GPR143 in melanocytes and retinal pigment epithelium cells

No Pathway Network information available for GPR143 in melanocytes and retinal pigment epithelium cells

Pathways in the GPR143 in melanocytes and retinal pigment epithelium cells SuperPath

#	Name	Source	Genes
1	GPR143 in melanocytes and retinal pigment epithelium cells	WikiPathways	ADCY2 ADCY4 ADCY9 ARRB1 ARRB2 ASIP CREB1 DCT GNA15 GNAQ GNAS GPR143 ITPR1 LOC105372522 MC1R MITF MLANA PLCB2 PLCB3 PMEL POMC PRKACA PRKACB PRKACG PRKCB SERPINF1 TYR TYRP1 VEGFA (see all 29) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	MC1R	Melanocortin 1 Receptor	Protein Coding	1
2	PLCB3	Phospholipase C Beta 3	Protein Coding	1
3	PLCB2	Phospholipase C Beta 2	Protein Coding	1
4	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	1
5	TYRP1	Tyrosinase Related Protein 1	Protein Coding	1
6	TYR	Tyrosinase	Protein Coding	1
7	PMEL	Premelanosome Protein	Protein Coding	1
8	PRKCB	Protein Kinase C Beta	Protein Coding	1
9	PRKACG	Protein Kinase CAMP-Activated Catalytic Subunit Gamma	Protein Coding	1
10	PRKACB	Protein Kinase CAMP-Activated Catalytic Subunit Beta	Protein Coding	1
11	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	1
12	POMC	Proopiomelanocortin	Protein Coding	1
13	SERPINF1	Serpin Family F Member 1	Protein Coding	1
14	GPR143	G Protein-Coupled Receptor 143	Protein Coding	1
15	ASIP	Agouti Signaling Protein	Protein Coding	1
16	MITF	Melanocyte Inducing Transcription Factor	Protein Coding	1
17	ARRB2	Arrestin Beta 2	Protein Coding	1
18	ARRB1	Arrestin Beta 1	Protein Coding	1
19	ITPR1	Inositol 1,4,5-Trisphosphate Receptor Type 1	Protein Coding	1
20	GNAS	GNAS Complex Locus	Protein Coding	1
21	GNAQ	G Protein Subunit Alpha Q	Protein Coding	1
22	MLANA	Melan-A	Protein Coding	1
23	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	1
24	ADCY2	Adenylate Cyclase 2	Protein Coding	1
25	ADCY4	Adenylate Cyclase 4	Protein Coding	1
26	DCT	Dopachrome Tautomerase	Protein Coding	1
27	ADCY9	Adenylate Cyclase 9	Protein Coding	1
28	LOC105372522	Uncharacterized LOC105372522	RNA Gene	1
29	GNA15	G Protein Subunit Alpha 15	Protein Coding	1

Disorders associated with GPR143 in melanocytes and retinal pigment epithelium cells SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Albinism	Enrichment	DCT, GPR143, TYR, TYRP1	9.58
2	Albinism, ocular, type i	Enrichment	GPR143, TYR, TYRP1	6.76
3	Melanoma, cutaneous malignant 8	Enrichment	MITF, TYR	5.36
4	Albinism, oculocutaneous, type ii	Enrichment	MC1R, TYRP1	4.36
5	Waardenburg syndrome, type 2e	Enrichment	MITF, TYR	4.04
6	Oculocutaneous albinism	Enrichment	TYR, TYRP1	4.04
7	Ellis-van creveld syndrome	Enrichment	PRKACA, PRKACB	3.80
8	Melanoma	Enrichment	MC1R, MITF	3.71
9	Melanoma, cutaneous malignant 1	Enrichment	MC1R, MITF	3.23
10	Nystagmus 6, congenital, x-linked	Enrichment	GPR143	2.67
11	Albinism, oculocutaneous, type ib	Enrichment	TYR	2.67
12	Pseudohypoparathyroidism, type ic	Enrichment	GNAS	2.67
13	Osseous heteroplasia, progressive	Enrichment	GNAS	2.67
14	Heterochromia iridis	Enrichment	MITF	2.67
15	Tietz albinism-deafness syndrome	Enrichment	MITF	2.67
16	Increased analgesia from kappa-opioid receptor agonist, female-specific	Enrichment	MC1R	2.67
17	Sturge-weber syndrome	Enrichment	GNAQ	2.67
18	Acth-independent macronodular adrenal hyperplasia 1	Enrichment	GNAS	2.67
19	Skin/hair/eye pigmentation, variation in, 3	Enrichment	TYR	2.67
20	Spondylometaphyseal dysplasia with corneal dystrophy	Enrichment	PLCB3	2.67
21	Pituitary adenoma 3, multiple types	Enrichment	GNAS	2.67
22	Skin/hair/eye pigmentation, variation in, 2	Enrichment	MC1R	2.67
23	Cardioacrofacial dysplasia 2	Enrichment	PRKACB	2.67
24	Coloboma, osteopetrosis, microphthalmia, macrocephaly, albinism, and deafness	Enrichment	MITF	2.67
25	Microvascular complications of diabetes 1	Enrichment	VEGFA	2.67
26	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	2.67
27	Melanoma, cutaneous malignant 5	Enrichment	MC1R	2.67
28	Skin/hair/eye pigmentation, variation in, 9	Enrichment	ASIP	2.67
29	Disorders of gnas inactivation	Enrichment	GNAS	2.67
30	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	2.67
31	Minimal pigment oculocutaneous albinism type 1	Enrichment	TYR	2.67
32	Monostotic fibrous dysplasia	Enrichment	GNAS	2.67
33	Mazabraud syndrome	Enrichment	GNAS	2.67
34	Hypopigmentation of the skin	Enrichment	TYR	2.67
35	Spinocerebellar ataxia 29	Enrichment	ITPR1	2.37
36	Pseudohypoparathyroidism, type ia	Enrichment	GNAS	2.37
37	Albinism, oculocutaneous, type iii	Enrichment	TYRP1	2.37
38	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	2.37
39	Pigmented nodular adrenocortical disease, primary, 1	Enrichment	GNAS	2.37
40	Pseudopseudohypoparathyroidism	Enrichment	GNAS	2.37
41	Bleeding disorder, platelet-type, 19	Enrichment	PRKACG	2.37
42	Albinism, oculocutaneous, type ia	Enrichment	TYR	2.37
43	Skin/hair/eye pigmentation, variation in, 11	Enrichment	TYRP1	2.37
44	Oculocutaneous albinism, type viii	Enrichment	DCT	2.37
45	Pseudohypoparathyroidism	Enrichment	GNAS	2.37
46	Papillary renal cell carcinoma	Enrichment	MITF	2.37
47	Fibrolamellar carcinoma	Enrichment	PRKACA	2.37
48	Acth-independent macronodular adrenal hyperplasia	Enrichment	GNAS	2.37
49	Phakomatosis cesioflammea	Enrichment	GNAQ	2.37
50	Body mass index quantitative trait locus 11	Enrichment	GNAS, POMC	2.29
51	Mccune-albright syndrome	Enrichment	GNAS	2.19
52	Waardenburg syndrome, type 2a	Enrichment	MITF	2.19
53	Gillespie syndrome	Enrichment	ITPR1	2.19
54	Obesity, early-onset, with adrenal insufficiency and red hair	Enrichment	POMC	2.19
55	Osteogenesis imperfecta, type vi	Enrichment	SERPINF1	2.19
56	Cushing syndrome due to bilateral macronodular adrenocortical disease	Enrichment	GNAS	2.19
57	Melanoma of soft tissue	Enrichment	CREB1	2.19
58	Anastomosing haemangioma	Enrichment	GNAQ	2.19
59	Obesity due to pro-opiomelanocortin deficiency	Enrichment	POMC	2.19
60	Pseudohypoparathyroidism, type ib	Enrichment	GNAS	2.07
61	Spinocerebellar ataxia 15	Enrichment	ITPR1	2.07
62	Clear cell papillary renal cell carcinoma	Enrichment	MITF	2.07
63	Capillary malformations, congenital	Enrichment	GNAQ	1.97
64	Klippel-trenaunay-weber syndrome	Enrichment	GNAQ	1.89
65	Melanoma, uveal	Enrichment	GNAQ	1.89
66	Waardenburg syndrome, type 4a	Enrichment	MITF	1.89
67	Spinocerebellar ataxia, autosomal recessive 16	Enrichment	ITPR1	1.89
68	Waardenburg syndrome	Enrichment	MITF	1.89
69	Waardenburg syndrome, type 1	Enrichment	MITF	1.83
70	Brachydactyly	Enrichment	GNAS	1.83
71	Spastic paraplegia 4, autosomal dominant	Enrichment	GNAS	1.77
72	Primary hyperaldosteronism	Enrichment	GNAS	1.72
73	Optic nerve disease	Enrichment	TYR	1.67
74	Osteogenesis imperfecta, type iv	Enrichment	SERPINF1	1.56
75	Multiple sclerosis	Enrichment	ITPR1	1.53
76	Osteogenesis imperfecta, type iii	Enrichment	SERPINF1	1.50
77	Myopia	Enrichment	TYR	1.50
78	Anterior segment dysgenesis	Enrichment	ITPR1	1.50
79	Skin disease	Enrichment	TYR	1.34
80	Brittle bone disorder	Enrichment	SERPINF1	1.32
81	Ear malformation	Enrichment	MITF	1.30
82	Strabismus	Enrichment	TYR	1.25
83	Eye disease	Enrichment	TYR	1.14
84	Non-syndromic genetic deafness	Enrichment	MITF	1.13
85	Nonsyndromic hearing loss	Enrichment	MITF	1.07
86	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	MITF	0.98
87	Spastic ataxia	Enrichment	ITPR1	0.97
88	Hereditary breast ovarian cancer syndrome	Enrichment	MITF	0.95
89	Rare genetic deafness	Enrichment	MITF	0.81
90	Inherited cancer-predisposing syndrome	Enrichment	MITF	0.61

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

GPR143 in melanocytes and retinal pigment epithelium cells

Pathway Network for GPR143 in melanocytes and retinal pigment epithelium cells

Member Pathways for GPR143 in melanocytes and retinal pigment epithelium cells

Pathways in the GPR143 in melanocytes and retinal pigment epithelium cells SuperPath

Associated Genes for GPR143 in melanocytes and retinal pigment epithelium cells

Associated Disorders for GPR143 in melanocytes and retinal pigment epithelium cells

Disorders associated with GPR143 in melanocytes and retinal pigment epithelium cells SuperPath

STRING Interaction Network for GPR143 in melanocytes and retinal pigment epithelium cells

Sources for GPR143 in melanocytes and retinal pigment epithelium cells