HIF Enhancers

No Pathway Network information available for HIF Enhancers

Pathways in the HIF Enhancers SuperPath

#	Name	Source	Genes
1	HIF Enhancers	R&D Systems	ARNT CBX4 CREBBP CTNNB1 EGLN3 EP300 EPAS1 HIF1A MAPK1 MAPK3 PKM SART1 SENP1 SRC SUMO1 SUMO3 SUMO4 UBE2I XPO1 (see all 19) (see less)
2	HIF Repressors	R&D Systems	ARNT CITED2 COMMD1 CREBBP CSNK1D EP300 EPAS1 HIF1A HIF1AN SENP3 SUMO1 SUMO3 SUMO4 UBE2I (see all 14) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	HIF1A	Hypoxia Inducible Factor 1 Subunit Alpha	Protein Coding	2
2	EP300	EP300 Lysine Acetyltransferase	Protein Coding	2
3	CREBBP	CREB Binding Lysine Acetyltransferase	Protein Coding	2
4	ARNT	Aryl Hydrocarbon Receptor Nuclear Translocator	Protein Coding	2
5	UBE2I	Ubiquitin Conjugating Enzyme E2 I	Protein Coding	2
6	SUMO1	Small Ubiquitin Like Modifier 1	Protein Coding	2
7	SUMO3	Small Ubiquitin Like Modifier 3	Protein Coding	2
8	SUMO4	Small Ubiquitin Like Modifier 4	Protein Coding	2
9	EPAS1	Endothelial PAS Domain Protein 1	Protein Coding	2
10	PKM	Pyruvate Kinase M1/2	Protein Coding	1
11	EGLN3	Egl-9 Family Hypoxia Inducible Factor 3	Protein Coding	1
12	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
13	CTNNB1	Catenin Beta 1	Protein Coding	1
14	SENP1	SUMO Specific Peptidase 1	Protein Coding	1
15	CBX4	Chromobox 4	Protein Coding	1
16	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
17	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
18	XPO1	Exportin 1	Protein Coding	1
19	SART1	Spliceosome Associated Factor 1, Recruiter Of U4/U6.U5 Tri-SnRNP	Protein Coding	1
20	HIF1AN	Hypoxia Inducible Factor 1 Subunit Alpha Inhibitor	Protein Coding	1
21	COMMD1	Copper Metabolism Domain Containing 1	Protein Coding	1
22	SENP3	SUMO Specific Peptidase 3	Protein Coding	1
23	CITED2	Cbp/P300 Interacting Transactivator With Glu/Asp Rich Carboxy-Terminal Domain 2	Protein Coding	1
24	CSNK1D	Casein Kinase 1 Delta	Protein Coding	1

Disorders associated with HIF Enhancers SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Rubinstein-taybi syndrome 1	Enrichment	CREBBP, EP300	4.83
2	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	CREBBP, EP300	4.83
3	Rare genetic intellectual disability	Enrichment	CREBBP, EP300	3.99
4	Colorectal cancer	Enrichment	CTNNB1, EP300, SRC	3.64
5	Microcephaly	Enrichment	CTNNB1, EP300, MAPK1	3.20
6	Advanced sleep phase syndrome, familial, 2	Enrichment	CSNK1D	2.99
7	Orofacial cleft 10	Enrichment	SUMO1	2.99
8	Type 1 diabetes mellitus 5	Enrichment	SUMO4	2.99
9	Erythrocytosis, familial, 4	Enrichment	EPAS1	2.99
10	Atrial septal defect 8	Enrichment	CITED2	2.99
11	Menke-hennekam syndrome 1	Enrichment	CREBBP	2.99
12	Rubinstein-taybi syndrome due to 16p13.3 microdeletion	Enrichment	CREBBP	2.99
13	Sinus venosus atrial septal defect	Enrichment	CITED2	2.99
14	Multiple paragangliomas associated with polycythemia	Enrichment	EPAS1	2.99
15	Menke-hennekam syndrome	Enrichment	CREBBP	2.99
16	Noonan syndrome 13	Enrichment	MAPK1	2.85
17	Thrombocytopenia 6	Enrichment	SRC	2.85
18	Adenoid ameloblastoma	Enrichment	CTNNB1	2.85
19	Microcystic stromal tumor	Enrichment	CTNNB1	2.85
20	Thumb deformity	Enrichment	CREBBP	2.69
21	Menke-hennekam syndrome 2	Enrichment	EP300	2.69
22	Acute myeloid leukemia with kat6a-crebbp fusion	Enrichment	CREBBP	2.69
23	Erythrocytosis, familial, 3	Enrichment	EPAS1	2.69
24	Ventricular septal defect 2	Enrichment	CITED2	2.69
25	Osteopathia striata with cranial sclerosis	Enrichment	CTNNB1	2.55
26	Childhood hepatocellular carcinoma	Enrichment	CTNNB1	2.55
27	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	2.55
28	Teratoma	Enrichment	CTNNB1	2.55
29	Primary mediastinal large b-cell lymphoma	Enrichment	XPO1	2.55
30	Tethered spinal cord syndrome	Enrichment	CREBBP	2.51
31	Intraocular pressure quantitative trait locus	Enrichment	CREBBP	2.51
32	Advanced sleep phase syndrome	Enrichment	CSNK1D	2.51
33	Enchondromatosis	Enrichment	HIF1A	2.51
34	Desmoid disease, hereditary	Enrichment	CTNNB1	2.38
35	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	2.38
36	Anus, imperforate	Enrichment	CTNNB1	2.38
37	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	2.38
38	Desmoid tumor	Enrichment	CTNNB1	2.38
39	Enchondromatosis, multiple, ollier type	Enrichment	HIF1A	2.29
40	Rubinstein-taybi syndrome 2	Enrichment	EP300	2.29
41	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	2.25
42	Pilomatrixoma	Enrichment	CTNNB1	2.25
43	Alazami syndrome	Enrichment	CTNNB1	2.25
44	Craniopharyngioma	Enrichment	CTNNB1	2.25
45	Hypertrichosis	Enrichment	CREBBP	2.21
46	Autosomal dominant secondary polycythemia	Enrichment	EPAS1	2.21
47	Sporadic pheochromocytoma/secreting paraganglioma	Enrichment	EPAS1	2.21
48	Exudative vitreoretinopathy 1	Enrichment	CTNNB1	2.16
49	Multiple enchondromatosis, maffucci type	Enrichment	HIF1A	2.14
50	Weyers acrofacial dysostosis	Enrichment	CTNNB1	2.08
51	Adrenocortical carcinoma	Enrichment	CTNNB1	2.08
52	Charge syndrome	Enrichment	EP300	2.03
53	Congenital nervous system abnormality	Enrichment	CREBBP, CTNNB1	2.02
54	Nervous system disease	Enrichment	CREBBP, CTNNB1	2.02
55	Myelofibrosis	Enrichment	SRC	2.01
56	Gallbladder cancer	Enrichment	CTNNB1	2.01
57	Exudative vitreoretinopathy	Enrichment	CTNNB1	1.95
58	Adult hepatocellular carcinoma	Enrichment	CTNNB1	1.90
59	Heart disease	Enrichment	CREBBP	1.84
60	Specific learning disability	Enrichment	MAPK1	1.82
61	Polydactyly, postaxial, type a1	Enrichment	EP300	1.81
62	Corpus callosum, agenesis of	Enrichment	CREBBP	1.81
63	Isolated corpus callosum agenesis	Enrichment	CREBBP	1.81
64	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CREBBP	1.81
65	Patent foramen ovale	Enrichment	CITED2	1.73
66	Osteoporosis	Enrichment	SRC	1.71
67	Medulloblastoma	Enrichment	CTNNB1	1.71
68	Diffuse large b-cell lymphoma	Enrichment	CREBBP	1.71
69	Tooth agenesis	Enrichment	SUMO1	1.65
70	Polycystic liver disease	Enrichment	CTNNB1	1.63
71	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1	1.63
72	Scoliosis	Enrichment	CREBBP	1.61
73	Heart, malformation of	Enrichment	MAPK1	1.60
74	Tetralogy of fallot	Enrichment	CITED2	1.58
75	Hepatoblastoma	Enrichment	CTNNB1	1.54
76	Hepatocellular carcinoma	Enrichment	CTNNB1	1.52
77	Visceral heterotaxy 5	Enrichment	CITED2	1.50
78	Bladder cancer	Enrichment	CTNNB1	1.40
79	Myeloma, multiple	Enrichment	CREBBP	1.25
80	Thrombocytopenia	Enrichment	SRC	1.19
81	Autism	Enrichment	CREBBP	1.14
82	Ovarian cancer	Enrichment	CTNNB1	0.88

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for HIF Enhancers

Member Pathways for HIF Enhancers

Pathways in the HIF Enhancers SuperPath

Associated Genes for HIF Enhancers

Associated Disorders for HIF Enhancers

Disorders associated with HIF Enhancers SuperPath

STRING Interaction Network for HIF Enhancers

Sources for HIF Enhancers