Granzyme Pathway

No Pathway Network information available for Granzyme Pathway

Pathways in the Granzyme Pathway SuperPath

#	Name	Source	Genes
1	Granzyme Pathway	QIAGEN	ANP32A APAF1 APEX1 BID CASP3 CASP6 CASP7 CASP8 CASP9 CYCS DFFA DFFB GZMA GZMB GZMH GZMK GZMM HMGB2 LMNA LMNB1 LMNB2 NME1 NUMA1 PARP1 PARP10 PARP11 PARP14 PARP15 PARP16 PARP3 PARP4 PARP8 PRF1 PRKDC SET (see all 35) (see less)
2	Granzyme-B Pathway	QIAGEN	APAF1 BID CASP3 CASP6 CASP7 CASP8 CASP9 CYCS DFFA ENDOG GZMB LMNB1 LMNB2 NUMA1 PARP1 PRF1 PRKDC (see all 17) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PARP1	Poly(ADP-Ribose) Polymerase 1	Protein Coding	2
2	APAF1	Apoptotic Peptidase Activating Factor 1	Protein Coding	2
3	BID	BH3 Interacting Domain Death Agonist	Protein Coding	2
4	CASP3	Caspase 3	Protein Coding	2
5	CASP6	Caspase 6	Protein Coding	2
6	CASP7	Caspase 7	Protein Coding	2
7	CASP8	Caspase 8	Protein Coding	2
8	CASP9	Caspase 9	Protein Coding	2
9	CYCS	Cytochrome C, Somatic	Protein Coding	2
10	DFFA	DNA Fragmentation Factor Subunit Alpha	Protein Coding	2
11	GZMB	Granzyme B	Protein Coding	2
12	LMNB1	Lamin B1	Protein Coding	2
13	LMNB2	Lamin B2	Protein Coding	2
14	NUMA1	Nuclear Mitotic Apparatus Protein 1	Protein Coding	2
15	PRF1	Perforin 1	Protein Coding	2
16	PRKDC	Protein Kinase, DNA-Activated, Catalytic Subunit	Protein Coding	2
17	PARP4	Poly(ADP-Ribose) Polymerase Family Member 4	Protein Coding	1
18	PARP3	Poly(ADP-Ribose) Polymerase Family Member 3	Protein Coding	1
19	ANP32A	Acidic Nuclear Phosphoprotein 32 Family Member A	Protein Coding	1
20	APEX1	Apurinic/Apyrimidinic Endodeoxyribonuclease 1	Protein Coding	1
21	PARP11	Poly(ADP-Ribose) Polymerase Family Member 11	Protein Coding	1
22	DFFB	DNA Fragmentation Factor Subunit Beta	Protein Coding	1
23	PARP10	Poly(ADP-Ribose) Polymerase Family Member 10	Protein Coding	1
24	PARP16	Poly(ADP-Ribose) Polymerase Family Member 16	Protein Coding	1
25	PARP8	Poly(ADP-Ribose) Polymerase Family Member 8	Protein Coding	1
26	PARP15	Poly(ADP-Ribose) Polymerase Family Member 15	Protein Coding	1
27	GZMA	Granzyme A	Protein Coding	1
28	GZMH	Granzyme H	Protein Coding	1
29	GZMK	Granzyme K	Protein Coding	1
30	GZMM	Granzyme M	Protein Coding	1
31	HMGB2	High Mobility Group Box 2	Protein Coding	1
32	PARP14	Poly(ADP-Ribose) Polymerase Family Member 14	Protein Coding	1
33	LMNA	Lamin A/C	Protein Coding	1
34	NME1	NME/NM23 Nucleoside Diphosphate Kinase 1	Protein Coding	1
35	SET	SET Nuclear Proto-Oncogene	Protein Coding	1
36	ENDOG	Endonuclease G	Protein Coding	1

Disorders associated with Granzyme Pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Leukodystrophy, demyelinating, adult-onset, autosomal dominant, typical	Enrichment	LMNB1	2.90
2	Hemophagocytic lymphohistiocytosis, familial, 2	Enrichment	PRF1	2.90
3	Caspase 8 deficiency	Enrichment	CASP8	2.90
4	Adult onset demyelinating leukodystrophy	Enrichment	LMNB1	2.90
5	Epilepsy, progressive myoclonic, 9	Enrichment	LMNB2	2.90
6	Thrombocytopenia 4	Enrichment	CYCS	2.90
7	Lipodystrophy, partial, acquired	Enrichment	LMNB2	2.90
8	Immunodeficiency 26 with or without neurologic abnormalities	Enrichment	PRKDC	2.90
9	Microcephaly 26, primary, autosomal dominant	Enrichment	LMNB1	2.90
10	Microcephaly 27, primary, autosomal dominant	Enrichment	LMNB2	2.90
11	Fatal post-viral neurodegenerative disorder	Enrichment	PRF1	2.90
12	Lipomatosis, multiple symmetric, with or without axonal peripheral neuropathy	Enrichment	LMNB2	2.60
13	Autosomal dominant primary microcephaly	Enrichment	LMNB1	2.60
14	Atypical werner syndrome	Enrichment	LMNA	2.59
15	Mandibuloacral dysplasia	Enrichment	LMNA	2.59
16	Atrioventricular block	Enrichment	LMNA	2.59
17	Lmna-related cardiocutaneous progeria syndrome	Enrichment	LMNA	2.59
18	Autosomal semi-dominant severe lipodystrophic laminopathy	Enrichment	LMNA	2.59
19	Autosomal recessive axonal hereditary motor and sensory neuropathy	Enrichment	LMNA	2.59
20	Laminopathy	Enrichment	LMNA	2.59
21	Mandibuloacral dysplasia with type a lipodystrophy	Enrichment	LMNA	2.29
22	Heart-hand syndrome, slovenian type	Enrichment	LMNA	2.29
23	Charcot-marie-tooth disease, axonal, type 2b1	Enrichment	LMNA	2.29
24	Cardiomyopathy, dilated, with hypergonadotropic hypogonadism	Enrichment	LMNA	2.29
25	Cardiomyopathy, dilated, 1d	Enrichment	LMNA	2.29
26	Restrictive dermopathy 2	Enrichment	LMNA	2.29
27	Emery-dreifuss muscular dystrophy 3, autosomal recessive	Enrichment	LMNA	2.29
28	Lipodystrophy, familial partial, type 1	Enrichment	LMNA	2.29
29	Intellectual developmental disorder, autosomal dominant 58	Enrichment	SET	2.29
30	Familial partial lipodystrophy	Enrichment	LMNA	2.29
31	Charcot-marie-tooth disease type 2b1	Enrichment	LMNA	2.29
32	Hemophagocytic lymphohistiocytosis, familial, 1	Enrichment	PRF1	2.20
33	Autosomal thrombocytopenia with normal platelets	Enrichment	CYCS	2.20
34	Idiopathic aplastic anemia	Enrichment	PRF1	2.20
35	Restrictive dermopathy 1	Enrichment	LMNA	2.11
36	Lipodystrophy, familial partial, type 2	Enrichment	LMNA	2.11
37	Muscular dystrophy, congenital, lmna-related	Enrichment	LMNA	2.11
38	Restrictive dermopathy	Enrichment	LMNA	2.11
39	Lymphoma, non-hodgkin, familial	Enrichment	PRF1	2.00
40	Hutchinson-gilford progeria syndrome	Enrichment	LMNA	1.99
41	Emery-dreifuss muscular dystrophy 1, x-linked	Enrichment	LMNA	1.99
42	Microtia-anotia	Enrichment	LMNA	1.99
43	Emery-dreifuss muscular dystrophy	Enrichment	LMNA	1.99
44	Sick sinus syndrome	Enrichment	LMNA	1.99
45	Adult hepatocellular carcinoma	Enrichment	CASP8	1.95
46	Aplastic anemia	Enrichment	PRF1	1.90
47	Autosomal recessive limb-girdle muscular dystrophy type 2b	Enrichment	LMNA	1.89
48	Histiocytoid hemangioma	Enrichment	LMNA	1.89
49	Emery-dreifuss muscular dystrophy 2, autosomal dominant	Enrichment	LMNA	1.81
50	Acute promyelocytic leukemia	Enrichment	NUMA1	1.79
51	Bethlem myopathy 1a	Enrichment	LMNA	1.75
52	Congenital muscular dystrophy	Enrichment	LMNA	1.69
53	Myocarditis	Enrichment	LMNA	1.69
54	Arrhythmogenic right ventricular dysplasia, familial, 9	Enrichment	LMNA	1.64
55	Hepatocellular carcinoma	Enrichment	CASP8	1.56
56	Autoinflammatory disease	Enrichment	PRF1	1.53
57	Cardiac conduction defect	Enrichment	LMNA	1.52
58	Muscular dystrophy, limb-girdle, autosomal recessive 2	Enrichment	LMNA	1.52
59	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant	Enrichment	LMNA	1.52
60	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant	Enrichment	LMNA	1.52
61	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	LMNA	1.45
62	Lung cancer	Enrichment	CASP8	1.40
63	Arrhythmogenic right ventricular cardiomyopathy	Enrichment	LMNA	1.39
64	Cardiomyopathy, dilated, 1e	Enrichment	LMNA	1.37
65	Neuromuscular disease	Enrichment	LMNA	1.34
66	Neuropathy, hereditary motor and sensory, okinawa type	Enrichment	LMNA	1.32
67	Cardiomyopathy, dilated, 1a	Enrichment	LMNA	1.28
68	Precursor t-cell acute lymphoblastic leukemia	Enrichment	SET	1.24
69	Thrombocytopenia	Enrichment	CYCS	1.23
70	Cardiomyopathy, familial hypertrophic, 1	Enrichment	LMNA	1.22
71	Muscular dystrophy	Enrichment	LMNA	1.22
72	Brugada syndrome	Enrichment	LMNA	1.19
73	Long qt syndrome	Enrichment	LMNA	1.11
74	Peripheral nervous system disease	Enrichment	LMNA	1.10
75	Neuropathy	Enrichment	LMNA	1.10
76	Left ventricular noncompaction	Enrichment	LMNA	1.06
77	Breast cancer	Enrichment	CASP8	1.05
78	Charcot-marie-tooth disease	Enrichment	LMNA	1.00
79	Autosomal dominant non-syndromic intellectual disability	Enrichment	SET	0.92
80	Familial isolated dilated cardiomyopathy	Enrichment	LMNA	0.89
81	Dilated cardiomyopathy	Enrichment	LMNA	0.73

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Granzyme Pathway

Member Pathways for Granzyme Pathway

Pathways in the Granzyme Pathway SuperPath

Associated Genes for Granzyme Pathway

Associated Disorders for Granzyme Pathway

Disorders associated with Granzyme Pathway SuperPath

STRING Interaction Network for Granzyme Pathway

Sources for Granzyme Pathway