Hair follicle development: cytodifferentiation - part 3 of 3

No Pathway Network information available for Hair follicle development: cytodifferentiation - part 3 of 3

Pathways in the Hair follicle development: cytodifferentiation - part 3 of 3 SuperPath

#	Name	Source	Genes
1	Hair follicle development: cytodifferentiation - part 3 of 3	WikiPathways	BMP4 BMP6 CCN2 CD34 DKK3 DKK4 DSC2 DSG1 DSG4 EGFR EGR2 FOS FOSB FOXE1 FOXN1 FST FZD1 GAS1 GLI2 GPRC5D GTPBP4 IFNG IGF1 JUN KLK13 KLK14 KLK4 KLK5 KLK6 KLK7 KRTAP15-1 KRTAP2-3 KRTAP2-4 KRTAP6-1 KRTAP8-1 LEF1 LGR5 LHX2 LRIG1 MSX1 MSX2 NFKB1 PERP PROM1 RUNX3 SFRP1 SMAD1 SMAD4 SOX2 TGFB1 TP63 WIF1 WNT5A ZBTB16 (see all 54) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	FOXE1	Forkhead Box E1	Protein Coding	1
2	LGR5	Leucine Rich Repeat Containing G Protein-Coupled Receptor 5	Protein Coding	1
3	PROM1	Prominin 1	Protein Coding	1
4	FOXN1	Forkhead Box N1	Protein Coding	1
5	DKK4	Dickkopf Wnt Signaling Pathway Inhibitor 4	Protein Coding	1
6	DKK3	Dickkopf Wnt Signaling Pathway Inhibitor 3	Protein Coding	1
7	CD34	CD34 Molecule	Protein Coding	1
8	KRTAP15-1	Keratin Associated Protein 15-1	Protein Coding	1
9	KRTAP6-1	Keratin Associated Protein 6-1	Protein Coding	1
10	KRTAP2-4	Keratin Associated Protein 2-4	Protein Coding	1
11	KRTAP2-3	Keratin Associated Protein 2-3	Protein Coding	1
12	KRTAP8-1	Keratin Associated Protein 8-1	Protein Coding	1
13	DSG4	Desmoglein 4	Protein Coding	1
14	DSC2	Desmocollin 2	Protein Coding	1
15	KLK4	Kallikrein Related Peptidase 4	Protein Coding	1
16	GTPBP4	GTP Binding Protein 4	Protein Coding	1
17	FZD1	Frizzled Class Receptor 1	Protein Coding	1
18	KLK7	Kallikrein Related Peptidase 7	Protein Coding	1
19	GPRC5D	G Protein-Coupled Receptor Class C Group 5 Member D	Protein Coding	1
20	BMP6	Bone Morphogenetic Protein 6	Protein Coding	1
21	KLK6	Kallikrein Related Peptidase 6	Protein Coding	1
22	SFRP1	Secreted Frizzled Related Protein 1	Protein Coding	1
23	MSX1	Msh Homeobox 1	Protein Coding	1
24	BMP4	Bone Morphogenetic Protein 4	Protein Coding	1
25	LEF1	Lymphoid Enhancer Binding Factor 1	Protein Coding	1
26	TP63	Tumor Protein P63	Protein Coding	1
27	SMAD1	SMAD Family Member 1	Protein Coding	1
28	MSX2	Msh Homeobox 2	Protein Coding	1
29	IFNG	Interferon Gamma	Protein Coding	1
30	CCN2	Cellular Communication Network Factor 2	Protein Coding	1
31	IGF1	Insulin Like Growth Factor 1	Protein Coding	1
32	FOSB	FosB Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
33	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
34	GAS1	Growth Arrest Specific 1	Protein Coding	1
35	GLI2	GLI Family Zinc Finger 2	Protein Coding	1
36	WNT5A	Wnt Family Member 5A	Protein Coding	1
37	RUNX3	RUNX Family Transcription Factor 3	Protein Coding	1
38	WIF1	Wnt Inhibitory Factor 1	Protein Coding	1
39	FST	Follistatin	Protein Coding	1
40	LRIG1	Leucine Rich Repeats And Immunoglobulin Like Domains 1	Protein Coding	1
41	DSG1	Desmoglein 1	Protein Coding	1
42	PERP	P53 Apoptosis Effector Related To PMP22	Protein Coding	1
43	KLK13	Kallikrein Related Peptidase 13	Protein Coding	1
44	KLK5	Kallikrein Related Peptidase 5	Protein Coding	1
45	KLK14	Kallikrein Related Peptidase 14	Protein Coding	1
46	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
47	SOX2	SRY-Box Transcription Factor 2	Protein Coding	1
48	EGR2	Early Growth Response 2	Protein Coding	1
49	SMAD4	SMAD Family Member 4	Protein Coding	1
50	LHX2	LIM Homeobox 2	Protein Coding	1
51	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
52	EGFR	Epidermal Growth Factor Receptor	Protein Coding	1
53	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	1
54	ZBTB16	Zinc Finger And BTB Domain Containing 16	Protein Coding	1

Disorders associated with Hair follicle development: cytodifferentiation - part 3 of 3 SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Cleft lip/palate	Enrichment	BMP4, MSX1, TP63	4.68
2	Cleft lip and alveolus	Enrichment	MSX1, TP63	4.03
3	Histiocytoid hemangioma	Enrichment	FOS, FOSB	3.81
4	Cleft upper lip	Enrichment	MSX1, TP63	3.81
5	Septopreoptic holoprosencephaly	Enrichment	GAS1, GLI2	2.80
6	Midline interhemispheric variant of holoprosencephaly	Enrichment	GAS1, GLI2	2.80
7	Microform holoprosencephaly	Enrichment	GAS1, GLI2	2.74
8	Lobar holoprosencephaly	Enrichment	GAS1, GLI2	2.74
9	Alobar holoprosencephaly	Enrichment	GAS1, GLI2	2.69
10	Semilobar holoprosencephaly	Enrichment	GAS1, GLI2	2.64
11	Rapp-hodgkin syndrome	Enrichment	TP63	2.40
12	Ankyloblepharon-ectodermal defects-cleft lip/palate	Enrichment	TP63	2.40
13	Parietal foramina with cleidocranial dysplasia	Enrichment	MSX2	2.40
14	Bamforth-lazarus syndrome	Enrichment	FOXE1	2.40
15	T-cell immunodeficiency, congenital alopecia, and nail dystrophy	Enrichment	FOXN1	2.40
16	Split-hand/foot malformation 4	Enrichment	TP63	2.40
17	Ankyloblepharon filiforme adnatum and cleft palate	Enrichment	TP63	2.40
18	Charcot-marie-tooth disease, demyelinating, type 1d	Enrichment	EGR2	2.40
19	Stargardt disease 4	Enrichment	PROM1	2.40
20	Skeletal defects, genital hypoplasia, and impaired intellectual development	Enrichment	ZBTB16	2.40
21	Parietal foramina 1	Enrichment	MSX2	2.40
22	Adult syndrome	Enrichment	TP63	2.40
23	Amelogenesis imperfecta, hypomaturation type, iia1	Enrichment	KLK4	2.40
24	Macular dystrophy, retinal, 2	Enrichment	PROM1	2.40
25	Culler-jones syndrome	Enrichment	GLI2	2.40
26	T-cell immunodeficiency with thymic aplasia	Enrichment	FOXN1	2.40
27	Ectodermal dysplasia 17 with or without limb malformations	Enrichment	LEF1	2.40
28	T-cell lymphopenia, infantile, with or without nail dystrophy, autosomal dominant	Enrichment	FOXN1	2.40
29	Immunodeficiency 69	Enrichment	IFNG	2.40
30	Microphthalmia, syndromic 6	Enrichment	BMP4	2.40
31	Orofacial cleft 11	Enrichment	BMP4	2.40
32	Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3	Enrichment	TP63	2.40
33	Limb-mammary syndrome	Enrichment	TP63	2.40
34	Craniosynostosis 2	Enrichment	MSX2	2.40
35	Holoprosencephaly 9	Enrichment	GLI2	2.40
36	Iron overload	Enrichment	BMP6	2.40
37	Premature ovarian failure 21	Enrichment	TP63	2.40
38	Olmsted syndrome 2	Enrichment	PERP	2.40
39	Retinitis pigmentosa 41	Enrichment	PROM1	2.40
40	Orofacial cleft 8	Enrichment	TP63	2.40
41	Thyroid cancer, nonmedullary, 4	Enrichment	FOXE1	2.40
42	Erythrokeratodermia variabilis et progressiva 7	Enrichment	PERP	2.40
43	Diffuse palmoplantar keratoderma with painful fissures	Enrichment	DSG1	2.40
44	Focal palmoplantar keratoderma with joint keratoses	Enrichment	DSG1	2.40
45	Heritable thoracic aortic disease	Enrichment	SMAD4	2.40
46	Amelogenesis imperfecta type 2a1	Enrichment	KLK4	2.40
47	Charcot-marie-tooth disease type 1d	Enrichment	EGR2	2.40
48	Tp63-related disorders	Enrichment	TP63	2.40
49	Diffuse palmoplantar keratoderma	Enrichment	DSG1	2.40
50	Postaxial polydactyly-anterior pituitary anomalies-facial dysmorphism syndrome	Enrichment	GLI2	2.40
51	Ectrodactyly and ectodermal dysplasia without cleft lip/palate	Enrichment	LEF1	2.10
52	Palmoplantar keratoderma i, striate, focal, or diffuse	Enrichment	DSG1	2.10
53	Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 1	Enrichment	TP63	2.10
54	Myhre syndrome	Enrichment	SMAD4	2.10
55	Camurati-engelmann disease 1	Enrichment	TGFB1	2.10
56	Kyphomelic dysplasia	Enrichment	CCN2	2.10
57	Arrhythmogenic right ventricular dysplasia, familial, 11	Enrichment	DSC2	2.10
58	Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome	Enrichment	SMAD4	2.10
59	Neuropathy, congenital hypomyelinating, 1, autosomal recessive	Enrichment	EGR2	2.10
60	Orofacial cleft 5	Enrichment	MSX1	2.10
61	White-sutton syndrome	Enrichment	GLI2	2.10
62	Witkop syndrome	Enrichment	MSX1	2.10
63	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.10
64	Spondyloepimetaphyseal dysplasia, li-shao-li type	Enrichment	CCN2	2.10
65	Inflammatory bowel disease, immunodeficiency, and encephalopathy	Enrichment	TGFB1	2.10
66	Bladder exstrophy	Enrichment	TP63	2.10
67	Parietal foramina	Enrichment	MSX2	2.10
68	Split hand-foot malformation	Enrichment	LEF1	2.10
69	Hypotrichosis 6	Enrichment	DSG4	2.10
70	Camurati-engelmann disease	Enrichment	TGFB1	2.10
71	Fissured tongue	Enrichment	TP63	2.10
72	Growth delay due to insulin-like growth factor type 1 deficiency	Enrichment	IGF1	2.10
73	Hereditary palmoplantar keratoderma	Enrichment	DSG1	2.10
74	Common variable immunodeficiency 12	Enrichment	NFKB1	2.10
75	Juvenile polyposis syndrome	Enrichment	SMAD4	1.92
76	Tuberous sclerosis 1	Enrichment	IFNG	1.92
77	Hepatitis c virus	Enrichment	IFNG	1.92
78	Cone-rod dystrophy 12	Enrichment	PROM1	1.92
79	Tuberous sclerosis 2	Enrichment	IFNG	1.92
80	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	1.92
81	Erythroderma, congenital, with palmoplantar keratoderma, hypotrichosis, and hyper-ige	Enrichment	DSG1	1.92
82	Keratosis palmoplantaris striata	Enrichment	DSG1	1.92
83	Mutilating palmoplantar keratoderma with periorificial keratotic plaques	Enrichment	PERP	1.92
84	Charcot-marie-tooth disease type 1	Enrichment	EGR2	1.92
85	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	1.92
86	Familial papillary or follicular thyroid carcinoma	Enrichment	FOXE1	1.92
87	Robinow syndrome, autosomal dominant 1	Enrichment	WNT5A	1.80
88	Microphthalmia, syndromic 3	Enrichment	SOX2	1.80
89	Congenital generalized lipodystrophy	Enrichment	FOS	1.80
90	Monilethrix	Enrichment	DSG4	1.80
91	Orofacial cleft	Enrichment	FST	1.80
92	Autosomal dominant robinow syndrome	Enrichment	WNT5A	1.80
93	Orofacial clefting syndrome	Enrichment	FST	1.80
94	Pseudomyogenic hemangioendothelioma	Enrichment	FOSB	1.80
95	Hypertrophic neuropathy of dejerine-sottas	Enrichment	EGR2	1.70
96	Arrhythmogenic right ventricular dysplasia, familial, 1	Enrichment	DSC2	1.70
97	Robinow syndrome, autosomal recessive 1	Enrichment	WNT5A	1.70
98	Insulin-like growth factor i	Enrichment	IGF1	1.70
99	Arrhythmogenic right ventricular dysplasia 1	Enrichment	DSC2	1.70
100	Diffuse cutaneous systemic sclerosis	Enrichment	CCN2	1.70
101	Generalized juvenile polyposis/juvenile polyposis coli	Enrichment	SMAD4	1.70
102	Idiopathic aplastic anemia	Enrichment	IFNG	1.70
103	Primary ovarian insufficiency	Enrichment	BMP6, TP63	1.64
104	Cowden syndrome 1	Enrichment	EGFR	1.63
105	Split-hand/foot malformation 1	Enrichment	LEF1	1.63
106	Anterior segment dysgenesis 5	Enrichment	BMP4	1.63
107	Inflammatory bowel disease 25, autosomal recessive	Enrichment	TGFB1	1.63
108	Autosomal recessive robinow syndrome	Enrichment	WNT5A	1.63
109	Limited scleroderma	Enrichment	CCN2	1.63
110	Il10-related early-onset inflammatory bowel disease	Enrichment	TGFB1	1.63
111	Lung squamous cell carcinoma	Enrichment	EGFR	1.63
112	Hypothyroidism, congenital, nongoitrous, 2	Enrichment	FOXE1	1.56
113	Squamous cell carcinoma, head and neck	Enrichment	EGFR	1.56
114	Gallbladder cancer	Enrichment	SMAD4	1.56
115	Hereditary hemorrhagic telangiectasia	Enrichment	SMAD4	1.56
116	Common variable immunodeficiency	Enrichment	NFKB1	1.56
117	Amelogenesis imperfecta type 2	Enrichment	KLK4	1.56
118	Hemochromatosis, type 1	Enrichment	BMP6	1.50
119	Leber congenital amaurosis 1	Enrichment	PROM1	1.50
120	Isolated split hand-split foot malformation	Enrichment	TP63	1.50
121	Combined pituitary hormone deficiency	Enrichment	GLI2	1.50
122	Tooth agenesis, selective, 1	Enrichment	MSX1	1.45
123	Familial isolated arrhythmogenic right ventricular dysplasia	Enrichment	DSC2	1.45
124	Hypotrichosis simplex	Enrichment	DSG4	1.45
125	Peters-plus syndrome	Enrichment	BMP4	1.41
126	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.41
127	Aplastic anemia	Enrichment	IFNG	1.41
128	Stickler syndrome	Enrichment	BMP4	1.41
129	Nanophthalmos	Enrichment	SOX2	1.37
130	Lung non-small cell carcinoma	Enrichment	EGFR	1.37
131	Septooptic dysplasia	Enrichment	SOX2	1.33
132	Renal hypodysplasia/aplasia 3	Enrichment	BMP4	1.33
133	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant	Enrichment	DSC2	1.33
134	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant	Enrichment	DSC2	1.33
135	Lip and oral cavity carcinoma	Enrichment	EGFR	1.33
136	Aortic valve disease 1	Enrichment	DSG1	1.30
137	Acute promyelocytic leukemia	Enrichment	ZBTB16	1.30
138	Premature menopause	Enrichment	TP63	1.30
139	Amelogenesis imperfecta	Enrichment	KLK4	1.30
140	Lung cancer susceptibility 3	Enrichment	EGFR	1.26
141	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	DSC2	1.26
142	Isolated macular dystrophy	Enrichment	PROM1	1.26
143	Male infertility with spermatogenesis disorder	Enrichment	TP63	1.24
144	Arrhythmogenic right ventricular cardiomyopathy	Enrichment	DSC2	1.21
145	Gliosarcoma	Enrichment	EGFR	1.21
146	Polycystic liver disease	Enrichment	DKK3	1.18
147	Giant cell glioblastoma	Enrichment	EGFR	1.18
148	Autosomal dominant polycystic liver disease	Enrichment	DKK3	1.18
149	Human immunodeficiency virus type 1	Enrichment	IFNG	1.16
150	Charcot-marie-tooth disease type 4	Enrichment	EGR2	1.16
151	Arteriovenous malformations of the brain	Enrichment	EGFR	1.14
152	Macs syndrome	Enrichment	SOX2	1.12
153	Craniosynostosis	Enrichment	GLI2	1.12
154	Cardiomyopathy, dilated, 1a	Enrichment	DSC2	1.09
155	Microphthalmia	Enrichment	SOX2	1.08
156	Tooth agenesis	Enrichment	MSX1	1.08
157	Skin disease	Enrichment	DSG1	1.08
158	Precursor t-cell acute lymphoblastic leukemia	Enrichment	ZBTB16	1.06
159	Pancreatic cancer	Enrichment	SMAD4	1.02
160	Inherited cancer-predisposing syndrome	Enrichment	EGFR, SMAD4	1.01
161	Bladder cancer	Enrichment	EGFR	0.96
162	Differentiated thyroid carcinoma	Enrichment	FOXE1	0.96
163	Stargardt disease 1	Enrichment	PROM1	0.95
164	Lung cancer	Enrichment	EGFR	0.92
165	Cystic fibrosis	Enrichment	TGFB1	0.92
166	Usher syndrome	Enrichment	PROM1	0.91
167	Severe combined immunodeficiency	Enrichment	FOXN1	0.91
168	Gastric cancer	Enrichment	SMAD4	0.80
169	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	SMAD4	0.79
170	Thrombocytopenia	Enrichment	SMAD4	0.76
171	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	GLI2	0.70
172	Cone-rod dystrophy 2	Enrichment	PROM1	0.62
173	Autism	Enrichment	FOXN1	0.60
174	Breast cancer	Enrichment	JUN	0.59
175	Colorectal cancer	Enrichment	SMAD4	0.53
176	Leber plus disease	Enrichment	PROM1	0.50
177	Ovarian cancer	Enrichment	EGFR	0.48
178	Retinitis pigmentosa	Enrichment	PROM1	0.24
179	Hereditary retinal dystrophy	Enrichment	PROM1	0.16
180	Fundus dystrophy	Enrichment	PROM1	0.16

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Hair follicle development: cytodifferentiation - part 3 of 3

Pathway Network for Hair follicle development: cytodifferentiation - part 3 of 3

Member Pathways for Hair follicle development: cytodifferentiation - part 3 of 3

Pathways in the Hair follicle development: cytodifferentiation - part 3 of 3 SuperPath

Associated Genes for Hair follicle development: cytodifferentiation - part 3 of 3

Associated Disorders for Hair follicle development: cytodifferentiation - part 3 of 3

Disorders associated with Hair follicle development: cytodifferentiation - part 3 of 3 SuperPath

STRING Interaction Network for Hair follicle development: cytodifferentiation - part 3 of 3

Sources for Hair follicle development: cytodifferentiation - part 3 of 3