GPCRs, class C metabotropic glutamate, pheromone

No Pathway Network information available for GPCRs, class C metabotropic glutamate, pheromone

Pathways in the GPCRs, class C metabotropic glutamate, pheromone SuperPath

#	Name	Source	Genes
1	GPCRs, class C metabotropic glutamate, pheromone	WikiPathways	CASR GABBR1 GABBR2 GPRC5A GPRC5B GPRC5C GPRC5D GRM1 GRM2 GRM3 GRM4 GRM5 GRM6 GRM7 GRM8 (see all 15) (see less)
2	Synaptic Neurotransmission: Glutamatergic Excitation	R&D Systems	FOLH1 GRIN1 GRIN2A GRIN2B GRIN2C GRM1 GRM3 GRM4 GRM5 GRM6 GRM7 GRM8 SLC1A3 (see all 13) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	GRM8	Glutamate Metabotropic Receptor 8	Protein Coding	2
2	GRM7	Glutamate Metabotropic Receptor 7	Protein Coding	2
3	GRM6	Glutamate Metabotropic Receptor 6	Protein Coding	2
4	GRM5	Glutamate Metabotropic Receptor 5	Protein Coding	2
5	GRM4	Glutamate Metabotropic Receptor 4	Protein Coding	2
6	GRM3	Glutamate Metabotropic Receptor 3	Protein Coding	2
7	GRM1	Glutamate Metabotropic Receptor 1	Protein Coding	2
8	GABBR2	Gamma-Aminobutyric Acid Type B Receptor Subunit 2	Protein Coding	1
9	GPRC5A	G Protein-Coupled Receptor Class C Group 5 Member A	Protein Coding	1
10	CASR	Calcium Sensing Receptor	Protein Coding	1
11	GRM2	Glutamate Metabotropic Receptor 2	Protein Coding	1
12	GABBR1	Gamma-Aminobutyric Acid Type B Receptor Subunit 1	Protein Coding	1
13	GPRC5C	G Protein-Coupled Receptor Class C Group 5 Member C	Protein Coding	1
14	GPRC5D	G Protein-Coupled Receptor Class C Group 5 Member D	Protein Coding	1
15	GPRC5B	G Protein-Coupled Receptor Class C Group 5 Member B	Protein Coding	1
16	FOLH1	Folate Hydrolase 1	Protein Coding	1
17	GRIN1	Glutamate Ionotropic Receptor NMDA Type Subunit 1	Protein Coding	1
18	GRIN2A	Glutamate Ionotropic Receptor NMDA Type Subunit 2A	Protein Coding	1
19	GRIN2B	Glutamate Ionotropic Receptor NMDA Type Subunit 2B	Protein Coding	1
20	GRIN2C	Glutamate Ionotropic Receptor NMDA Type Subunit 2C	Protein Coding	1
21	SLC1A3	Solute Carrier Family 1 Member 3	Protein Coding	1

Disorders associated with GPCRs, class C metabotropic glutamate, pheromone SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Early infantile developmental and epileptic encephalopathy	Enrichment	GRIN1, GRM7	3.89
2	Epilepsy	Enrichment	GRIN2A, GRIN2B	3.19
3	Benign epilepsy with centrotemporal spikes	Enrichment	GRIN1, GRIN2A	3.17
4	Centralopathic epilepsy	Enrichment	GRIN1, GRIN2A	3.13
5	West syndrome	Enrichment	GRIN1, GRIN2B	3.11
6	Epilepsy, focal, with speech disorder and with or without impaired intellectual development	Enrichment	GRIN2A	3.02
7	Episodic ataxia, type 6	Enrichment	SLC1A3	3.02
8	Developmental and epileptic encephalopathy 27	Enrichment	GRIN2B	3.02
9	Spinocerebellar ataxia, autosomal recessive 13	Enrichment	GRM1	3.02
10	Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal recessive	Enrichment	GRIN1	3.02
11	Intellectual developmental disorder, autosomal dominant 6, with or without seizures	Enrichment	GRIN2B	3.02
12	Developmental and epileptic encephalopathy 101	Enrichment	GRIN1	3.02
13	Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal dominant	Enrichment	GRIN1	3.02
14	Spinocerebellar ataxia 44	Enrichment	GRM1	3.02
15	Neurodevelopmental disorder with seizures, hypotonia, and brain imaging abnormalities	Enrichment	GRM7	3.02
16	Grin2b-related neurodevelopmental disorder	Enrichment	GRIN2B	3.02
17	Landau-kleffner syndrome	Enrichment	GRIN2A	3.02
18	Intellectual disability, autosomal dominant 8	Enrichment	GRIN1	3.02
19	Early-onset epileptic encephalopathy and intellectual disability due to grin2a mutation	Enrichment	GRIN2A	3.02
20	Grin2a-related disorders	Enrichment	GRIN2A	3.02
21	Chondromyxoid fibroma	Enrichment	GRM1	3.02
22	Autosomal dominant non-syndromic intellectual disability	Enrichment	GRIN1, GRIN2B	2.99
23	Hypocalcemia, autosomal dominant 1	Enrichment	CASR	2.96
24	Hypocalciuric hypercalcemia, familial, type i	Enrichment	CASR	2.96
25	Neurodevelopmental disorder with poor language and loss of hand skills	Enrichment	GABBR2	2.96
26	Developmental and epileptic encephalopathy 59	Enrichment	GABBR2	2.96
27	Epilepsy, idiopathic generalized 8	Enrichment	CASR	2.96
28	Neurodevelopmental disorder with language delay and variable cognitive abnormalities	Enrichment	GABBR1	2.96
29	Megalencephalic leukoencephalopathy with subcortical cysts 3	Enrichment	GPRC5B	2.96
30	Hypercalcemia	Enrichment	CASR	2.96
31	Familial hypocalciuric hypercalcemia	Enrichment	CASR	2.96
32	Autosomal recessive non-syndromic intellectual disability	Enrichment	GRIN1, GRM7	2.87
33	Bilateral generalized polymicrogyria	Enrichment	GRIN1	2.72
34	Intellectual developmental disorder, autosomal dominant 21	Enrichment	GRIN2A	2.72
35	Rolandic epilepsy-speech dyspraxia syndrome	Enrichment	GRIN2A	2.72
36	Epilepsy-aphasia spectrum	Enrichment	GRIN2A	2.72
37	Hyperparathyroidism, neonatal severe	Enrichment	CASR	2.66
38	Autosomal dominant hypocalcemia	Enrichment	CASR	2.66
39	Night blindness, congenital stationary, type 1b	Enrichment	GRM6	2.54
40	Auditory neuropathy and optic atrophy	Enrichment	GRIN2C	2.54
41	Familial isolated hypoparathyroidism	Enrichment	CASR	2.48
42	Parathyroid adenoma	Enrichment	CASR	2.48
43	Astigmatism	Enrichment	GRIN2B	2.42
44	Tobacco addiction	Enrichment	GABBR2	2.35
45	Primary hyperparathyroidism	Enrichment	CASR	2.35
46	Night blindness, congenital stationary, type 1c	Enrichment	GRM6	2.32
47	Sleep disorder	Enrichment	GRIN2B	2.32
48	Microcephaly	Enrichment	GRIN2B, GRM7	2.22
49	Alternating hemiplegia of childhood	Enrichment	SLC1A3	2.12
50	Rett syndrome	Enrichment	GABBR2	2.11
51	Rett syndrome, congenital variant	Enrichment	GABBR2	2.05
52	Neurofibromatosis, type i	Enrichment	GABBR1	2.00
53	Pancreatitis, hereditary	Enrichment	CASR	1.73
54	Craniosynostosis	Enrichment	GRIN2B	1.72
55	Congenital stationary night blindness	Enrichment	GRM6	1.66
56	Scoliosis	Enrichment	GRIN2B	1.64
57	Developmental and epileptic encephalopathy 1	Enrichment	GRIN1	1.63
58	Cerebral palsy	Enrichment	GRIN2B	1.43
59	Hypertrophic cardiomyopathy	Enrichment	CASR	1.33
60	Undetermined early-onset epileptic encephalopathy	Enrichment	GABBR2	1.22
61	Leber plus disease	Enrichment	GRM6	1.06
62	Autism spectrum disorder	Enrichment	GRIN2B	1.00
63	Complex neurodevelopmental disorder	Enrichment	GRIN2B	0.95
64	Hereditary retinal dystrophy	Enrichment	GRM6	0.61
65	Fundus dystrophy	Enrichment	GRM6	0.61

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

GPCRs, class C metabotropic glutamate, pheromone

Pathway Network for GPCRs, class C metabotropic glutamate, pheromone

Member Pathways for GPCRs, class C metabotropic glutamate, pheromone

Pathways in the GPCRs, class C metabotropic glutamate, pheromone SuperPath

Associated Genes for GPCRs, class C metabotropic glutamate, pheromone

Associated Disorders for GPCRs, class C metabotropic glutamate, pheromone

Disorders associated with GPCRs, class C metabotropic glutamate, pheromone SuperPath

STRING Interaction Network for GPCRs, class C metabotropic glutamate, pheromone

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