Head and neck squamous cell carcinoma

No Pathway Network information available for Head and neck squamous cell carcinoma

Pathways in the Head and neck squamous cell carcinoma SuperPath

#	Name	Source	Genes
1	Head and neck squamous cell carcinoma	WikiPathways	AJUBA AKT1 AKT2 AKT3 BIRC2 CASP8 CCND1 CDK4 CDK6 CDKN1A CDKN2A CSMD3 CTNNB1 CUL3 DDIT4 E2F1 EGFR EIF4E EIF4EBP1 ERBB2 FADD FAT1 FGFR1 FGFR2 FGFR3 FKBP1A GAB1 HRAS IGF1R IRF6 KEAP1 KRAS MAML1 MAPKAP1 MIRLET7C MLST8 MTOR NFE2L2 NFKB1 NFKB2 NOTCH1 NOTCH2 NRAS NUMB PDPK1 PIK3CA PIK3CB PIK3CG PIK3R1 PIK3R2 PIK3R5 PRKAA1 PRKAA2 PTEN RB1 REL RHEB RICTOR RPS6 RPS6KB2 RPTOR SESN1 SESN2 SMAD4 STK11 TERT TGFBR2 TP53 TP63 TRAF3 TSC1 TSC2 VEGFA (see all 73) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	KEAP1	Kelch Like ECH Associated Protein 1	Protein Coding	1
2	FADD	Fas Associated Via Death Domain	Protein Coding	1
3	TP63	Tumor Protein P63	Protein Coding	1
4	AJUBA	Ajuba LIM Protein	Protein Coding	1
5	CUL3	Cullin 3	Protein Coding	1
6	CASP8	Caspase 8	Protein Coding	1
7	SESN2	Sestrin 2	Protein Coding	1
8	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	1
9	TSC2	TSC Complex Subunit 2	Protein Coding	1
10	TSC1	TSC Complex Subunit 1	Protein Coding	1
11	TRAF3	TNF Receptor Associated Factor 3	Protein Coding	1
12	TP53	Tumor Protein P53	Protein Coding	1
13	TGFBR2	Transforming Growth Factor Beta Receptor 2	Protein Coding	1
14	TERT	Telomerase Reverse Transcriptase	Protein Coding	1
15	STK11	Serine/Threonine Kinase 11	Protein Coding	1
16	RPS6KB2	Ribosomal Protein S6 Kinase B2	Protein Coding	1
17	RPS6	Ribosomal Protein S6	Protein Coding	1
18	RHEB	Ras Homolog, MTORC1 Binding	Protein Coding	1
19	REL	REL Proto-Oncogene, NF-KB Subunit	Protein Coding	1
20	CCND1	Cyclin D1	Protein Coding	1
21	RB1	RB Transcriptional Corepressor 1	Protein Coding	1
22	RPTOR	Regulatory Associated Protein Of MTOR Complex 1	Protein Coding	1
23	PTEN	Phosphatase And Tensin Homolog	Protein Coding	1
24	PRKAA2	Protein Kinase AMP-Activated Catalytic Subunit Alpha 2	Protein Coding	1
25	PRKAA1	Protein Kinase AMP-Activated Catalytic Subunit Alpha 1	Protein Coding	1
26	DDIT4	DNA Damage Inducible Transcript 4	Protein Coding	1
27	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	1
28	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
29	PIK3CG	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma	Protein Coding	1
30	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	1
31	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
32	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	1
33	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	1
34	NOTCH2	Notch Receptor 2	Protein Coding	1
35	NOTCH1	Notch Receptor 1	Protein Coding	1
36	NFKB2	Nuclear Factor Kappa B Subunit 2	Protein Coding	1
37	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
38	NFE2L2	NFE2 Like BZIP Transcription Factor 2	Protein Coding	1
39	SMAD4	SMAD Family Member 4	Protein Coding	1
40	MIRLET7C	MicroRNA Let-7c	RNA Gene	1
41	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	1
42	IRF6	Interferon Regulatory Factor 6	Protein Coding	1
43	IGF1R	Insulin Like Growth Factor 1 Receptor	Protein Coding	1
44	BIRC2	Baculoviral IAP Repeat Containing 2	Protein Coding	1
45	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	1
46	GAB1	GRB2 Associated Binding Protein 1	Protein Coding	1
47	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	1
48	PIK3R5	Phosphoinositide-3-Kinase Regulatory Subunit 5	Protein Coding	1
49	FKBP1A	FKBP Prolyl Isomerase 1A	Protein Coding	1
50	FGFR2	Fibroblast Growth Factor Receptor 2	Protein Coding	1
51	FGFR3	Fibroblast Growth Factor Receptor 3	Protein Coding	1
52	FGFR1	Fibroblast Growth Factor Receptor 1	Protein Coding	1
53	FAT1	FAT Atypical Cadherin 1	Protein Coding	1
54	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	1
55	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
56	ERBB2	Erb-B2 Receptor Tyrosine Kinase 2	Protein Coding	1
57	EIF4EBP1	Eukaryotic Translation Initiation Factor 4E Binding Protein 1	Protein Coding	1
58	EIF4E	Eukaryotic Translation Initiation Factor 4E	Protein Coding	1
59	EGFR	Epidermal Growth Factor Receptor	Protein Coding	1
60	E2F1	E2F Transcription Factor 1	Protein Coding	1
61	CTNNB1	Catenin Beta 1	Protein Coding	1
62	CSMD3	CUB And Sushi Multiple Domains 3	Protein Coding	1
63	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	1
64	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	1
65	CDK6	Cyclin Dependent Kinase 6	Protein Coding	1
66	CDK4	Cyclin Dependent Kinase 4	Protein Coding	1
67	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	1
68	MAML1	Mastermind Like Transcriptional Coactivator 1	Protein Coding	1
69	NUMB	NUMB Endocytic Adaptor Protein	Protein Coding	1
70	MAPKAP1	MAPK Associated Protein 1	Protein Coding	1
71	MLST8	MTOR Associated Protein MLST8	Protein Coding	1
72	SESN1	Sestrin 1	Protein Coding	1
73	RICTOR	RPTOR Independent Companion Of MTOR Complex 2	Protein Coding	1

Disorders associated with Head and neck squamous cell carcinoma SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Bladder cancer	Enrichment	CDKN1A, CDKN2A, CTNNB1, EGFR, ERBB2, FGFR3, HRAS, KRAS, PIK3CA, PTEN, RB1, TERT, TP53, TSC1	16.00
2	Gastric cancer	Enrichment	CDK4, CDKN2A, ERBB2, FGFR2, KRAS, PIK3CA, PTEN, SMAD4, STK11, TP53	16.00
3	Adult hepatocellular carcinoma	Enrichment	CASP8, CTNNB1, PIK3CA, TP53, TSC1, TSC2	16.00
4	Ovarian cancer	Enrichment	AKT1, CDKN2A, CTNNB1, EGFR, ERBB2, KRAS, PIK3CA, PTEN, RB1, TP53, TSC2	11.16
5	Lip and oral cavity carcinoma	Enrichment	CDKN2A, EGFR, HRAS, PIK3CA, RB1, STK11, TP53	11.14
6	Colorectal cancer	Enrichment	AKT1, CCND1, CTNNB1, ERBB2, FGFR2, FGFR3, NFE2L2, NRAS, PIK3CA, PIK3R1, SMAD4, TP53	10.99
7	Hemimegalencephaly	Enrichment	AKT3, MTOR, PIK3CA, PTEN, RHEB	10.94
8	Lung non-small cell carcinoma	Enrichment	EGFR, ERBB2, HRAS, KRAS, NRAS, PIK3CA	10.57
9	Lung squamous cell carcinoma	Enrichment	CDKN2A, EGFR, FGFR3, KRAS, PIK3CA	10.37
10	Nevus, epidermal	Enrichment	FGFR3, HRAS, KRAS, NRAS, PIK3CA	10.08
11	Gallbladder cancer	Enrichment	CTNNB1, KRAS, PIK3CA, SMAD4, TP53	10.08
12	Focal cortical dysplasia, type ii	Enrichment	MTOR, RHEB, TSC1, TSC2	9.10
13	Isolated focal cortical dysplasia type ii	Enrichment	MTOR, RHEB, TSC1, TSC2	9.10
14	Inherited cancer-predisposing syndrome	Enrichment	CDK4, CDKN2A, EGFR, PTEN, RB1, SMAD4, STK11, TP53, TSC1, TSC2	8.70
15	Lung cancer susceptibility 3	Enrichment	EGFR, ERBB2, KRAS, RB1, TP53	8.12
16	Adrenocortical carcinoma	Enrichment	CDKN2A, CTNNB1, TERT, TP53	7.94
17	Breast adenocarcinoma	Enrichment	AKT1, KRAS, PIK3CA, TP53	7.94
18	Lung cancer	Enrichment	CASP8, EGFR, ERBB2, KRAS, NFE2L2, PIK3CA	7.80
19	Hepatocellular carcinoma	Enrichment	CASP8, CTNNB1, PIK3CA, TERT, TP53	7.02
20	Hamartoma	Enrichment	FGFR3, TSC1, TSC2	6.83
21	Keratoacanthoma	Enrichment	NOTCH1, NOTCH2, PIK3CA	6.83
22	Pancreatic cancer	Enrichment	CDKN2A, KRAS, SMAD4, STK11, TP53	6.72
23	Meningioma	Enrichment	AKT1, PIK3CA, PTEN, TERT	6.43
24	Myeloma, multiple	Enrichment	CCND1, FAT1, FGFR3, KRAS, PIK3R2, TP53	6.29
25	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	6.22
26	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3, PIK3CA, PIK3R2	6.22
27	Lung sarcomatoid carcinoma	Enrichment	KRAS, TERT, TP53	6.22
28	Gliosarcoma	Enrichment	EGFR, FGFR1, FGFR3, TP53	5.87
29	Melanoma, cutaneous malignant 1	Enrichment	CDK4, CDKN2A, STK11, TERT	5.76
30	Giant cell glioblastoma	Enrichment	EGFR, FGFR1, FGFR3, TP53	5.76
31	Cowden syndrome 1	Enrichment	EGFR, PIK3CA, PTEN	5.53
32	Breast cancer	Enrichment	AKT1, CASP8, KRAS, PIK3CA, PTEN, TP53	5.53
33	Hereditary breast carcinoma	Enrichment	AKT1, KRAS, PIK3CA, PTEN, TP53	5.44
34	Hepatoblastoma	Enrichment	CTNNB1, FGFR3, TERT, TP53	5.37
35	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS, NRAS, PTEN	5.29
36	Squamous cell carcinoma, head and neck	Enrichment	EGFR, PTEN, TP53	5.29
37	Follicular thyroid carcinoma	Enrichment	HRAS, NRAS, PTEN	5.29
38	Cowden syndrome	Enrichment	AKT1, PIK3CA, PTEN	4.91
39	Differentiated thyroid carcinoma	Enrichment	HRAS, KRAS, NRAS, TERT	4.78
40	Melanoma	Enrichment	CDKN2A, PTEN, STK11	4.76
41	Cervical cancer	Enrichment	FGFR3, TP53	4.54
42	Lymphangioleiomyomatosis	Enrichment	TSC1, TSC2	4.54
43	Keratosis, seborrheic	Enrichment	FGFR3, PIK3CA	4.54
44	Pfeiffer syndrome	Enrichment	FGFR1, FGFR2	4.54
45	Jackson-weiss syndrome	Enrichment	FGFR1, FGFR2	4.54
46	Encephalocraniocutaneous lipomatosis	Enrichment	FGFR1, KRAS	4.54
47	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	4.54
48	Rosette-forming glioneuronal tumor	Enrichment	FGFR1, PIK3CA	4.54
49	Cervix carcinoma	Enrichment	FGFR3, TP53	4.54
50	Nk-cell enteropathy	Enrichment	CUL3, IGF1R, PIK3CB	4.39
51	Leukemia, acute myeloid	Enrichment	KRAS, NRAS, TERT, TP53	4.22
52	Lynch syndrome	Enrichment	KRAS, PIK3CA, TGFBR2	4.19
53	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, KRAS, NRAS	4.19
54	Rhabdomyosarcoma	Enrichment	HRAS, PTEN, TP53	4.10
55	Crouzon syndrome	Enrichment	FGFR2, FGFR3	4.07
56	Lacrimoauriculodentodigital syndrome 1	Enrichment	FGFR2, FGFR3	4.07
57	Tuberous sclerosis 1	Enrichment	TSC1, TSC2	4.07
58	Osteogenic sarcoma	Enrichment	RB1, TP53	4.07
59	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.07
60	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	4.07
61	Testicular germ cell cancer	Enrichment	FGFR3, STK11	4.07
62	Squamous cell carcinoma	Enrichment	RB1, TP53	4.07
63	Bone osteosarcoma	Enrichment	RB1, TP53	4.07
64	Spermatocytoma	Enrichment	FGFR3, HRAS	4.07
65	Testicular cancer	Enrichment	FGFR3, STK11	4.07
66	Small cell cancer of the lung	Enrichment	RB1, TP53	3.77
67	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3, PIK3R2	3.77
68	Saethre-chotzen syndrome	Enrichment	FGFR2, FGFR3	3.77
69	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	3.77
70	Tuberous sclerosis	Enrichment	TSC1, TSC2	3.77
71	Glioma	Enrichment	FGFR2, PTEN	3.77
72	Cleft lip and alveolus	Enrichment	IRF6, TP63	3.77
73	Endometrial cancer	Enrichment	FGFR2, PIK3CA, PTEN	3.73
74	Noonan syndrome 1	Enrichment	HRAS, KRAS, NRAS	3.61
75	Hemifacial hyperplasia	Enrichment	FGFR2, FGFR3	3.55
76	Acute megakaryocytic leukemia	Enrichment	PTEN, TP53	3.55
77	Cleft upper lip	Enrichment	IRF6, TP63	3.55
78	Generalized juvenile polyposis/juvenile polyposis coli	Enrichment	SMAD4, STK11	3.55
79	Rasopathy	Enrichment	HRAS, KRAS, NRAS	3.45
80	Li-fraumeni syndrome	Enrichment	CDKN2A, TP53	3.37
81	Testicular germ cell tumor	Enrichment	FGFR3, STK11	3.37
82	Prostate cancer	Enrichment	PIK3CA, PTEN, TP53	3.31
83	Esophageal cancer	Enrichment	TGFBR2, TP53	3.23
84	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, PIK3CA	3.23
85	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	3.23
86	Noonan syndrome 3	Enrichment	HRAS, KRAS	3.23
87	Pilomyxoid astrocytoma	Enrichment	FGFR1, KRAS	3.23
88	Common variable immunodeficiency	Enrichment	NFKB1, NFKB2	3.23
89	Overgrowth syndrome	Enrichment	MTOR, PIK3R1	3.23
90	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	CDKN2A, TP53	3.23
91	Connective tissue disease	Enrichment	FGFR3, NOTCH1, TGFBR2	3.18
92	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, NRAS	3.11
93	Glioma susceptibility 1	Enrichment	ERBB2, TP53	3.11
94	Arteriovenous malformation	Enrichment	HRAS, PIK3CA	3.00
95	Leukemia, chronic lymphocytic	Enrichment	CCND1, TP53	2.90
96	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, PIK3CA	2.90
97	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	NOTCH1, SMAD4, TGFBR2	2.77
98	Juvenile myelomonocytic leukemia	Enrichment	KRAS, NRAS	2.74
99	Cleft lip/palate	Enrichment	IRF6, TP63	2.60
100	Congenital nervous system abnormality	Enrichment	CTNNB1, FGFR3, PTEN, TSC2	2.60
101	Nervous system disease	Enrichment	CTNNB1, FGFR3, PTEN, TSC2	2.60
102	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS, PTEN, TP53	2.49
103	Primary ovarian insufficiency	Enrichment	NOTCH2, RICTOR, TP63	2.41
104	Arteriovenous malformations of the brain	Enrichment	EGFR, KRAS	2.34
105	Diffuse large b-cell lymphoma	Enrichment	PTEN, TP53	2.34
106	Craniosynostosis	Enrichment	FGFR2, FGFR3	2.29
107	Rapp-hodgkin syndrome	Enrichment	TP63	2.27
108	Ankyloblepharon-ectodermal defects-cleft lip/palate	Enrichment	TP63	2.27
109	Hypochondroplasia	Enrichment	FGFR3	2.27
110	Macrodactyly	Enrichment	PIK3CA	2.27
111	Proteus syndrome	Enrichment	AKT1	2.27
112	Beare-stevenson cutis gyrata syndrome	Enrichment	FGFR2	2.27
113	Paget disease, extramammary	Enrichment	ERBB2	2.27
114	Osteoglophonic dysplasia	Enrichment	FGFR1	2.27
115	Thanatophoric dysplasia, type i	Enrichment	FGFR3	2.27
116	Trigonocephaly 1	Enrichment	FGFR1	2.27
117	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.27
118	Oculoectodermal syndrome	Enrichment	KRAS	2.27
119	Muenke syndrome	Enrichment	FGFR3	2.27
120	Vacterl association with hydrocephalus	Enrichment	PTEN	2.27
121	Split-hand/foot malformation 4	Enrichment	TP63	2.27
122	Deafness, autosomal recessive 26	Enrichment	GAB1	2.27
123	Ankyloblepharon filiforme adnatum and cleft palate	Enrichment	TP63	2.27
124	Caspase 8 deficiency	Enrichment	CASP8	2.27
125	Melanoma, cutaneous malignant 3	Enrichment	CDK4	2.27
126	Orofacial cleft 6	Enrichment	IRF6	2.27
127	Scaphocephaly, maxillary retrusion, and impaired intellectual development	Enrichment	FGFR2	2.27
128	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.27
129	Apert syndrome	Enrichment	FGFR2	2.27
130	Hajdu-cheney syndrome	Enrichment	NOTCH2	2.27
131	Alagille syndrome 2	Enrichment	NOTCH2	2.27
132	Popliteal pterygium syndrome	Enrichment	IRF6	2.27
133	Adult syndrome	Enrichment	TP63	2.27
134	Cowden syndrome 5	Enrichment	PIK3CA	2.27
135	Microcephaly 12, primary, autosomal recessive	Enrichment	CDK6	2.27
136	Pseudohypoaldosteronism, type iie	Enrichment	CUL3	2.27
137	Melanosis, neurocutaneous	Enrichment	NRAS	2.27
138	Thanatophoric dysplasia, type ii	Enrichment	FGFR3	2.27
139	Noonan syndrome 6	Enrichment	NRAS	2.27
140	Camptodactyly, tall stature, and hearing loss syndrome	Enrichment	FGFR3	2.27
141	Ataxia-oculomotor apraxia 3	Enrichment	PIK3R5	2.27
142	Bent bone dysplasia syndrome 1	Enrichment	FGFR2	2.27
143	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.27
144	Visceral neuropathy, familial, 2, autosomal recessive	Enrichment	ERBB2	2.27
145	Immunodeficiency 92	Enrichment	REL	2.27
146	Short syndrome	Enrichment	PIK3R1	2.27
147	Bone marrow failure syndrome 5	Enrichment	TP53	2.27
148	Immunodeficiency, developmental delay, and hypohomocysteinemia	Enrichment	NFE2L2	2.27
149	Papilloma of choroid plexus	Enrichment	TP53	2.27
150	Basal cell carcinoma 7	Enrichment	TP53	2.27
151	Immunodeficiency 132a	Enrichment	TRAF3	2.27
152	Immunodeficiency 132b	Enrichment	TRAF3	2.27
153	Autism 19	Enrichment	EIF4E	2.27
154	Anaplastic thyroid carcinoma	Enrichment	TP53	2.27
155	Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3	Enrichment	TP63	2.27
156	Papillary tumor of the pineal region	Enrichment	PTEN	2.27
157	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	2.27
158	Limb-mammary syndrome	Enrichment	TP63	2.27
159	Microvascular complications of diabetes 1	Enrichment	VEGFA	2.27
160	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.27
161	Crouzon syndrome with acanthosis nigricans	Enrichment	FGFR3	2.27
162	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.27
163	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.27
164	Colorectal cancer, hereditary nonpolyposis, type 6	Enrichment	TGFBR2	2.27
165	Premature ovarian failure 21	Enrichment	TP63	2.27
166	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.27
167	Immunodeficiency 90 with encephalopathy, functional hyposplenia, and hepatic dysfunction	Enrichment	FADD	2.27
168	Cowden syndrome 6	Enrichment	AKT1	2.27
169	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.27
170	Immunodeficiency 97 with autoinflammation	Enrichment	PIK3CG	2.27
171	Glioma susceptibility 2	Enrichment	PTEN	2.27
172	Achondroplasia, severe, with developmental delay and acanthosis nigricans	Enrichment	FGFR3	2.27
173	Ductal carcinoma in situ	Enrichment	TP53	2.27
174	Hartsfield syndrome	Enrichment	FGFR1	2.27
175	Orofacial cleft 8	Enrichment	TP63	2.27
176	Neurodevelopmental disorder with or without autism or seizures	Enrichment	CUL3	2.27
177	Irf6-related disorders	Enrichment	IRF6	2.27
178	Autosomal dominant popliteal pterygium syndrome	Enrichment	IRF6	2.27
179	Deficiency in anterior pituitary function - variable immunodeficiency syndrome	Enrichment	NFKB2	2.27
180	Autosomal recessive dyskeratosis congenita 4	Enrichment	TERT	2.27
181	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.27
182	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.27
183	Trilateral retinoblastoma	Enrichment	RB1	2.27
184	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.27
185	Adenoid ameloblastoma	Enrichment	CTNNB1	2.27
186	Lacrimoauriculodentodigital syndrome 2	Enrichment	FGFR3	2.27
187	Cdkn2a cancer predisposition	Enrichment	CDKN2A	2.27
188	Heritable thoracic aortic disease	Enrichment	SMAD4	2.27
189	Hypospadias	Enrichment	PIK3CA	2.27
190	Capillary hemangioma	Enrichment	AKT3	2.27
191	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.27
192	Tp63-related disorders	Enrichment	TP63	2.27
193	Congenital pulmonary airway malformation	Enrichment	KRAS	2.27
194	Choroid plexus cancer	Enrichment	TP53	2.27
195	Rare venous malformation	Enrichment	PIK3CA	2.27
196	Diaphragmatic eventration	Enrichment	PIK3CA	2.27
197	Fgfr3-related chondrodysplasia	Enrichment	FGFR3	2.27
198	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.27
199	Camptodactyly-tall stature-scoliosis-hearing loss syndrome	Enrichment	FGFR3	2.27
200	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.27
201	Rare combined vascular malformation	Enrichment	PIK3CA	2.27
202	Cavernous lymphangioma	Enrichment	PIK3CA	2.27
203	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.27
204	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.27
205	Segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome	Enrichment	PTEN	2.27
206	Intestinal polyposis syndrome	Enrichment	STK11	2.27
207	Hartsfield-bixler-demyer syndrome	Enrichment	FGFR1	2.27
208	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.27
209	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.27
210	Non-syndromic unicoronal craniosynostosis	Enrichment	FGFR2	2.27
211	Macrodactyly of toe	Enrichment	PIK3CA	2.27
212	Serous carcinoma of the corpus uteri	Enrichment	ERBB2	2.27
213	Neurocutaneous melanocytosis	Enrichment	NRAS	2.27
214	Microcystic stromal tumor	Enrichment	CTNNB1	2.27
215	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.27
216	Lung oat cell carcinoma	Enrichment	RB1	2.27
217	Tooth agenesis	Enrichment	FGFR1, IRF6	2.21
218	Melanoma-astrocytoma syndrome	Enrichment	CDKN2A	1.97
219	Peutz-jeghers syndrome	Enrichment	STK11	1.97
220	Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 1	Enrichment	TP63	1.97
221	Myhre syndrome	Enrichment	SMAD4	1.97
222	Adrenocortical carcinoma, hereditary	Enrichment	TP53	1.97
223	Costello syndrome	Enrichment	HRAS	1.97
224	Osteopathia striata with cranial sclerosis	Enrichment	CTNNB1	1.97
225	Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2	Enrichment	PIK3R5	1.97
226	Loeys-dietz syndrome 2	Enrichment	TGFBR2	1.97
227	Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome	Enrichment	SMAD4	1.97
228	Pseudohypoaldosteronism, type i, autosomal dominant	Enrichment	CUL3	1.97
229	Microvascular complications of diabetes 5	Enrichment	TGFBR2	1.97
230	Aural atresia, congenital	Enrichment	FGFR2	1.97
231	Melanoma, cutaneous malignant 2	Enrichment	CDKN2A	1.97
232	Goiter, multinodular 1, with or without sertoli-leydig cell tumors	Enrichment	KEAP1	1.97
233	Adams-oliver syndrome 5	Enrichment	NOTCH1	1.97
234	Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 1	Enrichment	TERT	1.97
235	Chromosome 13q14 deletion syndrome	Enrichment	RB1	1.97
236	Noonan syndrome 8	Enrichment	PIK3CA	1.97
237	Lymphoma, hodgkin, classic	Enrichment	TP53	1.97
238	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	1.97
239	Immunodeficiency, common variable, 10	Enrichment	NFKB2	1.97
240	Myasthenic syndrome, congenital, 12	Enrichment	FAT1	1.97
241	Antley-bixler syndrome without genital anomalies or disordered steroidogenesis	Enrichment	FGFR2	1.97
242	Cebalid syndrome	Enrichment	MTOR	1.97
243	Childhood hepatocellular carcinoma	Enrichment	CTNNB1	1.97
244	Bladder exstrophy	Enrichment	TP63	1.97
245	Senior-loken syndrome 7	Enrichment	AKT3	1.97
246	Split hand-foot malformation	Enrichment	FGFR2	1.97
247	Melanoma-pancreatic cancer syndrome	Enrichment	CDKN2A	1.97
248	Congenital fibrosarcoma	Enrichment	TP53	1.97
249	Li-fraumeni syndrome 1	Enrichment	TP53	1.97
250	Sarcoma	Enrichment	TP53	1.97
251	Melanoma, cutaneous malignant 9	Enrichment	TERT	1.97
252	Hodgkin's lymphoma	Enrichment	TP53	1.97
253	Bardet-biedl syndrome 16	Enrichment	AKT3	1.97
254	Smith-kingsmore syndrome	Enrichment	MTOR	1.97
255	Idiopathic interstitial pneumonia	Enrichment	TERT	1.97
256	Fissured tongue	Enrichment	TP63	1.97
257	Interfrontal craniofaciosynostosis	Enrichment	FGFR1	1.97
258	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	1.97
259	Autosomal dominant nonsyndromic deafness	Enrichment	FGFR2	1.97
260	Vacterl with hydrocephalus	Enrichment	PTEN	1.97
261	Van der woude syndrome	Enrichment	IRF6	1.97
262	Teratoma	Enrichment	CTNNB1	1.97
263	Familial retinoblastoma	Enrichment	RB1	1.97
264	Common variable immunodeficiency 12	Enrichment	NFKB1	1.97
265	Juvenile polyposis of infancy	Enrichment	PTEN	1.97
266	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	1.97
267	Oculootodental syndrome	Enrichment	FADD	1.97
268	Wooly hair nevus	Enrichment	HRAS	1.97
269	Non-immune hydrops fetalis	Enrichment	HRAS, KRAS	1.92
270	Desmoid disease, hereditary	Enrichment	CTNNB1	1.79
271	Achondroplasia	Enrichment	FGFR3	1.79
272	Van der woude syndrome 1	Enrichment	IRF6	1.79
273	Hypogonadotropic hypogonadism 2 with or without anosmia	Enrichment	FGFR1	1.79
274	Larsen syndrome	Enrichment	FGFR3	1.79
275	Retinoblastoma	Enrichment	RB1	1.79
276	Pseudohypoaldosteronism, type iia	Enrichment	CUL3	1.79
277	Juvenile polyposis syndrome	Enrichment	SMAD4	1.79
278	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.79
279	Polycystic kidney disease, infantile severe, with tuberous sclerosis	Enrichment	TSC2	1.79
280	Langerhans cell histiocytosis	Enrichment	NRAS	1.79
281	Nasopharyngeal carcinoma	Enrichment	TP53	1.79
282	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	1.79
283	Tuberous sclerosis 2	Enrichment	TSC2	1.79
284	Chromosome 8p11 myeloproliferative syndrome	Enrichment	FGFR1	1.79
285	Woolly hair, autosomal recessive 3	Enrichment	RB1	1.79
286	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	1.79
287	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	1.79
288	Anus, imperforate	Enrichment	CTNNB1	1.79
289	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	1.79
290	Hypotrichosis 8	Enrichment	RB1	1.79
291	Desmoid tumor	Enrichment	CTNNB1	1.79
292	Dedifferentiated liposarcoma	Enrichment	CDK4	1.79
293	Loeys-dietz syndrome 1	Enrichment	TGFBR2	1.79
294	Interstitial lung disease	Enrichment	TERT	1.79
295	Atypical teratoid rhabdoid tumor	Enrichment	TP53	1.79
296	Anaplastic astrocytoma	Enrichment	TP53	1.79
297	Xanthinuria, type ii	Enrichment	TSC2	1.79
298	Immunodeficiency 14	Enrichment	PIK3R1	1.79
299	Macrocytic anemia	Enrichment	TERT	1.79
300	Adenocarcinoma	Enrichment	TP53	1.79
301	Laryngeal squamous cell carcinoma	Enrichment	PTEN	1.79
302	Growth delay due to insulin-like growth factor i resistance	Enrichment	IGF1R	1.79
303	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	1.79
304	Well-differentiated liposarcoma	Enrichment	CDK4	1.79
305	Apc-associated polyposis conditions	Enrichment	STK11	1.79
306	Autism spectrum disorder	Enrichment	CUL3, PTEN, TSC2	1.68
307	Cardiofaciocutaneous syndrome 1	Enrichment	KRAS	1.67
308	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	1.67
309	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	1.67
310	Immunodeficiency, common variable, 1	Enrichment	NFKB2	1.67
311	Pilomatrixoma	Enrichment	CTNNB1	1.67
312	Barrett esophagus	Enrichment	ERBB2	1.67
313	Lynch syndrome 4	Enrichment	RB1	1.67
314	Alazami syndrome	Enrichment	CTNNB1	1.67
315	Mantle cell lymphoma	Enrichment	CCND1	1.67
316	Cardiofaciocutaneous syndrome	Enrichment	KRAS	1.67
317	Cerebrovascular disease	Enrichment	PIK3CA	1.67
318	Embryonal rhabdomyosarcoma	Enrichment	TP53	1.67
319	Craniopharyngioma	Enrichment	CTNNB1	1.67
320	Pilocytic astrocytoma	Enrichment	KRAS	1.67
321	Epidermolytic nevus	Enrichment	HRAS	1.67
322	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.67
323	Non-syndromic bicoronal craniosynostosis	Enrichment	FGFR3	1.67
324	Capillary malformations, congenital	Enrichment	PIK3CA	1.57
325	Exudative vitreoretinopathy 1	Enrichment	CTNNB1	1.57
326	Von hippel-lindau syndrome	Enrichment	CCND1	1.57
327	Rhabdomyosarcoma 2	Enrichment	TP53	1.57
328	Macrocephaly/autism syndrome	Enrichment	PTEN	1.57
329	Insulin-like growth factor i	Enrichment	IGF1R	1.57
330	Familial adenomatous polyposis 1	Enrichment	STK11	1.57
331	Lymphoma	Enrichment	TP53	1.57
332	Holoprosencephaly	Enrichment	FGFR1	1.57
333	Hemangioma	Enrichment	PTEN	1.57
334	Herpes simplex virus encephalitis	Enrichment	TRAF3	1.57
335	Primary hypereosinophilic syndrome	Enrichment	FGFR1	1.57
336	Idiopathic aplastic anemia	Enrichment	TERT	1.57
337	Hypertelorism	Enrichment	FGFR2, PIK3CA	1.50
338	Dyskeratosis congenita, autosomal dominant 1	Enrichment	TERT	1.50
339	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.50
340	Weyers acrofacial dysostosis	Enrichment	CTNNB1	1.50
341	Split-hand/foot malformation 1	Enrichment	FGFR2	1.50
342	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.50
343	Holoprosencephaly 1	Enrichment	FGFR1	1.50
344	Keratoconus	Enrichment	TSC1	1.50
345	Pulmonary fibrosis	Enrichment	TERT	1.50
346	Hoyeraal-hreidarsson syndrome	Enrichment	TERT	1.50
347	46,xy disorder of sex development	Enrichment	FGFR3	1.50
348	Kidney clear cell sarcoma	Enrichment	TERT	1.50
349	Polycystic kidney disease 1 with or without polycystic liver disease	Enrichment	TSC2	1.43
350	Multiple endocrine neoplasia, type i	Enrichment	CDKN1A	1.43
351	Renal cell carcinoma, papillary, 1	Enrichment	MTOR	1.43
352	Dyskeratosis congenita, autosomal dominant 2	Enrichment	TERT	1.43
353	Adams-oliver syndrome	Enrichment	NOTCH1	1.43
354	Polycystic kidney disease 1	Enrichment	TSC2	1.43
355	Essential thrombocythemia	Enrichment	TP53	1.43
356	Hereditary hemorrhagic telangiectasia	Enrichment	SMAD4	1.43
357	Megacolon	Enrichment	AKT3	1.43
358	Lymphoma, non-hodgkin, familial	Enrichment	TP53	1.37
359	Exudative vitreoretinopathy	Enrichment	CTNNB1	1.37
360	Hypoplastic left heart syndrome	Enrichment	NOTCH1	1.37
361	Isolated split hand-split foot malformation	Enrichment	TP63	1.37
362	Nephrotic syndrome, type 1	Enrichment	FAT1	1.32
363	Loeys-dietz syndrome	Enrichment	TGFBR2	1.32
364	Hypogonadotropic hypogonadism	Enrichment	FGFR1	1.32
365	Primary hyperaldosteronism	Enrichment	TP53	1.32
366	Marfan syndrome	Enrichment	TGFBR2	1.28
367	Meier-gorlin syndrome 1	Enrichment	FGFR2	1.28
368	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.28
369	Aplastic anemia	Enrichment	TERT	1.28
370	Polymicrogyria	Enrichment	AKT3	1.28
371	Familial colorectal cancer	Enrichment	TP53	1.28
372	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.28
373	Primary bone dysplasia	Enrichment	FGFR3	1.28
374	Meningioma, familial	Enrichment	PTEN	1.24
375	Leukemia, acute lymphoblastic	Enrichment	CDKN2A	1.24
376	Myelodysplastic syndrome	Enrichment	TP53	1.24
377	Osteochondrodysplasia	Enrichment	FGFR3	1.24
378	Uterine corpus cancer	Enrichment	PTEN	1.24
379	Septooptic dysplasia	Enrichment	FGFR1	1.20
380	Renal hypodysplasia/aplasia 3	Enrichment	FGFR3	1.20
381	Aortic valve disease 1	Enrichment	NOTCH1	1.17
382	Premature menopause	Enrichment	TP63	1.17
383	Protein-deficiency anemia	Enrichment	NRAS	1.17
384	Hypogonadotropic hypogonadism 7 with or without anosmia	Enrichment	FGFR1	1.14
385	Medulloblastoma	Enrichment	CTNNB1	1.14
386	Aortic aneurysm, familial thoracic 1	Enrichment	NOTCH1	1.14
387	Renal cell carcinoma, nonpapillary	Enrichment	MTOR	1.11
388	Hydrocephalus	Enrichment	FGFR2	1.11
389	Autosomal dominant polycystic kidney disease	Enrichment	TSC2	1.11
390	Kidney disease	Enrichment	TSC1	1.11
391	Rare genetic intellectual disability	Enrichment	MTOR	1.11
392	Male infertility with spermatogenesis disorder	Enrichment	TP63	1.11
393	Microform holoprosencephaly	Enrichment	FGFR1	1.08
394	Lobar holoprosencephaly	Enrichment	FGFR1	1.08
395	Cleft palate, isolated	Enrichment	IRF6	1.06
396	Interstitial lung disease 2	Enrichment	TERT	1.06
397	Polycystic liver disease	Enrichment	CTNNB1	1.06
398	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1	1.06
399	Semilobar holoprosencephaly	Enrichment	FGFR1	1.03
400	Normosmic congenital hypogonadotropic hypogonadism	Enrichment	FGFR1	1.03
401	Ehlers-danlos syndrome	Enrichment	TGFBR2	1.01
402	Dyskeratosis congenita	Enrichment	TERT	1.01
403	Multisystem inflammatory syndrome in children	Enrichment	TRAF3	0.95
404	Diamond-blackfan anemia 1	Enrichment	TP53	0.93
405	Kallmann syndrome	Enrichment	FGFR1	0.93
406	Precursor t-cell acute lymphoblastic leukemia	Enrichment	CDKN2A	0.93
407	Tetralogy of fallot	Enrichment	NOTCH1	0.88
408	Hydrops fetalis, nonimmune	Enrichment	HRAS	0.88
409	Microcephaly	Enrichment	CTNNB1, IGF1R	0.85
410	Hirschsprung disease 1	Enrichment	ERBB2	0.84
411	Primary autosomal recessive microcephaly	Enrichment	CDK6	0.80
412	Diamond-blackfan anemia	Enrichment	TP53	0.75
413	Type 2 diabetes mellitus	Enrichment	AKT2	0.69
414	Nephrotic syndrome	Enrichment	FAT1	0.68
415	West syndrome	Enrichment	TSC2	0.67
416	Thrombocytopenia	Enrichment	SMAD4	0.64
417	Complex neurodevelopmental disorder	Enrichment	CUL3	0.31

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Head and neck squamous cell carcinoma

Pathway Network for Head and neck squamous cell carcinoma

Member Pathways for Head and neck squamous cell carcinoma

Pathways in the Head and neck squamous cell carcinoma SuperPath

Associated Genes for Head and neck squamous cell carcinoma

Associated Disorders for Head and neck squamous cell carcinoma

Disorders associated with Head and neck squamous cell carcinoma SuperPath

STRING Interaction Network for Head and neck squamous cell carcinoma

Sources for Head and neck squamous cell carcinoma