GPR40 pathway

No Pathway Network information available for GPR40 pathway

Pathways in the GPR40 pathway SuperPath

#	Name	Source	Genes
1	GPR40 pathway	WikiPathways	FFAR1 GNA11 ITPR3 LOC105372522 PKD1 PLCB2 PLCB3 PLCD1 PLCD3 PLCE1 PLCG1 PLCG2 PLCH1 PLCL1 PLCZ1 (see all 15) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PLCB3	Phospholipase C Beta 3	Protein Coding	1
2	PLCB2	Phospholipase C Beta 2	Protein Coding	1
3	PLCH1	Phospholipase C Eta 1	Protein Coding	1
4	PLCD3	Phospholipase C Delta 3	Protein Coding	1
5	PLCZ1	Phospholipase C Zeta 1	Protein Coding	1
6	PLCG2	Phospholipase C Gamma 2	Protein Coding	1
7	PLCG1	Phospholipase C Gamma 1	Protein Coding	1
8	PLCD1	Phospholipase C Delta 1	Protein Coding	1
9	PKD1	Polycystin 1, Transient Receptor Potential Channel Interacting	Protein Coding	1
10	PLCE1	Phospholipase C Epsilon 1	Protein Coding	1
11	ITPR3	Inositol 1,4,5-Trisphosphate Receptor Type 3	Protein Coding	1
12	GNA11	G Protein Subunit Alpha 11	Protein Coding	1
13	LOC105372522	Uncharacterized LOC105372522	RNA Gene	1
14	PLCL1	Phospholipase C Like 1 (Inactive)	Protein Coding	1
15	FFAR1	Free Fatty Acid Receptor 1	Protein Coding	1

Disorders associated with GPR40 pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Hypocalciuric hypercalcemia, familial, type ii	Enrichment	GNA11	2.96
2	Nail disorder, nonsyndromic congenital, 3	Enrichment	PLCD1	2.96
3	Spondylometaphyseal dysplasia with corneal dystrophy	Enrichment	PLCB3	2.96
4	Charcot-marie-tooth disease, demyelinating, type 1j	Enrichment	ITPR3	2.96
5	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.96
6	Autoinflammation, antibody deficiency, and immune dysregulation	Enrichment	PLCG2	2.96
7	Hypocalcemia, autosomal dominant 2	Enrichment	GNA11	2.96
8	Familial cold autoinflammatory syndrome 3	Enrichment	PLCG2	2.96
9	Holoprosencephaly 14	Enrichment	PLCH1	2.96
10	Immunodeficiency 133 with ectodermal dysplasia with or without peripheral neuropathy	Enrichment	ITPR3	2.96
11	Renovascular hypertension	Enrichment	PKD1	2.96
12	Phakomatosis cesiomarmorata	Enrichment	GNA11	2.96
13	Cutis marmorata telangiectatica congenita	Enrichment	GNA11	2.66
14	Spermatogenic failure 17	Enrichment	PLCZ1	2.66
15	Autosomal dominant hypocalcemia	Enrichment	GNA11	2.66
16	Polycystic kidney disease 3	Enrichment	PKD1	2.66
17	Phakomatosis cesioflammea	Enrichment	GNA11	2.66
18	Polycystic kidney disease, infantile severe, with tuberous sclerosis	Enrichment	PKD1	2.48
19	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	GNA11	2.48
20	Nephrotic syndrome, type 3	Enrichment	PLCE1	2.48
21	Tuberous sclerosis 2	Enrichment	PKD1	2.48
22	End stage renal disease	Enrichment	PKD1	2.48
23	Anastomosing haemangioma	Enrichment	GNA11	2.48
24	Tuberous sclerosis	Enrichment	PKD1	2.35
25	Capillary malformations, congenital	Enrichment	GNA11	2.26
26	Polycystic liver disease 1 with or without kidney cysts	Enrichment	PKD1	2.26
27	Polycystic kidney disease 3 with or without polycystic liver disease	Enrichment	PKD1	2.26
28	Polycystic liver disease 1	Enrichment	PKD1	2.26
29	Hemangioma	Enrichment	PKD1	2.26
30	Melanoma, uveal	Enrichment	GNA11	2.18
31	Renal dysplasia, cystic	Enrichment	PKD1	2.18
32	Multicystic kidney dysplasia	Enrichment	PKD1	2.18
33	Multicystic dysplastic kidney	Enrichment	PKD1	2.18
34	Polycystic kidney disease 1 with or without polycystic liver disease	Enrichment	PKD1	2.11
35	Polycystic kidney disease 1	Enrichment	PKD1	2.11
36	Polycystic kidney disease 4 with or without polycystic liver disease	Enrichment	PKD1	2.05
37	Nephrotic syndrome, type 1	Enrichment	PLCE1	2.00
38	Cystic kidney disease	Enrichment	PKD1	2.00
39	Congenital long qt syndrome	Enrichment	ITPR3	1.88
40	Autosomal dominant polycystic kidney disease	Enrichment	PKD1	1.78
41	Kidney disease	Enrichment	PKD1	1.78
42	Creatine phosphokinase, elevated serum	Enrichment	PKD1	1.76
43	Hypertension	Enrichment	PKD1	1.76
44	Isolated elevated serum creatine phosphokinase levels	Enrichment	PKD1	1.76
45	Alobar holoprosencephaly	Enrichment	PLCH1	1.73
46	Polycystic kidney disease	Enrichment	PKD1	1.70
47	Focal segmental glomerulosclerosis	Enrichment	PLCE1	1.66
48	Long qt syndrome 1	Enrichment	ITPR3	1.49
49	Genetic steroid-resistant nephrotic syndrome	Enrichment	PLCE1	1.43
50	Nephrotic syndrome	Enrichment	PLCE1	1.33
51	Inherited cancer-predisposing syndrome	Enrichment	PKD1	0.86

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for GPR40 pathway

Member Pathways for GPR40 pathway

Pathways in the GPR40 pathway SuperPath

Associated Genes for GPR40 pathway

Associated Disorders for GPR40 pathway

Disorders associated with GPR40 pathway SuperPath

STRING Interaction Network for GPR40 pathway

Sources for GPR40 pathway