Hedgehog signaling pathway

No Pathway Network information available for Hedgehog signaling pathway

Pathways in the Hedgehog signaling pathway SuperPath

#	Name	Source	Genes
1	Hedgehog signaling pathway	WikiPathways	ARRB1 ARRB2 BCL2 BOC CCND1 CCND2 CDON CSNK1A1 CSNK1A1L CSNK1D CSNK1E CSNK1G1 CSNK1G2 CSNK1G3 CUL3 DHH EVC2 FBXL17 GAS1 GLI1 GLI2 GLI3 GPR161 GRK2 GRK3 HHIP IHH KIF3A KIF7 LRP2 PRKACA PRKACB PRKACG PTCH1 PTCH2 SHH SMO SMURF1 SMURF2 SPOP SPOPL SUFU (see all 42) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	BOC	BOC Cell Adhesion Associated, Oncogene Regulated	Protein Coding	1
2	CCND2	Cyclin D2	Protein Coding	1
3	PTCH2	Patched 2	Protein Coding	1
4	CUL3	Cullin 3	Protein Coding	1
5	SPOP	Speckle Type BTB/POZ Protein	Protein Coding	1
6	SMO	Smoothened, Frizzled Class Receptor	Protein Coding	1
7	SHH	Sonic Hedgehog Signaling Molecule	Protein Coding	1
8	HHIP	Hedgehog Interacting Protein	Protein Coding	1
9	BCL2	BCL2 Apoptosis Regulator	Protein Coding	1
10	CCND1	Cyclin D1	Protein Coding	1
11	PTCH1	Patched 1	Protein Coding	1
12	SMURF1	SMAD Specific E3 Ubiquitin Protein Ligase 1	Protein Coding	1
13	PRKACG	Protein Kinase CAMP-Activated Catalytic Subunit Gamma	Protein Coding	1
14	PRKACB	Protein Kinase CAMP-Activated Catalytic Subunit Beta	Protein Coding	1
15	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	1
16	SUFU	SUFU Negative Regulator Of Hedgehog Signaling	Protein Coding	1
17	CDON	Cell Adhesion Associated, Oncogene Regulated	Protein Coding	1
18	DHH	Desert Hedgehog Signaling Molecule	Protein Coding	1
19	ARRB2	Arrestin Beta 2	Protein Coding	1
20	ARRB1	Arrestin Beta 1	Protein Coding	1
21	LRP2	LDL Receptor Related Protein 2	Protein Coding	1
22	KIF7	Kinesin Family Member 7	Protein Coding	1
23	IHH	Indian Hedgehog Signaling Molecule	Protein Coding	1
24	GLI3	GLI Family Zinc Finger 3	Protein Coding	1
25	GLI2	GLI Family Zinc Finger 2	Protein Coding	1
26	GLI1	GLI Family Zinc Finger 1	Protein Coding	1
27	GAS1	Growth Arrest Specific 1	Protein Coding	1
28	GPR161	G Protein-Coupled Receptor 161	Protein Coding	1
29	GRK3	G Protein-Coupled Receptor Kinase 3	Protein Coding	1
30	GRK2	G Protein-Coupled Receptor Kinase 2	Protein Coding	1
31	CSNK1D	Casein Kinase 1 Delta	Protein Coding	1
32	CSNK1A1	Casein Kinase 1 Alpha 1	Protein Coding	1
33	EVC2	EvC Ciliary Complex Subunit 2	Protein Coding	1
34	KIF3A	Kinesin Family Member 3A	Protein Coding	1
35	CSNK1G3	Casein Kinase 1 Gamma 3	Protein Coding	1
36	CSNK1G2	Casein Kinase 1 Gamma 2	Protein Coding	1
37	CSNK1E	Casein Kinase 1 Epsilon	Protein Coding	1
38	CSNK1A1L	Casein Kinase 1 Alpha 1 Like	Protein Coding	1
39	FBXL17	F-Box And Leucine Rich Repeat Protein 17	Protein Coding	1
40	SMURF2	SMAD Specific E3 Ubiquitin Protein Ligase 2	Protein Coding	1
41	CSNK1G1	Casein Kinase 1 Gamma 1	Protein Coding	1
42	SPOPL	Speckle Type BTB/POZ Protein Like	Protein Coding	1

Disorders associated with Hedgehog signaling pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Microform holoprosencephaly	Enrichment	CDON, GAS1, GLI2, PTCH1, SHH, SUFU	10.39
2	Septopreoptic holoprosencephaly	Enrichment	CDON, GAS1, GLI2, PTCH1, SHH	9.18
3	Midline interhemispheric variant of holoprosencephaly	Enrichment	CDON, GAS1, GLI2, PTCH1, SHH	9.18
4	Lobar holoprosencephaly	Enrichment	CDON, GAS1, GLI2, PTCH1, SHH	9.01
5	Alobar holoprosencephaly	Enrichment	CDON, GAS1, GLI2, PTCH1, SHH	8.88
6	Semilobar holoprosencephaly	Enrichment	CDON, GAS1, GLI2, PTCH1, SHH	8.73
7	Ellis-van creveld syndrome	Enrichment	EVC2, GLI1, PRKACA, PRKACB	8.00
8	Medulloblastoma	Enrichment	GPR161, PTCH1, PTCH2, SUFU	7.11
9	Basal cell nevus syndrome 1	Enrichment	PTCH1, PTCH2, SUFU	6.26
10	Postaxial polydactyly type b	Enrichment	GLI1, GLI3	5.03
11	Polydactyly, postaxial, type a1	Enrichment	GLI1, GLI3, PTCH1	4.91
12	Acrocallosal syndrome	Enrichment	GLI3, KIF7	4.55
13	Polydactyly, preaxial ii	Enrichment	PTCH1, SHH	4.25
14	Hirschsprung disease 1	Enrichment	GLI3, IHH, SMO	4.02
15	Basal cell carcinoma 1	Enrichment	PTCH1, PTCH2	3.86
16	Meningioma	Enrichment	SMO, SUFU	3.22
17	Pituitary stalk interruption syndrome	Enrichment	CDON, GPR161	3.08
18	Macs syndrome	Enrichment	PTCH1, SHH	2.77
19	Craniosynostosis	Enrichment	GLI2, GLI3	2.77
20	Jeune thoracic dystrophy	Enrichment	EVC2, GRK2	2.57
21	Holoprosencephaly 3	Enrichment	SHH	2.51
22	Pallister-hall syndrome	Enrichment	GLI3	2.51
23	Greig cephalopolysyndactyly syndrome	Enrichment	GLI3	2.51
24	46,xy sex reversal 7	Enrichment	DHH	2.51
25	Curry-jones syndrome	Enrichment	SMO	2.51
26	Schilbach-rott syndrome	Enrichment	PTCH1	2.51
27	Polydactyly, preaxial iv	Enrichment	GLI3	2.51
28	Hydrolethalus syndrome 2	Enrichment	KIF7	2.51
29	Microphthalmia/coloboma 5	Enrichment	SHH	2.51
30	Polydactyly, preaxial i	Enrichment	GLI1	2.51
31	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3	Enrichment	CCND2	2.51
32	Donnai-barrow syndrome	Enrichment	LRP2	2.51
33	Pseudohypoaldosteronism, type iie	Enrichment	CUL3	2.51
34	Advanced sleep phase syndrome, familial, 2	Enrichment	CSNK1D	2.51
35	Culler-jones syndrome	Enrichment	GLI2	2.51
36	Nabais sa-de vries syndrome, type 2	Enrichment	SPOP	2.51
37	Polydactyly, postaxial, type a8	Enrichment	GLI1	2.51
38	Joubert syndrome 32	Enrichment	SUFU	2.51
39	Al-gazali-bakalinova syndrome	Enrichment	KIF7	2.51
40	Cardioacrofacial dysplasia 2	Enrichment	PRKACB	2.51
41	Acrocapitofemoral dysplasia	Enrichment	IHH	2.51
42	Holoprosencephaly 9	Enrichment	GLI2	2.51
43	Holoprosencephaly 11	Enrichment	CDON	2.51
44	Nabais sa-de vries syndrome, type 1	Enrichment	SPOP	2.51
45	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	2.51
46	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	2.51
47	Neurodevelopmental disorder with or without autism or seizures	Enrichment	CUL3	2.51
48	Multiple epiphyseal dysplasia, al-gazali type	Enrichment	KIF7	2.51
49	Prolactin-producing pituitary gland adenoma	Enrichment	LRP2	2.51
50	Turner syndrome	Enrichment	PTCH1	2.51
51	Monosomy 9q22.3	Enrichment	PTCH1	2.51
52	Postaxial polydactyly-anterior pituitary anomalies-facial dysmorphism syndrome	Enrichment	GLI2	2.51
53	Autosomal dominant preaxial polydactyly-upperback hypertrichosis syndrome	Enrichment	SHH	2.51
54	Asphyxiating thoracic dystrophy	Enrichment	EVC2, GRK2	2.47
55	Short-rib thoracic dysplasia 1 with or without polydactyly	Enrichment	EVC2, GRK2	2.33
56	Pallister-hall-like syndrome	Enrichment	SMO	2.21
57	46,xy gonadal dysgenesis with minifascicular neuropathy	Enrichment	DHH	2.21
58	Pseudohypoaldosteronism, type i, autosomal dominant	Enrichment	CUL3	2.21
59	Solitary median maxillary central incisor	Enrichment	SHH	2.21
60	Bleeding disorder, platelet-type, 19	Enrichment	PRKACG	2.21
61	White-sutton syndrome	Enrichment	GLI2	2.21
62	Intravascular large b-cell lymphoma	Enrichment	BCL2	2.21
63	Tibial hemimelia	Enrichment	GLI3	2.21
64	Synpolydactyly	Enrichment	GLI3	2.21
65	Congenital fibrosarcoma	Enrichment	SUFU	2.21
66	Fibrolamellar carcinoma	Enrichment	PRKACA	2.21
67	Basal cell nevus syndrome 2	Enrichment	SUFU	2.21
68	Non-syndromic syndactyly	Enrichment	LRP2	2.21
69	Isolated radial hemimelia	Enrichment	SHH	2.21
70	Commissural facial cleft	Enrichment	PTCH2	2.21
71	Brachydactyly, type a1	Enrichment	IHH	2.03
72	Pseudohypoaldosteronism, type iia	Enrichment	CUL3	2.03
73	Syndactyly, type iv	Enrichment	SHH	2.03
74	Aarskog-scott syndrome	Enrichment	GLI3	2.03
75	Holoprosencephaly 7	Enrichment	PTCH1	2.03
76	Umbilical hernia	Enrichment	GLI3	2.03
77	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	BCL2	2.03
78	Hydrolethalus syndrome	Enrichment	KIF7	2.03
79	Hypoplastic or aplastic tibia with polydactyly	Enrichment	SHH	2.03
80	Desmoplastic/nodular medulloblastoma	Enrichment	SUFU	2.03
81	Advanced sleep phase syndrome	Enrichment	CSNK1D	2.03
82	Schizencephaly	Enrichment	SHH	1.91
83	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	CCND2	1.91
84	Mantle cell lymphoma	Enrichment	CCND1	1.91
85	Prolactinoma	Enrichment	LRP2	1.91
86	Oculomotor apraxia	Enrichment	SUFU	1.91
87	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	KIF7	1.91
88	Von hippel-lindau syndrome	Enrichment	CCND1	1.81
89	Follicular lymphoma	Enrichment	BCL2	1.81
90	Weyers acrofacial dysostosis	Enrichment	EVC2	1.73
91	Congenital hydrocephalus	Enrichment	PTCH1	1.67
92	Overgrowth syndrome	Enrichment	PTCH1	1.67
93	Short-rib thoracic dysplasia 12	Enrichment	EVC2	1.61
94	Combined pituitary hormone deficiency	Enrichment	GLI2	1.61
95	Leukemia, chronic lymphocytic	Enrichment	CCND1	1.52
96	Orofaciodigital syndrome vi	Enrichment	KIF7	1.47
97	Meningioma, familial	Enrichment	SUFU	1.47
98	46,xy complete gonadal dysgenesis	Enrichment	DHH	1.47
99	Septooptic dysplasia	Enrichment	SHH	1.44
100	Short-rib thoracic dysplasia 6 with or without polydactyly	Enrichment	EVC2	1.44
101	Microphthalmia/coloboma 12	Enrichment	CDON	1.40
102	Diaphragmatic hernia, congenital	Enrichment	GLI3	1.40
103	Bardet-biedl syndrome 1	Enrichment	KIF7	1.40
104	Nk-cell enteropathy	Enrichment	CUL3	1.40
105	Coloboma of macula	Enrichment	CDON	1.34
106	Hydrocephalus, congenital, 1	Enrichment	KIF7	1.31
107	Rhabdomyosarcoma	Enrichment	PTCH1	1.31
108	Inherited cancer-predisposing syndrome	Enrichment	PTCH1, SUFU	1.20
109	Microphthalmia	Enrichment	PTCH1	1.18
110	Developmental and epileptic encephalopathy 1	Enrichment	CSNK1E	1.13
111	Strabismus	Enrichment	KIF7	1.09
112	Meckel syndrome, type 1	Enrichment	EVC2	1.07
113	Isolated joubert syndrome	Enrichment	SUFU	1.05
114	West syndrome	Enrichment	CSNK1E	0.89
115	Hereditary breast ovarian cancer syndrome	Enrichment	PTCH1	0.80
116	Myeloma, multiple	Enrichment	CCND1	0.80
117	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	GLI2	0.80
118	Autism	Enrichment	SHH	0.70
119	Breast cancer	Enrichment	PTCH2	0.68
120	Colorectal cancer	Enrichment	CCND1	0.63
121	Ovarian cancer	Enrichment	PTCH1	0.57
122	Autism spectrum disorder	Enrichment	CUL3	0.54
123	Complex neurodevelopmental disorder	Enrichment	CUL3	0.49
124	Hereditary retinal dystrophy	Enrichment	LRP2	0.22
125	Fundus dystrophy	Enrichment	LRP2	0.22

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Hedgehog signaling pathway

Pathway Network for Hedgehog signaling pathway

Member Pathways for Hedgehog signaling pathway

Pathways in the Hedgehog signaling pathway SuperPath

Associated Genes for Hedgehog signaling pathway

Associated Disorders for Hedgehog signaling pathway

Disorders associated with Hedgehog signaling pathway SuperPath

STRING Interaction Network for Hedgehog signaling pathway

Sources for Hedgehog signaling pathway