Hfe effect on hepcidin production

No Pathway Network information available for Hfe effect on hepcidin production

#	Name	Source	Genes
1	Hfe effect on hepcidin production	WikiPathways	BMP6 HAMP HFE HJV ID1 SMAD7 TMPRSS6 (see all 7) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	BMP6	Bone Morphogenetic Protein 6	Protein Coding	1
2	HAMP	Hepcidin Antimicrobial Peptide	Protein Coding	1
3	SMAD7	SMAD Family Member 7	Protein Coding	1
4	ID1	Inhibitor Of DNA Binding 1	Protein Coding	1
5	HFE	Homeostatic Iron Regulator	Protein Coding	1
6	TMPRSS6	Transmembrane Serine Protease 6	Protein Coding	1
7	HJV	Hemojuvelin BMP Co-Receptor	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Hemochromatosis, type 1	Enrichment	BMP6, HAMP, HFE, HJV	10.44
2	Digenic hemochromatosis	Enrichment	HAMP, HFE, HJV	9.43
3	Hemochromatosis type 2	Enrichment	HFE, HJV	6.64
4	Hjv or hamp-related hemochromatosis	Enrichment	HAMP, HJV	6.64
5	Iron-refractory iron deficiency anemia	Enrichment	TMPRSS6	3.29
6	Hemochromatosis, type 2a	Enrichment	HJV	3.29
7	Iron overload	Enrichment	BMP6	3.29
8	Hemochromatosis, type 2b	Enrichment	HAMP	3.29
9	Colorectal cancer 3	Enrichment	SMAD7	3.29
10	Porphyria cutanea tarda, type i	Enrichment	HFE	2.99
11	Microcytic anemia	Enrichment	TMPRSS6	2.99
12	Microvascular complications of diabetes 7	Enrichment	HFE	2.81
13	Transferrin serum level quantitative trait locus 2	Enrichment	HFE	2.81
14	Familial porphyria cutanea tarda	Enrichment	HFE	2.81
15	Porphyria cutanea tarda	Enrichment	HFE	2.69
16	Variegate porphyria	Enrichment	HFE	2.59
17	Pain disorder	Enrichment	HFE	2.51
18	Alzheimer's disease 1	Enrichment	HFE	2.44
19	Alzheimer's disease	Enrichment	HFE	2.17
20	Alzheimer disease, familial, 1	Enrichment	HFE	2.06
21	Cystic fibrosis	Enrichment	HFE	1.79
22	Peripheral nervous system disease	Enrichment	HFE	1.79
23	Neuropathy	Enrichment	HFE	1.79
24	Primary ovarian insufficiency	Enrichment	BMP6	1.52
25	Congenital nervous system abnormality	Enrichment	HFE	1.27
26	Nervous system disease	Enrichment	HFE	1.27
27	Inherited cancer-predisposing syndrome	Enrichment	HFE	1.18

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Hfe effect on hepcidin production