Hippo-Merlin signaling dysregulation

No Pathway Network information available for Hippo-Merlin signaling dysregulation

Pathways in the Hippo-Merlin signaling dysregulation SuperPath

#	Name	Source	Genes
1	Hippo-Merlin signaling dysregulation	WikiPathways	AJUBA AMOT CCND1 CD44 CSF1R CTNNB1 CUL4A CXCL10 DCAF1 DDB1 EGFR EPHA2 FGFR1 FGFR2 FGFR3 FGFR4 FLT1 FLT3 FLT4 IGF1R INSR KDR KIT LATS1 LIN28B MET MIR98 MST1 NF2 NGFR NTRK1 NTRK2 PDGFRA PDGFRB PPP1CA PPP1CB PPP1CC PPP1R12A PPP1R14A PRKAR1B PTK2 RBX1 SAV1 TAFAZZIN TEAD1 TEAD2 TEAD3 TEAD4 TEK VGLL4 YY1AP1 (see all 51) (see less)
2	Hippo signaling regulation pathways	WikiPathways	CDC42 CSF1R CTNNB1 EGFR EPHA2 FGFR1 FGFR2 FGFR3 FGFR4 FLT1 FLT3 FLT4 IGF1R INSR KDR KIT LATS1 LEF1 MET MST1 MTOR NF2 NGFR NTRK1 NTRK2 PDGFRA PDGFRB RAC1 RHOA SMAD2 TAFAZZIN TCF7 TCF7L1 TCF7L2 TEAD1 TEAD2 TEAD3 TEAD4 TEK YY1AP1 (see all 40) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	LATS1	Large Tumor Suppressor Kinase 1	Protein Coding	2
2	TEAD2	TEA Domain Transcription Factor 2	Protein Coding	2
3	TEK	TEK Receptor Tyrosine Kinase	Protein Coding	2
4	TEAD1	TEA Domain Transcription Factor 1	Protein Coding	2
5	TAFAZZIN	Tafazzin, Phospholipid-Lysophospholipid Transacylase	Protein Coding	2
6	YY1AP1	YY1 Associated Protein 1	Protein Coding	2
7	PDGFRB	Platelet Derived Growth Factor Receptor Beta	Protein Coding	2
8	PDGFRA	Platelet Derived Growth Factor Receptor Alpha	Protein Coding	2
9	NTRK2	Neurotrophic Receptor Tyrosine Kinase 2	Protein Coding	2
10	NTRK1	Neurotrophic Receptor Tyrosine Kinase 1	Protein Coding	2
11	NGFR	Nerve Growth Factor Receptor	Protein Coding	2
12	NF2	NF2, Moesin-Ezrin-Radixin Like (MERLIN) Tumor Suppressor	Protein Coding	2
13	MST1	Macrophage Stimulating 1	Protein Coding	2
14	MET	MET Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	2
15	KIT	KIT Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	2
16	KDR	Kinase Insert Domain Receptor	Protein Coding	2
17	INSR	Insulin Receptor	Protein Coding	2
18	IGF1R	Insulin Like Growth Factor 1 Receptor	Protein Coding	2
19	FLT4	Fms Related Receptor Tyrosine Kinase 4	Protein Coding	2
20	FLT3	Fms Related Receptor Tyrosine Kinase 3	Protein Coding	2
21	FLT1	Fms Related Receptor Tyrosine Kinase 1	Protein Coding	2
22	FGFR4	Fibroblast Growth Factor Receptor 4	Protein Coding	2
23	FGFR2	Fibroblast Growth Factor Receptor 2	Protein Coding	2
24	FGFR3	Fibroblast Growth Factor Receptor 3	Protein Coding	2
25	FGFR1	Fibroblast Growth Factor Receptor 1	Protein Coding	2
26	EPHA2	EPH Receptor A2	Protein Coding	2
27	EGFR	Epidermal Growth Factor Receptor	Protein Coding	2
28	CTNNB1	Catenin Beta 1	Protein Coding	2
29	CSF1R	Colony Stimulating Factor 1 Receptor	Protein Coding	2
30	TEAD3	TEA Domain Transcription Factor 3	Protein Coding	2
31	TEAD4	TEA Domain Transcription Factor 4	Protein Coding	2
32	RBX1	Ring-Box 1	Protein Coding	1
33	CD44	CD44 Molecule (IN Blood Group)	Protein Coding	1
34	PPP1R14A	Protein Phosphatase 1 Regulatory Inhibitor Subunit 14A	Protein Coding	1
35	AJUBA	Ajuba LIM Protein	Protein Coding	1
36	CUL4A	Cullin 4A	Protein Coding	1
37	CCND1	Cyclin D1	Protein Coding	1
38	PTK2	Protein Tyrosine Kinase 2	Protein Coding	1
39	PPP1CC	Protein Phosphatase 1 Catalytic Subunit Gamma	Protein Coding	1
40	MIR98	MicroRNA 98	RNA Gene	1
41	LIN28B	Lin-28 RNA Binding Posttranscriptional Regulator B	Protein Coding	1
42	CXCL10	C-X-C Motif Chemokine Ligand 10	Protein Coding	1
43	DDB1	Damage Specific DNA Binding Protein 1	Protein Coding	1
44	AMOT	Angiomotin	Protein Coding	1
45	VGLL4	Vestigial Like Family Member 4	Protein Coding	1
46	SAV1	Salvador Family WW Domain Containing Protein 1	Protein Coding	1
47	PRKAR1B	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Beta	Protein Coding	1
48	PPP1CB	Protein Phosphatase 1 Catalytic Subunit Beta	Protein Coding	1
49	PPP1CA	Protein Phosphatase 1 Catalytic Subunit Alpha	Protein Coding	1
50	PPP1R12A	Protein Phosphatase 1 Regulatory Subunit 12A	Protein Coding	1
51	DCAF1	DDB1 And CUL4 Associated Factor 1	Protein Coding	1
52	CDC42	Cell Division Cycle 42	Protein Coding	1
53	TCF7L1	Transcription Factor 7 Like 1	Protein Coding	1
54	TCF7L2	Transcription Factor 7 Like 2	Protein Coding	1
55	TCF7	Transcription Factor 7	Protein Coding	1
56	RAC1	Rac Family Small GTPase 1	Protein Coding	1
57	LEF1	Lymphoid Enhancer Binding Factor 1	Protein Coding	1
58	SMAD2	SMAD Family Member 2	Protein Coding	1
59	RHOA	Ras Homolog Family Member A	Protein Coding	1
60	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	1

Disorders associated with Hippo-Merlin signaling dysregulation SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Primary hypereosinophilic syndrome	Enrichment	FGFR1, PDGFRA, PDGFRB	6.63
2	Ovarian cancer	Enrichment	CTNNB1, EGFR, KIT, MET, NTRK1, PDGFRA	6.34
3	Pfeiffer syndrome	Enrichment	FGFR1, FGFR2	5.07
4	Jackson-weiss syndrome	Enrichment	FGFR1, FGFR2	5.07
5	Childhood hepatocellular carcinoma	Enrichment	CTNNB1, MET	5.07
6	Split hand-foot malformation	Enrichment	FGFR2, LEF1	5.07
7	Gliosarcoma	Enrichment	EGFR, FGFR1, FGFR3	4.89
8	Giant cell glioblastoma	Enrichment	EGFR, FGFR1, FGFR3	4.80
9	Colorectal cancer	Enrichment	CCND1, CTNNB1, FGFR2, FGFR3, MET	4.74
10	Crouzon syndrome	Enrichment	FGFR2, FGFR3	4.60
11	Lacrimoauriculodentodigital syndrome 1	Enrichment	FGFR2, FGFR3	4.60
12	Testicular germ cell cancer	Enrichment	FGFR3, KIT	4.60
13	Inherited cancer-predisposing syndrome	Enrichment	EGFR, KIT, MET, NF2, PDGFRA	4.39
14	Saethre-chotzen syndrome	Enrichment	FGFR2, FGFR3	4.30
15	Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)	Enrichment	FLT3, KIT	4.30
16	Myeloma, multiple	Enrichment	CCND1, FGFR3, FLT3, LATS1	4.25
17	Bladder cancer	Enrichment	CTNNB1, EGFR, FGFR3	4.08
18	Hemifacial hyperplasia	Enrichment	FGFR2, FGFR3	4.07
19	Acute myeloid leukemia with maturation	Enrichment	FLT3, KIT	4.07
20	Acute myeloid leukemia with t(8;21)(q22;q22) translocation	Enrichment	FLT3, KIT	4.07
21	Split-hand/foot malformation 1	Enrichment	FGFR2, LEF1	3.90
22	Testicular germ cell tumor	Enrichment	FGFR3, KIT	3.90
23	Hemangioma, capillary infantile	Enrichment	FLT4, KDR	3.90
24	Lung squamous cell carcinoma	Enrichment	EGFR, FGFR3	3.90
25	46,xy disorder of sex development	Enrichment	FGFR3, INSR	3.90
26	Gastrointestinal stromal tumor	Enrichment	KIT, PDGFRA	3.75
27	Renal cell carcinoma, papillary, 1	Enrichment	MET, MTOR	3.75
28	Pilomyxoid astrocytoma	Enrichment	FGFR1, NTRK2	3.75
29	Lip and oral cavity carcinoma	Enrichment	EGFR, KIT	3.26
30	Renal cell carcinoma, nonpapillary	Enrichment	MET, MTOR	3.06
31	Hydrocephalus	Enrichment	FGFR2, PDGFRB	3.06
32	Craniosynostosis	Enrichment	FGFR2, FGFR3	2.81
33	Hepatoblastoma	Enrichment	CTNNB1, FGFR3	2.76
34	Dandy-walker syndrome	Enrichment	PDGFRB, PPP1CB	2.74
35	Hepatocellular carcinoma	Enrichment	CTNNB1, MET	2.72
36	Tetralogy of fallot	Enrichment	FLT4, KDR	2.58
37	Hypochondroplasia	Enrichment	FGFR3	2.53
38	Beare-stevenson cutis gyrata syndrome	Enrichment	FGFR2	2.53
39	Osteoglophonic dysplasia	Enrichment	FGFR1	2.53
40	Thanatophoric dysplasia, type i	Enrichment	FGFR3	2.53
41	Trigonocephaly 1	Enrichment	FGFR1	2.53
42	Donohue syndrome	Enrichment	INSR	2.53
43	Muenke syndrome	Enrichment	FGFR3	2.53
44	Premature aging syndrome, penttinen type	Enrichment	PDGFRB	2.53
45	Hyperinsulinemic hypoglycemia, familial, 5	Enrichment	INSR	2.53
46	Pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities	Enrichment	INSR	2.53
47	Diabetes mellitus, insulin-resistant, with acanthosis nigricans	Enrichment	INSR	2.53
48	Hypereosinophilic syndrome, idiopathic	Enrichment	PDGFRA	2.53
49	Mastocytosis, cutaneous	Enrichment	KIT	2.53
50	Scaphocephaly, maxillary retrusion, and impaired intellectual development	Enrichment	FGFR2	2.53
51	Schwannomatosis, vestibular	Enrichment	NF2	2.53
52	Apert syndrome	Enrichment	FGFR2	2.53
53	Myofibromatosis, infantile, 1	Enrichment	PDGFRB	2.53
54	Thanatophoric dysplasia, type ii	Enrichment	FGFR3	2.53
55	Gist-plus syndrome	Enrichment	PDGFRA	2.53
56	Camptodactyly, tall stature, and hearing loss syndrome	Enrichment	FGFR3	2.53
57	Bent bone dysplasia syndrome 1	Enrichment	FGFR2	2.53
58	Ectodermal dysplasia 17 with or without limb malformations	Enrichment	LEF1	2.53
59	Developmental and epileptic encephalopathy 58	Enrichment	NTRK2	2.53
60	Venous malformations, multiple cutaneous and mucosal	Enrichment	TEK	2.53
61	Osteofibrous dysplasia	Enrichment	MET	2.53
62	Myeloid and lymphoid neoplasms associated with pdgfra rearrangement	Enrichment	PDGFRA	2.53
63	Deafness, autosomal recessive 97	Enrichment	MET	2.53
64	Crouzon syndrome with acanthosis nigricans	Enrichment	FGFR3	2.53
65	Autism 9	Enrichment	MET	2.53
66	Basal ganglia calcification, idiopathic, 4	Enrichment	PDGFRB	2.53
67	Myeloid and lymphoid neoplasms associated with pdgfrb rearrangement	Enrichment	PDGFRB	2.53
68	Loeys-dietz syndrome 6	Enrichment	SMAD2	2.53
69	Acute myeloid leukemia with minimal differentiation	Enrichment	FLT3	2.53
70	Obesity, hyperphagia, and developmental delay	Enrichment	NTRK2	2.53
71	Achondroplasia, severe, with developmental delay and acanthosis nigricans	Enrichment	FGFR3	2.53
72	Kosaki overgrowth syndrome	Enrichment	PDGFRB	2.53
73	Hartsfield syndrome	Enrichment	FGFR1	2.53
74	Congenital heart defects, multiple types, 7	Enrichment	FLT4	2.53
75	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.53
76	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.53
77	Glaucoma 3, primary congenital, e	Enrichment	TEK	2.53
78	Brain abnormalities, neurodegeneration, and dysosteosclerosis	Enrichment	CSF1R	2.53
79	Ocular pterygium-digital keloid dysplasia syndrome	Enrichment	PDGFRB	2.53
80	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.53
81	Chronic mast cell leukemia	Enrichment	KIT	2.53
82	Tufted angioma of skin	Enrichment	KDR	2.53
83	Congenital heart defects, multiple types, 8, with or without heterotaxy	Enrichment	SMAD2	2.53
84	Adenoid ameloblastoma	Enrichment	CTNNB1	2.53
85	Arthrogryposis, distal, type 11	Enrichment	MET	2.53
86	Lacrimoauriculodentodigital syndrome 2	Enrichment	FGFR3	2.53
87	Csf1r-related disorder	Enrichment	CSF1R	2.53
88	Bockenheimer syndrome	Enrichment	TEK	2.53
89	Isolated bone marrow mastocytosis	Enrichment	KIT	2.53
90	Smoldering systemic mastocytosis	Enrichment	KIT	2.53
91	Fgfr3-related chondrodysplasia	Enrichment	FGFR3	2.53
92	Acoustic neuroma	Enrichment	NF2	2.53
93	Nocarh syndrome	Enrichment	CDC42	2.53
94	Mastocytosis	Enrichment	KIT	2.53
95	Camptodactyly-tall stature-scoliosis-hearing loss syndrome	Enrichment	FGFR3	2.53
96	Early-onset calcifying leukoencephalopathy-skeletal dysplasia	Enrichment	CSF1R	2.53
97	Cutaneous mastocytoma	Enrichment	KIT	2.53
98	Typical urticaria pigmentosa	Enrichment	KIT	2.53
99	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.53
100	Nodular urticaria pigmentosa	Enrichment	KIT	2.53
101	Hartsfield-bixler-demyer syndrome	Enrichment	FGFR1	2.53
102	Pseudoxanthomatous diffuse cutaneous mastocytosis	Enrichment	KIT	2.53
103	Telangiectasia macularis eruptiva perstans	Enrichment	KIT	2.53
104	Acute mast cell leukemia	Enrichment	KIT	2.53
105	Non-syndromic unicoronal craniosynostosis	Enrichment	FGFR2	2.53
106	Plaque-form urticaria pigmentosa	Enrichment	KIT	2.53
107	Bullous diffuse cutaneous mastocytosis	Enrichment	KIT	2.53
108	Microcystic stromal tumor	Enrichment	CTNNB1	2.53
109	Testis seminoma	Enrichment	KIT	2.53
110	White-kernohan syndrome	Enrichment	DDB1	2.42
111	Noonan syndrome-like disorder with loose anagen hair 2	Enrichment	PPP1CB	2.42
112	Prkar1b-related neurodegenerative dementia with intermediate filaments	Enrichment	PRKAR1B	2.42
113	Lung cancer	Enrichment	EGFR, MET	2.40
114	Lymphatic malformation 1	Enrichment	FLT4	2.23
115	Ectrodactyly and ectodermal dysplasia without cleft lip/palate	Enrichment	LEF1	2.23
116	Blue rubber bleb nevus	Enrichment	TEK	2.23
117	Sveinsson chorioretinal atrophy	Enrichment	TEAD1	2.23
118	Myeloproliferative disorder, chronic, with eosinophilia	Enrichment	PDGFRB	2.23
119	Insensitivity to pain, congenital, with anhidrosis	Enrichment	NTRK1	2.23
120	Intracranial hypertension, idiopathic	Enrichment	FLT4	2.23
121	Osteopathia striata with cranial sclerosis	Enrichment	CTNNB1	2.23
122	Grange syndrome	Enrichment	YY1AP1	2.23
123	Cervical cancer	Enrichment	FGFR3	2.23
124	Schwannomatosis 1	Enrichment	NF2	2.23
125	Piebald trait	Enrichment	KIT	2.23
126	Hyperinsulinemic hypoglycemia, familial, 4	Enrichment	INSR	2.23
127	Aural atresia, congenital	Enrichment	FGFR2	2.23
128	Keratosis, seborrheic	Enrichment	FGFR3	2.23
129	Encephalocraniocutaneous lipomatosis	Enrichment	FGFR1	2.23
130	Angioma, tufted	Enrichment	KDR	2.23
131	Pain sensitivity quantitative trait locus 1	Enrichment	NTRK1	2.23
132	Antley-bixler syndrome without genital anomalies or disordered steroidogenesis	Enrichment	FGFR2	2.23
133	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.23
134	Cebalid syndrome	Enrichment	MTOR	2.23
135	Infantile myofibromatosis	Enrichment	PDGFRB	2.23
136	Retinitis pigmentosa 14	Enrichment	TEAD3	2.23
137	Rosette-forming glioneuronal tumor	Enrichment	FGFR1	2.23
138	Papillary renal cell carcinoma	Enrichment	MET	2.23
139	Cervix carcinoma	Enrichment	FGFR3	2.23
140	Immune system disease	Enrichment	CDC42	2.23
141	Smith-kingsmore syndrome	Enrichment	MTOR	2.23
142	Hereditary lymphedema i	Enrichment	FLT4	2.23
143	Acute myeloid leukemia without maturation	Enrichment	FLT3	2.23
144	Interfrontal craniofaciosynostosis	Enrichment	FGFR1	2.23
145	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	2.23
146	Autosomal dominant nonsyndromic deafness	Enrichment	FGFR2	2.23
147	Chronic eosinophilic leukemia	Enrichment	PDGFRA	2.23
148	Teratoma	Enrichment	CTNNB1	2.23
149	B-lymphoblastic leukemia/lymphoma with recurrent genetic abnormality	Enrichment	PDGFRA	2.23
150	Mixed phenotype acute leukemia with t(9;22)(q34.1;q11.2)	Enrichment	FLT3	2.23
151	B-lymphoblastic leukemia/lymphoma with t	Enrichment	KIT	2.23
152	Malignant peritoneal mesothelioma	Enrichment	LATS1	2.23
153	Leukemia, acute myeloid	Enrichment	FLT3, KIT	2.21
154	Type 2 diabetes mellitus	Enrichment	INSR, TCF7L2	2.17
155	Genitourinary and/or brain malformation syndrome	Enrichment	PPP1R12A	2.12
156	Marbach-schaaf neurodevelopmental syndrome	Enrichment	PRKAR1B	2.12
157	Noonan syndrome-like disorder with loose anagen hair	Enrichment	PPP1CB	2.12
158	Ciliary dyskinesia, primary, 18	Enrichment	PRKAR1B	2.12
159	Desmoid disease, hereditary	Enrichment	CTNNB1	2.05
160	Achondroplasia	Enrichment	FGFR3	2.05
161	Hypogonadotropic hypogonadism 2 with or without anosmia	Enrichment	FGFR1	2.05
162	Larsen syndrome	Enrichment	FGFR3	2.05
163	Thyroid carcinoma, familial medullary	Enrichment	NTRK1	2.05
164	Leukoencephalopathy, hereditary diffuse, with spheroids 1	Enrichment	CSF1R	2.05
165	Barth syndrome	Enrichment	TAFAZZIN	2.05
166	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	2.05
167	Chromosome 8p11 myeloproliferative syndrome	Enrichment	FGFR1	2.05
168	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	2.05
169	Anus, imperforate	Enrichment	CTNNB1	2.05
170	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	2.05
171	Desmoid tumor	Enrichment	CTNNB1	2.05
172	Loeys-dietz syndrome 1	Enrichment	SMAD2	2.05
173	Hamartoma	Enrichment	FGFR3	2.05
174	Cellular ependymoma	Enrichment	NF2	2.05
175	Tanycytic ependymoma	Enrichment	NF2	2.05
176	Papillary ependymoma	Enrichment	NF2	2.05
177	Spermatocytoma	Enrichment	FGFR3	2.05
178	Growth delay due to insulin-like growth factor i resistance	Enrichment	IGF1R	2.05
179	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	2.05
180	Spindle cell sarcoma	Enrichment	NF2	2.05
181	Mixed phenotype acute leukemia with t	Enrichment	FLT3	2.05
182	Clear cell ependymoma	Enrichment	NF2	2.05
183	Renal cell carcinoma	Enrichment	MET	2.05
184	Testicular cancer	Enrichment	FGFR3	2.05
185	Glaucoma 3, primary infantile, b	Enrichment	TEK	1.93
186	Focal cortical dysplasia, type ii	Enrichment	MTOR	1.93
187	Pilomatrixoma	Enrichment	CTNNB1	1.93
188	Alazami syndrome	Enrichment	CTNNB1	1.93
189	Chronic myelomonocytic leukemia	Enrichment	FLT3	1.93
190	Craniopharyngioma	Enrichment	CTNNB1	1.93
191	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42	1.93
192	Non-syndromic bicoronal craniosynostosis	Enrichment	FGFR3	1.93
193	Full schwannomatosis	Enrichment	NF2	1.93
194	Systemic mastocytosis with associated hematologic neoplasm	Enrichment	KIT	1.93
195	Isolated focal cortical dysplasia type ii	Enrichment	MTOR	1.93
196	Glioma	Enrichment	FGFR2	1.93
197	Benign ependymoma	Enrichment	NF2	1.93
198	Primary ovarian insufficiency	Enrichment	KDR, NTRK1	1.88
199	Cataract 6, multiple types	Enrichment	EPHA2	1.83
200	Exudative vitreoretinopathy 1	Enrichment	CTNNB1	1.83
201	Insulin-like growth factor i	Enrichment	IGF1R	1.83
202	Cholangitis, primary sclerosing	Enrichment	MST1	1.83
203	Pre-eclampsia	Enrichment	FLT1	1.83
204	Holoprosencephaly	Enrichment	FGFR1	1.83
205	Hemimegalencephaly	Enrichment	MTOR	1.83
206	Aniridia	Enrichment	EPHA2	1.83
207	Mantle cell lymphoma	Enrichment	CCND1	1.83
208	Cowden syndrome 1	Enrichment	EGFR	1.76
209	Weyers acrofacial dysostosis	Enrichment	CTNNB1	1.76
210	Hemihyperplasia, isolated	Enrichment	RHOA	1.76
211	Holoprosencephaly 1	Enrichment	FGFR1	1.76
212	Adrenocortical carcinoma	Enrichment	CTNNB1	1.76
213	Von hippel-lindau syndrome	Enrichment	CCND1	1.73
214	Nevus, epidermal	Enrichment	FGFR3	1.69
215	Glaucoma 3, primary congenital, a	Enrichment	TEK	1.69
216	Squamous cell carcinoma, head and neck	Enrichment	EGFR	1.69
217	Neuropathy, hereditary sensory and autonomic, type v	Enrichment	NTRK1	1.69
218	Gallbladder cancer	Enrichment	CTNNB1	1.69
219	Overgrowth syndrome	Enrichment	MTOR	1.69
220	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	FLT3	1.69
221	Arthrogryposis, distal, type 1a	Enrichment	MET	1.63
222	Basal ganglia calcification, idiopathic, 1	Enrichment	PDGFRB	1.63
223	Exudative vitreoretinopathy	Enrichment	CTNNB1	1.63
224	Early-onset posterior polar cataract	Enrichment	EPHA2	1.63
225	Loeys-dietz syndrome	Enrichment	SMAD2	1.58
226	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.58
227	Arteriovenous malformation	Enrichment	TEK	1.58
228	Atypical chronic myeloid leukemia, bcr-abl1 negative	Enrichment	FLT3	1.58
229	Adult hepatocellular carcinoma	Enrichment	CTNNB1	1.58
230	Hypogonadotropic hypogonadism	Enrichment	FGFR1	1.58
231	Ventricular septal defect	Enrichment	TEK	1.58
232	Meier-gorlin syndrome 1	Enrichment	FGFR2	1.54
233	Myopathy, x-linked, with excessive autophagy	Enrichment	TEK	1.54
234	Primary bone dysplasia	Enrichment	FGFR3	1.54
235	Neuroblastoma	Enrichment	LIN28B	1.53
236	Frontotemporal dementia 1	Enrichment	CSF1R	1.50
237	Meningioma, familial	Enrichment	NF2	1.50
238	Leukemia, acute lymphoblastic	Enrichment	FLT3	1.50
239	Osteochondrodysplasia	Enrichment	FGFR3	1.50
240	Lung non-small cell carcinoma	Enrichment	EGFR	1.50
241	Septooptic dysplasia	Enrichment	FGFR1	1.46
242	Renal hypodysplasia/aplasia 3	Enrichment	FGFR3	1.46
243	Meningioma	Enrichment	NF2	1.46
244	Leukemia, chronic lymphocytic	Enrichment	CCND1	1.43
245	Alzheimer's disease	Enrichment	CSF1R	1.42
246	Nk-cell enteropathy	Enrichment	IGF1R	1.42
247	Congenital nervous system abnormality	Enrichment	CTNNB1, FGFR3	1.41
248	Nervous system disease	Enrichment	CTNNB1, FGFR3	1.41
249	Hypogonadotropic hypogonadism 7 with or without anosmia	Enrichment	FGFR1	1.39
250	Medulloblastoma	Enrichment	CTNNB1	1.39
251	Lung cancer susceptibility 3	Enrichment	EGFR	1.39
252	Cataract	Enrichment	EPHA2	1.39
253	Cleft lip/palate	Enrichment	PDGFRA	1.39
254	Rare genetic intellectual disability	Enrichment	MTOR	1.36
255	Microform holoprosencephaly	Enrichment	FGFR1	1.34
256	Lobar holoprosencephaly	Enrichment	FGFR1	1.34
257	Alzheimer disease, familial, 1	Enrichment	CSF1R	1.31
258	Cataract 44	Enrichment	EPHA2	1.31
259	Polycystic liver disease	Enrichment	CTNNB1	1.31
260	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1	1.31
261	Microcephaly	Enrichment	CTNNB1, IGF1R	1.29
262	Semilobar holoprosencephaly	Enrichment	FGFR1	1.29
263	Normosmic congenital hypogonadotropic hypogonadism	Enrichment	FGFR1	1.29
264	Early-onset nuclear cataract	Enrichment	EPHA2	1.29
265	Arteriovenous malformations of the brain	Enrichment	EGFR	1.26
266	Endometrial cancer	Enrichment	FGFR2	1.22
267	Tooth agenesis	Enrichment	FGFR1	1.20
268	Kallmann syndrome	Enrichment	FGFR1	1.18
269	Precursor t-cell acute lymphoblastic leukemia	Enrichment	FLT3	1.18
270	Hydrops fetalis, nonimmune	Enrichment	FLT4	1.13
271	Differentiated thyroid carcinoma	Enrichment	NTRK1	1.09
272	Noonan syndrome 1	Enrichment	PPP1CB	1.08
273	Non-immune hydrops fetalis	Enrichment	FLT4	1.06
274	Connective tissue disease	Enrichment	FGFR3	1.04
275	Rasopathy	Enrichment	PPP1CB	1.03
276	Left ventricular noncompaction	Enrichment	TAFAZZIN	1.01
277	Cerebral palsy	Enrichment	PDGFRB	0.96
278	Gastric cancer	Enrichment	FGFR2	0.92
279	West syndrome	Enrichment	NTRK2	0.91
280	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	SMAD2	0.91
281	Hypertelorism	Enrichment	FGFR2	0.85
282	Familial isolated dilated cardiomyopathy	Enrichment	TAFAZZIN	0.84
283	Undetermined early-onset epileptic encephalopathy	Enrichment	NTRK2	0.82
284	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	CSF1R	0.80
285	Autism	Enrichment	TCF7L2	0.72
286	Dilated cardiomyopathy	Enrichment	TAFAZZIN	0.68
287	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	MET	0.63
288	Leber plus disease	Enrichment	TEAD3	0.61
289	Primary ciliary dyskinesia	Enrichment	PRKAR1B	0.60
290	Complex neurodevelopmental disorder	Enrichment	TCF7L2	0.51
291	Hereditary retinal dystrophy	Enrichment	TEAD3	0.24
292	Fundus dystrophy	Enrichment	TEAD3	0.24

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Hippo-Merlin signaling dysregulation

Pathway Network for Hippo-Merlin signaling dysregulation

Member Pathways for Hippo-Merlin signaling dysregulation

Pathways in the Hippo-Merlin signaling dysregulation SuperPath

Associated Genes for Hippo-Merlin signaling dysregulation

Associated Disorders for Hippo-Merlin signaling dysregulation

Disorders associated with Hippo-Merlin signaling dysregulation SuperPath

STRING Interaction Network for Hippo-Merlin signaling dysregulation

Sources for Hippo-Merlin signaling dysregulation