Growth hormone receptor signaling

No Pathway Network information available for Growth hormone receptor signaling

Pathways in the Growth hormone receptor signaling SuperPath

#	Name	Source	Genes
1	Growth hormone receptor signaling	Reactome	ADAM17 CISH CSH1 GH1 GH2 GHR IRS1 IRS2 JAK2 LYN MAPK1 MAPK3 PRL PRLR PTPN1 PTPN6 SH2B1 SOCS1 SOCS2 SOCS3 STAT1 STAT3 STAT5A STAT5B (see all 24) (see less)
2	Prolactin receptor signaling	Reactome	BTRC CSH1 CUL1 GH1 GH2 GHR JAK2 PRL PRLR PTPN11 RBX1 SH2B1 SKP1 STAT5A STAT5B (see all 15) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CSH1	Chorionic Somatomammotropin Hormone 1	Protein Coding	2
2	SH2B1	SH2B Adaptor Protein 1	Protein Coding	2
3	GH1	Growth Hormone 1	Protein Coding	2
4	GH2	Growth Hormone 2	Protein Coding	2
5	GHR	Growth Hormone Receptor	Protein Coding	2
6	JAK2	Janus Kinase 2	Protein Coding	2
7	PRL	Prolactin	Protein Coding	2
8	PRLR	Prolactin Receptor	Protein Coding	2
9	STAT5A	Signal Transducer And Activator Of Transcription 5A	Protein Coding	2
10	STAT5B	Signal Transducer And Activator Of Transcription 5B	Protein Coding	2
11	CISH	Cytokine Inducible SH2 Containing Protein	Protein Coding	1
12	IRS1	Insulin Receptor Substrate 1	Protein Coding	1
13	LYN	LYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
14	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
15	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
16	PTPN1	Protein Tyrosine Phosphatase Non-Receptor Type 1	Protein Coding	1
17	PTPN6	Protein Tyrosine Phosphatase Non-Receptor Type 6	Protein Coding	1
18	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	1
19	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
20	ADAM17	ADAM Metallopeptidase Domain 17	Protein Coding	1
21	SOCS1	Suppressor Of Cytokine Signaling 1	Protein Coding	1
22	IRS2	Insulin Receptor Substrate 2	Protein Coding	1
23	SOCS2	Suppressor Of Cytokine Signaling 2	Protein Coding	1
24	SOCS3	Suppressor Of Cytokine Signaling 3	Protein Coding	1
25	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	1
26	SKP1	S-Phase Kinase Associated Protein 1	Protein Coding	1
27	CUL1	Cullin 1	Protein Coding	1
28	BTRC	Beta-Transducin Repeat Containing E3 Ubiquitin Protein Ligase	Protein Coding	1
29	RBX1	Ring-Box 1	Protein Coding	1

Disorders associated with Growth hormone receptor signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK2, STAT3	5.05
2	Primary ovarian insufficiency	Enrichment	JAK2, PRLR, SH2B1	4.47
3	Type 2 diabetes mellitus	Enrichment	IRS1, IRS2, PTPN1	4.27
4	Specific learning disability	Enrichment	GHR, PTPN11	4.20
5	Acute promyelocytic leukemia	Enrichment	STAT3, STAT5B	3.64
6	Diffuse large b-cell lymphoma	Enrichment	SOCS1, STAT3	3.30
7	Metachondromatosis	Enrichment	PTPN11	2.96
8	Leopard syndrome 1	Enrichment	PTPN11	2.96
9	Multiple fibroadenomas of the breast	Enrichment	PRLR	2.96
10	Growth hormone insensitivity syndrome with immune dysregulation 2, autosomal dominant	Enrichment	STAT5B	2.96
11	Laron syndrome	Enrichment	GHR	2.96
12	Hyperprolactinemia	Enrichment	PRLR	2.96
13	Growth hormone insensitivity, partial	Enrichment	GHR	2.96
14	Familial hyperprolactinemia	Enrichment	PRLR	2.96
15	Severe early-onset obesity-insulin resistance syndrome due to sh2b1 deficiency	Enrichment	SH2B1	2.96
16	Malignant astrocytoma	Enrichment	PTPN11	2.96
17	Dermatitis, atopic, 4	Enrichment	SOCS3	2.75
18	Noonan syndrome 13	Enrichment	MAPK1	2.75
19	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.75
20	Immunodeficiency 31a	Enrichment	STAT1	2.75
21	Immunodeficiency 31b	Enrichment	STAT1	2.75
22	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.75
23	Autoinflammatory disease, systemic, with vasculitis	Enrichment	LYN	2.75
24	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.75
25	Vegetative pyoderma gangrenosum	Enrichment	PTPN6	2.75
26	Bullous pyoderma gangrenosum	Enrichment	PTPN6	2.75
27	Pustular pyoderma gangrenosum	Enrichment	PTPN6	2.75
28	Classic pyoderma gangrenosum	Enrichment	PTPN6	2.75
29	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.75
30	Growth hormone insensitivity syndrome with immune dysregulation 1, autosomal recessive	Enrichment	STAT5B	2.66
31	Chromosome 16p11.2 deletion syndrome, 220-kb	Enrichment	SH2B1	2.66
32	Growth hormone deficiency, isolated partial	Enrichment	GHR	2.66
33	Thrombocythemia 3	Enrichment	JAK2	2.66
34	Werner syndrome	Enrichment	PTPN11	2.66
35	Kowarski syndrome	Enrichment	GH1	2.66
36	Chromosome 16p11.2 deletion syndrome, 593-kb	Enrichment	SH2B1	2.66
37	Polycythemia	Enrichment	JAK2	2.66
38	Short stature due to growth hormone qualitative anomaly	Enrichment	GH1	2.66
39	Hypereosinophilic syndrome	Enrichment	JAK2	2.66
40	Laron syndrome with immunodeficiency	Enrichment	STAT5B	2.66
41	Polycythemia vera	Enrichment	JAK2	2.48
42	Isolated growth hormone deficiency, type ib	Enrichment	GH1	2.48
43	Tricuspid valve insufficiency	Enrichment	PTPN11	2.48
44	Immunodeficiency 31c	Enrichment	STAT1	2.45
45	Inflammatory skin and bowel disease, neonatal, 1	Enrichment	ADAM17	2.45
46	Isolated growth hormone deficiency, type ii	Enrichment	GH1	2.35
47	Erythrocytosis, familial, 1	Enrichment	JAK2	2.35
48	Budd-chiari syndrome	Enrichment	JAK2	2.35
49	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	PTPN11	2.35
50	Noonan syndrome with multiple lentigines	Enrichment	PTPN11	2.35
51	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	2.28
52	Immune thrombocytopenia	Enrichment	SOCS1	2.28
53	Neutrophilic dermatosis, acute febrile	Enrichment	PTPN6	2.28
54	Autoinflammatory syndrome, familial, with or without immunodeficiency	Enrichment	SOCS1	2.28
55	Bacteremia 2	Enrichment	CISH	2.28
56	Hyper ige syndrome	Enrichment	STAT3	2.28
57	Neonatal inflammatory skin and bowel disease	Enrichment	ADAM17	2.28
58	Lymphoma	Enrichment	PTPN11	2.26
59	Myeloproliferative neoplasm	Enrichment	JAK2	2.26
60	Patent ductus arteriosus	Enrichment	PTPN11	2.18
61	Anemia, autoimmune hemolytic	Enrichment	SOCS1	2.15
62	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	2.15
63	Tuberculosis	Enrichment	CISH	2.15
64	Myelofibrosis	Enrichment	JAK2	2.11
65	Noonan syndrome 3	Enrichment	PTPN11	2.11
66	Essential thrombocythemia	Enrichment	JAK2	2.11
67	Isolated growth hormone deficiency, type ia	Enrichment	GH1	2.05
68	Isolated split hand-split foot malformation	Enrichment	BTRC	2.05
69	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	2.00
70	Chronic mucocutaneous candidiasis	Enrichment	STAT1	1.98
71	Pectus excavatum	Enrichment	PTPN11	1.92
72	Epicanthus	Enrichment	PTPN11	1.88
73	Juvenile myelomonocytic leukemia	Enrichment	PTPN11	1.88
74	Congenital long qt syndrome	Enrichment	PTPN11	1.88
75	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.85
76	Hypercholesterolemia, familial, 1	Enrichment	GHR	1.85
77	Familial hypercholesterolemia	Enrichment	GHR	1.78
78	Noonan syndrome and noonan-related syndrome	Enrichment	PTPN11	1.78
79	Patent foramen ovale	Enrichment	PTPN11	1.70
80	Noonan syndrome 1	Enrichment	PTPN11	1.60
81	Scoliosis	Enrichment	PTPN11	1.58
82	Hydrops fetalis, nonimmune	Enrichment	PTPN11	1.55
83	Rasopathy	Enrichment	PTPN11	1.55
84	Strabismus	Enrichment	PTPN11	1.53
85	Heart, malformation of	Enrichment	MAPK1	1.50
86	Long qt syndrome 1	Enrichment	PTPN11	1.49
87	Non-immune hydrops fetalis	Enrichment	PTPN11	1.47
88	Malaria	Enrichment	CISH	1.40
89	Leukemia, acute myeloid	Enrichment	JAK2	1.36
90	Hypertrophic cardiomyopathy	Enrichment	PTPN11	1.33
91	Thrombocytopenia	Enrichment	PTPN11	1.29
92	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	1.22
93	Systemic lupus erythematosus	Enrichment	SOCS1	1.18
94	Autism spectrum disorder	Enrichment	PTPN11	0.94
95	Microcephaly	Enrichment	PTPN11	0.89
96	Inherited cancer-predisposing syndrome	Enrichment	PTPN11	0.86

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Growth hormone receptor signaling

Pathway Network for Growth hormone receptor signaling

Member Pathways for Growth hormone receptor signaling

Pathways in the Growth hormone receptor signaling SuperPath

Associated Genes for Growth hormone receptor signaling

Associated Disorders for Growth hormone receptor signaling

Disorders associated with Growth hormone receptor signaling SuperPath

STRING Interaction Network for Growth hormone receptor signaling

Sources for Growth hormone receptor signaling