histidine degradation

Sources:

#	Name	Source	Genes
1	histidine degradation	PubChem	AMDHD1 FTCD HAL MTHFD1 UROC1
2	Histidine catabolism	Reactome	AMDHD1 CARNMT1 CARNS1 FTCD HAL HDC HNMT UROC1 (see all 8) (see less)
3	L-histidine degradation III	PubChem	HAL MTHFD1
4	histamine biosynthesis	PubChem	HDC
5	formate assimilation into 5,10-methylenetetrahydrofolate	PubChem	MTHFD1
6	L-histidine degradation VI	PubChem	HAL

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	HAL	Histidine Ammonia-Lyase	Protein Coding	4
2	MTHFD1	Methylenetetrahydrofolate Dehydrogenase, Cyclohydrolase And Formyltetrahydrofolate Synthetase 1	Protein Coding	3
3	UROC1	Urocanate Hydratase 1	Protein Coding	2
4	AMDHD1	Amidohydrolase Domain Containing 1	Protein Coding	2
5	FTCD	Formimidoyltransferase Cyclodeaminase	Protein Coding	2
6	HDC	Histidine Decarboxylase	Protein Coding	2
7	CARNMT1	Carnosine N-Methyltransferase 1	Protein Coding	1
8	HNMT	Histamine N-Methyltransferase	Protein Coding	1
9	CARNS1	Carnosine Synthase 1	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Histidinemia	Enrichment	HAL	4.13
2	Gilles de la tourette syndrome	Enrichment	HDC	3.83
3	Combined immunodeficiency and megaloblastic anemia with or without hyperhomocysteinemia	Enrichment	MTHFD1	3.83
4	Neural tube defects, folate-sensitive	Enrichment	MTHFD1	3.53
5	Urocanase deficiency	Enrichment	UROC1	3.43
6	Intellectual developmental disorder, autosomal recessive 51	Enrichment	HNMT	3.23
7	Glutamate formiminotransferase deficiency	Enrichment	FTCD	3.13
8	Severe combined immunodeficiency	Enrichment	MTHFD1	2.61
9	Asthma	Enrichment	HNMT	2.19
10	Autosomal recessive non-syndromic intellectual disability	Enrichment	HNMT	1.47

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for histidine degradation