GPCRs, other

No Pathway Network information available for GPCRs, other

Pathways in the GPCRs, other SuperPath

#	Name	Source	Genes
1	GPCRs, other	WikiPathways	ACKR1 ADGRD1 ADGRE2 ADGRE3 ADGRF5 ADGRG1 ADGRL2 ADGRL3 ADGRV1 ADORA2A ADORA3 ADRA1D ADRB2 ALG6 C5AR2 CCKBR CCR5 CELSR1 CELSR2 CELSR3 CHRM2 CHRM3 CNR1 CXCR1 CXCR2 CXCR3 DRD3 DRD4 EDNRA F2R FSHR GHRHR GNRHR GPR132 GPR135 GPR143 GPR162 GPR17 GPR176 GPR18 GPR183 GPR55 GPR61 GPR62 GPR83 GPR84 GPR88 GRM1 GRM8 GRPR HRH4 HTR1F HTR2A HTR7 LGR6 LTB4R2 MCHR2 NTSR1 OR10A2 OR10A5 OR1E1 OR1E3 OR1F1 OR1G1 OR1N1 OR1R1 OR2A20P OR2A4 OR2A5 OR2B6 OR2F1 OR2H1 OR2M4 OR3A1 OR3A3 OR51A1P OR5D3 OR7A17 OR7E18P OR7E19P OR7E24 OR7E35P OR8G1 OR8G2P P2RY11 P2RY13 PROKR2 PTGFR RXFP1 RXFP3 S1PR1 SMO SSTR2 TAAR2 TAAR3P TAAR5 UTS2R VN1R1 (see all 98) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	GHRHR	Growth Hormone Releasing Hormone Receptor	Protein Coding	1
2	GPR55	G Protein-Coupled Receptor 55	Protein Coding	1
3	ADGRG1	Adhesion G Protein-Coupled Receptor G1	Protein Coding	1
4	CCKBR	Cholecystokinin B Receptor	Protein Coding	1
5	ADGRV1	Adhesion G Protein-Coupled Receptor V1	Protein Coding	1
6	SSTR2	Somatostatin Receptor 2	Protein Coding	1
7	SMO	Smoothened, Frizzled Class Receptor	Protein Coding	1
8	GPR135	G Protein-Coupled Receptor 135	Protein Coding	1
9	LGR6	Leucine Rich Repeat Containing G Protein-Coupled Receptor 6	Protein Coding	1
10	RXFP1	Relaxin Family Peptide Receptor 1	Protein Coding	1
11	HRH4	Histamine Receptor H4	Protein Coding	1
12	PTGFR	Prostaglandin F Receptor	Protein Coding	1
13	GPR88	G Protein-Coupled Receptor 88	Protein Coding	1
14	P2RY11	Purinergic Receptor P2Y11	Protein Coding	1
15	GPR143	G Protein-Coupled Receptor 143	Protein Coding	1
16	NTSR1	Neurotensin Receptor 1	Protein Coding	1
17	CXCR2	C-X-C Motif Chemokine Receptor 2	Protein Coding	1
18	CXCR1	C-X-C Motif Chemokine Receptor 1	Protein Coding	1
19	HTR7	5-Hydroxytryptamine Receptor 7	Protein Coding	1
20	HTR2A	5-Hydroxytryptamine Receptor 2A	Protein Coding	1
21	HTR1F	5-Hydroxytryptamine Receptor 1F	Protein Coding	1
22	ADGRE2	Adhesion G Protein-Coupled Receptor E2	Protein Coding	1
23	ALG6	ALG6 Alpha-1,3-Glucosyltransferase	Protein Coding	1
24	GRPR	Gastrin Releasing Peptide Receptor	Protein Coding	1
25	GRM8	Glutamate Metabotropic Receptor 8	Protein Coding	1
26	GRM1	Glutamate Metabotropic Receptor 1	Protein Coding	1
27	GPR17	G Protein-Coupled Receptor 17	Protein Coding	1
28	CXCR3	C-X-C Motif Chemokine Receptor 3	Protein Coding	1
29	GNRHR	Gonadotropin Releasing Hormone Receptor	Protein Coding	1
30	ACKR1	Atypical Chemokine Receptor 1 (Duffy Blood Group)	Protein Coding	1
31	FSHR	Follicle Stimulating Hormone Receptor	Protein Coding	1
32	ADGRL3	Adhesion G Protein-Coupled Receptor L3	Protein Coding	1
33	F2R	Coagulation Factor II Thrombin Receptor	Protein Coding	1
34	CELSR2	Cadherin EGF LAG Seven-Pass G-Type Receptor 2	Protein Coding	1
35	CELSR3	Cadherin EGF LAG Seven-Pass G-Type Receptor 3	Protein Coding	1
36	EDNRA	Endothelin Receptor Type A	Protein Coding	1
37	S1PR1	Sphingosine-1-Phosphate Receptor 1	Protein Coding	1
38	GPR183	G Protein-Coupled Receptor 183	Protein Coding	1
39	DRD4	Dopamine Receptor D4	Protein Coding	1
40	DRD3	Dopamine Receptor D3	Protein Coding	1
41	ADRB2	Adrenoceptor Beta 2	Protein Coding	1
42	ADRA1D	Adrenoceptor Alpha 1D	Protein Coding	1
43	ADORA3	Adenosine A3 Receptor	Protein Coding	1
44	ADORA2A	Adenosine A2a Receptor	Protein Coding	1
45	PROKR2	Prokineticin Receptor 2	Protein Coding	1
46	CNR1	Cannabinoid Receptor 1	Protein Coding	1
47	CCR5	C-C Motif Chemokine Receptor 5	Protein Coding	1
48	CHRM3	Cholinergic Receptor Muscarinic 3	Protein Coding	1
49	CHRM2	Cholinergic Receptor Muscarinic 2	Protein Coding	1
50	CELSR1	Cadherin EGF LAG Seven-Pass G-Type Receptor 1	Protein Coding	1
51	OR1R1	Olfactory Receptor Family 1 Subfamily R Member 1	Protein Coding	1
52	TAAR3P	Trace Amine Associated Receptor 3, Pseudogene	Pseudogene	1
53	TAAR2	Trace Amine Associated Receptor 2	Protein Coding	1
54	TAAR5	Trace Amine Associated Receptor 5	Protein Coding	1
55	OR5D3	Olfactory Receptor Family 5 Subfamily D Member 3	Protein Coding	1
56	ADGRE3	Adhesion G Protein-Coupled Receptor E3	Protein Coding	1
57	MCHR2	Melanin Concentrating Hormone Receptor 2	Protein Coding	1
58	OR3A3	Olfactory Receptor Family 3 Subfamily A Member 3	Protein Coding	1
59	OR1G1	Olfactory Receptor Family 1 Subfamily G Member 1	Protein Coding	1
60	OR1E3	Olfactory Receptor Family 1 Subfamily E Member 3 (Gene/Pseudogene)	Pseudogene	1
61	GPR61	G Protein-Coupled Receptor 61	Protein Coding	1
62	OR1E1	Olfactory Receptor Family 1 Subfamily E Member 1	Protein Coding	1
63	OR10A5	Olfactory Receptor Family 10 Subfamily A Member 5	Protein Coding	1
64	OR1N1	Olfactory Receptor Family 1 Subfamily N Member 1	Protein Coding	1
65	GPR62	G Protein-Coupled Receptor 62	Protein Coding	1
66	GPR176	G Protein-Coupled Receptor 176	Protein Coding	1
67	GPR83	G Protein-Coupled Receptor 83	Protein Coding	1
68	OR2A4	Olfactory Receptor Family 2 Subfamily A Member 4	Protein Coding	1
69	VN1R1	Vomeronasal 1 Receptor 1	Protein Coding	1
70	LTB4R2	Leukotriene B4 Receptor 2	Protein Coding	1
71	GPR84	G Protein-Coupled Receptor 84	Protein Coding	1
72	P2RY13	Purinergic Receptor P2Y13	Protein Coding	1
73	RXFP3	Relaxin Family Peptide Receptor 3	Protein Coding	1
74	OR3A1	Olfactory Receptor Family 3 Subfamily A Member 1	Protein Coding	1
75	OR1F1	Olfactory Receptor Family 1 Subfamily F Member 1	Protein Coding	1
76	OR2A20P	Olfactory Receptor Family 2 Subfamily A Member 20 Pseudogene	Pseudogene	1
77	OR2A5	Olfactory Receptor Family 2 Subfamily A Member 5	Protein Coding	1
78	OR7E35P	Olfactory Receptor Family 7 Subfamily E Member 35 Pseudogene	Pseudogene	1
79	OR7E18P	Olfactory Receptor Family 7 Subfamily E Member 18 Pseudogene	Pseudogene	1
80	OR10A2	Olfactory Receptor Family 10 Subfamily A Member 2	Protein Coding	1
81	GPR132	G Protein-Coupled Receptor 132	Protein Coding	1
82	GPR18	G Protein-Coupled Receptor 18	Protein Coding	1
83	UTS2R	Urotensin 2 Receptor	Protein Coding	1
84	ADGRD1	Adhesion G Protein-Coupled Receptor D1	Protein Coding	1
85	GPR162	G Protein-Coupled Receptor 162	Protein Coding	1
86	C5AR2	Complement C5a Receptor 2	Protein Coding	1
87	OR2H1	Olfactory Receptor Family 2 Subfamily H Member 1	Protein Coding	1
88	OR7E19P	Olfactory Receptor Family 7 Subfamily E Member 19 Pseudogene	Pseudogene	1
89	OR7E24	Olfactory Receptor Family 7 Subfamily E Member 24	Protein Coding	1
90	OR51A1P	Olfactory Receptor Family 51 Subfamily A Member 1 Pseudogene	Pseudogene	1
91	OR8G1	Olfactory Receptor Family 8 Subfamily G Member 1	Protein Coding	1
92	OR8G2P	Olfactory Receptor Family 8 Subfamily G Member 2 Pseudogene	Pseudogene	1
93	OR7A17	Olfactory Receptor Family 7 Subfamily A Member 17	Protein Coding	1
94	OR2M4	Olfactory Receptor Family 2 Subfamily M Member 4	Protein Coding	1
95	OR2B6	Olfactory Receptor Family 2 Subfamily B Member 6	Protein Coding	1
96	OR2F1	Olfactory Receptor Family 2 Subfamily F Member 1	Protein Coding	1
97	ADGRL2	Adhesion G Protein-Coupled Receptor L2	Protein Coding	1
98	ADGRF5	Adhesion G Protein-Coupled Receptor F5	Protein Coding	1

Disorders associated with GPCRs, other SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Hypogonadotropic hypogonadism	Enrichment	GNRHR, PROKR2	2.74
2	Hypogonadotropic hypogonadism 7 with or without anosmia	Enrichment	GNRHR, PROKR2	2.35
3	Vibratory urticaria	Enrichment	ADGRE2	2.14
4	Hypogonadotropic hypogonadism 3 with or without anosmia	Enrichment	PROKR2	2.14
5	Nystagmus 6, congenital, x-linked	Enrichment	GPR143	2.14
6	Curry-jones syndrome	Enrichment	SMO	2.14
7	Cortical dysplasia, complex, with other brain malformations 14a	Enrichment	ADGRG1	2.14
8	White blood cell count quantitative trait locus 1	Enrichment	ACKR1	2.14
9	Mandibulofacial dysostosis with alopecia	Enrichment	EDNRA	2.14
10	Tremor, hereditary essential, 1	Enrichment	DRD3	2.14
11	Ovarian dysgenesis 1	Enrichment	FSHR	2.14
12	Spinocerebellar ataxia, autosomal recessive 13	Enrichment	GRM1	2.14
13	Twinning, dizygotic	Enrichment	FSHR	2.14
14	Febrile seizures, familial, 4	Enrichment	ADGRV1	2.14
15	Congenital disorder of glycosylation, type ic	Enrichment	ALG6	2.14
16	Ovarian hyperstimulation syndrome	Enrichment	FSHR	2.14
17	Amenorrhea	Enrichment	FSHR	2.14
18	Cortical dysplasia, complex, with other brain malformations 14b	Enrichment	ADGRG1	2.14
19	Type 1 diabetes mellitus 22	Enrichment	CCR5	2.14
20	Chorea, childhood-onset, with psychomotor retardation	Enrichment	GPR88	2.14
21	Celsr1-related late-onset primary lymphedema	Enrichment	CELSR1	2.14
22	Spinocerebellar ataxia 44	Enrichment	GRM1	2.14
23	Isolated growth hormone deficiency, type iv	Enrichment	GHRHR	2.14
24	Whim syndrome 2	Enrichment	CXCR2	2.14
25	Isolated gonadotropin-releasing hormone deficiency	Enrichment	GNRHR	2.14
26	Autonomic nervous system disease	Enrichment	DRD4	2.14
27	Acute encephalopathy with biphasic seizures and late reduced diffusion	Enrichment	ADORA2A	2.14
28	Autosomal recessive severe congenital neutropenia due to cxcr2 deficiency	Enrichment	CXCR2	2.14
29	Chondromyxoid fibroma	Enrichment	GRM1	2.14
30	Human immunodeficiency virus type 1	Enrichment	CCR5, CXCR1	2.13
31	Normosmic congenital hypogonadotropic hypogonadism	Enrichment	GNRHR, PROKR2	2.13
32	Pallister-hall-like syndrome	Enrichment	SMO	1.84
33	West nile virus	Enrichment	CCR5	1.84
34	Usher syndrome, type iic	Enrichment	ADGRV1	1.84
35	Obsessive-compulsive disorder	Enrichment	HTR2A	1.84
36	Lymphatic malformation 9	Enrichment	CELSR1	1.84
37	Prune belly syndrome	Enrichment	CHRM3	1.67
38	Hypogonadotropic hypogonadism 2 with or without anosmia	Enrichment	PROKR2	1.67
39	Hepatitis c virus	Enrichment	CCR5	1.67
40	Isolated growth hormone deficiency, type ib	Enrichment	GHRHR	1.67
41	Gonadal dysgenesis	Enrichment	FSHR	1.67
42	Orofaciodigital syndrome iii	Enrichment	CELSR2	1.54
43	Hypogonadotropic hypogonadism 1 with or without anosmia	Enrichment	PROKR2	1.45
44	Major depressive disorder	Enrichment	HTR2A	1.45
45	Albinism, ocular, type i	Enrichment	GPR143	1.37
46	Congenital anomalies of kidney and urinary tract 1	Enrichment	CELSR3	1.37
47	Albinism	Enrichment	GPR143	1.37
48	Infertility	Enrichment	GNRHR	1.37
49	Usher syndrome, type iia	Enrichment	ADGRV1	1.31
50	Narcolepsy 1	Enrichment	P2RY11	1.25
51	Essential tremor	Enrichment	DRD3	1.25
52	Tracheoesophageal fistula with or without esophageal atresia	Enrichment	CELSR2	1.20
53	Bilateral perisylvian polymicrogyria	Enrichment	ADGRG1	1.20
54	Schizophrenia	Enrichment	DRD3, HTR2A	1.17
55	Isolated tracheo-esophageal fistula	Enrichment	CELSR2	1.16
56	Epilepsy, idiopathic generalized	Enrichment	ADGRV1	1.12
57	Usher syndrome type 2	Enrichment	ADGRV1	1.12
58	Septooptic dysplasia	Enrichment	PROKR2	1.08
59	Meningioma	Enrichment	SMO	1.08
60	46 xx gonadal dysgenesis	Enrichment	FSHR	1.08
61	Neural tube defects	Enrichment	CELSR1	1.05
62	Generalized epilepsy with febrile seizures plus	Enrichment	ADGRV1	1.02
63	Pituitary stalk interruption syndrome	Enrichment	PROKR2	1.02
64	Usher syndrome, type i	Enrichment	ADGRV1	0.99
65	Male infertility with spermatogenesis disorder	Enrichment	PROKR2	0.99
66	Perrault syndrome 1	Enrichment	FSHR	0.96
67	Esophageal atresia/tracheoesophageal fistula	Enrichment	CELSR2	0.89
68	Attention deficit-hyperactivity disorder	Enrichment	DRD4	0.83
69	Malaria	Enrichment	ACKR1	0.81
70	Kallmann syndrome	Enrichment	PROKR2	0.81
71	Ear malformation	Enrichment	ADGRV1	0.80
72	Strabismus	Enrichment	ADGRG1	0.75
73	Hirschsprung disease 1	Enrichment	SMO	0.72
74	Cystic fibrosis	Enrichment	EDNRA	0.68
75	Usher syndrome	Enrichment	ADGRV1	0.67
76	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PROKR2	0.48
77	Deafness, autosomal recessive	Enrichment	ADGRV1	0.43
78	Autosomal recessive nonsyndromic deafness	Enrichment	ADGRV1	0.43
79	Rare genetic deafness	Enrichment	ADGRV1	0.36
80	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	ADGRV1	0.32
81	Congenital nervous system abnormality	Enrichment	ADGRG1	0.27
82	Nervous system disease	Enrichment	ADGRG1	0.27
83	Retinitis pigmentosa	Enrichment	ADGRV1	0.10
84	Hereditary retinal dystrophy	Enrichment	ADGRV1	0.06
85	Fundus dystrophy	Enrichment	ADGRV1	0.06

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for GPCRs, other

Member Pathways for GPCRs, other

Pathways in the GPCRs, other SuperPath

Associated Genes for GPCRs, other

Associated Disorders for GPCRs, other

Disorders associated with GPCRs, other SuperPath

STRING Interaction Network for GPCRs, other

Sources for GPCRs, other