Hedgehog signaling events mediated by Gli proteins

No Pathway Network information available for Hedgehog signaling events mediated by Gli proteins

Pathways in the Hedgehog signaling events mediated by Gli proteins SuperPath

#	Name	Source	Genes
1	Hedgehog signaling events mediated by Gli proteins	PubChem	AKT1 ARRB2 BTRC CREBBP FBXW11 FOXA2 GLI1 GLI2 GLI3 GNB1 GNG2 GSK3B HDAC1 HDAC2 IFT172 IFT88 KIF3A KITLG LGALS3 MAP2K1 MTSS1 PIAS1 PRKACA PRKCD PTCH1 RAB23 RBBP4 RBBP7 SAP18 SAP30 SHH SIN3A SIN3B SMO SPOP STK36 SUFU XPO1 (see all 38) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	MTSS1	MTSS I-BAR Domain Containing 1	Protein Coding	1
2	RAB23	RAB23, Member RAS Oncogene Family	Protein Coding	1
3	STK36	Serine/Threonine Kinase 36	Protein Coding	1
4	KITLG	KIT Ligand	Protein Coding	1
5	SPOP	Speckle Type BTB/POZ Protein	Protein Coding	1
6	SIN3B	SIN3 Transcription Regulator Family Member B	Protein Coding	1
7	SHH	Sonic Hedgehog Signaling Molecule	Protein Coding	1
8	SAP30	Sin3A Associated Protein 30	Protein Coding	1
9	SAP18	Sin3A Associated Protein 18	Protein Coding	1
10	LGALS3	Galectin 3	Protein Coding	1
11	FBXW11	F-Box And WD Repeat Domain Containing 11	Protein Coding	1
12	RBBP7	RB Binding Protein 7, Chromatin Remodeling Factor	Protein Coding	1
13	RBBP4	RB Binding Protein 4, Chromatin Remodeling Factor	Protein Coding	1
14	GLI3	GLI Family Zinc Finger 3	Protein Coding	1
15	SUFU	SUFU Negative Regulator Of Hedgehog Signaling	Protein Coding	1
16	GLI1	GLI Family Zinc Finger 1	Protein Coding	1
17	GLI2	GLI Family Zinc Finger 2	Protein Coding	1
18	PTCH1	Patched 1	Protein Coding	1
19	BTRC	Beta-Transducin Repeat Containing E3 Ubiquitin Protein Ligase	Protein Coding	1
20	SMO	Smoothened, Frizzled Class Receptor	Protein Coding	1
21	XPO1	Exportin 1	Protein Coding	1
22	PRKCD	Protein Kinase C Delta	Protein Coding	1
23	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
24	SIN3A	SIN3 Transcription Regulator Family Member A	Protein Coding	1
25	ARRB2	Arrestin Beta 2	Protein Coding	1
26	HDAC2	Histone Deacetylase 2	Protein Coding	1
27	FOXA2	Forkhead Box A2	Protein Coding	1
28	CREBBP	CREB Binding Lysine Acetyltransferase	Protein Coding	1
29	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	1
30	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
31	IFT172	Intraflagellar Transport 172	Protein Coding	1
32	IFT88	Intraflagellar Transport 88	Protein Coding	1
33	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	1
34	KIF3A	Kinesin Family Member 3A	Protein Coding	1
35	GNB1	G Protein Subunit Beta 1	Protein Coding	1
36	GNG2	G Protein Subunit Gamma 2	Protein Coding	1
37	PIAS1	Protein Inhibitor Of Activated STAT 1	Protein Coding	1
38	HDAC1	Histone Deacetylase 1	Protein Coding	1

Disorders associated with Hedgehog signaling events mediated by Gli proteins SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Microform holoprosencephaly	Enrichment	GLI2, PTCH1, SHH, SUFU	7.03
2	Meningioma	Enrichment	AKT1, SMO, SUFU	5.36
3	Witteveen-kolk syndrome	Enrichment	SIN3A, SIN3B	5.12
4	Postaxial polydactyly type b	Enrichment	GLI1, GLI3	5.12
5	Polydactyly, postaxial, type a1	Enrichment	GLI1, GLI3, PTCH1	5.04
6	Septopreoptic holoprosencephaly	Enrichment	GLI2, PTCH1, SHH	5.04
7	Midline interhemispheric variant of holoprosencephaly	Enrichment	GLI2, PTCH1, SHH	5.04
8	Lobar holoprosencephaly	Enrichment	GLI2, PTCH1, SHH	4.96
9	Alobar holoprosencephaly	Enrichment	GLI2, PTCH1, SHH	4.87
10	Semilobar holoprosencephaly	Enrichment	GLI2, PTCH1, SHH	4.79
11	Polydactyly, preaxial ii	Enrichment	PTCH1, SHH	4.34
12	Basal cell nevus syndrome 1	Enrichment	PTCH1, SUFU	3.94
13	Combined pituitary hormone deficiency	Enrichment	FOXA2, GLI2	3.67
14	Ellis-van creveld syndrome	Enrichment	GLI1, PRKACA	3.57
15	Medulloblastoma	Enrichment	PTCH1, SUFU	3.17
16	Macs syndrome	Enrichment	PTCH1, SHH	2.85
17	Craniosynostosis	Enrichment	GLI2, GLI3	2.85
18	Holoprosencephaly 3	Enrichment	SHH	2.55
19	Pallister-hall syndrome	Enrichment	GLI3	2.55
20	Proteus syndrome	Enrichment	AKT1	2.55
21	Greig cephalopolysyndactyly syndrome	Enrichment	GLI3	2.55
22	Spermatogenic failure, x-linked, 9	Enrichment	RBBP7	2.55
23	Curry-jones syndrome	Enrichment	SMO	2.55
24	Schilbach-rott syndrome	Enrichment	PTCH1	2.55
25	Polydactyly, preaxial iv	Enrichment	GLI3	2.55
26	Melorheostosis, isolated	Enrichment	MAP2K1	2.55
27	Hyperpigmentation with or without hypopigmentation, familial progressive	Enrichment	KITLG	2.55
28	Microphthalmia/coloboma 5	Enrichment	SHH	2.55
29	Polydactyly, preaxial i	Enrichment	GLI1	2.55
30	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.55
31	Culler-jones syndrome	Enrichment	GLI2	2.55
32	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	2.55
33	Nabais sa-de vries syndrome, type 2	Enrichment	SPOP	2.55
34	Polydactyly, postaxial, type a8	Enrichment	GLI1	2.55
35	Joubert syndrome 32	Enrichment	SUFU	2.55
36	Neurodevelopmental, jaw, eye, and digital syndrome	Enrichment	FBXW11	2.55
37	Skin/hair/eye pigmentation, variation in, 7	Enrichment	KITLG	2.55
38	Melorheostosis	Enrichment	MAP2K1	2.55
39	Holoprosencephaly 9	Enrichment	GLI2	2.55
40	Cowden syndrome 6	Enrichment	AKT1	2.55
41	Nabais sa-de vries syndrome, type 1	Enrichment	SPOP	2.55
42	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	2.55
43	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	2.55
44	Intellectual developmental disorder, autosomal dominant 42	Enrichment	GNB1	2.55
45	Menke-hennekam syndrome 1	Enrichment	CREBBP	2.55
46	Ciliary dyskinesia, primary, 46	Enrichment	STK36	2.55
47	Deafness, autosomal dominant 69	Enrichment	KITLG	2.55
48	Rubinstein-taybi syndrome due to 16p13.3 microdeletion	Enrichment	CREBBP	2.55
49	Non-acquired combined pituitary hormone deficiency	Enrichment	FOXA2	2.55
50	Chromosome 15q24 deletion syndrome	Enrichment	SIN3A	2.55
51	Turner syndrome	Enrichment	PTCH1	2.55
52	Menke-hennekam syndrome	Enrichment	CREBBP	2.55
53	Familial progressive hyperpigmentation	Enrichment	KITLG	2.55
54	Monosomy 9q22.3	Enrichment	PTCH1	2.55
55	Postaxial polydactyly-anterior pituitary anomalies-facial dysmorphism syndrome	Enrichment	GLI2	2.55
56	Familial progressive hyper- and hypopigmentation	Enrichment	KITLG	2.55
57	Autosomal dominant preaxial polydactyly-upperback hypertrichosis syndrome	Enrichment	SHH	2.55
58	Hirschsprung disease 1	Enrichment	GLI3, SMO	2.53
59	Pallister-hall-like syndrome	Enrichment	SMO	2.25
60	Thumb deformity	Enrichment	CREBBP	2.25
61	Solitary median maxillary central incisor	Enrichment	SHH	2.25
62	White-sutton syndrome	Enrichment	GLI2	2.25
63	Bardet-biedl syndrome 22	Enrichment	IFT172	2.25
64	Carpenter syndrome 1	Enrichment	RAB23	2.25
65	Waardenburg syndrome, type 2f	Enrichment	KITLG	2.25
66	Tibial hemimelia	Enrichment	GLI3	2.25
67	Acute myeloid leukemia with kat6a-crebbp fusion	Enrichment	CREBBP	2.25
68	Synpolydactyly	Enrichment	GLI3	2.25
69	Congenital fibrosarcoma	Enrichment	SUFU	2.25
70	Fibrolamellar carcinoma	Enrichment	PRKACA	2.25
71	Basal cell nevus syndrome 2	Enrichment	SUFU	2.25
72	Primary mediastinal large b-cell lymphoma	Enrichment	XPO1	2.25
73	Isolated radial hemimelia	Enrichment	SHH	2.25
74	Cerebral visual impairment	Enrichment	GNB1	2.25
75	Acrocallosal syndrome	Enrichment	GLI3	2.08
76	Syndactyly, type iv	Enrichment	SHH	2.08
77	Aarskog-scott syndrome	Enrichment	GLI3	2.08
78	Langerhans cell histiocytosis	Enrichment	MAP2K1	2.08
79	Holoprosencephaly 7	Enrichment	PTCH1	2.08
80	Tethered spinal cord syndrome	Enrichment	CREBBP	2.08
81	Umbilical hernia	Enrichment	GLI3	2.08
82	Hypoplastic or aplastic tibia with polydactyly	Enrichment	SHH	2.08
83	Intraocular pressure quantitative trait locus	Enrichment	CREBBP	2.08
84	Desmoplastic/nodular medulloblastoma	Enrichment	SUFU	2.08
85	Cardiofaciocutaneous syndrome 1	Enrichment	MAP2K1	1.95
86	Schizencephaly	Enrichment	SHH	1.95
87	Short-rib thoracic dysplasia 10 with or without polydactyly	Enrichment	IFT172	1.95
88	Retinitis pigmentosa 71	Enrichment	IFT172	1.95
89	Bardet-biedl syndrome 20	Enrichment	IFT172	1.95
90	Cardiofaciocutaneous syndrome	Enrichment	MAP2K1	1.95
91	Oculomotor apraxia	Enrichment	SUFU	1.95
92	Short-rib thoracic dysplasia 9 with or without polydactyly	Enrichment	IFT172	1.86
93	Rubinstein-taybi syndrome 1	Enrichment	CREBBP	1.78
94	Testicular germ cell tumor	Enrichment	KITLG	1.78
95	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	CREBBP	1.78
96	Basal cell carcinoma 1	Enrichment	PTCH1	1.78
97	Breast adenocarcinoma	Enrichment	AKT1	1.78
98	Hypertrichosis	Enrichment	CREBBP	1.78
99	Autism	Enrichment	CREBBP, SHH	1.76
100	Waardenburg syndrome, type 2e	Enrichment	KITLG	1.71
101	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1	1.71
102	Congenital hydrocephalus	Enrichment	PTCH1	1.71
103	Overgrowth syndrome	Enrichment	PTCH1	1.71
104	Hypothyroidism	Enrichment	GNB1	1.65
105	Isolated split hand-split foot malformation	Enrichment	BTRC	1.65
106	Arteriovenous malformation	Enrichment	MAP2K1	1.60
107	Cowden syndrome	Enrichment	AKT1	1.60
108	Myopathy, x-linked, with excessive autophagy	Enrichment	MAP2K1	1.56
109	Meningioma, familial	Enrichment	SUFU	1.52
110	Leukemia, acute lymphoblastic	Enrichment	GNB1	1.52
111	Myelodysplastic syndrome	Enrichment	GNB1	1.52
112	Lung non-small cell carcinoma	Enrichment	MAP2K1	1.52
113	Ovarian cancer	Enrichment	AKT1, PTCH1	1.49
114	Septooptic dysplasia	Enrichment	SHH	1.48
115	Short-rib thoracic dysplasia 6 with or without polydactyly	Enrichment	IFT172	1.48
116	Diaphragmatic hernia, congenital	Enrichment	GLI3	1.45
117	Autism spectrum disorder	Enrichment	GNB1, MAP2K1	1.43
118	Heart disease	Enrichment	CREBBP	1.41
119	Corpus callosum, agenesis of	Enrichment	CREBBP	1.38
120	Isolated corpus callosum agenesis	Enrichment	CREBBP	1.38
121	Rare genetic intellectual disability	Enrichment	CREBBP	1.38
122	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CREBBP	1.38
123	Noonan syndrome and noonan-related syndrome	Enrichment	MAP2K1	1.38
124	Rhabdomyosarcoma	Enrichment	PTCH1	1.36
125	Cleft palate, isolated	Enrichment	GNB1	1.33
126	Diffuse large b-cell lymphoma	Enrichment	CREBBP	1.28
127	Inherited cancer-predisposing syndrome	Enrichment	PTCH1, SUFU	1.28
128	Microphthalmia	Enrichment	PTCH1	1.22
129	Noonan syndrome 1	Enrichment	MAP2K1	1.20
130	Scoliosis	Enrichment	CREBBP	1.19
131	Rasopathy	Enrichment	MAP2K1	1.15
132	Strabismus	Enrichment	GNB1	1.14
133	Isolated joubert syndrome	Enrichment	SUFU	1.09
134	Short-rib thoracic dysplasia 1 with or without polydactyly	Enrichment	IFT172	1.05
135	Nephronophthisis	Enrichment	PIAS1	1.05
136	Dystonia	Enrichment	GNB1	1.03
137	Cerebral palsy	Enrichment	GNB1	0.98
138	Bardet-biedl syndrome	Enrichment	IFT172	0.95
139	Hereditary breast carcinoma	Enrichment	AKT1	0.93
140	Retinitis pigmentosa	Enrichment	IFT172, IFT88	0.93
141	Joubert syndrome 1	Enrichment	IFT172	0.88
142	Autosomal dominant non-syndromic intellectual disability	Enrichment	GNB1	0.88
143	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	KITLG	0.87
144	Hereditary breast ovarian cancer syndrome	Enrichment	PTCH1	0.84
145	Myeloma, multiple	Enrichment	CREBBP	0.84
146	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	GLI2	0.84
147	Breast cancer	Enrichment	AKT1	0.72
148	Primary ciliary dyskinesia	Enrichment	STK36	0.72
149	Colorectal cancer	Enrichment	AKT1	0.66
150	Congenital nervous system abnormality	Enrichment	CREBBP	0.59
151	Nervous system disease	Enrichment	CREBBP	0.59
152	Microcephaly	Enrichment	GNB1	0.53
153	Complex neurodevelopmental disorder	Enrichment	FBXW11	0.53
154	Hereditary retinal dystrophy	Enrichment	IFT172	0.25
155	Fundus dystrophy	Enrichment	IFT172	0.25

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Hedgehog signaling events mediated by Gli proteins

Pathway Network for Hedgehog signaling events mediated by Gli proteins

Member Pathways for Hedgehog signaling events mediated by Gli proteins

Pathways in the Hedgehog signaling events mediated by Gli proteins SuperPath

Associated Genes for Hedgehog signaling events mediated by Gli proteins

Associated Disorders for Hedgehog signaling events mediated by Gli proteins

Disorders associated with Hedgehog signaling events mediated by Gli proteins SuperPath

STRING Interaction Network for Hedgehog signaling events mediated by Gli proteins

Sources for Hedgehog signaling events mediated by Gli proteins