HIF-1-alpha transcription factor network

No Pathway Network information available for HIF-1-alpha transcription factor network

Pathways in the HIF-1-alpha transcription factor network SuperPath

#	Name	Source	Genes
1	HIF-1-alpha transcription factor network	PubChem	ABCB1 ABCG2 ADM AKT1 ALDOA ARNT BHLHE40 BHLHE41 BNIP3 CA9 CITED2 COPS5 CP CREB1 CXCL12 CXCR4 EDN1 EGLN1 EGLN3 ENG ENO1 EPO ETS1 FECH FOS FURIN GATA2 GCK HDAC7 HIF1A HK1 HK2 HMOX1 HNF4A ID2 IGFBP1 ITGB2 JUN LDHA LEP MCL1 NCOA1 NCOA2 NDRG1 NOS2 NPM1 NT5E PFKFB3 PFKL PGK1 PGM1 PKM PLIN2 RORA SERPINE1 SLC2A1 SLC2A3 SMAD3 SMAD4 SP1 TERT TF TFF3 TFRC VEGFA (see all 65) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	BNIP3	BCL2 Interacting Protein 3	Protein Coding	1
2	ID2	Inhibitor Of DNA Binding 2	Protein Coding	1
3	ENG	Endoglin	Protein Coding	1
4	HDAC7	Histone Deacetylase 7	Protein Coding	1
5	EGLN1	Egl-9 Family Hypoxia Inducible Factor 1	Protein Coding	1
6	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	1
7	HK2	Hexokinase 2	Protein Coding	1
8	MCL1	MCL1 Apoptosis Regulator, BCL2 Family Member	Protein Coding	1
9	GATA2	GATA Binding Protein 2~Name Same As:- HGNC:18350	Protein Coding	1
10	HMOX1	Heme Oxygenase 1	Protein Coding	1
11	NDRG1	N-Myc Downstream Regulated 1	Protein Coding	1
12	BHLHE40	Basic Helix-Loop-Helix Family Member E40	Protein Coding	1
13	BHLHE41	Basic Helix-Loop-Helix Family Member E41	Protein Coding	1
14	HK1	Hexokinase 1	Protein Coding	1
15	NPM1	Nucleophosmin 1	Protein Coding	1
16	IGFBP1	Insulin Like Growth Factor Binding Protein 1	Protein Coding	1
17	ETS1	ETS Proto-Oncogene 1, Transcription Factor	Protein Coding	1
18	CITED2	Cbp/P300 Interacting Transactivator With Glu/Asp Rich Carboxy-Terminal Domain 2	Protein Coding	1
19	EGLN3	Egl-9 Family Hypoxia Inducible Factor 3	Protein Coding	1
20	ARNT	Aryl Hydrocarbon Receptor Nuclear Translocator	Protein Coding	1
21	EPO	Erythropoietin	Protein Coding	1
22	TFF3	Trefoil Factor 3	Protein Coding	1
23	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
24	TERT	Telomerase Reverse Transcriptase	Protein Coding	1
25	HIF1A	Hypoxia Inducible Factor 1 Subunit Alpha	Protein Coding	1
26	EDN1	Endothelin 1	Protein Coding	1
27	FECH	Ferrochelatase	Protein Coding	1
28	NT5E	5''-Nucleotidase Ecto	Protein Coding	1
29	LDHA	Lactate Dehydrogenase A	Protein Coding	1
30	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
31	PLIN2	Perilipin 2	Protein Coding	1
32	RORA	RAR Related Orphan Receptor A	Protein Coding	1
33	PGM1	Phosphoglucomutase 1	Protein Coding	1
34	FURIN	Furin, Paired Basic Amino Acid Cleaving Enzyme	Protein Coding	1
35	SERPINE1	Serpin Family E Member 1	Protein Coding	1
36	ITGB2	Integrin Subunit Beta 2	Protein Coding	1
37	PKM	Pyruvate Kinase M1/2	Protein Coding	1
38	SP1	Sp1 Transcription Factor	Protein Coding	1
39	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
40	LEP	Leptin	Protein Coding	1
41	NCOA1	Nuclear Receptor Coactivator 1	Protein Coding	1
42	NCOA2	Nuclear Receptor Coactivator 2	Protein Coding	1
43	SMAD4	SMAD Family Member 4	Protein Coding	1
44	SMAD3	SMAD Family Member 3	Protein Coding	1
45	CXCR4	C-X-C Motif Chemokine Receptor 4	Protein Coding	1
46	CXCL12	C-X-C Motif Chemokine Ligand 12	Protein Coding	1
47	COPS5	COP9 Signalosome Subunit 5	Protein Coding	1
48	TFRC	Transferrin Receptor	Protein Coding	1
49	TF	Transferrin	Protein Coding	1
50	CP	Ceruloplasmin	Protein Coding	1
51	SLC2A3	Solute Carrier Family 2 Member 3	Protein Coding	1
52	SLC2A1	Solute Carrier Family 2 Member 1	Protein Coding	1
53	ALDOA	Aldolase, Fructose-Bisphosphate A	Protein Coding	1
54	PGK1	Phosphoglycerate Kinase 1	Protein Coding	1
55	PFKL	Phosphofructokinase, Liver Type	Protein Coding	1
56	PFKFB3	6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3	Protein Coding	1
57	ENO1	Enolase 1	Protein Coding	1
58	ABCB1	ATP Binding Cassette Subfamily B Member 1	Protein Coding	1
59	ADM	Adrenomedullin	Protein Coding	1
60	NOS2	Nitric Oxide Synthase 2	Protein Coding	1
61	HNF4A	Hepatocyte Nuclear Factor 4 Alpha	Protein Coding	1
62	GCK	Glucokinase	Protein Coding	1
63	CA9	Carbonic Anhydrase 9	Protein Coding	1
64	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	1
65	ABCG2	ATP Binding Cassette Subfamily G Member 2 (JR Blood Group)	Protein Coding	1

Disorders associated with HIF-1-alpha transcription factor network SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Maturity-onset diabetes of the young, type 1	Enrichment	GCK, HNF4A	4.65
2	Maturity-onset diabetes of the young, type 3	Enrichment	GCK, HNF4A	3.87
3	Generalized juvenile polyposis/juvenile polyposis coli	Enrichment	ENG, SMAD4	3.65
4	Autosomal dominant secondary polycythemia	Enrichment	EGLN1, EPO	3.48
5	Hereditary hemorrhagic telangiectasia	Enrichment	ENG, SMAD4	3.33
6	Leukemia, acute myeloid	Enrichment	GATA2, NPM1, TERT	3.04
7	Meningioma	Enrichment	AKT1, TERT	2.84
8	Dyskeratosis congenita	Enrichment	NPM1, TERT	2.44
9	Maturity-onset diabetes of the young	Enrichment	GCK, HNF4A	2.39
10	Proteus syndrome	Enrichment	AKT1	2.32
11	Calcification of joints and arteries	Enrichment	NT5E	2.32
12	Anemia, congenital, nonspherocytic hemolytic, 5	Enrichment	HK1	2.32
13	Phosphoglycerate kinase 1 deficiency	Enrichment	PGK1	2.32
14	Aceruloplasminemia	Enrichment	CP	2.32
15	Stomatin-deficient cryohydrocytosis with neurologic defects	Enrichment	SLC2A1	2.32
16	Maturity-onset diabetes of the young, type 2	Enrichment	GCK	2.32
17	Colchicine resistance	Enrichment	ABCB1	2.32
18	Short sleep, familial natural, 1	Enrichment	BHLHE41	2.32
19	Uric acid concentration, serum, quantitative trait locus 1	Enrichment	ABCG2	2.32
20	Fanconi renotubular syndrome 4 with maturity-onset diabetes of the young	Enrichment	HNF4A	2.32
21	Microvascular complications of diabetes 2	Enrichment	EPO	2.32
22	Whim syndrome 1	Enrichment	CXCR4	2.32
23	Retinitis pigmentosa 79	Enrichment	HK1	2.32
24	Atransferrinemia	Enrichment	TF	2.32
25	Auriculocondylar syndrome 3	Enrichment	EDN1	2.32
26	Encephalopathy, acute transient	Enrichment	ABCB1	2.32
27	Lymphedema, primary, with myelodysplasia	Enrichment	GATA2	2.32
28	Hemoglobin, high altitude adaptation	Enrichment	EGLN1	2.32
29	Plasminogen activator inhibitor-1 deficiency	Enrichment	SERPINE1	2.32
30	Hyperinsulinemic hypoglycemia, familial, 3	Enrichment	GCK	2.32
31	Microvascular complications of diabetes 1	Enrichment	VEGFA	2.32
32	Inflammatory bowel disease 13	Enrichment	ABCB1	2.32
33	Question mark ears, isolated	Enrichment	EDN1	2.32
34	Neuropathy, hereditary motor and sensory, russe type	Enrichment	HK1	2.32
35	Neurodevelopmental disorder with visual defects and brain anomalies	Enrichment	HK1	2.32
36	Immunodeficiency 21	Enrichment	GATA2	2.32
37	Epilepsy, idiopathic generalized 12	Enrichment	SLC2A1	2.32
38	Cowden syndrome 6	Enrichment	AKT1	2.32
39	Immunodeficiency 46	Enrichment	TFRC	2.32
40	Atrial septal defect 8	Enrichment	CITED2	2.32
41	Blood group, junior system	Enrichment	ABCG2	2.32
42	Heme oxygenase 1 deficiency	Enrichment	HMOX1	2.32
43	Erythrocytosis, familial, 5	Enrichment	EPO	2.32
44	Deafness-lymphedema-leukemia syndrome	Enrichment	GATA2	2.32
45	Autosomal recessive dyskeratosis congenita 4	Enrichment	TERT	2.32
46	Heritable thoracic aortic disease	Enrichment	SMAD4	2.32
47	Gestational diabetes	Enrichment	GCK	2.32
48	Sinus venosus atrial septal defect	Enrichment	CITED2	2.32
49	Hyperinsulinism due to hnf4a deficiency	Enrichment	HNF4A	2.32
50	Acute myeloid leukemia with multilineage dysplasia	Enrichment	NPM1	2.32
51	Acute myeloid leukemia with npm1 somatic mutations	Enrichment	NPM1	2.32
52	Epilepsy with myoclonic absences	Enrichment	SLC2A1	2.32
53	Congenital plasminogen activator inhibitor type 1 deficiency	Enrichment	SERPINE1	2.32
54	Male infertility due to obstructive azoospermia	Enrichment	PGK1	2.32
55	Hereditary cryohydrocytosis with reduced stomatin	Enrichment	SLC2A1	2.32
56	Leukocyte adhesion deficiency, type i	Enrichment	ITGB2	2.02
57	Myhre syndrome	Enrichment	SMAD4	2.02
58	Fanconi-bickel syndrome	Enrichment	LDHA	2.02
59	Dystonia 9	Enrichment	SLC2A1	2.02
60	Pulmonary arteriovenous fistulas	Enrichment	ENG	2.02
61	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	2.02
62	Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome	Enrichment	SMAD4	2.02
63	Glut1 deficiency syndrome 1	Enrichment	SLC2A1	2.02
64	Protoporphyria, erythropoietic, 1	Enrichment	FECH	2.02
65	Diabetes mellitus, permanent neonatal, 1	Enrichment	GCK	2.02
66	Leukocyte adhesion deficiency, type iii	Enrichment	ITGB2	2.02
67	Bone marrow failure syndrome 2	Enrichment	GCK	2.02
68	Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 1	Enrichment	TERT	2.02
69	Congenital disorder of glycosylation, type it	Enrichment	PGM1	2.02
70	Loeys-dietz syndrome 3	Enrichment	SMAD3	2.02
71	Hermansky-pudlak syndrome 3	Enrichment	CP	2.02
72	Charcot-marie-tooth disease, demyelinating, type 4d	Enrichment	NDRG1	2.02
73	Diamond-blackfan anemia-like	Enrichment	EPO	2.02
74	Glucose transporter type 1 deficiency syndrome	Enrichment	SLC2A1	2.02
75	Glycogen storage disease xii	Enrichment	ALDOA	2.02
76	Erythrocytosis, familial, 3	Enrichment	EGLN1	2.02
77	Ventricular septal defect 2	Enrichment	CITED2	2.02
78	Melanoma, cutaneous malignant 9	Enrichment	TERT	2.02
79	Idiopathic interstitial pneumonia	Enrichment	TERT	2.02
80	Intellectual developmental disorder with or without epilepsy or cerebellar ataxia	Enrichment	RORA	2.02
81	Acute myeloid leukemia without maturation	Enrichment	NPM1	2.02
82	Charcot-marie-tooth disease type 4d	Enrichment	NDRG1	2.02
83	Lymphomatoid papulosis	Enrichment	NPM1	2.02
84	Hyperinsulinism	Enrichment	HNF4A	2.02
85	Hyperinsulinism due to hnf1a deficiency	Enrichment	HNF4A	2.02
86	Autosomal erythropoietic protoporphyria	Enrichment	FECH	2.02
87	Erythropoietic protoporphyria, autosomal recessive	Enrichment	FECH	2.02
88	Primary cutaneous anaplastic large cell lymphoma	Enrichment	NPM1	2.02
89	Jacobsen syndrome	Enrichment	ETS1	1.84
90	Juvenile polyposis syndrome	Enrichment	SMAD4	1.84
91	Nijmegen breakage syndrome	Enrichment	GCK	1.84
92	Glut1 deficiency syndrome 2	Enrichment	SLC2A1	1.84
93	Chromosome 17q23.1-q23.2 deletion syndrome	Enrichment	SLC2A1	1.84
94	Interstitial lung disease	Enrichment	TERT	1.84
95	Macrocytic anemia	Enrichment	TERT	1.84
96	Melanoma of soft tissue	Enrichment	CREB1	1.84
97	Enchondromatosis	Enrichment	HIF1A	1.84
98	Systemic lupus erythematosus	Enrichment	ENG, ETS1	1.83
99	Type 2 diabetes mellitus	Enrichment	GCK, HNF4A	1.76
100	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	SMAD3, SMAD4	1.73
101	Huntington disease	Enrichment	SLC2A3	1.72
102	Auriculocondylar syndrome 1	Enrichment	EDN1	1.72
103	Leptin deficiency or dysfunction	Enrichment	LEP	1.72
104	Congenital generalized lipodystrophy	Enrichment	FOS	1.72
105	Lung sarcomatoid carcinoma	Enrichment	TERT	1.72
106	Aortic aneurysm	Enrichment	SMAD3	1.72
107	Pseudomyogenic hemangioendothelioma	Enrichment	SERPINE1	1.72
108	Enchondromatosis, multiple, ollier type	Enrichment	HIF1A	1.62
109	Acute myeloid leukemia with maturation	Enrichment	NPM1	1.62
110	Histiocytoid hemangioma	Enrichment	FOS	1.62
111	Idiopathic aplastic anemia	Enrichment	TERT	1.62
112	Familial cerebral saccular aneurysm	Enrichment	ENG	1.62
113	Dyskeratosis congenita, autosomal dominant 1	Enrichment	TERT	1.55
114	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	ENG	1.55
115	Hyperinsulinemic hypoglycemia, familial, 1	Enrichment	GCK	1.55
116	Pulmonary fibrosis	Enrichment	TERT	1.55
117	Adrenocortical carcinoma	Enrichment	TERT	1.55
118	Hoyeraal-hreidarsson syndrome	Enrichment	TERT	1.55
119	Breast adenocarcinoma	Enrichment	AKT1	1.55
120	Kidney clear cell sarcoma	Enrichment	TERT	1.55
121	Nonsyndromic genetic hyperinsulinism	Enrichment	GCK	1.55
122	Dyskeratosis congenita, autosomal dominant 2	Enrichment	TERT	1.48
123	Multiple enchondromatosis, maffucci type	Enrichment	HIF1A	1.48
124	Gallbladder cancer	Enrichment	SMAD4	1.48
125	Paroxysmal dystonia	Enrichment	SLC2A1	1.48
126	Alternating hemiplegia of childhood	Enrichment	SLC2A1	1.42
127	Permanent neonatal diabetes mellitus	Enrichment	GCK	1.42
128	Myoclonic-atonic epilepsy	Enrichment	SLC2A1	1.37
129	Loeys-dietz syndrome	Enrichment	SMAD3	1.37
130	Cowden syndrome	Enrichment	AKT1	1.37
131	Familial thoracic aortic aneurysm and dissection	Enrichment	SMAD3	1.37
132	Aplastic anemia	Enrichment	TERT	1.33
133	Neurodegeneration with brain iron accumulation	Enrichment	CP	1.33
134	Breast cancer	Enrichment	AKT1, JUN	1.30
135	Epilepsy, idiopathic generalized	Enrichment	ABCB1	1.29
136	Myelodysplastic syndrome	Enrichment	GATA2	1.29
137	Combined immunodeficiency	Enrichment	TFRC	1.29
138	Combined t cell and b cell immunodeficiency	Enrichment	TFRC	1.29
139	Diabetes mellitus	Enrichment	GCK	1.29
140	Heritable pulmonary arterial hypertension	Enrichment	ENG	1.29
141	Combined t and b cell immunodeficiency	Enrichment	TFRC	1.29
142	Pulmonary hypertension, primary, 1	Enrichment	ENG	1.22
143	Pulmonary disease, chronic obstructive	Enrichment	HMOX1	1.22
144	Acute promyelocytic leukemia	Enrichment	NPM1	1.22
145	Aortic aneurysm, familial thoracic 1	Enrichment	SMAD3	1.19
146	Colorectal cancer	Enrichment	AKT1, SMAD4	1.19
147	Hermansky-pudlak syndrome	Enrichment	CP	1.16
148	Hermansky-pudlak syndrome 1	Enrichment	CP	1.13
149	Melanoma, cutaneous malignant 1	Enrichment	TERT	1.11
150	Interstitial lung disease 2	Enrichment	TERT	1.11
151	Congenital disorder of glycosylation, type in	Enrichment	PGM1	1.11
152	Polycystic liver disease	Enrichment	HNF4A	1.11
153	Autosomal dominant polycystic liver disease	Enrichment	HNF4A	1.11
154	Human immunodeficiency virus type 1	Enrichment	CXCL12	1.08
155	Charcot-marie-tooth disease type 4	Enrichment	NDRG1	1.08
156	Patent foramen ovale	Enrichment	CITED2	1.08
157	Arteriovenous malformations of the brain	Enrichment	ENG	1.06
158	Ehlers-danlos syndrome	Enrichment	SMAD3	1.06
159	Hepatoblastoma	Enrichment	TERT	1.02
160	Hepatocellular carcinoma	Enrichment	TERT	1.00
161	Malaria	Enrichment	NOS2	0.98
162	Pancreatic cancer	Enrichment	SMAD4	0.95
163	Developmental and epileptic encephalopathy 1	Enrichment	SLC2A1	0.95
164	Tetralogy of fallot	Enrichment	CITED2	0.93
165	Strabismus	Enrichment	SLC2A1	0.91
166	Bladder cancer	Enrichment	TERT	0.89
167	Differentiated thyroid carcinoma	Enrichment	TERT	0.89
168	Visceral heterotaxy 5	Enrichment	CITED2	0.86
169	Cystic fibrosis	Enrichment	HMOX1	0.85
170	Connective tissue disease	Enrichment	SMAD3	0.85
171	Epilepsy	Enrichment	SLC2A1	0.76
172	Charcot-marie-tooth disease	Enrichment	NDRG1	0.75
173	Benign epilepsy with centrotemporal spikes	Enrichment	SLC2A1	0.75
174	Centralopathic epilepsy	Enrichment	SLC2A1	0.73
175	Gastric cancer	Enrichment	SMAD4	0.73
176	West syndrome	Enrichment	SLC2A1	0.72
177	Hereditary breast carcinoma	Enrichment	AKT1	0.72
178	Thrombocytopenia	Enrichment	SMAD4	0.69
179	Ovarian cancer	Enrichment	AKT1	0.41
180	Autism spectrum disorder	Enrichment	HK1	0.39
181	Microcephaly	Enrichment	SLC2A1	0.35
182	Complex neurodevelopmental disorder	Enrichment	RORA	0.35
183	Inherited cancer-predisposing syndrome	Enrichment	SMAD4	0.33
184	Retinitis pigmentosa	Enrichment	HK1	0.19
185	Hereditary retinal dystrophy	Enrichment	HK1	0.12
186	Fundus dystrophy	Enrichment	HK1	0.12

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

HIF-1-alpha transcription factor network

Pathway Network for HIF-1-alpha transcription factor network

Member Pathways for HIF-1-alpha transcription factor network

Pathways in the HIF-1-alpha transcription factor network SuperPath

Associated Genes for HIF-1-alpha transcription factor network

Associated Disorders for HIF-1-alpha transcription factor network

Disorders associated with HIF-1-alpha transcription factor network SuperPath

STRING Interaction Network for HIF-1-alpha transcription factor network

Sources for HIF-1-alpha transcription factor network