGA4	1.13
957	Aminoacylase 1 deficiency	Enrichment	ACTB	1.13
958	Weill-marchesani syndrome	Enrichment	LTBP2	1.13
959	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42	1.13
960	Knobloch syndrome	Enrichment	PAK2	1.13
961	Silver-russell syndrome due to a point mutation	Enrichment	IGF2	1.13
962	Intermediate nemaline myopathy	Enrichment	ACTA1	1.13
963	Gingival fibromatosis	Enrichment	SOS1	1.13
964	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	SOS2	1.13
965	Pseudomyogenic hemangioendothelioma	Enrichment	ACTB	1.13
966	Endometrial cancer	Enrichment	BRCA2, FGFR2	1.13
967	Microcephaly	Enrichment	EP300, GNAO1, GNB1, HDAC8, IGF1R, MAPK1	1.12
968	Renal cell carcinoma, papillary, 1	Enrichment	MET	1.12
969	Brachydactyly	Enrichment	GNAS	1.12
970	Common variable immunodeficiency	Enrichment	NFKB1	1.12
971	Overgrowth syndrome	Enrichment	PIK3R1	1.12
972	Hypophosphatemic rickets	Enrichment	FGF23	1.12
973	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	ADCY1, MET, ROR1	1.11
974	Visceral heterotaxy	Enrichment	LEFTY2, MMP21	1.09
975	Dystonia	Enrichment	CAMK2B, GNAL, GNB1	1.08
976	Chordoma	Enrichment	BRCA2	1.08
977	Polyposis syndrome, hereditary mixed, 1	Enrichment	BRCA2	1.08
978	Budd-chiari syndrome	Enrichment	JAK2	1.08
979	Lynch syndrome 4	Enrichment	RB1	1.08
980	Mantle cell lymphoma	Enrichment	CCND1	1.08
981	Embryonal rhabdomyosarcoma	Enrichment	TP53	1.08
982	Pregnancy loss, recurrent 1	Enrichment	CCNB3	1.08
983	Adenosine deaminase deficiency	Enrichment	JAK3	1.08
984	Pediatric systemic lupus erythematosus	Enrichment	STAT4	1.08
985	Primary hyperparathyroidism	Enrichment	CDKN1B	1.08
986	Temporal arteritis	Enrichment	HLA-DRB1	1.07
987	Spinocerebellar ataxia 15	Enrichment	ITPR1	1.07
988	Transposition of the great arteries	Enrichment	GATA4	1.07
989	Macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss	Enrichment	TUBB1	1.07
990	Cortical dysplasia, complex, with other brain malformations 5	Enrichment	TUBB2A	1.07
991	Hypomyelination neuropathy-arthrogryposis syndrome	Enrichment	ADCY6	1.07
992	Arthrogryposis, distal, type 1a	Enrichment	MET	1.07
993	Spastic paraplegia 4, autosomal dominant	Enrichment	GNAS	1.07
994	Hypothyroidism	Enrichment	GNB1	1.07
995	Neuroblastoma	Enrichment	ALK	1.07
996	Early-onset posterior polar cataract	Enrichment	EPHA2	1.07
997	Arrhythmogenic right ventricular dysplasia, familial, 1	Enrichment	TGFB3	1.04
998	Visceral myopathy 1	Enrichment	ACTG2	1.04
999	Epidermolysis bullosa simplex 1c, localized	Enrichment	ITGB4	1.04
1000	Congenital myopathy 3 with rigid spine	Enrichment	ACTA1	1.04
1001	Rheumatoid arthritis, systemic juvenile	Enrichment	IL6	1.04
1002	Atrioventricular septal defect	Enrichment	BMP5	1.04
1003	Knobloch syndrome 1	Enrichment	PAK2	1.04
1004	Mosaic variegated aneuploidy syndrome 1	Enrichment	PAK6	1.04
1005	Glanzmann thrombasthenia 2	Enrichment	ITGB3	1.04
1006	Epidermolysis bullosa	Enrichment	ITGA6	1.04
1007	Juvenile glaucoma	Enrichment	LTBP2	1.04
1008	Arrhythmogenic right ventricular dysplasia 1	Enrichment	TGFB3	1.04
1009	Aplasia cutis congenita	Enrichment	ITGB4	1.04
1010	Coloboma of choroid and retina	Enrichment	ACTG1	1.04
1011	Severe congenital nemaline myopathy	Enrichment	ACTA1	1.04
1012	Malaria	Enrichment	FCGR2A, IKBKG	1.04
1013	Neurodevelopmental disorder with hypotonia and variable intellectual and behavioral abnormalities	Enrichment	POLR2A	1.03
1014	Arthrogryposis multiplex congenita 3, myogenic type	Enrichment	ESR1	1.03
1015	Hereditary ataxia	Enrichment	PRKCG	1.02
1016	Orofacial cleft 1	Enrichment	FGF10	1.02
1017	Cardiomyopathy, familial hypertrophic, 4	Enrichment	BRAF	1.02
1018	Nephrotic syndrome, type 1	Enrichment	PLCE1	1.02
1019	Developmental and epileptic encephalopathy 14	Enrichment	PLCB1	1.02
1020	Atypical chronic myeloid leukemia, bcr-abl1 negative	Enrichment	FLT3	1.02
1021	Hypogonadotropic hypogonadism	Enrichment	FGFR1	1.02
1022	Cowden syndrome	Enrichment	AKT1	1.02
1023	Martsolf syndrome 1	Enrichment	ARHGAP5	1.00
1024	Von hippel-lindau syndrome	Enrichment	CCND1	0.99
1025	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-negative	Enrichment	JAK3	0.99
1026	Rhabdomyosarcoma 2	Enrichment	TP53	0.99
1027	Breast-ovarian cancer, familial 2	Enrichment	BRCA2	0.99
1028	Follicular lymphoma	Enrichment	BCL2	0.99
1029	Lymphoma	Enrichment	TP53	0.99
1030	Myeloproliferative neoplasm	Enrichment	JAK2	0.99
1031	Acute megakaryocytic leukemia	Enrichment	TP53	0.99
1032	Hemimegalencephaly	Enrichment	AKT3	0.99
1033	Generalized juvenile polyposis/juvenile polyposis coli	Enrichment	SMAD4	0.99
1034	Congenital stationary night blindness	Enrichment	GNAT1, GNB3	0.98
1035	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	0.98
1036	Meier-gorlin syndrome 1	Enrichment	FGFR2	0.97
1037	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	0.97
1038	Myasthenic syndrome, congenital, 4c, associated with acetylcholine receptor deficiency	Enrichment	MUSK	0.97
1039	Primary bone dysplasia	Enrichment	FGFR3	0.97
1040	Body mass index quantitative trait locus 11	Enrichment	ADCY3, GNAS	0.97
1041	Epidermolysis bullosa, junctional 1a, intermediate	Enrichment	ITGB4	0.97
1042	Wilms tumor, aniridia, genitourinary anomalies, and impaired intellectual development syndrome	Enrichment	BDNF	0.97
1043	Moyamoya disease 1	Enrichment	ACTA2	0.97
1044	Type 1 diabetes mellitus	Enrichment	IL6	0.97
1045	Dental anomalies and short stature	Enrichment	LTBP3	0.97
1046	Anterior segment dysgenesis 5	Enrichment	BMP4	0.97
1047	Mitochondrial dna depletion syndrome 1	Enrichment	TYMP	0.97
1048	Inflammatory bowel disease 25, autosomal recessive	Enrichment	TGFB1	0.97
1049	Junctional epidermolysis bullosa non-herlitz type	Enrichment	ITGB4	0.97
1050	Intestinal pseudo-obstruction	Enrichment	ACTG2	0.97
1051	Il10-related early-onset inflammatory bowel disease	Enrichment	TGFB1	0.97
1052	Typical nemaline myopathy	Enrichment	ACTA1	0.97
1053	Chorea, benign hereditary	Enrichment	ADCY5	0.95
1054	Alzheimer disease 2	Enrichment	NOS3	0.94
1055	Chondrosarcoma, extraskeletal myxoid	Enrichment	TAF15	0.94
1056	Night blindness, congenital stationary, type 1c	Enrichment	GNAT1	0.94
1057	Rubinstein-taybi syndrome 2	Enrichment	EP300	0.94
1058	Nonsyndromic 46,xx testicular disorders/differences of sex development	Enrichment	NR0B1	0.94
1059	Hereditary breast ovarian cancer syndrome	Enrichment	BRCA2, KRAS, TP53	0.94
1060	Frontotemporal dementia 1	Enrichment	CSF1R	0.94
1061	Osteochondrodysplasia	Enrichment	FGFR3	0.94
1062	Specific learning disability	Enrichment	MAPK1	0.94
1063	Lymphoma, mucosa-associated lymphoid type	Enrichment	BCL10	0.93
1064	Klippel-trenaunay-weber syndrome	Enrichment	RASA1	0.92
1065	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	RASA1	0.92
1066	Basal cell carcinoma 1	Enrichment	RASA1	0.92
1067	Kabuki syndrome 1	Enrichment	BRCA2	0.91
1068	Chronic mucocutaneous candidiasis	Enrichment	STAT1	0.91
1069	Classic ehlers-danlos syndrome	Enrichment	TGFBR1	0.91
1070	Silver-russell syndrome 1	Enrichment	IGF2	0.90
1071	Waardenburg syndrome, type 2e	Enrichment	KITLG	0.90
1072	Epidermolysis bullosa simplex	Enrichment	ITGB4	0.90
1073	Childhood-onset nemaline myopathy	Enrichment	ACTA1	0.90
1074	Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy	Enrichment	CALM1	0.90
1075	Granulomatosis with polyangiitis	Enrichment	HLA-DPA1	0.90
1076	Spinocerebellar ataxia, autosomal recessive 16	Enrichment	ITPR1	0.90
1077	Lissencephaly	Enrichment	TUBB2B, TUBB3	0.90
1078	Septooptic dysplasia	Enrichment	FGFR1	0.90
1079	Postsynaptic congenital myasthenic syndromes	Enrichment	MUSK	0.90
1080	Undetermined early-onset epileptic encephalopathy	Enrichment	FGF12, NTRK2, PPP3CA	0.90
1081	Angelman syndrome	Enrichment	UBE3A	0.87
1082	Hypertrichosis	Enrichment	CREBBP	0.87
1083	Alzheimer's disease	Enrichment	CSF1R	0.87
1084	Protein-deficiency anemia	Enrichment	NRAS	0.87
1085	Oligoarticular juvenile idiopathic arthritis	Enrichment	CD247	0.86
1086	Rheumatoid factor-negative juvenile idiopathic arthritis	Enrichment	CD247	0.86
1087	Renal hypodysplasia/aplasia 1	Enrichment	ITGA8	0.85
1088	Mitochondrial dna depletion syndrome 4b	Enrichment	TYMP	0.85
1089	Lennox-gastaut syndrome	Enrichment	MAPK10	0.85
1090	Mosaic variegated aneuploidy syndrome	Enrichment	PAK6	0.85
1091	Adams-oliver syndrome	Enrichment	NOTCH1	0.85
1092	Megacolon	Enrichment	AKT3	0.85
1093	Amelogenesis imperfecta type 2	Enrichment	MMP20	0.85
1094	Hypogonadotropic hypogonadism 7 with or without anosmia	Enrichment	FGFR1	0.84
1095	Generalized epilepsy with febrile seizures plus	Enrichment	FGF13	0.84
1096	Cataract	Enrichment	EPHA2	0.84
1097	Long qt syndrome	Enrichment	CALM1, CALM2	0.83
1098	Renal cell carcinoma, nonpapillary	Enrichment	MET	0.81
1099	Cystic fibrosis	Enrichment	FCGR2A, TGFB1	0.80
1100	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	0.80
1101	Congenital central hypoventilation syndrome	Enrichment	BDNF	0.80
1102	Mitochondrial neurogastrointestinal encephalomyopathy	Enrichment	TYMP	0.80
1103	Permanent neonatal diabetes mellitus	Enrichment	STAT3	0.80
1104	Hypoplastic left heart syndrome	Enrichment	NOTCH1	0.80
1105	Catecholaminergic polymorphic ventricular tachycardia 1	Enrichment	CALM1	0.79
1106	Cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 1	Enrichment	TUBB2B	0.79
1107	Cleft palate, isolated	Enrichment	GNB1	0.76
1108	Cataract 44	Enrichment	EPHA2	0.76
1109	Cat eye syndrome	Enrichment	ACTG1	0.76
1110	Peters-plus syndrome	Enrichment	BMP4	0.76
1111	Amelogenesis imperfecta, type ie	Enrichment	ITGB6	0.76
1112	Stickler syndrome	Enrichment	BMP4	0.76
1113	Nemaline myopathy	Enrichment	ACTA1	0.76
1114	Fanconi anemia, complementation group c	Enrichment	HDAC8	0.75
1115	Choreatic disease	Enrichment	GNAO1	0.75
1116	Tracheoesophageal fistula with or without esophageal atresia	Enrichment	BRCA2	0.75
1117	Polydactyly	Enrichment	BRCA2	0.75
1118	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	0.75
1119	Familial thoracic aortic aneurysm and dissection	Enrichment	SMAD3	0.75
1120	Coronary heart disease 5	Enrichment	IKBKG	0.74
1121	Early-onset nuclear cataract	Enrichment	EPHA2	0.74
1122	Distal arthrogryposis	Enrichment	ACTA1, ROR2	0.73
1123	Polymicrogyria, bilateral perisylvian, x-linked	Enrichment	TUBB2B	0.72
1124	Pectus excavatum	Enrichment	ARF3	0.72
1125	Meningioma, familial	Enrichment	PDGFB	0.72
1126	Heritable pulmonary arterial hypertension	Enrichment	GDF2	0.72
1127	Charge syndrome	Enrichment	EP300	0.71
1128	Polymicrogyria	Enrichment	AKT3	0.71
1129	Familial colorectal cancer	Enrichment	TP53	0.71
1130	Isolated tracheo-esophageal fistula	Enrichment	BRCA2	0.71
1131	Focal segmental glomerulosclerosis	Enrichment	PLCE1	0.70
1132	Cutis laxa	Enrichment	LTBP4	0.69
1133	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant	Enrichment	TGFB3	0.69
1134	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant	Enrichment	TGFB3	0.69
1135	Charcot-marie-tooth disease	Enrichment	ARHGEF10, PLD3	0.67
1136	Uterine corpus cancer	Enrichment	BRCA2	0.67
1137	Familial colorectal cancer type x	Enrichment	BRCA2	0.67
1138	Stroke, ischemic	Enrichment	NOS3	0.67
1139	Achromatopsia	Enrichment	GNAT2	0.67
1140	Immune deficiency disease	Enrichment	SYK	0.66
1141	Combined immunodeficiency	Enrichment	ZAP70	0.66
1142	Combined t cell and b cell immunodeficiency	Enrichment	ZAP70	0.66
1143	Combined t and b cell immunodeficiency	Enrichment	ZAP70	0.66
1144	Attention deficit-hyperactivity disorder	Enrichment	GNB5	0.66
1145	Neural tube defects	Enrichment	ITGB1	0.66
1146	Pulmonary hypertension, primary, 1	Enrichment	GDF2	0.66
1147	Amelogenesis imperfecta	Enrichment	LTBP3	0.66
1148	Dilated cardiomyopathy	Enrichment	BRAF, RAF1	0.65
1149	Nephrotic syndrome	Enrichment	ITGA3, PLCE1	0.64
1150	Migraine with or without aura 1	Enrichment	ESR1	0.63
1151	Atrial heart septal defect	Enrichment	HDAC8	0.63
1152	46,xy complete gonadal dysgenesis	Enrichment	NR0B1	0.63
1153	Movement disease	Enrichment	GNAO1	0.63
1154	Interatrial communication	Enrichment	HDAC8	0.63
1155	Osteoporosis	Enrichment	SRC	0.63
1156	Periventricular nodular heterotopia	Enrichment	ARF1	0.63
1157	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	TGFB3	0.63
1158	Isolated macular dystrophy	Enrichment	ITGA4	0.63
1159	Congenital long qt syndrome	Enrichment	ITPR3	0.63
1160	Bilateral perisylvian polymicrogyria	Enrichment	TUBB2B	0.63
1161	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	0.63
1162	Breast-ovarian cancer, familial 1	Enrichment	BRCA2	0.61
1163	Chromosome 1p36 deletion syndrome	Enrichment	MMP23B	0.61
1164	Osteogenesis imperfecta, type iii	Enrichment	BMP1	0.60
1165	Congenital nervous system abnormality	Enrichment	CREBBP, FGFR3, GNAO1, GNB5	0.60
1166	Nervous system disease	Enrichment	CREBBP, FGFR3, GNAO1, GNB5	0.60
1167	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	ACTG1, KITLG	0.59
1168	Strabismus	Enrichment	GNB1	0.58
1169	Medulloblastoma	Enrichment	BRCA2	0.58
1170	Heart disease	Enrichment	GATA4	0.57
1171	Anterior segment dysgenesis	Enrichment	ITPR1	0.54
1172	Developmental and epileptic encephalopathy	Enrichment	ARHGEF15, GNAO1	0.54
1173	Cone-rod dystrophy 6	Enrichment	GNAT2	0.54
1174	Beckwith-wiedemann syndrome	Enrichment	IGF2	0.54
1175	Human immunodeficiency virus type 1	Enrichment	CXCL12	0.54
1176	Neuromuscular disease	Enrichment	ACTA1	0.54
1177	Congenital hypothyroidism	Enrichment	TUBB1	0.52
1178	Congenital myopathy	Enrichment	ACTA1	0.52
1179	Polydactyly, postaxial, type a1	Enrichment	EP300	0.52
1180	Corpus callosum, agenesis of	Enrichment	CREBBP	0.52
1181	Isolated corpus callosum agenesis	Enrichment	CREBBP	0.52
1182	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CREBBP	0.52
1183	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	0.51
1184	Sudden infant death syndrome	Enrichment	CALM2	0.50
1185	Genetic steroid-resistant nephrotic syndrome	Enrichment	PLCE1	0.50
1186	Charcot-marie-tooth disease type 4	Enrichment	PLD3	0.50
1187	Macs syndrome	Enrichment	GDF6	0.50
1188	Left ventricular noncompaction	Enrichment	RAF1	0.49
1189	Centronuclear myopathy	Enrichment	ACTA1	0.48
1190	Patent foramen ovale	Enrichment	GATA4	0.48
1191	Syndromic intellectual disability	Enrichment	TAF6	0.47
1192	Behcet syndrome	Enrichment	STAT4	0.47
1193	Esophageal atresia/tracheoesophageal fistula	Enrichment	BRCA2	0.47
1194	Myocardial infarction	Enrichment	ITGB3	0.47
1195	Skin disease	Enrichment	ITGB4	0.47
1196	Autism spectrum disorder	Enrichment	GNB1, MAP2K1	0.46
1197	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	FGF8, GATA4	0.45
1198	Polycystic kidney disease	Enrichment	HDAC8	0.45
1199	Early infantile developmental and epileptic encephalopathy	Enrichment	GNAO1	0.45
1200	Brittle bone disorder	Enrichment	BMP1	0.45
1201	Familial isolated dilated cardiomyopathy	Enrichment	RAF1, TAF1A	0.44
1202	Scoliosis	Enrichment	ARF3	0.44
1203	Benign epilepsy with centrotemporal spikes	Enrichment	PLCB1	0.43
1204	Parkinson's disease	Enrichment	TBP	0.43
1205	Cardiomyopathy, dilated, 1a	Enrichment	NFATC2	0.43
1206	Centralopathic epilepsy	Enrichment	PLCB1	0.42
1207	Brugada syndrome	Enrichment	SEMA3A	0.41
1208	Diamond-blackfan anemia 1	Enrichment	TP53	0.40
1209	Familial atrial fibrillation	Enrichment	GATA4	0.38
1210	Severe covid-19	Enrichment	ITGAV	0.37
1211	Developmental and epileptic encephalopathy 1	Enrichment	CSNK1E	0.37
1212	Parkinson disease, late-onset	Enrichment	TBP	0.36
1213	Cone dystrophy	Enrichment	GNAT2	0.36
1214	Hypertelorism	Enrichment	FGFR2	0.35
1215	Williams-beuren syndrome	Enrichment	LIMK1	0.35
1216	Peripheral nervous system disease	Enrichment	NGF	0.34
1217	Neuropathy	Enrichment	NGF	0.34
1218	Spastic ataxia	Enrichment	ITPR1, TUBB3	0.33
1219	Complex neurodevelopmental disorder	Enrichment	PAK3, RAC3, RALA	0.32
1220	Visceral heterotaxy 5	Enrichment	MMP21	0.31
1221	Non-syndromic x-linked intellectual disability	Enrichment	ARHGEF6	0.30
1222	Non-syndromic genetic deafness	Enrichment	ACTG1	0.30
1223	Myopathy	Enrichment	ACTA1	0.27
1224	Fanconi anemia, complementation group a	Enrichment	BRCA2	0.27
1225	Primary autosomal recessive microcephaly	Enrichment	TAF13	0.27
1226	Diamond-blackfan anemia	Enrichment	TP53	0.26
1227	Primary ciliary dyskinesia	Enrichment	DRC4, PRKAR1B	0.26
1228	Nonsyndromic hearing loss	Enrichment	ACTG1	0.26
1229	Eye disease	Enrichment	GNAT2	0.24
1230	Sensorineural hearing loss	Enrichment	HGF	0.22
1231	Cone-rod dystrophy 2	Enrichment	ITGA4	0.14
1232	Optic atrophy plus syndrome	Enrichment	TUBB6	0.14
1233	Autism	Enrichment	ARF3	0.13
1234	Rare genetic deafness	Enrichment	ACTG1	0.11
1235	Mitochondrial disease	Enrichment	GFER	0.09
1236	Leber plus disease	Enrichment	GDF6	0.08
1237	Retinitis pigmentosa	Enrichment	MERTK	0.04
1238	Hereditary retinal dystrophy	Enrichment	ITGA4, MERTK, TIMP3	0.04
1239	Fundus dystrophy	Enrichment	ITGA4, MERTK, TIMP3	0.04

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

GPCR Pathway

Pathway Network for GPCR Pathway

Pathway network for the GPCR Pathway SuperPath

Member Pathways for GPCR Pathway

Pathways in the GPCR Pathway SuperPath

Gene overlap in member pathways for GPCR Pathway SuperPath

Associated Genes for GPCR Pathway

Associated Disorders for GPCR Pathway

Disorders associated with GPCR Pathway SuperPath

STRING Interaction Network for GPCR Pathway

Sources for GPCR Pathway