Guidance Cues and Growth Cone Motility

No Pathway Network information available for Guidance Cues and Growth Cone Motility

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

Disorders associated with Guidance Cues and Growth Cone Motility SuperPath

according to GeneCards Suite gene sharing
#DisorderTypeGenesScore
1Mirror movements 1EnrichmentDCC, NTN13.36
2Neuropathy, hereditary sensory and autonomic, type vEnrichmentNGF, NTRK12.82
3Pilomyxoid astrocytomaEnrichmentNTRK2, SRGAP32.82
4CakutEnrichmentROBO1, SLIT2, SRGAP12.51
5Heart diseaseEnrichmentABL1, MYL22.20
6Arthritis, sacroiliacEnrichmentRELN2.06
7Cystic angiomatosis of bone, diffuseEnrichmentRASA12.06
8Nystagmus 8, congenital, autosomal recessiveEnrichmentROBO12.06
9Intellectual developmental disorder, x-linked 30EnrichmentPAK32.06
10Developmental and epileptic encephalopathy 8EnrichmentARHGEF92.06
11Immunodeficiency 73a with defective neutrophil chemotaxis and leukocytosisEnrichmentRAC22.06
12Cardiomyopathy, familial hypertrophic, 8EnrichmentMYL32.06
13Amyloidosis, finnish typeEnrichmentGSN2.06
14Ataxia-oculomotor apraxia 3EnrichmentPIK3R52.06
15Lissencephaly 7 with cerebellar hypoplasiaEnrichmentCDK52.06
16Immunodeficiency 62EnrichmentARHGEF12.06
17Neurodevelopmental disorder with midbrain and hindbrain malformationsEnrichmentARHGEF22.06
18Developmental and epileptic encephalopathy 58EnrichmentNTRK22.06
19Knobloch syndrome 2EnrichmentPAK22.06
20Neurodevelopmental disorder with structural brain anomalies and dysmorphic faciesEnrichmentRAC32.06
21Short syndromeEnrichmentPIK3R12.06
22Intellectual developmental disorder with macrocephaly, seizures, and speech delayEnrichmentPAK12.06
23Immune dysregulation, autoimmunity, and autoinflammationEnrichmentPLCG12.06
24Mirror movements 4EnrichmentNTN12.06
25Intellectual developmental disorder, x-linked 46EnrichmentARHGEF62.06
26Immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemiaEnrichmentRAC22.06
27Atrial fibrillation, familial, 18EnrichmentMYL42.06
28Nemaline myopathy 7EnrichmentCFL22.06
29Slowed nerve conduction velocity, autosomal dominantEnrichmentARHGEF102.06
30Immunodeficiency 36 with lymphoproliferationEnrichmentPIK3R12.06
31Autoinflammation, antibody deficiency, and immune dysregulationEnrichmentPLCG22.06
32Hypogonadotropic hypogonadism 16 with or without anosmiaEnrichmentSEMA3A2.06
33Spinocerebellar ataxia 37EnrichmentDAB12.06
34SynovitisEnrichmentRELN2.06
35Agammaglobulinemia 7, autosomal recessiveEnrichmentPIK3R12.06
36Obesity, hyperphagia, and developmental delayEnrichmentNTRK22.06
37Brain small vessel disease 5 with osteoporosisEnrichmentARHGEF152.06
38Familial cold autoinflammatory syndrome 3EnrichmentPLCG22.06
39Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomaliesEnrichmentRHOA2.06
40Spastic paraplegia 75, autosomal recessiveEnrichmentMAG2.06
41Takenouchi-kosaki syndromeEnrichmentCDC422.06
42Gaze palsy, familial horizontal, with progressive scoliosis 2, with impaired intellectual developmentEnrichmentDCC2.06
43Autosomal recessive congenital nystagmusEnrichmentROBO12.06
44Congenital myopathy 14EnrichmentMYL12.06
45Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomaliesEnrichmentRHOA2.06
46Immunodeficiency 73b with defective neutrophil chemotaxis and lymphopeniaEnrichmentRAC22.06
47Pituitary hormone deficiency, combined or isolated, 8EnrichmentROBO12.06
48Immunodeficiency 129EnrichmentRHOH2.06
49Ritscher-schinzel syndrome 4EnrichmentDPYSL52.06
50Cerebellar hypoplasiaEnrichmentVLDLR2.06
51Neurooculorenal syndromeEnrichmentROBO12.06
52T-cell immunodeficiency with epidermodysplasia verruciformisEnrichmentRHOH2.06
53Gorham's diseaseEnrichmentRASA12.06
54Infantile lad-like disease due to rac2 deficiencyEnrichmentRAC22.06
55Reticular dysgenesis-like severe combined immunodeficiencyEnrichmentRAC22.06
56Nocarh syndromeEnrichmentCDC422.06
57Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndromEnrichmentRAC12.06
58Rac2-related combined immunodeficiency-bronchiectasis-cancer-predisposing syndromeEnrichmentRAC22.06
59Congenital nystagmusEnrichmentROBO12.06
60Kallmann syndromeEnrichmentDCC, SEMA3A1.78
61Insensitivity to pain, congenital, with anhidrosisEnrichmentNTRK11.77
62Charcot-marie-tooth disease, demyelinating, type 4aEnrichmentGDAP11.77
63Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2EnrichmentPIK3R51.77
64Charcot-marie-tooth disease, axonal, with vocal cord paresis, autosomal recessiveEnrichmentGDAP11.77
65Charcot-marie-tooth disease, recessive intermediate aEnrichmentGDAP11.77
66Pain sensitivity quantitative trait locus 1EnrichmentNTRK11.77
67Intellectual developmental disorder, autosomal dominant 48EnrichmentRAC11.77
68Congenital heart defects and skeletal malformations syndromeEnrichmentABL11.77
69Cerebellar ataxia, impaired intellectual development, and dysequilibrium syndromeEnrichmentVLDLR1.77
70Cardiomyopathy, familial hypertrophic, 10EnrichmentMYL21.77
71Congenital mesoblastic nephromaEnrichmentNTRK31.77
72Charcot-marie-tooth disease, axonal, type 2hEnrichmentGDAP11.77
73Axonal neuropathyEnrichmentGDAP11.77
74Immune system diseaseEnrichmentCDC421.77
75FibrosarcomaEnrichmentNTRK31.77
76Myopathy, myofibrillar, 12, infantile-onset, with cardiomyopathyEnrichmentMYL21.77
77Arthrogryposis, distal, type 1cEnrichmentMYL111.77
78Megacystis-microcolon-intestinal hypoperistalsis syndrome 4EnrichmentMYL91.77
79Horizontal gaze palsy with progressive scoliosisEnrichmentDCC1.77
80ArthritisEnrichmentRELN1.77
81Charcot-marie-tooth disease type 4aEnrichmentGDAP11.77
82Thyroid carcinoma, familial medullaryEnrichmentNTRK11.59
83Congenital lipomatous overgrowth, vascular malformations, and epidermal neviEnrichmentPIK3R11.59
84Charcot-marie-tooth disease, axonal, type 2kEnrichmentGDAP11.59
85Epilepsy, familial temporal lobe, 7EnrichmentRELN1.59
86Immunodeficiency 14a with lymphoproliferation, autosomal dominantEnrichmentPIK3R11.59
87Wieacker-wolff syndromeEnrichmentRASA11.59
88Immunodeficiency 14EnrichmentPIK3R11.59
89KyphosisEnrichmentRELN1.59
90T-cell acute lymphoblastic leukemiaEnrichmentABL11.59
91Epilepsy with auditory featuresEnrichmentRELN1.59
92Differentiated thyroid carcinomaEnrichmentNTRK1, NTRK31.59
93Peripheral nervous system diseaseEnrichmentGDAP1, NGF1.51
94NeuropathyEnrichmentGDAP1, NGF1.51
95Familial hypertrophic cardiomyopathyEnrichmentMYL2, MYL31.49
96Amyotrophy, monomelicEnrichmentSLIT11.47
97Megalencephaly-capillary malformation-polymicrogyria syndromeEnrichmentPIK3R21.47
98Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1EnrichmentPIK3R21.47
99Chronic myelogenous leukemia, bcr-abl1 positiveEnrichmentABL11.47
100Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemiaEnrichmentCDC421.47
101Knobloch syndromeEnrichmentPAK21.47
102GliomaEnrichmentNTRK31.47
103Cataract 6, multiple typesEnrichmentEPHA21.37
104Capillary malformations, congenitalEnrichmentRASA11.37
105Knobloch syndrome 1EnrichmentPAK21.37
106Mosaic variegated aneuploidy syndrome 1EnrichmentPAK61.37
107Lissencephaly 2EnrichmentRELN1.37
108Cholangitis, primary sclerosingEnrichmentSEMA4D1.37
109PolyneuropathyEnrichmentGDAP11.37
110AniridiaEnrichmentEPHA21.37
111Sensory peripheral neuropathyEnrichmentGDAP11.37
112Charcot-marie-tooth diseaseEnrichmentARHGEF10, GDAP11.31
113Klippel-trenaunay-weber syndromeEnrichmentRASA11.30
114Telangiectasia, hereditary hemorrhagic, type 1EnrichmentRASA11.30
115Cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 1EnrichmentVLDLR1.30
116Hemihyperplasia, isolatedEnrichmentRHOA1.30
117Wilms tumor, aniridia, genitourinary anomalies, and impaired intellectual development syndromeEnrichmentBDNF1.30
118Ritscher-schinzel syndrome 1EnrichmentDPYSL51.30
119Hemangioma, capillary infantileEnrichmentRASA11.30
120Basal cell carcinoma 1EnrichmentRASA11.30
121Typical nemaline myopathyEnrichmentCFL21.30
122Hypertrophic cardiomyopathyEnrichmentMYL2, MYL31.28
123Esophageal cancerEnrichmentDCC1.23
124Thyroid cancer, nonmedullary, 2EnrichmentSRGAP11.23
125Capillary malformation-arteriovenous malformation 1EnrichmentRASA11.23
126Leukemia, chronic myeloidEnrichmentABL11.23
127Hereditary hemorrhagic telangiectasiaEnrichmentRASA11.23
128Follicular thyroid carcinomaEnrichmentSRGAP11.23
129Overgrowth syndromeEnrichmentPIK3R11.23
130Familial isolated restrictive cardiomyopathyEnrichmentMYL21.23
131Moyamoya angiopathyEnrichmentABL11.23
132B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)EnrichmentABL11.23
133Mosaic variegated aneuploidy syndromeEnrichmentPAK61.17
134Early-onset posterior polar cataractEnrichmentEPHA21.17
135Neurodevelopmental disorder with dysmorphic facies and distal limb anomaliesEnrichmentRAC11.12
136Arteriovenous malformationEnrichmentRASA11.12
137Congenital central hypoventilation syndromeEnrichmentBDNF1.12
138Renal agenesis, bilateralEnrichmentROBO11.12
139Myopathy, x-linked, with excessive autophagyEnrichmentRASA11.08
140Autosomal non-syndromic agammaglobulinemiaEnrichmentPIK3R11.08
141Undetermined early-onset epileptic encephalopathyEnrichmentLIMK1, NTRK21.08
142Complex neurodevelopmental disorderEnrichmentDPYSL5, PAK3, RAC31.04
143SchizophreniaEnrichmentRELN, RTN4R1.04
144Lip and oral cavity carcinomaEnrichmentABL11.01
145CataractEnrichmentEPHA20.94
146Pituitary stalk interruption syndromeEnrichmentROBO10.94
147Congenital myopathy 4a, autosomal dominantEnrichmentMYL20.91
148Corpus callosum, agenesis ofEnrichmentDCC0.91
149Isolated corpus callosum agenesisEnrichmentDCC0.91
150Intellectual disability-hypoplastic corpus callosum-preauricular tag syndromeEnrichmentDCC0.91
151Creatine phosphokinase, elevated serumEnrichmentGDAP10.89
152Isolated elevated serum creatine phosphokinase levelsEnrichmentGDAP10.89
153Alzheimer disease, familial, 1EnrichmentUNC5C0.86
154Cardiomyopathy, dilated, 1eEnrichmentMYL20.86
155Cataract 44EnrichmentEPHA20.86
156Early-onset nuclear cataractEnrichmentEPHA20.84
157Williams-beuren syndromeEnrichmentLIMK10.80
158LissencephalyEnrichmentRELN0.78
159Centronuclear myopathyEnrichmentCFL20.78
160Colorectal cancerEnrichmentDCC, PIK3R10.76
161Myocardial infarctionEnrichmentLRP80.76
162Precursor t-cell acute lymphoblastic leukemiaEnrichmentABL10.74
163Familial atrial fibrillationEnrichmentMYL40.73
164ScoliosisEnrichmentRELN0.73
165Tetralogy of fallotEnrichmentROBO10.70
166Brugada syndromeEnrichmentSEMA3A0.70
167Hirschsprung disease 1EnrichmentDSCAM0.65
168Non-syndromic x-linked intellectual disabilityEnrichmentARHGEF60.57
169Developmental and epileptic encephalopathyEnrichmentARHGEF150.57
170MicrocephalyEnrichmentABL1, PAK30.54
171Benign epilepsy with centrotemporal spikesEnrichmentRELN0.52
172Distal arthrogryposisEnrichmentMYL110.52
173Centralopathic epilepsyEnrichmentRELN0.51
174West syndromeEnrichmentNTRK20.50
175Body mass index quantitative trait locus 11EnrichmentBDNF0.45
176Spastic ataxiaEnrichmentDAB10.43
177Myeloma, multipleEnrichmentPIK3R20.41
178Primary ovarian insufficiencyEnrichmentNTRK10.40
179Dilated cardiomyopathyEnrichmentMYL20.30
180Ovarian cancerEnrichmentNTRK10.23
181Congenital nervous system abnormalityEnrichmentVLDLR0.22
182Nervous system diseaseEnrichmentVLDLR0.22
183Autism spectrum disorderEnrichmentDCC0.21

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