HETE and HPETE biosynthesis and metabolism

Sources:

#	Name	Source	Genes
1	HETE and HPETE biosynthesis and metabolism	GeneGo (Thomson Reuters)	ALOX12 ALOX12B ALOX15 ALOX15B ALOX5 CYP2C8 CYP2C9 CYP2E1 CYP2J2 CYP4A11 CYP4F2 CYP4F3 EPHX2 GPX1 GPX4 MGST2 MGST3 PTGIS PTGS1 PTGS2 TBXAS1 (see all 21) (see less)
2	Arachidonic acid (AA, ARA) oxylipin metabolism	WikiPathways	EPHX2 PTGS1 PTGS2 TBXAS1
3	Docosahexaenoic acid oxylipin metabolism	WikiPathways	EPHX2 PTGS2

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	EPHX2	Epoxide Hydrolase 2	Protein Coding	3
2	PTGS2	Prostaglandin-Endoperoxide Synthase 2	Protein Coding	3
3	PTGS1	Prostaglandin-Endoperoxide Synthase 1	Protein Coding	2
4	TBXAS1	Thromboxane A Synthase 1	Protein Coding	2
5	ALOX12	Arachidonate 12-Lipoxygenase, 12S Type	Protein Coding	1
6	ALOX5	Arachidonate 5-Lipoxygenase	Protein Coding	1
7	ALOX12B	Arachidonate 12-Lipoxygenase, 12R Type	Protein Coding	1
8	ALOX15	Arachidonate 15-Lipoxygenase	Protein Coding	1
9	ALOX15B	Arachidonate 15-Lipoxygenase Type B	Protein Coding	1
10	CYP2C8	Cytochrome P450 Family 2 Subfamily C Member 8	Protein Coding	1
11	CYP2C9	Cytochrome P450 Family 2 Subfamily C Member 9	Protein Coding	1
12	CYP2E1	Cytochrome P450 Family 2 Subfamily E Member 1	Protein Coding	1
13	CYP2J2	Cytochrome P450 Family 2 Subfamily J Member 2	Protein Coding	1
14	CYP4A11	Cytochrome P450 Family 4 Subfamily A Member 11	Protein Coding	1
15	GPX1	Glutathione Peroxidase 1	Protein Coding	1
16	GPX4	Glutathione Peroxidase 4	Protein Coding	1
17	CYP4F3	Cytochrome P450 Family 4 Subfamily F Member 3	Protein Coding	1
18	MGST2	Microsomal Glutathione S-Transferase 2	Protein Coding	1
19	MGST3	Microsomal Glutathione S-Transferase 3	Protein Coding	1
20	PTGIS	Prostaglandin I2 Synthase	Protein Coding	1
21	CYP4F2	Cytochrome P450 Family 4 Subfamily F Member 2	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Ghosal hematodiaphyseal dysplasia	Enrichment	TBXAS1	3.53
2	Bleeding disorder, platelet-type, 14	Enrichment	TBXAS1	3.23
3	Spondylometaphyseal dysplasia, sedaghatian type	Enrichment	GPX4	2.81
4	Drug metabolism, altered, cyp2c8-related	Enrichment	CYP2C8	2.81
5	Glutathione peroxidase deficiency	Enrichment	GPX1	2.81
6	Atherosclerosis	Enrichment	ALOX5	2.81
7	Hypercholesterolemia, familial, 1	Enrichment	EPHX2	2.72
8	Familial hypercholesterolemia	Enrichment	EPHX2	2.66
9	Coumarin resistance	Enrichment	CYP2C9	2.33
10	Self-improving collodion baby	Enrichment	ALOX12B	2.33
11	Ichthyosis, congenital, autosomal recessive 2	Enrichment	ALOX12B	2.11
12	Leukoencephalopathy, brain calcifications, and cysts	Enrichment	ALOX12B	1.97
13	Congenital nonbullous ichthyosiform erythroderma	Enrichment	ALOX12B	1.81
14	Asthma	Enrichment	ALOX5	1.77
15	Ichthyosis	Enrichment	ALOX12B	1.77
16	Pulmonary disease, chronic obstructive	Enrichment	MGST3	1.70
17	Autosomal recessive congenital ichthyosis	Enrichment	ALOX12B	1.64
18	Hypertension, essential	Enrichment	PTGIS	1.58

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for HETE and HPETE biosynthesis and metabolism