HIF-2-alpha transcription factor network

No Pathway Network information available for HIF-2-alpha transcription factor network

Pathways in the HIF-2-alpha transcription factor network SuperPath

#	Name	Source	Genes
1	HIF-2-alpha transcription factor network	PubChem	ABCG2 ADORA2A APEX1 ARNT BHLHE40 CITED2 EFNA1 EGLN2 EIF3E ELK1 ELOB ELOC EPAS1 EPO ETS1 FLT1 FXN HIF1AN KDR MMP14 PGK1 POU5F1 SERPINE1 SIRT1 SLC11A2 SLC2A1 SP1 TWIST1 VEGFA VHL (see all 30) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	EFNA1	Ephrin A1	Protein Coding	1
2	BHLHE40	Basic Helix-Loop-Helix Family Member E40	Protein Coding	1
3	EIF3E	Eukaryotic Translation Initiation Factor 3 Subunit E	Protein Coding	1
4	ETS1	ETS Proto-Oncogene 1, Transcription Factor	Protein Coding	1
5	CITED2	Cbp/P300 Interacting Transactivator With Glu/Asp Rich Carboxy-Terminal Domain 2	Protein Coding	1
6	HIF1AN	Hypoxia Inducible Factor 1 Subunit Alpha Inhibitor	Protein Coding	1
7	EGLN2	Egl-9 Family Hypoxia Inducible Factor 2	Protein Coding	1
8	ARNT	Aryl Hydrocarbon Receptor Nuclear Translocator	Protein Coding	1
9	VHL	Von Hippel-Lindau Tumor Suppressor	Protein Coding	1
10	EPO	Erythropoietin	Protein Coding	1
11	FLT1	Fms Related Receptor Tyrosine Kinase 1	Protein Coding	1
12	ELK1	ETS Transcription Factor ELK1	Protein Coding	1
13	ADORA2A	Adenosine A2a Receptor	Protein Coding	1
14	APEX1	Apurinic/Apyrimidinic Endodeoxyribonuclease 1	Protein Coding	1
15	FXN	Frataxin	Protein Coding	1
16	MMP14	Matrix Metallopeptidase 14	Protein Coding	1
17	SERPINE1	Serpin Family E Member 1	Protein Coding	1
18	TWIST1	Twist Family BHLH Transcription Factor 1	Protein Coding	1
19	SP1	Sp1 Transcription Factor	Protein Coding	1
20	SIRT1	Sirtuin 1	Protein Coding	1
21	POU5F1	POU Class 5 Homeobox 1	Protein Coding	1
22	EPAS1	Endothelial PAS Domain Protein 1	Protein Coding	1
23	ELOB	Elongin B	Protein Coding	1
24	ELOC	Elongin C	Protein Coding	1
25	SLC11A2	Solute Carrier Family 11 Member 2	Protein Coding	1
26	SLC2A1	Solute Carrier Family 2 Member 1	Protein Coding	1
27	PGK1	Phosphoglycerate Kinase 1	Protein Coding	1
28	KDR	Kinase Insert Domain Receptor	Protein Coding	1
29	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	1
30	ABCG2	ATP Binding Cassette Subfamily G Member 2 (JR Blood Group)	Protein Coding	1

Disorders associated with HIF-2-alpha transcription factor network SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Autosomal dominant secondary polycythemia	Enrichment	EPAS1, EPO	4.15
2	Sporadic pheochromocytoma/secreting paraganglioma	Enrichment	EPAS1, VHL	4.15
3	Tetralogy of fallot	Enrichment	CITED2, KDR	2.83
4	Phosphoglycerate kinase 1 deficiency	Enrichment	PGK1	2.66
5	Stomatin-deficient cryohydrocytosis with neurologic defects	Enrichment	SLC2A1	2.66
6	Uric acid concentration, serum, quantitative trait locus 1	Enrichment	ABCG2	2.66
7	Microvascular complications of diabetes 2	Enrichment	EPO	2.66
8	Anemia, hypochromic microcytic, with iron overload 1	Enrichment	SLC11A2	2.66
9	Winchester syndrome	Enrichment	MMP14	2.66
10	Plasminogen activator inhibitor-1 deficiency	Enrichment	SERPINE1	2.66
11	Microvascular complications of diabetes 1	Enrichment	VEGFA	2.66
12	Erythrocytosis, familial, 4	Enrichment	EPAS1	2.66
13	Epilepsy, idiopathic generalized 12	Enrichment	SLC2A1	2.66
14	Atrial septal defect 8	Enrichment	CITED2	2.66
15	Blood group, junior system	Enrichment	ABCG2	2.66
16	Erythrocytosis, familial, 5	Enrichment	EPO	2.66
17	Tufted angioma of skin	Enrichment	KDR	2.66
18	Sinus venosus atrial septal defect	Enrichment	CITED2	2.66
19	Multiple paragangliomas associated with polycythemia	Enrichment	EPAS1	2.66
20	Acute encephalopathy with biphasic seizures and late reduced diffusion	Enrichment	ADORA2A	2.66
21	Epilepsy with myoclonic absences	Enrichment	SLC2A1	2.66
22	Congenital plasminogen activator inhibitor type 1 deficiency	Enrichment	SERPINE1	2.66
23	Male infertility due to obstructive azoospermia	Enrichment	PGK1	2.66
24	Hereditary cryohydrocytosis with reduced stomatin	Enrichment	SLC2A1	2.66
25	Retinal hemangioblastoma	Enrichment	VHL	2.66
26	Robinow-sorauf syndrome	Enrichment	TWIST1	2.35
27	Dystonia 9	Enrichment	SLC2A1	2.35
28	Glut1 deficiency syndrome 1	Enrichment	SLC2A1	2.35
29	Angioma, tufted	Enrichment	KDR	2.35
30	Diamond-blackfan anemia-like	Enrichment	EPO	2.35
31	Sweeney-cox syndrome	Enrichment	TWIST1	2.35
32	Glucose transporter type 1 deficiency syndrome	Enrichment	SLC2A1	2.35
33	Erythrocytosis, familial, 3	Enrichment	EPAS1	2.35
34	Ventricular septal defect 2	Enrichment	CITED2	2.35
35	Acute leukemia of ambiguous lineage	Enrichment	VHL	2.35
36	Non-syndromic sagittal craniosynostosis	Enrichment	TWIST1	2.35
37	Craniosynostosis 1	Enrichment	TWIST1	2.18
38	Jacobsen syndrome	Enrichment	ETS1	2.18
39	Friedreich ataxia	Enrichment	FXN	2.18
40	Myasthenic syndrome, congenital, 6, presynaptic	Enrichment	VHL	2.18
41	Multicentric osteolysis, nodulosis, and arthropathy	Enrichment	MMP14	2.18
42	Glut1 deficiency syndrome 2	Enrichment	SLC2A1	2.18
43	Primary polycythemia	Enrichment	VHL	2.18
44	Chromosome 17q23.1-q23.2 deletion syndrome	Enrichment	SLC2A1	2.18
45	Erythrocytosis, familial, 2	Enrichment	VHL	2.05
46	Saethre-chotzen syndrome	Enrichment	TWIST1	2.05
47	Au-kline syndrome	Enrichment	VHL	2.05
48	Non-syndromic bicoronal craniosynostosis	Enrichment	TWIST1	2.05
49	Pseudomyogenic hemangioendothelioma	Enrichment	SERPINE1	2.05
50	Fanconi anemia, complementation group d2	Enrichment	VHL	1.96
51	Von hippel-lindau syndrome	Enrichment	VHL	1.96
52	Pre-eclampsia	Enrichment	FLT1	1.96
53	Hemangioma, capillary infantile	Enrichment	KDR	1.88
54	Renal cell carcinoma, papillary, 1	Enrichment	VHL	1.81
55	Multiple enchondromatosis, maffucci type	Enrichment	VHL	1.81
56	Paroxysmal dystonia	Enrichment	SLC2A1	1.81
57	Alternating hemiplegia of childhood	Enrichment	SLC2A1	1.76
58	Myoclonic-atonic epilepsy	Enrichment	SLC2A1	1.70
59	Pheochromocytoma	Enrichment	VHL	1.52
60	Renal cell carcinoma, nonpapillary	Enrichment	VHL	1.49
61	Patent foramen ovale	Enrichment	CITED2	1.41
62	Hereditary paraganglioma-pheochromocytoma syndromes	Enrichment	VHL	1.34
63	Developmental and epileptic encephalopathy 1	Enrichment	SLC2A1	1.27
64	Strabismus	Enrichment	SLC2A1	1.24
65	Visceral heterotaxy 5	Enrichment	CITED2	1.18
66	Fanconi anemia, complementation group a	Enrichment	VHL	1.13
67	Systemic lupus erythematosus	Enrichment	ETS1	1.08
68	Epilepsy	Enrichment	SLC2A1	1.07
69	Benign epilepsy with centrotemporal spikes	Enrichment	SLC2A1	1.06
70	Centralopathic epilepsy	Enrichment	SLC2A1	1.04
71	West syndrome	Enrichment	SLC2A1	1.03
72	Primary ovarian insufficiency	Enrichment	KDR	0.91
73	Microcephaly	Enrichment	SLC2A1	0.62
74	Inherited cancer-predisposing syndrome	Enrichment	VHL	0.59

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

HIF-2-alpha transcription factor network

Pathway Network for HIF-2-alpha transcription factor network

Member Pathways for HIF-2-alpha transcription factor network

Pathways in the HIF-2-alpha transcription factor network SuperPath

Associated Genes for HIF-2-alpha transcription factor network

Associated Disorders for HIF-2-alpha transcription factor network

Disorders associated with HIF-2-alpha transcription factor network SuperPath

STRING Interaction Network for HIF-2-alpha transcription factor network

Sources for HIF-2-alpha transcription factor network