Heparin-induced Thrombocytopenia Pathway, Adverse Drug Reaction

No Pathway Network information available for Heparin-induced Thrombocytopenia Pathway, Adverse Drug Reaction

Pathways in the Heparin-induced Thrombocytopenia Pathway, Adverse Drug Reaction SuperPath

#	Name	Source	Genes
1	Heparin-induced Thrombocytopenia Pathway, Adverse Drug Reaction	PharmGKB	ACP1 BLK CD4 F2 F3 FCGR1A FCGR2A FCGR3A FGR FRK FYN GPR65 HCK HLA-DRA HLA-DRB1 IGHG1 IGHG2 IGHG3 IGHG4 IGKC IGKJ IGKV@ IGLJ IGLV@ IL10 ITGA2B ITGB3 LCK LYN PECAM1 PF4 PTPRJ SRC TRA TRB UBASH3B YES1 (see all 37) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	BLK	BLK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
2	IL10	Interleukin 10	Protein Coding	1
3	YES1	YES Proto-Oncogene 1, Src Family Tyrosine Kinase	Protein Coding	1
4	FCGR1A	Fc Gamma Receptor Ia	Protein Coding	1
5	FCGR2A	Fc Gamma Receptor IIa	Protein Coding	1
6	FCGR3A	Fc Gamma Receptor IIIa	Protein Coding	1
7	FGR	FGR Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
8	IGKJ	Immunoglobulin Kappa Joining Cluster	Genetic Locus	1
9	TRA	T Cell Receptor Alpha Locus	Protein Coding	1
10	TRB	T Cell Receptor Beta Locus	Protein Coding	1
11	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
12	IGLJ	Immunoglobulin Lambda Joining Cluster	Genetic Locus	1
13	ITGA2B	Integrin Subunit Alpha 2b	Protein Coding	1
14	ITGB3	Integrin Subunit Beta 3	Protein Coding	1
15	CD4	CD4 Molecule	Protein Coding	1
16	PECAM1	Platelet And Endothelial Cell Adhesion Molecule 1	Protein Coding	1
17	PF4	Platelet Factor 4	Protein Coding	1
18	ACP1	Acid Phosphatase 1	Protein Coding	1
19	GPR65	G Protein-Coupled Receptor 65	Protein Coding	1
20	HLA-DRA	Major Histocompatibility Complex, Class II, DR Alpha	Protein Coding	1
21	HLA-DRB1	Major Histocompatibility Complex, Class II, DR Beta 1	Protein Coding	1
22	F2	Coagulation Factor II, Thrombin	Protein Coding	1
23	F3	Coagulation Factor III, Tissue Factor	Protein Coding	1
24	FRK	Fyn Related Src Family Tyrosine Kinase	Protein Coding	1
25	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
26	IGHG1	Immunoglobulin Heavy Constant Gamma 1 (G1m Marker)	Protein Coding	1
27	IGHG2	Immunoglobulin Heavy Constant Gamma 2 (G2m Marker)	Protein Coding	1
28	IGHG3	Immunoglobulin Heavy Constant Gamma 3 (G3m Marker)	Protein Coding	1
29	IGHG4	Immunoglobulin Heavy Constant Gamma 4 (G4m Marker)	Protein Coding	1
30	IGKC	Immunoglobulin Kappa Constant	Protein Coding	1
31	IGKV@	Immunoglobulin Kappa Variable Cluster	Gene Cluster	1
32	IGLV@	Immunoglobulin Lambda Variable Cluster	Gene Cluster	1
33	PTPRJ	Protein Tyrosine Phosphatase Receptor Type J	Protein Coding	1
34	LCK	LCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
35	LYN	LYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
36	HCK	HCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
37	UBASH3B	Ubiquitin Associated And SH3 Domain Containing B	Protein Coding	1

Disorders associated with Heparin-induced Thrombocytopenia Pathway, Adverse Drug Reaction SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Systemic lupus erythematosus	Enrichment	BLK, FCGR2A, HLA-DRB1, IGHG1, IL10	7.21
2	Bleeding disorder, platelet-type, 16	Enrichment	ITGA2B, ITGB3	4.66
3	Recurrent infections associated with rare immunoglobulin isotypes deficiency	Enrichment	IGHG2, IGKC	4.66
4	Fetomaternal alloimmune thrombocytopenia 1	Enrichment	ITGA2B, ITGB3	3.97
5	Glanzmann thrombasthenia 1	Enrichment	ITGA2B, ITGB3	3.82
6	Thrombocytopenia	Enrichment	ITGA2B, ITGB3, SRC	3.53
7	Autosomal dominant macrothrombocytopenia	Enrichment	ITGA2B, ITGB3	3.49
8	Precursor t-cell acute lymphoblastic leukemia	Enrichment	TRA, TRB	2.75
9	Prothrombin deficiency, congenital	Enrichment	F2	2.56
10	Immunodeficiency 20	Enrichment	FCGR3A	2.56
11	Fetomaternal alloimmune thrombocytopenia 2	Enrichment	ITGA2B	2.56
12	Okt4 epitope deficiency	Enrichment	CD4	2.56
13	Graft-versus-host disease	Enrichment	IL10	2.56
14	Pulmonary alveolar proteinosis, acquired	Enrichment	HLA-DRB1	2.56
15	Graham little-piccardi-lassueur syndrome	Enrichment	HLA-DRA	2.56
16	Pregnancy loss, recurrent 2	Enrichment	F2	2.56
17	Immunodeficiency 22	Enrichment	LCK	2.56
18	Thrombocytopenia 6	Enrichment	SRC	2.56
19	Autoinflammatory disease, systemic, with vasculitis	Enrichment	LYN	2.56
20	Immunodeficiency 79	Enrichment	CD4	2.56
21	Autoinflammation with pulmonary and cutaneous vasculitis	Enrichment	HCK	2.56
22	Thrombocytopenia 10	Enrichment	PTPRJ	2.56
23	Prothrombin deficiency	Enrichment	F2	2.56
24	Immunoglobulin kappa light chain deficiency	Enrichment	IGKC	2.26
25	Maturity-onset diabetes of the young, type 11	Enrichment	BLK	2.26
26	Sarcoidosis 1	Enrichment	HLA-DRB1	2.26
27	Trypsinogen deficiency	Enrichment	TRB	2.26
28	Bullous pemphigoid	Enrichment	HLA-DRB1	2.26
29	Pediatric multiple sclerosis	Enrichment	HLA-DRB1	2.26
30	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	ITGB3	2.09
31	Immunodeficiency 7	Enrichment	TRA	2.09
32	Bleeding disorder, platelet-type, 24	Enrichment	ITGB3	2.09
33	Cerebral sinovenous thrombosis	Enrichment	F2	2.09
34	Vogt-koyanagi-harada disease	Enrichment	HLA-DRB1	2.09
35	Temporal arteritis	Enrichment	HLA-DRB1	1.96
36	Systemic-onset juvenile idiopathic arthritis	Enrichment	HLA-DRB1	1.96
37	Vitamin d-dependent rickets, type 2a	Enrichment	TRB	1.87
38	Narcolepsy 2	Enrichment	HLA-DRB1	1.87
39	Glanzmann thrombasthenia 2	Enrichment	ITGB3	1.87
40	Follicular lymphoma	Enrichment	HLA-DRB1	1.87
41	Diffuse cutaneous systemic sclerosis	Enrichment	HLA-DRB1	1.87
42	Limited scleroderma	Enrichment	HLA-DRB1	1.79
43	Il10-related early-onset inflammatory bowel disease	Enrichment	IL10	1.79
44	Thrombophilia due to thrombin defect	Enrichment	F2	1.72
45	Myelofibrosis	Enrichment	SRC	1.72
46	Narcolepsy 1	Enrichment	HLA-DRB1	1.67
47	Colorectal cancer	Enrichment	PTPRJ, SRC	1.63
48	Rheumatoid arthritis	Enrichment	IL10	1.61
49	Leukemia, chronic lymphocytic	Enrichment	IGHG1	1.57
50	Stroke, ischemic	Enrichment	F2	1.57
51	Multiple sclerosis	Enrichment	HLA-DRB1	1.43
52	Osteoporosis	Enrichment	SRC	1.43
53	Hereditary chronic pancreatitis	Enrichment	TRB	1.43
54	Pancreatitis, hereditary	Enrichment	TRB	1.34
55	Human immunodeficiency virus type 1	Enrichment	IL10	1.32
56	Behcet syndrome	Enrichment	IL10	1.30
57	Maturity-onset diabetes of the young	Enrichment	BLK	1.27
58	Myocardial infarction	Enrichment	ITGB3	1.23
59	Malaria	Enrichment	FCGR2A	1.22
60	Cystic fibrosis	Enrichment	FCGR2A	1.08
61	Severe combined immunodeficiency	Enrichment	LCK	1.06
62	Cerebral palsy	Enrichment	F2	0.99

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Heparin-induced Thrombocytopenia Pathway, Adverse Drug Reaction

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Pathways in the Heparin-induced Thrombocytopenia Pathway, Adverse Drug Reaction SuperPath

Associated Genes for Heparin-induced Thrombocytopenia Pathway, Adverse Drug Reaction

Associated Disorders for Heparin-induced Thrombocytopenia Pathway, Adverse Drug Reaction

Disorders associated with Heparin-induced Thrombocytopenia Pathway, Adverse Drug Reaction SuperPath

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